| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 13,670,944 | 13,536,832 | -134,112 | 0.01 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 8,253,573 | 7,796,579 | -456,994 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,928,788 | 3,484,046 | +555,258 | 0.05 | 0.04 | -0.00 | buy |
| Pictet Asset Management Holding SA | 3,385,245 | 3,327,214 | -58,031 | 0.06 | 0.06 | -0.01 | sell |
| Soleus Capital Management, L.P. | 650,000 | 3,168,456 | +2,518,456 | 1.23 | 4.23 | +3.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,139,764 | 3,153,593 | +13,829 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,096,646 | 3,107,444 | +10,798 | 0.01 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 2,215,000 | 2,280,000 | +65,000 | 10.06 | 7.56 | -2.50 | buy |
| BANK OF AMERICA CORP /DE/ | 583,088 | 2,201,450 | +1,618,362 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 1,984,962 | +1,984,962 | 0.00 | 1.78 | +1.78 | buy |
| CITADEL ADVISORS LLC | 464,462 | 1,878,333 | +1,413,871 | 0.01 | 0.03 | +0.02 | buy |
| 683 Capital Management, LLC | 1,675,000 | 1,625,000 | -50,000 | 2.86 | 2.52 | -0.34 | sell |
| Hood River Capital Management LLC | 0 | 1,474,037 | +1,474,037 | 0.00 | 0.50 | +0.50 | buy |
| Woodline Partners LP | 1,768,434 | 1,404,597 | -363,837 | 0.33 | 0.20 | -0.13 | sell |
| FMR LLC | 1,579,511 | 1,396,552 | -182,959 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,350,935 | 1,300,388 | -50,547 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,649,837 | 1,286,428 | -363,409 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,489,483 | 1,171,737 | -317,746 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,131,896 | 1,145,569 | +13,673 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,948,657 | 1,082,360 | -866,297 | 0.06 | 0.02 | -0.03 | sell |
| Vestal Point Capital, LP | 0 | 1,050,000 | +1,050,000 | 0.00 | 1.32 | +1.32 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 839,200 | 840,600 | +1,400 | 0.02 | 0.02 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 439,474 | 718,814 | +279,340 | 0.12 | 0.17 | +0.05 | buy |
| NORGES BANK | 1,075,037 | 711,690 | -363,347 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 72,733 | 683,013 | +610,280 | 0.02 | 0.12 | +0.10 | buy |
| GROUP ONE TRADING LLC | 996,842 | 608,282 | -388,560 | 0.54 | 0.33 | -0.21 | sell |
| Invesco Ltd. | 709,747 | 563,639 | -146,108 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 54,230 | 561,592 | +507,362 | 0.01 | 0.11 | +0.09 | buy |
| Rafferty Asset Management, LLC | 571,126 | 546,519 | -24,607 | 0.04 | 0.03 | -0.01 | sell |
| CITIGROUP INC | 365,344 | 528,569 | +163,225 | 0.01 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 404,162 | 524,861 | +120,699 | 0.03 | 0.04 | +0.00 | buy |
| UBS Group AG | 564,836 | 524,622 | -40,214 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 337,149 | 491,098 | +153,949 | 0.05 | 0.06 | +0.01 | buy |
| Bank of New York Mellon Corp | 473,663 | 444,122 | -29,541 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 266,768 | 364,675 | +97,907 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 282,600 | 284,100 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| Duquesne Family Office LLC | 0 | 280,000 | +280,000 | 0.00 | 0.11 | +0.11 | buy |
| Marex Group plc | 275,000 | 275,000 | 0 | 0.18 | 0.14 | -0.05 | hold |
| TWO SIGMA INVESTMENTS, LP | 154,800 | 263,878 | +109,078 | 0.01 | 0.01 | +0.00 | buy |
| GTS SECURITIES LLC | 410,771 | 243,511 | -167,260 | 0.15 | 0.10 | -0.05 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 346,204 | 232,347 | -113,857 | 0.03 | 0.02 | -0.01 | sell |
| Exome Asset Management LLC | 203,300 | 230,300 | +27,000 | 3.43 | 3.00 | -0.43 | buy |
| Susquehanna Portfolio Strategies, LLC | 228,304 | 228,304 | 0 | 0.07 | 0.08 | +0.01 | hold |
| JANE STREET GROUP, LLC | 594,925 | 224,262 | -370,663 | 0.01 | 0.00 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 155,237 | 224,224 | +68,987 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 193,478 | 199,473 | +5,995 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 11,300 | 191,900 | +180,600 | 0.00 | 0.10 | +0.09 | buy |
| SIMPLEX TRADING, LLC | 217,721 | 189,849 | -27,872 | 0.12 | 0.08 | -0.03 | sell |
| Hennion & Walsh Asset Management, Inc. | 158,054 | 184,815 | +26,761 | 0.15 | 0.15 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 184,510 | 184,634 | +124 | 0.01 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 38,567 | 168,562 | +129,995 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 167,220 | 167,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 161,927 | 161,927 | 0 | 0.00 | 0.00 | -0.00 | hold |
| M28 Capital Management LP | 216,600 | 161,600 | -55,000 | 3.06 | 1.82 | -1.25 | sell |
| BARCLAYS PLC | 428,013 | 156,380 | -271,633 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 205,317 | 155,039 | -50,278 | 0.50 | 0.29 | -0.21 | sell |
| TUDOR INVESTMENT CORP ET AL | 41,835 | 154,496 | +112,661 | 0.01 | 0.03 | +0.02 | buy |
| Legal & General Group Plc | 147,098 | 149,256 | +2,158 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 150,578 | 143,321 | -7,257 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 126,818 | 130,418 | +3,600 | 0.00 | 0.00 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 160,000 | 123,500 | -36,500 | 0.27 | 0.18 | -0.09 | sell |
| FRANKLIN RESOURCES INC | 64,926 | 117,017 | +52,091 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 92,568 | 114,502 | +21,934 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 107,363 | +107,363 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 91,081 | 103,604 | +12,523 | 0.65 | 0.58 | -0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.16 | 0.16 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 92,157 | 95,184 | +3,027 | 0.00 | 0.00 | -0.00 | buy |
| NJ State Employees Deferred Compensation Plan | 91,600 | 91,600 | 0 | 0.22 | 0.18 | -0.04 | hold |
| D. E. Shaw & Co., Inc. | 262,778 | 89,602 | -173,176 | 0.01 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 293,607 | 86,601 | -207,006 | 0.01 | 0.00 | -0.01 | sell |
| PROFUND ADVISORS LLC | 93,489 | 85,796 | -7,693 | 0.07 | 0.05 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 80,588 | 85,603 | +5,015 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 64,448 | 79,823 | +15,375 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,215 | 77,793 | +7,578 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 49,179 | 76,616 | +27,437 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 81,181 | 74,538 | -6,643 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 93,381 | 72,381 | -21,000 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 72,322 | 72,322 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Gotham Asset Management, LLC | 96,250 | 71,576 | -24,674 | 0.03 | 0.02 | -0.01 | sell |
| Ensign Peak Advisors, Inc | 82,910 | 71,017 | -11,893 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 68,928 | 68,341 | -587 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 65,026 | 65,035 | +9 | 0.00 | 0.00 | -0.00 | buy |
| Cetera Investment Advisers | 36,384 | 63,077 | +26,693 | 0.01 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 325,824 | 61,284 | -264,540 | 0.02 | 0.00 | -0.02 | sell |
| GUGGENHEIM CAPITAL LLC | 58,747 | 61,194 | +2,447 | 0.01 | 0.01 | -0.00 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 59,447 | +59,447 | 0.00 | 0.32 | +0.32 | buy |
| OSAIC HOLDINGS, INC. | 99,345 | 56,323 | -43,022 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 56,208 | 56,151 | -57 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 48,800 | 55,600 | +6,800 | 0.07 | 0.06 | -0.01 | buy |
| Entropy Technologies, LP | 28,936 | 53,969 | +25,033 | 0.09 | 0.09 | -0.00 | buy |
| Russell Investments Group, Ltd. | 22,416 | 52,339 | +29,923 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 52,149 | +52,149 | 0.00 | 0.02 | +0.02 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 27,663 | 50,724 | +23,061 | 0.12 | 0.17 | +0.05 | buy |
| ALGERT GLOBAL LLC | 51,070 | 50,100 | -970 | 0.04 | 0.03 | -0.01 | sell |
| BANK OF MONTREAL /CAN/ | 0 | 48,675 | +48,675 | 0.00 | 0.00 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 154,837 | 46,577 | -108,260 | 0.03 | 0.01 | -0.02 | sell |
| FIL Ltd | 43,226 | 46,500 | +3,274 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 54,988 | 45,536 | -9,452 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 45,000 | +45,000 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 17,887 | 44,364 | +26,477 | 0.00 | 0.00 | +0.00 | buy |