Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| JOHNSON & JOHNSON(JNJ) | 0 | 66,444 | +66,444 | 0 | 13,751 | 8.19% | +13,751 |
| TERNS PHARMACEUTICALS INC | 323,159 | 345,880 | +22,721 | 2,427 | 13,974 | 8.32% | +11,547 |
| VIKING THERAPEUTICS INC(VKTX) | 193,689 | 336,849 | +143,160 | 5,090 | 11,850 | 7.06% | +6,760 |
| ABIVAX SA(ABVX) | 41,620 | 75,644 | +34,024 | 3,513 | 10,201 | 6.08% | +6,688 |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 70,000 | +70,000 | 0 | 5,354 | 3.19% | +5,354 |
| UNITED THERAPEUTICS CORP DEL(UTHR) | 0 | 10,000 | +10,000 | 0 | 4,873 | 2.90% | +4,873 |
| CAPRICOR THERAPEUTICS INC(CAPR) | 0 | 158,075 | +158,075 | 0 | 4,562 | 2.72% | +4,562 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 0 | 10,000 | +10,000 | 0 | 4,534 | 2.70% | +4,534 |
| BIOAGE LABS INC(BIOA) | 0 | 271,164 | +271,164 | 0 | 3,588 | 2.14% | +3,588 |
| CORCEPT THERAPEUTICS INC(CORT) | 0 | 97,445 | +97,445 | 0 | 3,391 | 2.02% | +3,391 |
| COGENT BIOSCIENCES INC(COGT) | 97,813 | 131,852 | +34,039 | 1,405 | 4,683 | 2.79% | +3,279 |
| TENAX THERAPEUTICS INC(TENX) | 0 | 243,170 | +243,170 | 0 | 2,964 | 1.77% | +2,964 |
| IRONWOOD PHARMACEUTICALS INC(IRWD) | 0 | 683,611 | +683,611 | 0 | 2,304 | 1.37% | +2,304 |
| CENTESSA PHARMACEUTICALS PLC | 0 | 90,000 | +90,000 | 0 | 2,251 | 1.34% | +2,251 |
| REPLIMUNE GROUP INC(REPL) | 0 | 230,997 | +230,997 | 0 | 2,245 | 1.34% | +2,245 |
| ELI LILLY & CO(LLY) | 0 | 2,000 | +2,000 | 0 | 2,149 | 1.28% | +2,149 |
| LIPOCINE INC NEW(LPCN) | 0 | 260,939 | +260,939 | 0 | 2,095 | 1.25% | +2,095 |
| RELMADA THERAPEUTICS INC(RLMD) | 0 | 389,395 | +389,395 | 0 | 1,881 | 1.12% | +1,881 |
| ANNEXON INC(ANNX) | 0 | 350,000 | +350,000 | 0 | 1,757 | 1.05% | +1,757 |
| VENTYX BIOSCIENCES INC | 71,204 | 200,000 | +128,796 | 221 | 1,806 | 1.08% | +1,585 |
| INVENTIVA SA(IVA) | 0 | 334,251 | +334,251 | 0 | 1,554 | 0.93% | +1,554 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 0 | 190,928 | +190,928 | 0 | 1,489 | 0.89% | +1,489 |
| TG THERAPEUTICS INC(TGTX) | 60,748 | 123,283 | +62,535 | 2,195 | 3,675 | 2.19% | +1,481 |
| ANI PHARMACEUTICALS INC(ANIP) | 31,400 | 53,354 | +21,954 | 2,876 | 4,212 | 2.51% | +1,336 |
| RIGEL PHARMACEUTICALS INC(RIGL) | 0 | 30,000 | +30,000 | 0 | 1,285 | 0.77% | +1,285 |
| MAPLIGHT THERAPEUTICS INC(MPLT) | 0 | 63,791 | +63,791 | 0 | 1,120 | 0.67% | +1,120 |
| UNIQURE NV(QURE) | 0 | 45,000 | +45,000 | 0 | 1,077 | 0.64% | +1,077 |
| ENANTA PHARMACEUTICALS INC(ENTA) | 0 | 65,138 | +65,138 | 0 | 1,027 | 0.61% | +1,027 |
| PROTHENA CORP PLC SHS | 0 | 106,539 | +106,539 | 0 | 1,017 | 0.61% | +1,017 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 0 | 62,281 | +62,281 | 0 | 977 | 0.58% | +977 |
| DESIGN THERAPEUTICS INC(DSGN) | 0 | 100,320 | +100,320 | 0 | 941 | 0.56% | +941 |
| INOVIO PHARMACEUTICALS INC(INO) | 0 | 533,682 | +533,682 | 0 | 929 | 0.55% | +929 |
| MINERALYS THERAPEUTICS INC(MLYS) | 0 | 25,000 | +25,000 | 0 | 907 | 0.54% | +907 |
| LIQUIDIA CORPORATION(LQDA) | 0 | 21,881 | +21,881 | 0 | 755 | 0.45% | +755 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 0 | 30,000 | +30,000 | 0 | 744 | 0.44% | +744 |
| XERIS BIOPHARMA HOLDINGS INC | 74,753 | 170,568 | +95,815 | 608 | 1,339 | 0.80% | +730 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 0 | 21,114 | +21,114 | 0 | 657 | 0.39% | +657 |
| VIR BIOTECHNOLOGY INC(VIR) | 0 | 100,000 | +100,000 | 0 | 603 | 0.36% | +603 |
| MANNKIND CORP(MNKD) | 212,475 | 302,000 | +89,525 | 1,141 | 1,712 | 1.02% | +571 |
| LIGAND PHARMACEUTICALS INC(LGND) | 0 | 2,987 | +2,987 | 0 | 565 | 0.34% | +565 |
| UPSTREAM BIO INC(UPB) | 0 | 20,500 | +20,500 | 0 | 557 | 0.33% | +557 |
| STOKE THERAPEUTICS INC(STOK) | 0 | 17,181 | +17,181 | 0 | 545 | 0.32% | +545 |
| IMMUNOME INC(IMNM) | 0 | 22,500 | +22,500 | 0 | 483 | 0.29% | +483 |
| PELTHOS THERAPEUTICS INC(PTHS) | 10,498 | 25,000 | +14,502 | 294 | 775 | 0.46% | +481 |
| TREVI THERAPEUTICS INC(TRVI) | 85,830 | 97,184 | +11,354 | 785 | 1,217 | 0.72% | +431 |
| PALISADE BIO INC(PALI) | 0 | 166,049 | +166,049 | 0 | 390 | 0.23% | +390 |
| AYTU BIOPHARMA INC | 272,670 | 305,788 | +33,118 | 513 | 795 | 0.47% | +282 |
| AARDVARK THERAPEUTICS INC | 0 | 15,882 | +15,882 | 0 | 208 | 0.12% | +208 |
| REVOLUTION MEDICINES INC(RVMD) | 59,079 | 37,020 | -22,059 | 2,759 | 2,949 | 1.76% | +190 |
| PLIANT THERAPEUTICS INC(PLRX) | 0 | 144,914 | +144,914 | 0 | 177 | 0.11% | +177 |
| BEONE MEDICINES LTD(ONC) | 0 | 7,500 | +7,500 | 0 | 173 | 0.10% | +173 |
| TALPHERA INC(TLPH) | 0 | 136,923 | +136,923 | 0 | 156 | 0.09% | +156 |
| EQUILLIUM INC(EQ) | 300,000 | 347,393 | +47,393 | 429 | 538 | 0.32% | +109 |
| INHIBRX BIOSCIENCES INC(INBX) | 0 | 1,299 | +1,299 | 0 | 103 | 0.06% | +103 |
| EDESA BIOTECH INC(EDSA) | 0 | 54,025 | +54,025 | 0 | 77 | 0.05% | +77 |
| PROQR THRAPEUTICS N V SHS EURO | 157,694 | 167,532 | +9,838 | 336 | 338 | 0.20% | +3 |
| PURETECH HEALTH PLC(PRTCY) | 7,324 | 7,442 | +118 | 135 | 124 | 0.07% | -12 |
| PMV PHARMACEUTICALS INC(PMVP) | 11,300 | 0 | -11,300 | 16 | 0 | — | -16 |
| NEUPHORIA THERAPEUTICS INC | 21,452 | 50,000 | +28,548 | 253 | 194 | 0.12% | -59 |
| FOGHORN THERAPEUTICS INC(FHTX) | 50,000 | 30,630 | -19,370 | 245 | 165 | 0.10% | -79 |
| TVARDI THERAPEUTICS INC(TVRD) | 2,185 | 0 | -2,185 | 85 | 0 | — | -85 |
| ANAPTYSBIO INC | 3,295 | 0 | -3,295 | 101 | 0 | — | -101 |
| RELAY THERAPEUTICS INC(RLAY) | 43,616 | 0 | -43,616 | 228 | 0 | — | -228 |
| OVID THERAPEUTICS INC(OVID) | 187,739 | 0 | -187,739 | 244 | 0 | — | -244 |
| CLIMB BIO INC(CLYM) | 136,488 | 0 | -136,488 | 274 | 0 | — | -274 |
| PACIRA BIOSCIENCES INC(PCRX) | 58,926 | 48,025 | -10,901 | 1,519 | 1,243 | 0.74% | -276 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 9,189 | 0 | -9,189 | 276 | 0 | — | -276 |
| PYXIS ONCOLOGY INC(PYXS) | 150,000 | 0 | -150,000 | 333 | 0 | — | -333 |
| ALECTOR INC | 136,023 | 0 | -136,023 | 403 | 0 | — | -403 |
| TENAYA THERAPEUTICS INC(TNYA) | 315,519 | 0 | -315,519 | 511 | 0 | — | -511 |
| MODERNA INC(MRNA) | 20,000 | 0 | -20,000 | 517 | 0 | — | -517 |
| CYTOMX THERAPEUTICS INC(CTMX) | 185,286 | 0 | -185,286 | 591 | 0 | — | -591 |
| ARDELYX INC | 400,000 | 252,198 | -147,802 | 2,204 | 1,470 | 0.88% | -734 |
| ARCTURUS THERAPEUTICS HLDGS(ARCT) | 48,811 | 0 | -48,811 | 900 | 0 | — | -900 |
| REVIVA PHARMACEUTCLS HLDGS I | 2,506,921 | 0 | -2,506,921 | 924 | 0 | — | -924 |
| CATALYST PHARMACEUTICALS INC | 50,000 | 0 | -50,000 | 985 | 0 | — | -985 |
| SUPERNUS PHARMACEUTICALS INC(SUPN) | 22,348 | 0 | -22,348 | 1,068 | 0 | — | -1,068 |
| HARMONY BIOSCIENCES HLDGS IN(HRMY) | 50,000 | 7,500 | -42,500 | 1,378 | 281 | 0.17% | -1,097 |
| VISTAGEN THERAPEUTICS INC(VTGN) | 349,789 | 100,000 | -249,789 | 1,242 | 66 | 0.04% | -1,176 |
| MIND MEDICINE MINDMED INC | 105,891 | 0 | -105,891 | 1,248 | 0 | — | -1,248 |
| UROGEN PHARMA LTD(URGN) | 90,000 | 21,810 | -68,190 | 1,796 | 511 | 0.30% | -1,285 |
| AVIDITY BIOSCIENCES INC | 30,000 | 0 | -30,000 | 1,307 | 0 | — | -1,307 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 100,000 | 0 | -100,000 | 1,359 | 0 | — | -1,359 |
| NOVO-NORDISK A S(NVO) | 25,000 | 0 | -25,000 | 1,387 | 0 | — | -1,387 |
| PROTAGONIST THERAPEUTICS INC | 51,185 | 22,700 | -28,485 | 3,400 | 1,983 | 1.18% | -1,418 |
| ROIVANT SCIENCES LTD(ROIV) | 120,000 | 0 | -120,000 | 1,816 | 0 | — | -1,816 |
| IMMUNOCORE HLDGS PLC(IMCR) | 124,384 | 70,300 | -54,084 | 4,519 | 2,440 | 1.45% | -2,079 |
| ALKERMES PLC(ALKS) | 72,079 | 0 | -72,079 | 2,162 | 0 | — | -2,162 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 10,000 | 5,341 | -4,659 | 4,560 | 2,124 | 1.26% | -2,436 |
| APOGEE THERAPEUTICS INC(APGE) | 64,250 | 0 | -64,250 | 2,553 | 0 | — | -2,553 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 212,877 | 146,361 | -66,516 | 11,529 | 8,698 | 5.18% | -2,831 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 23,140 | 0 | -23,140 | 3,050 | 0 | — | -3,050 |
| ASCENDIS PHARMA A/S(ASND) | 27,572 | 6,840 | -20,732 | 5,482 | 1,459 | 0.87% | -4,023 |
| NEKTAR THERAPEUTICS(NKTR) | 75,000 | 0 | -75,000 | 4,268 | 0 | — | -4,267 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 37,754 | 0 | -37,754 | 5,300 | 0 | — | -5,300 |
| INDIVIOR PLC | 254,252 | 17,320 | -236,932 | 6,130 | 621 | 0.37% | -5,509 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 130,000 | 0 | -130,000 | 5,863 | 0 | — | -5,863 |
| VAXCYTE INC(PCVX) | 218,285 | 22,972 | -195,313 | 7,863 | 1,060 | 0.63% | -6,803 |
| REGENERON PHARMACEUTICALS(REGN) | 30,160 | 10,300 | -19,860 | 16,958 | 7,950 | 4.73% | -9,008 |
| SOLENO THERAPEUTICS INC | 177,330 | 26,892 | -150,438 | 11,988 | 1,245 | 0.74% | -10,742 |