| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 21,956,197 | 21,898,758 | -57,439 | 0.01 | 0.01 | +0.00 | sell |
| VANGUARD GROUP INC | 15,387,290 | 15,596,480 | +209,190 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 9,094,158 | 9,199,908 | +105,750 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,205,228 | 3,193,505 | -11,723 | 0.01 | 0.01 | +0.00 | sell |
| Pictet Asset Management Holding SA | 3,582,583 | 2,793,931 | -788,652 | 0.09 | 0.09 | -0.00 | sell |
| Soleus Capital Management, L.P. | 2,534,540 | 2,681,242 | +146,702 | 4.93 | 6.11 | +1.18 | buy |
| Opaleye Management Inc. | 2,280,000 | 2,260,000 | -20,000 | 8.89 | 11.90 | +3.01 | sell |
| MORGAN STANLEY | 2,164,468 | 2,164,434 | -34 | 0.00 | 0.00 | +0.00 | sell |
| Clearbridge Investments, LLC | 0 | 1,835,127 | +1,835,127 | 0.00 | 0.04 | +0.04 | buy |
| 1832 Asset Management L.P. | 0 | 1,655,100 | +1,655,100 | 0.00 | 0.09 | +0.09 | buy |
| GOLDMAN SACHS GROUP INC | 2,556,427 | 1,574,357 | -982,070 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,412,144 | 1,532,929 | +120,785 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 1,630,349 | 1,455,323 | -175,026 | 0.62 | 0.65 | +0.03 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,184,609 | 1,269,513 | +84,904 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 1,184,158 | 1,031,419 | -152,739 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 918,754 | 929,743 | +10,989 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 835,809 | 923,488 | +87,679 | 0.00 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 772,188 | 830,184 | +57,996 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 602,388 | 827,105 | +224,717 | 0.02 | 0.04 | +0.01 | buy |
| GROUP ONE TRADING LLC | 618,369 | 757,519 | +139,150 | 0.57 | 0.77 | +0.20 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 718,814 | 718,814 | 0 | 0.29 | 0.39 | +0.10 | hold |
| 683 Capital Management, LLC | 1,135,000 | 697,000 | -438,000 | 2.70 | 2.06 | -0.64 | sell |
| UBS Group AG | 665,955 | 647,097 | -18,858 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,062,860 | 606,208 | -456,652 | 0.06 | 0.04 | -0.01 | sell |
| CITADEL ADVISORS LLC | 125,134 | 513,960 | +388,826 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 459,372 | 459,037 | -335 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 456,017 | 456,017 | 0 | 0.02 | 0.02 | +0.01 | hold |
| BRAUN STACEY ASSOCIATES INC | 0 | 442,805 | +442,805 | 0.00 | 0.50 | +0.50 | buy |
| NORGES BANK | 437,464 | 401,495 | -35,969 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 384,836 | 391,388 | +6,552 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 382,609 | 383,113 | +504 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 720,798 | 382,959 | -337,839 | 0.00 | 0.00 | -0.00 | sell |
| Penn Capital Management Company, LLC | 0 | 351,408 | +351,408 | 0.00 | 1.04 | +1.04 | buy |
| CITIGROUP INC | 168,277 | 347,177 | +178,900 | 0.00 | 0.01 | +0.01 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 283,000 | 332,577 | +49,577 | 0.04 | 0.04 | +0.01 | buy |
| Rafferty Asset Management, LLC | 340,469 | 331,412 | -9,057 | 0.03 | 0.04 | +0.01 | sell |
| WELLS FARGO & COMPANY/MN | 178,721 | 331,403 | +152,682 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 347,057 | 317,563 | -29,494 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 59,515 | 299,396 | +239,881 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 81,500 | 297,101 | +215,601 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 291,240 | +291,240 | 0.00 | 2.50 | +2.50 | buy |
| Swiss National Bank | 286,600 | 289,300 | +2,700 | 0.00 | 0.01 | +0.00 | buy |
| Castellan Group | 0 | 283,679 | +283,679 | 0.00 | 3.70 | +3.70 | buy |
| FIRST TRUST ADVISORS LP | 28,351 | 275,496 | +247,145 | 0.00 | 0.01 | +0.01 | buy |
| Marex Group plc | 275,000 | 275,000 | 0 | 0.15 | 0.14 | -0.01 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 54,973 | 273,739 | +218,766 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 293,927 | 272,370 | -21,557 | 0.00 | 0.00 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 171,500 | 262,500 | +91,000 | 0.33 | 0.81 | +0.49 | buy |
| BANK OF AMERICA CORP /DE/ | 1,697,372 | 230,939 | -1,466,433 | 0.00 | 0.00 | -0.00 | sell |
| CASTLEARK MANAGEMENT LLC | 168,810 | 211,370 | +42,560 | 0.16 | 0.22 | +0.06 | buy |
| Squarepoint Ops LLC | 48,713 | 210,795 | +162,082 | 0.00 | 0.02 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 192,975 | 195,164 | +2,189 | 0.01 | 0.02 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 198,037 | 189,112 | -8,925 | 0.01 | 0.01 | +0.00 | sell |
| LPL Financial LLC | 114,322 | 185,062 | +70,740 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 31,759 | 180,098 | +148,339 | 0.03 | 0.15 | +0.13 | buy |
| IFP Advisors, Inc | 123,564 | 178,547 | +54,983 | 0.10 | 0.18 | +0.07 | buy |
| ALLIANCEBERNSTEIN L.P. | 193,570 | 174,020 | -19,550 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 305,337 | 168,575 | -136,762 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 394,779 | 168,503 | -226,276 | 0.01 | 0.01 | -0.01 | sell |
| M28 Capital Management LP | 161,600 | 161,600 | 0 | 4.15 | 4.78 | +0.62 | hold |
| PANAGORA ASSET MANAGEMENT INC | 106,207 | 160,642 | +54,435 | 0.01 | 0.02 | +0.01 | buy |
| Hillsdale Investment Management Inc. | 0 | 150,200 | +150,200 | 0.00 | 0.23 | +0.23 | buy |
| Integral Health Asset Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.40 | +0.40 | buy |
| DEUTSCHE BANK AG\ | 104,748 | 147,020 | +42,272 | 0.00 | 0.00 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 0 | 140,154 | +140,154 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 138,351 | 137,002 | -1,349 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 103,801 | 130,688 | +26,887 | 0.01 | 0.01 | +0.00 | buy |
| Informed Momentum Co LLC | 175,959 | 128,923 | -47,036 | 0.62 | 0.55 | -0.07 | sell |
| CANADA LIFE ASSURANCE Co | 132,368 | 128,637 | -3,731 | 0.01 | 0.01 | +0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 104,764 | 103,168 | -1,596 | 0.00 | 0.01 | +0.00 | sell |
| Assenagon Asset Management S.A. | 170,234 | 103,080 | -67,154 | 0.01 | 0.01 | -0.00 | sell |
| Quantum Private Wealth, LLC | 103,804 | 102,804 | -1,000 | 0.82 | 0.99 | +0.17 | sell |
| OSAIC HOLDINGS, INC. | 67,235 | 101,794 | +34,559 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.17 | 0.20 | +0.03 | hold |
| PFM Health Sciences, LP | 233,410 | 98,674 | -134,736 | 0.31 | 0.23 | -0.09 | sell |
| Hennion & Walsh Asset Management, Inc. | 98,629 | 97,633 | -996 | 0.11 | 0.13 | +0.03 | sell |
| FRANKLIN RESOURCES INC | 128,985 | 97,538 | -31,447 | 0.00 | 0.00 | -0.00 | sell |
| Altium Capital Management LLC | 0 | 95,000 | +95,000 | 0.00 | 0.89 | +0.89 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 89,793 | 92,683 | +2,890 | 0.00 | 0.01 | +0.00 | buy |
| NJ State Employees Deferred Compensation Plan | 91,600 | 91,600 | 0 | 0.25 | 0.34 | +0.08 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 85,360 | +85,360 | 0.00 | 0.08 | +0.08 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 180,338 | 84,589 | -95,749 | 0.02 | 0.01 | -0.01 | sell |
| MetLife Investment Management, LLC | 80,608 | 84,360 | +3,752 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 109,706 | 84,147 | -25,559 | 0.24 | 0.22 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 64,898 | 81,292 | +16,394 | 0.02 | 0.03 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 52,390 | 79,518 | +27,128 | 0.02 | 0.03 | +0.02 | buy |
| Illinois Municipal Retirement Fund | 0 | 78,101 | +78,101 | 0.00 | 0.03 | +0.03 | buy |
| State of Alaska, Department of Revenue | 76,130 | 75,856 | -274 | 0.02 | 0.03 | +0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 79,191 | 75,327 | -3,864 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 79,894 | 74,117 | -5,777 | 0.01 | 0.01 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 123,401 | 73,117 | -50,284 | 0.01 | 0.01 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 48,263 | 71,833 | +23,570 | 0.01 | 0.02 | +0.01 | buy |
| State of New Jersey Common Pension Fund D | 82,752 | 69,234 | -13,518 | 0.01 | 0.01 | +0.00 | sell |
| PROFUND ADVISORS LLC | 71,641 | 68,023 | -3,618 | 0.06 | 0.07 | +0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 59,436 | 67,867 | +8,431 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 88,895 | 65,032 | -23,863 | 0.00 | 0.00 | -0.00 | sell |
| Louisiana State Employees Retirement System | 64,500 | 64,500 | 0 | 0.03 | 0.04 | +0.01 | hold |
| JANUS HENDERSON GROUP PLC | 64,357 | 64,357 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 73,320 | 63,513 | -9,807 | 0.00 | 0.00 | +0.00 | sell |
| State of Tennessee, Department of Treasury | 46,655 | 59,883 | +13,228 | 0.00 | 0.01 | +0.00 | buy |