| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Pictet Asset Management Holding SA | 820,403 | 3,385,245 | +2,564,842 | 0.01 | 0.06 | +0.06 | buy |
| Woodline Partners LP | 152,139 | 1,768,434 | +1,616,295 | 0.01 | 0.33 | +0.31 | buy |
| GROUP ONE TRADING LLC | 657,039 | 996,842 | +339,803 | 0.31 | 0.75 | +0.44 | buy |
| Opaleye Management Inc. | 1,890,000 | 2,215,000 | +325,000 | 5.14 | 10.06 | +4.92 | buy |
| 683 Capital Management, LLC | 1,350,000 | 1,675,000 | +325,000 | 0.88 | 2.34 | +1.47 | buy |
| Hennion & Walsh Asset Management, Inc. | 126,186 | 158,054 | +31,868 | 0.07 | 0.15 | +0.09 | buy |
| North Star Investment Management Corp. | 4,400 | 30,400 | +26,000 | 0.00 | 0.04 | +0.04 | buy |
| Gotham Asset Management, LLC | 71,423 | 96,250 | +24,827 | 0.01 | 0.03 | +0.02 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 15,779 | 27,663 | +11,884 | 0.04 | 0.12 | +0.08 | buy |
| Prospera Financial Services Inc | 31,475 | 38,340 | +6,865 | 0.01 | 0.02 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 13,644 | 18,577 | +4,933 | 0.01 | 0.03 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 3,634 | 5,143 | +1,509 | 0.02 | 0.06 | +0.04 | buy |
| Valeo Financial Advisors, LLC | 61,800 | 63,300 | +1,500 | 0.02 | 0.04 | +0.02 | buy |
| PSI Advisors, LLC | 275 | 1,000 | +725 | 0.00 | 0.01 | +0.01 | buy |
| LIBERTY ONE INVESTMENT MANAGEMENT, LLC | 540 | 1,122 | +582 | 0.00 | 0.00 | +0.00 | buy |
| Raleigh Capital Management Inc. | 1,228 | 1,428 | +200 | 0.01 | 0.01 | +0.01 | buy |
| CLARK FINANCIAL SERVICES GROUP INC /BD | 14,195 | 14,356 | +161 | 0.16 | 0.32 | +0.15 | buy |
| Itau Unibanco Holding S.A. | 224 | 190 | -34 | 0.00 | 0.00 | +0.00 | sell |
| PSI Advisors, LLC | 275 | 200 | -75 | 0.00 | 0.00 | +0.00 | sell |
| Newbridge Financial Services Group, Inc. | 5,258 | 4,812 | -446 | 0.02 | 0.04 | +0.02 | sell |
| Brookstone Capital Management | 17,555 | 16,867 | -688 | 0.00 | 0.01 | +0.00 | sell |
| Clear Creek Financial Management, LLC | 20,100 | 19,350 | -750 | 0.03 | 0.05 | +0.02 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 405,618 | 404,162 | -1,456 | 0.02 | 0.03 | +0.01 | sell |
| WEALTH EFFECTS LLC | 15,500 | 14,000 | -1,500 | 0.06 | 0.09 | +0.03 | sell |
| Aquatic Capital Management LLC | 14,800 | 11,300 | -3,500 | 0.01 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 209,319 | 205,317 | -4,002 | 0.32 | 0.50 | +0.18 | sell |
| AVAII WEALTH MANAGEMENT, LLC | 34,022 | 29,283 | -4,739 | 0.22 | 0.33 | +0.11 | sell |
| ALGERT GLOBAL LLC | 56,660 | 51,070 | -5,590 | 0.02 | 0.04 | +0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 58,752 | 48,800 | -9,952 | 0.04 | 0.07 | +0.03 | sell |
| E Fund Management Co., Ltd. | 44,010 | 30,553 | -13,457 | 0.03 | 0.03 | +0.01 | sell |
| Engineers Gate Manager LP | 115,994 | 91,396 | -24,598 | 0.04 | 0.05 | +0.01 | sell |
| Dana Investment Advisors, Inc. | 57,559 | 20,754 | -36,805 | 0.02 | 0.02 | -0.01 | sell |
| Trexquant Investment LP | 390,507 | 350,218 | -40,289 | 0.08 | 0.14 | +0.05 | sell |
| PROFUND ADVISORS LLC | 143,581 | 93,489 | -50,092 | 0.07 | 0.07 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 195,167 | 54,230 | -140,937 | 0.02 | 0.01 | -0.01 | sell |
| Parkwood LLC | 165,414 | 24,347 | -141,067 | 0.66 | 0.22 | -0.44 | sell |
| TWINBEECH CAPITAL LP | 390,232 | 243,988 | -146,244 | 0.06 | 0.07 | +0.00 | sell |
| Rafferty Asset Management, LLC | 856,837 | 571,126 | -285,711 | 0.04 | 0.04 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,376,462 | 839,200 | -537,262 | 0.02 | 0.02 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 1,367,400 | 337,149 | -1,030,251 | 0.11 | 0.05 | -0.06 | sell |
| Paradigm Biocapital Advisors LP | 3,619,015 | 2,171,419 | -1,447,596 | 2.06 | 1.74 | -0.33 | sell |
| Soleus Capital Management, L.P. | 2,884,382 | 650,000 | -2,234,382 | 2.43 | 1.23 | -1.20 | sell |