| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,587,228 | 2,456,537 | +869,309 | 0.55 | 0.71 | +0.17 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 87,455 | 153,010 | +65,555 | 0.02 | 0.03 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 1,328,456 | 1,296,959 | +31,497 | 0.17 | 0.19 | 0.00 | sell |
| R Squared Ltd | 18,700 | 38,655 | +19,955 | 0.03 | 0.06 | +0.03 | buy |
| Bouvel Investment Partners, LLC | 496,782 | 505,020 | +8,238 | 0.28 | 0.33 | +0.05 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 280,616 | 281,554 | +938 | 0.00 | 0.00 | 0.00 | buy |
| Avanza Fonder AB | 109,852 | 110,315 | +463 | 0.01 | 0.01 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 15,963 | 12,264 | -3,699 | 0.06 | 0.01 | -0.04 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 50,305 | 44,693 | -5,612 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 3,494,897 | 3,482,335 | -12,562 | 0.04 | 0.03 | -0.00 | sell |
| Joel Isaacson & Co., LLC | 60,000 | 40,000 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 1,544,300 | 1,519,200 | -25,100 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 19,477,339 | 19,351,087 | -126,252 | 0.32 | 0.30 | -0.02 | sell |
| ARK Investment Management LLC | 20,814,752 | 20,655,142 | -159,610 | 0.27 | 0.29 | +0.02 | sell |
| Nikko Asset Management Americas, Inc. | 6,461,684 | 6,190,889 | -270,795 | 0.11 | 0.11 | +0.00 | sell |
| Sepio Capital, LP | 643,500 | 303,500 | -340,000 | 0.08 | 0.03 | -0.05 | sell |
| Senvest Management, LLC | 6,393,979 | 4,405,568 | -1,988,411 | 0.30 | 0.26 | -0.05 | sell |