| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 7,062,077 | 7,616,563 | +554,486 | 1.12 | 1.24 | +0.13 | buy |
| Swedbank AB | 792,187 | 1,314,787 | +522,600 | 0.05 | 0.06 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 851,556 | 1,332,836 | +481,280 | 0.57 | 0.80 | +0.23 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 139,900 | 328,550 | +188,650 | 1.26 | 2.45 | +1.20 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 104,659 | 248,224 | +143,565 | 0.33 | 0.69 | +0.36 | buy |
| Redmile Group, LLC | 173,859 | 265,169 | +91,310 | 0.65 | 1.02 | +0.37 | buy |
| Rhenman & Partners Asset Management AB | 207,000 | 290,500 | +83,500 | 1.44 | 1.57 | +0.13 | buy |
| EASTERLY INVESTMENT PARTNERS LLC | 246,929 | 329,387 | +82,458 | 1.06 | 0.96 | -0.10 | buy |
| Bridgewater Associates, LP | 206,911 | 274,911 | +68,000 | 0.05 | 0.06 | +0.01 | buy |
| Edgestream Partners, L.P. | 34,055 | 100,897 | +66,842 | 0.06 | 0.17 | +0.11 | buy |
| SECTOR GAMMA AS | 239,918 | 294,918 | +55,000 | 3.20 | 3.66 | +0.46 | buy |
| APG Asset Management N.V. | 94,944 | 130,277 | +35,333 | 0.01 | 0.02 | +0.00 | buy |
| SYSTEMATIC FINANCIAL MANAGEMENT LP | 255,354 | 290,249 | +34,895 | 0.33 | 0.33 | +0.00 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 10,608 | 43,061 | +32,453 | 0.01 | 0.02 | +0.02 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 146,923 | 162,714 | +15,791 | 0.31 | 0.30 | -0.01 | buy |
| Capital Research Global Investors | 3,491,386 | 3,504,387 | +13,001 | 0.03 | 0.03 | -0.00 | buy |
| Secure Asset Management, LLC | 70,420 | 78,208 | +7,788 | 0.63 | 0.63 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 18,830 | 22,930 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| Cascade Investment Advisors, Inc. | 22,735 | 26,465 | +3,730 | 0.76 | 0.83 | +0.07 | buy |
| Everhart Financial Group, Inc. | 5,211 | 6,995 | +1,784 | 0.03 | 0.03 | +0.00 | buy |
| FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ | 714,536 | 715,646 | +1,110 | 0.22 | 0.21 | -0.02 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 686,030 | 687,030 | +1,000 | 0.56 | 0.52 | -0.04 | buy |
| PRAXIS INVESTMENT MANAGEMENT INC | 5,611 | 6,584 | +973 | 0.02 | 0.02 | +0.00 | buy |
| NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC | 43,040 | 43,479 | +439 | 0.04 | 0.03 | -0.01 | buy |
| GRANDFIELD & DODD, LLC | 17,861 | 18,243 | +382 | 0.06 | 0.05 | -0.00 | buy |
| LBP AM SA | 3,594 | 3,839 | +245 | 0.00 | 0.00 | -0.00 | buy |
| SECURIAN ASSET MANAGEMENT, INC | 14,160 | 14,278 | +118 | 0.03 | 0.03 | -0.00 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 236 | 316 | +80 | 0.01 | 0.01 | -0.00 | buy |
| 4WEALTH ADVISORS, INC. | 3,880 | 3,906 | +26 | 0.18 | 0.17 | -0.01 | buy |
| Aspect Partners, LLC | 43 | 59 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Global X Japan Co., Ltd. | 348 | 350 | +2 | 0.00 | 0.00 | -0.00 | buy |
| Quaker Wealth Management, LLC | 8 | 4 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Kentucky Retirement Systems Insurance Trust Fund | 5,003 | 4,980 | -23 | 19.23 | 17.06 | -2.17 | sell |
| Linden Thomas Advisory Services, LLC | 12,303 | 12,277 | -26 | 0.07 | 0.06 | -0.01 | sell |
| INSPIRION WEALTH ADVISORS, LLC | 9,328 | 9,283 | -45 | 0.07 | 0.06 | -0.00 | sell |
| TOTH FINANCIAL ADVISORY CORP | 173 | 87 | -86 | 0.00 | 0.00 | -0.00 | sell |
| Michels Family Financial, LLC | 4,068 | 3,918 | -150 | 0.17 | 0.14 | -0.02 | sell |
| Motley Fool Asset Management LLC | 3,952 | 3,797 | -155 | 0.01 | 0.01 | -0.00 | sell |
| PARAGON CAPITAL MANAGEMENT INC | 24,704 | 24,200 | -504 | 1.18 | 1.03 | -0.15 | sell |
| TEALWOOD ASSET MANAGEMENT INC | 18,002 | 17,324 | -678 | 0.46 | 0.38 | -0.08 | sell |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 46,200 | 45,200 | -1,000 | 0.01 | 0.01 | -0.00 | sell |
| Regal Investment Advisors LLC | 10,592 | 9,366 | -1,226 | 0.03 | 0.03 | -0.01 | sell |
| KNIGHTSBRIDGE ASSET MANAGEMENT, LLC | 5,011 | 3,509 | -1,502 | 0.04 | 0.03 | -0.01 | sell |
| NorthCrest Asset Manangement, LLC | 10,726 | 7,974 | -2,752 | 0.02 | 0.01 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 34,129 | 30,761 | -3,368 | 0.15 | 0.11 | -0.04 | sell |
| Curi Capital, LLC | 13,242 | 9,442 | -3,800 | 0.01 | 0.01 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 14,194,005 | 14,190,183 | -3,822 | 0.63 | 0.48 | -0.15 | sell |
| WADDELL & ASSOCIATES, LLC | 9,370 | 5,470 | -3,900 | 0.03 | 0.02 | -0.01 | sell |
| AIA Group Ltd | 7,707 | 3,764 | -3,943 | 0.01 | 0.00 | -0.00 | sell |
| CREDIT INDUSTRIEL ET COMMERCIAL | 40,013 | 33,013 | -7,000 | 0.36 | 0.20 | -0.16 | sell |
| Sivia Capital Partners, LLC | 18,420 | 5,929 | -12,491 | 0.20 | 0.04 | -0.16 | sell |
| Voleon Capital Management LP | 32,074 | 16,478 | -15,596 | 0.04 | 0.02 | -0.02 | sell |
| J. Safra Sarasin Holding AG | 43,719 | 26,891 | -16,828 | 0.04 | 0.02 | -0.02 | sell |
| Retirement Systems of Alabama | 235,522 | 199,911 | -35,611 | 0.04 | 0.03 | -0.01 | sell |
| SummitTX Capital, L.P. | 90,632 | 50,737 | -39,895 | 0.16 | 0.07 | -0.09 | sell |
| Robeco Institutional Asset Management B.V. | 545,135 | 408,215 | -136,920 | 0.04 | 0.03 | -0.02 | sell |
| Motley Fool Wealth Management, LLC | 247,877 | 3,533 | -244,344 | 1.58 | 3.07 | +1.49 | sell |
| River Road Asset Management, LLC | 917,612 | 542,990 | -374,622 | 0.59 | 0.35 | -0.24 | sell |
| Sofinnova Investments, Inc. | 781,982 | 358,568 | -423,414 | 1.68 | 1.06 | -0.62 | sell |