| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 650,000 | 3,168,456 | +2,518,456 | 1.23 | 4.23 | +3.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,928,788 | 3,484,046 | +555,258 | 0.06 | 0.06 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 54,230 | 561,592 | +507,362 | 0.01 | 0.11 | +0.10 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 439,474 | 718,814 | +279,340 | 0.12 | 0.17 | +0.05 | buy |
| Aquatic Capital Management LLC | 11,300 | 191,900 | +180,600 | 0.00 | 0.10 | +0.09 | buy |
| Schonfeld Strategic Advisors LLC | 337,149 | 491,098 | +153,949 | 0.05 | 0.06 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 404,162 | 524,861 | +120,699 | 0.03 | 0.04 | +0.00 | buy |
| Opaleye Management Inc. | 2,215,000 | 2,280,000 | +65,000 | 10.06 | 7.56 | -2.50 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 49,179 | 76,616 | +27,437 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 203,300 | 230,300 | +27,000 | 3.43 | 3.00 | -0.43 | buy |
| Hennion & Walsh Asset Management, Inc. | 158,054 | 184,815 | +26,761 | 0.15 | 0.15 | -0.00 | buy |
| Entropy Technologies, LP | 28,936 | 53,969 | +25,033 | 0.09 | 0.09 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 27,663 | 50,724 | +23,061 | 0.12 | 0.17 | +0.05 | buy |
| Dana Investment Advisors, Inc. | 20,754 | 37,895 | +17,141 | 0.02 | 0.02 | +0.00 | buy |
| Quantum Private Wealth, LLC | 91,081 | 103,604 | +12,523 | 0.65 | 0.58 | -0.07 | buy |
| DAYMARK WEALTH PARTNERS, LLC | 13,500 | 23,500 | +10,000 | 0.01 | 0.02 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 48,800 | 55,600 | +6,800 | 0.07 | 0.06 | -0.01 | buy |
| FIL Ltd | 43,226 | 46,500 | +3,274 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH EFFECTS LLC | 14,000 | 16,500 | +2,500 | 0.09 | 0.09 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 839,200 | 840,600 | +1,400 | 0.02 | 0.02 | -0.00 | buy |
| Prospera Financial Services Inc | 38,340 | 39,090 | +750 | 0.02 | 0.02 | -0.00 | buy |
| J.W. COLE ADVISORS, INC. | 18,659 | 19,359 | +700 | 0.02 | 0.01 | -0.00 | buy |
| AVAII WEALTH MANAGEMENT, LLC | 29,283 | 29,891 | +608 | 0.33 | 0.27 | -0.06 | buy |
| Clear Creek Financial Management, LLC | 19,350 | 19,850 | +500 | 0.05 | 0.04 | -0.01 | buy |
| Raleigh Capital Management Inc. | 1,428 | 1,728 | +300 | 0.01 | 0.01 | +0.00 | buy |
| LIBERTY ONE INVESTMENT MANAGEMENT, LLC | 1,122 | 1,051 | -71 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 7,897 | 7,592 | -305 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 5,143 | 4,815 | -328 | 0.06 | 0.04 | -0.02 | sell |
| CLARK FINANCIAL SERVICES GROUP INC /BD | 14,356 | 13,911 | -445 | 0.32 | 0.25 | -0.06 | sell |
| ALGERT GLOBAL LLC | 51,070 | 50,100 | -970 | 0.04 | 0.03 | -0.01 | sell |
| Newbridge Financial Services Group, Inc. | 4,812 | 3,662 | -1,150 | 0.04 | 0.02 | -0.02 | sell |
| E Fund Management Co., Ltd. | 30,553 | 25,826 | -4,727 | 0.03 | 0.02 | -0.01 | sell |
| PROFUND ADVISORS LLC | 93,489 | 85,796 | -7,693 | 0.07 | 0.05 | -0.02 | sell |
| Parkwood LLC | 24,347 | 16,071 | -8,276 | 0.22 | 0.78 | +0.55 | sell |
| North Star Investment Management Corp. | 30,400 | 18,900 | -11,500 | 0.04 | 0.02 | -0.02 | sell |
| Valeo Financial Advisors, LLC | 63,300 | 43,344 | -19,956 | 0.04 | 0.02 | -0.02 | sell |
| Rafferty Asset Management, LLC | 571,126 | 546,519 | -24,607 | 0.04 | 0.03 | -0.01 | sell |
| Gotham Asset Management, LLC | 96,250 | 71,576 | -24,674 | 0.03 | 0.02 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 160,000 | 123,500 | -36,500 | 0.27 | 0.18 | -0.09 | sell |
| 683 Capital Management, LLC | 1,675,000 | 1,625,000 | -50,000 | 2.34 | 1.81 | -0.53 | sell |
| Parkman Healthcare Partners LLC | 205,317 | 155,039 | -50,278 | 0.50 | 0.29 | -0.21 | sell |
| M28 Capital Management LP | 216,600 | 161,600 | -55,000 | 3.06 | 1.82 | -1.25 | sell |
| Pictet Asset Management Holding SA | 3,385,245 | 3,327,214 | -58,031 | 0.06 | 0.06 | -0.01 | sell |
| Bayesian Capital Management, LP | 116,067 | 44,267 | -71,800 | 0.21 | 0.06 | -0.15 | sell |
| JUPITER ASSET MANAGEMENT LTD | 154,837 | 46,577 | -108,260 | 0.03 | 0.01 | -0.02 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 346,204 | 232,347 | -113,857 | 0.03 | 0.02 | -0.01 | sell |
| TWINBEECH CAPITAL LP | 243,988 | 35,730 | -208,258 | 0.07 | 0.01 | -0.06 | sell |
| Woodline Partners LP | 1,768,434 | 1,404,597 | -363,837 | 0.33 | 0.20 | -0.13 | sell |
| GROUP ONE TRADING LLC | 996,842 | 608,282 | -388,560 | 0.75 | 0.41 | -0.34 | sell |