Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| SOLENO THERAPEUTICS INC | 93,002 | 284,152 | +191,150 | 6,645 | 23,806 | 14.80% | +17,161 |
| AMGEN INC(AMGN) | 0 | 52,100 | +52,100 | 0 | 14,547 | 9.04% | +14,547 |
| SPDR SERIES TRUST(Call) ST STR SP BIOT | 0 | 100,000 | +100,000 | 0 | 8,293 | — | +8,293 |
| REVOLUTION MEDICINES INC(RVMD)(Call) | 0 | 200,000 | +200,000 | 0 | 7,358 | — | +7,358 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 52,877 | 192,877 | +140,000 | 3,738 | 10,602 | 6.59% | +6,865 |
| TG THERAPEUTICS INC(TGTX) | 207,883 | 371,448 | +163,565 | 8,197 | 13,368 | 8.31% | +5,172 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 62,247 | 94,042 | +31,795 | 6,885 | 11,820 | 7.35% | +4,936 |
| ARS PHARMACEUTICALS INC(Call) | 0 | 280,700 | +280,700 | 0 | 4,898 | — | +4,898 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 0 | 10,000 | +10,000 | 0 | 4,452 | 2.77% | +4,452 |
| PROTAGONIST THERAPEUTICS INC | 0 | 76,185 | +76,185 | 0 | 4,211 | 2.62% | +4,211 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE)(Call) | 117,000 | 217,000 | +100,000 | 4,237 | 7,890 | — | +3,654 |
| GILEAD SCIENCES INC(GILD) | 0 | 30,000 | +30,000 | 0 | 3,326 | 2.07% | +3,326 |
| VAXCYTE INC(PCVX) | 92,385 | 198,285 | +105,900 | 3,488 | 6,446 | 4.01% | +2,958 |
| REVOLUTION MEDICINES INC(RVMD) | 0 | 79,079 | +79,079 | 0 | 2,909 | 1.81% | +2,909 |
| ALTIMMUNE INC(Call) | 418,800 | 1,262,900 | +844,100 | 2,094 | 4,887 | — | +2,793 |
| VIKING THERAPEUTICS INC(VKTX) | 104,121 | 197,468 | +93,347 | 2,515 | 5,233 | 3.25% | +2,718 |
| MEREO BIOPHARMA GROUP PLC(Call) | 515,200 | 1,317,600 | +802,400 | 1,159 | 3,571 | — | +2,411 |
| APOGEE THERAPEUTICS INC(APGE)(Call) | 126,300 | 156,300 | +30,000 | 4,719 | 6,788 | — | +2,070 |
| ITEOS THERAPEUTICS INC | 0 | 206,200 | +206,200 | 0 | 2,056 | 1.28% | +2,056 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 0 | 53,985 | +53,985 | 0 | 1,963 | 1.22% | +1,963 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX)(Put) | 0 | 41,300 | +41,300 | 0 | 1,949 | — | +1,949 |
| ACADIA PHARMACEUTICALS INC(Call) | 0 | 88,900 | +88,900 | 0 | 1,918 | — | +1,918 |
| SCPHARMACEUTICALS INC(Call) | 0 | 486,500 | +486,500 | 0 | 1,854 | — | +1,854 |
| CRISPR THERAPEUTICS AG(CRSP)(Call) | 0 | 112,000 | +112,000 | 0 | 5,448 | — | +5,448 |
| MERCK & CO INC(MRK) | 0 | 20,000 | +20,000 | 0 | 1,583 | 0.98% | +1,583 |
| REVIVA PHARMACEUTCLS HLDGS I(Call) | 0 | 4,000,000 | +4,000,000 | 0 | 1,524 | — | +1,524 |
| BIOHAVEN LTD(BHVN)(Call) | 0 | 100,000 | +100,000 | 0 | 1,411 | — | +1,411 |
| MODERNA INC(MRNA)(Call) | 52,100 | 102,100 | +50,000 | 1,477 | 2,817 | — | +1,340 |
| UROGEN PHARMA LTD(URGN) | 76,220 | 150,000 | +73,780 | 843 | 2,055 | 1.28% | +1,212 |
| BRIDGEBIO PHARMA INC(BBIO)(Call) | 131,400 | 131,400 | 0 | 4,542 | 5,674 | — | +1,131 |
| SUMMIT THERAPEUTICS INC(SMMT)(Call) | 24,700 | 74,700 | +50,000 | 476 | 1,590 | — | +1,113 |
| AMGEN INC(AMGN)(Put) | 52,100 | 62,100 | +10,000 | 16,232 | 17,339 | — | +1,107 |
| SUMMIT THERAPEUTICS INC(SMMT)(Put) | 0 | 50,000 | +50,000 | 0 | 1,064 | — | +1,064 |
| CAPRICOR THERAPEUTICS INC(CAPR)(Put) | 0 | 106,600 | +106,600 | 0 | 1,059 | — | +1,059 |
| MIND MEDICINE MINDMED INC | 0 | 158,536 | +158,536 | 0 | 1,029 | 0.64% | +1,029 |
| BIOMEA FUSION INC(Call) | 0 | 568,900 | +568,900 | 0 | 1,024 | — | +1,024 |
| TANGO THERAPEUTICS INC(TNGX)(Call) | 0 | 200,000 | +200,000 | 0 | 1,024 | — | +1,024 |
| SELLAS LIFE SCIENCES GROUP I(SLS)(Call) | 0 | 400,000 | +400,000 | 0 | 876 | — | +876 |
| SCPHARMACEUTICALS INC | 0 | 217,623 | +217,623 | 0 | 829 | 0.52% | +829 |
| TERNS PHARMACEUTICALS INC | 0 | 259,852 | +259,852 | 0 | 969 | 0.60% | +969 |
| ARVINAS INC | 0 | 96,455 | +96,455 | 0 | 710 | 0.44% | +710 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 100,000 | 253,657 | +153,657 | 376 | 1,081 | 0.67% | +705 |
| ALTIMMUNE INC(Put) | 0 | 171,400 | +171,400 | 0 | 663 | — | +663 |
| PROTHENA CORP PLC(Call) SHS | 0 | 100,000 | +100,000 | 0 | 607 | — | +607 |
| TERNS PHARMACEUTICALS INC(Call) | 0 | 160,900 | +160,900 | 0 | 600 | — | +600 |
| AGIOS PHARMACEUTICALS INC(AGIO)(Call) | 119,700 | 122,100 | +2,400 | 3,507 | 4,061 | — | +554 |
| ATYR PHARMA INC(Call) | 54,700 | 128,700 | +74,000 | 165 | 653 | — | +487 |
| COGENT BIOSCIENCES INC(COGT) | 392,213 | 392,213 | 0 | 2,349 | 2,816 | 1.75% | +467 |
| PACIRA BIOSCIENCES INC(PCRX) | 38,926 | 58,926 | +20,000 | 967 | 1,408 | 0.88% | +441 |
| REVIVA PHARMACEUTCLS HLDGS I | 650,723 | 2,735,457 | +2,084,734 | 621 | 1,042 | 0.65% | +422 |
| IMMUNOCORE HLDGS PLC(IMCR) | 96,984 | 104,384 | +7,400 | 2,878 | 3,276 | 2.04% | +398 |
| PHATHOM PHARMACEUTICALS INC(PHAT) | 0 | 40,294 | +40,294 | 0 | 386 | 0.24% | +386 |
| NUVALENT INC(NUVL) | 0 | 5,000 | +5,000 | 0 | 382 | 0.24% | +382 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 0 | 62,926 | +62,926 | 0 | 2,229 | 1.39% | +2,229 |
| ATYR PHARMA INC(Put) | 11,800 | 76,200 | +64,400 | 36 | 386 | — | +351 |
| OCULAR THERAPEUTIX INC(OCUL)(Call) | 136,700 | 136,700 | 0 | 1,002 | 1,269 | — | +267 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 87,189 | 104,473 | +17,284 | 10,825 | 11,087 | 6.89% | +262 |
| COGENT BIOSCIENCES INC(COGT)(Put) | 201,400 | 201,400 | 0 | 1,206 | 1,446 | — | +240 |
| ELEVATION ONCOLOGY INC | 0 | 362,935 | +362,935 | 0 | 133 | 0.08% | +133 |
| PURETECH HEALTH PLC | 0 | 7,324 | +7,324 | 0 | 126 | 0.08% | +126 |
| ZYMEWORKS INC(ZYME)(Call) | 179,300 | 179,300 | 0 | 2,135 | 2,250 | — | +115 |
| GOSSAMER BIO INC(Call) | 824,800 | 824,800 | 0 | 907 | 1,015 | — | +107 |
| NEKTAR THERAPEUTICS(NKTR)(Call) | 0 | 47,474 | +47,474 | 0 | 86 | — | +86 |
| CLIMB BIO INC | 669,803 | 702,135 | +32,332 | 817 | 871 | 0.54% | +53 |
| COGENT BIOSCIENCES INC(COGT)(Call) | 0 | 6,900 | +6,900 | 0 | 50 | — | +50 |
| PROQR THRAPEUTICS N V SHS EURO | 0 | 157,694 | +157,694 | 0 | 322 | 0.20% | +322 |
| SUMMIT THERAPEUTICS INC(SMMT) | 0 | 932 | +932 | 0 | 20 | 0.01% | +20 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE)(Put) | 123,300 | 123,300 | 0 | 4,465 | 4,483 | — | +18 |
| MEREO BIOPHARMA GROUP PLC(Put) | 39,400 | 39,400 | 0 | 89 | 107 | — | +18 |
| ZAI LAB LTD(ZLAB) | 0 | 3,785 | +3,785 | 0 | 13 | 0.01% | +13 |
| CARDIFF ONCOLOGY INC(Call) | 208,100 | 208,100 | 0 | 653 | 656 | — | +2 |
| VISTAGEN THERAPEUTICS INC(Call) | 200 | 200 | 0 | 1 | 0 | — | -0 |
| JAZZ PHARMACEUTICALS PLC(JAZZ)(Put) | 100 | 0 | -100 | 12 | 0 | — | -12 |
| CASSAVA SCIENCES INC(Put) | 0 | 0 | 0 | 0 | 0 | — | 0 |
| ELEDON PHARMACEUTICALS INC | 64,613 | 64,613 | 0 | 219 | 175 | 0.11% | -44 |
| MODERNA INC(MRNA)(Put) | 100,000 | 100,000 | 0 | 2,835 | 2,759 | — | -76 |
| TREVI THERAPEUTICS INC(TRVI) | 180,000 | 185,830 | +5,830 | 1,132 | 1,016 | 0.63% | -116 |
| CANDEL THERAPEUTICS INC | 25,045 | 0 | -25,045 | 142 | 0 | — | -142 |
| SAGIMET BIOSCIENCES INC | 46,019 | 0 | -46,019 | 150 | 0 | — | -150 |
| RECURSION PHARMACEUTICALS IN(RXRX)(Call) | 698,400 | 698,400 | 0 | 3,695 | 3,534 | — | -161 |
| MEREO BIOPHARMA GROUP PLC | 492,215 | 0 | -492,215 | 169 | 0 | — | -169 |
| UNIQURE NV(QURE)(Call) | 0 | 104,100 | +104,100 | 0 | 1,451 | — | +1,451 |
| ALECTOR INC | 456,546 | 266,023 | -190,523 | 562 | 372 | 0.23% | -189 |
| UNITY BIOTECHNOLOGY INC(Put) | 215,200 | 0 | -215,200 | 224 | 0 | — | -224 |
| CAPRICOR THERAPEUTICS INC(CAPR)(Call) | 0 | 0 | 0 | 0 | 0 | — | 0 |
| GOSSAMER BIO INC | 269,589 | 0 | -269,589 | 297 | 0 | — | -297 |
| AMICUS THERAPEUTICS INC(Call) COM | 131,400 | 131,400 | 0 | 1,072 | 753 | — | -319 |
| RELAY THERAPEUTICS INC(RLAY)(Call) | 131,400 | 0 | -131,400 | 344 | 0 | — | -344 |
| IMMUNIC INC(Call) | 317,800 | 0 | -317,800 | 346 | 0 | — | -346 |
| UNITY BIOTECHNOLOGY INC(Call) | 346,900 | 0 | -346,900 | 361 | 0 | — | -361 |
| BIOMEA FUSION INC(Put) | 170,100 | 0 | -170,100 | 362 | 0 | — | -362 |
| COMPASS THERAPEUTICS INC(Call) | 200,000 | 0 | -200,000 | 380 | 0 | — | -380 |
| UNIQURE NV(QURE) | 36,500 | 0 | -36,500 | 387 | 0 | — | -387 |
| REPLIMUNE GROUP INC(REPL) | 0 | 32,483 | +32,483 | 0 | 302 | 0.19% | +302 |
| CASSAVA SCIENCES INC(Call) | 300,000 | 0 | -300,000 | 450 | 0 | — | -450 |
| NEKTAR THERAPEUTICS(NKTR)(Call) | 678,200 | 0 | -678,200 | 461 | 0 | — | -461 |
| ELI LILLY & CO(LLY)(Call) | 10,000 | 10,000 | 0 | 8,259 | 7,795 | — | -464 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 162,063 | 122,061 | -40,002 | 2,185 | 1,706 | 1.06% | -478 |
| VERVE THERAPEUTICS INC(Call) | 116,900 | 0 | -116,900 | 534 | 0 | — | -534 |
| EVOLUS INC(Put) | 50,000 | 0 | -50,000 | 602 | 0 | — | -601 |