| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 650,000 | 3,168,456 | +2,518,456 | 1.23 | 4.23 | +3.00 | buy |
| Sofinnova Investments, Inc. | 0 | 1,984,962 | +1,984,962 | 0.00 | 1.78 | +1.78 | buy |
| BANK OF AMERICA CORP /DE/ | 583,088 | 2,201,450 | +1,618,362 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 0 | 1,474,037 | +1,474,037 | 0.00 | 0.50 | +0.50 | buy |
| CITADEL ADVISORS LLC | 464,462 | 1,878,333 | +1,413,871 | 0.01 | 0.03 | +0.02 | buy |
| Vestal Point Capital, LP | 0 | 1,050,000 | +1,050,000 | 0.00 | 1.32 | +1.32 | buy |
| Cubist Systematic Strategies, LLC | 72,733 | 683,013 | +610,280 | 0.02 | 0.12 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,928,788 | 3,484,046 | +555,258 | 0.05 | 0.04 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 54,230 | 561,592 | +507,362 | 0.01 | 0.11 | +0.09 | buy |
| Duquesne Family Office LLC | 0 | 280,000 | +280,000 | 0.00 | 0.11 | +0.11 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 439,474 | 718,814 | +279,340 | 0.12 | 0.17 | +0.05 | buy |
| Aquatic Capital Management LLC | 11,300 | 191,900 | +180,600 | 0.00 | 0.10 | +0.09 | buy |
| CITIGROUP INC | 365,344 | 528,569 | +163,225 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 337,149 | 491,098 | +153,949 | 0.05 | 0.06 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 38,567 | 168,562 | +129,995 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 404,162 | 524,861 | +120,699 | 0.03 | 0.04 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 41,835 | 154,496 | +112,661 | 0.01 | 0.03 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 154,800 | 263,878 | +109,078 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 107,363 | +107,363 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 266,768 | 364,675 | +97,907 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 155,237 | 224,224 | +68,987 | 0.01 | 0.01 | +0.00 | buy |
| Opaleye Management Inc. | 2,215,000 | 2,280,000 | +65,000 | 10.06 | 7.56 | -2.50 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 59,447 | +59,447 | 0.00 | 0.32 | +0.32 | buy |
| Magnetar Financial LLC | 0 | 52,149 | +52,149 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 64,926 | 117,017 | +52,091 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 48,675 | +48,675 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 45,000 | +45,000 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 44,279 | +44,279 | 0.00 | 0.02 | +0.02 | buy |
| WOLVERINE TRADING, LLC | 0 | 44,240 | +44,240 | 0.00 | 0.01 | +0.01 | buy |
| NOMURA HOLDINGS INC | 0 | 42,520 | +42,520 | 0.00 | 0.01 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 39,627 | +39,627 | 0.00 | 0.05 | +0.05 | buy |
| SEI INVESTMENTS CO | 0 | 38,840 | +38,840 | 0.00 | 0.00 | +0.00 | buy |
| Concentric Capital Strategies, LP | 0 | 38,033 | +38,033 | 0.00 | 0.04 | +0.04 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 33,413 | +33,413 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 22,416 | 52,339 | +29,923 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 49,179 | 76,616 | +27,437 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 203,300 | 230,300 | +27,000 | 3.43 | 3.00 | -0.43 | buy |
| Hennion & Walsh Asset Management, Inc. | 158,054 | 184,815 | +26,761 | 0.15 | 0.15 | -0.00 | buy |
| Cetera Investment Advisers | 36,384 | 63,077 | +26,693 | 0.01 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 17,887 | 44,364 | +26,477 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 28,936 | 53,969 | +25,033 | 0.09 | 0.09 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 23,746 | +23,746 | 0.00 | 0.09 | +0.09 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 27,663 | 50,724 | +23,061 | 0.12 | 0.17 | +0.05 | buy |
| LPL Financial LLC | 92,568 | 114,502 | +21,934 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 230 | 19,300 | +19,070 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 18,846 | +18,846 | 0.00 | 0.00 | +0.00 | buy |
| Dana Investment Advisors, Inc. | 20,754 | 37,895 | +17,141 | 0.02 | 0.02 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 16,172 | +16,172 | 0.00 | 0.05 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 64,448 | 79,823 | +15,375 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,139,764 | 3,153,593 | +13,829 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,131,896 | 1,145,569 | +13,673 | 0.00 | 0.00 | -0.00 | buy |
| Quantum Private Wealth, LLC | 91,081 | 103,604 | +12,523 | 0.65 | 0.58 | -0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,096,646 | 3,107,444 | +10,798 | 0.01 | 0.00 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 10,782 | +10,782 | 0.00 | 0.00 | +0.00 | buy |
| DAYMARK WEALTH PARTNERS, LLC | 13,500 | 23,500 | +10,000 | 0.01 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,215 | 77,793 | +7,578 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 48,800 | 55,600 | +6,800 | 0.07 | 0.06 | -0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 6,073 | +6,073 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 193,478 | 199,473 | +5,995 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 28,805 | 34,763 | +5,958 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 5,500 | +5,500 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 80,588 | 85,603 | +5,015 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 4,361 | +4,361 | 0.00 | 0.02 | +0.02 | buy |
| nVerses Capital, LLC | 0 | 4,300 | +4,300 | 0.00 | 0.16 | +0.16 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 39,163 | 43,283 | +4,120 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 3,724 | +3,724 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 126,818 | 130,418 | +3,600 | 0.00 | 0.00 | -0.00 | buy |
| FIL Ltd | 43,226 | 46,500 | +3,274 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 92,157 | 95,184 | +3,027 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 14,104 | 16,657 | +2,553 | 0.00 | 0.00 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 2,542 | +2,542 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 18,522 | 21,043 | +2,521 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH EFFECTS LLC | 14,000 | 16,500 | +2,500 | 0.09 | 0.09 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 58,747 | 61,194 | +2,447 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 147,098 | 149,256 | +2,158 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 22,953 | 24,914 | +1,961 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 282,600 | 284,100 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 839,200 | 840,600 | +1,400 | 0.02 | 0.02 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 34,052 | 35,374 | +1,322 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 9,764 | 11,017 | +1,253 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 5,087 | 6,230 | +1,143 | 0.00 | 0.00 | +0.00 | buy |
| Prospera Financial Services Inc | 38,340 | 39,090 | +750 | 0.02 | 0.02 | -0.00 | buy |
| J.W. COLE ADVISORS, INC. | 18,659 | 19,359 | +700 | 0.02 | 0.01 | -0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 689 | +689 | 0.00 | 0.00 | +0.00 | buy |
| AVAII WEALTH MANAGEMENT, LLC | 29,283 | 29,891 | +608 | 0.33 | 0.27 | -0.06 | buy |
| Clear Creek Financial Management, LLC | 19,350 | 19,850 | +500 | 0.05 | 0.04 | -0.01 | buy |
| CWM, LLC | 12,218 | 12,683 | +465 | 0.00 | 0.00 | -0.00 | buy |
| Raleigh Capital Management Inc. | 1,428 | 1,728 | +300 | 0.01 | 0.01 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 269 | +269 | 0.00 | 0.00 | +0.00 | buy |
| FIDELIS CAPITAL PARTNERS, LLC | 0 | 261 | +261 | 0.00 | 0.02 | +0.02 | buy |
| HUNTINGTON NATIONAL BANK | 429 | 614 | +185 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,180 | 5,316 | +136 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 184,510 | 184,634 | +124 | 0.01 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |
| Balefire, LLC | 0 | 75 | +75 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 10,475 | 10,540 | +65 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 64 | +64 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,807 | 2,866 | +59 | 0.00 | 0.00 | -0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |