| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 19,135,108 | 19,818,301 | +683,193 | 0.02 | 0.02 | +0.00 | buy |
| DODGE & COX | 14,572,384 | 14,561,759 | -10,625 | 0.47 | 0.45 | -0.02 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 14,549,314 | 14,194,005 | -355,309 | 0.65 | 0.63 | -0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 6,686,916 | 7,676,541 | +989,625 | 0.21 | 0.20 | -0.01 | buy |
| STATE STREET CORP | 7,523,218 | 7,295,079 | -228,139 | 0.01 | 0.01 | -0.00 | sell |
| VIKING GLOBAL INVESTORS LP | 6,036,936 | 7,062,077 | +1,025,141 | 0.95 | 1.12 | +0.16 | buy |
| CITADEL ADVISORS LLC | 1,364,691 | 4,512,634 | +3,147,943 | 0.06 | 0.18 | +0.13 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,674,089 | 3,819,441 | +145,352 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 3,321,754 | 3,802,930 | +481,176 | 0.04 | 0.04 | +0.00 | buy |
| Vestal Point Capital, LP | 3,000,000 | 3,575,000 | +575,000 | 6.54 | 5.65 | -0.89 | buy |
| FMR LLC | 1,837,071 | 3,567,031 | +1,729,960 | 0.01 | 0.01 | +0.01 | buy |
| Capital Research Global Investors | 2,547,287 | 3,491,386 | +944,099 | 0.03 | 0.03 | +0.00 | buy |
| Focus Partners Wealth | 3,423,000 | 3,348,000 | -75,000 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,037,616 | 3,010,308 | -27,308 | 0.13 | 0.13 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 3,000,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BNP Paribas Asset Management Holding S.A. | 2,900,000 | 2,900,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Assenagon Asset Management S.A. | 1,419,067 | 1,920,658 | +501,591 | 0.13 | 0.17 | +0.05 | buy |
| FIRST TRUST ADVISORS LP | 1,166,799 | 1,672,491 | +505,692 | 0.05 | 0.07 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 1,600,000 | +1,600,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,423,712 | 1,587,683 | +163,971 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,547,965 | 1,586,384 | +38,419 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 2,211,721 | 1,496,852 | -714,869 | 0.03 | 0.02 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,362,752 | +1,362,752 | 0.00 | 0.15 | +0.15 | buy |
| MORGAN STANLEY | 2,315,620 | 1,321,665 | -993,955 | 0.01 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 1,359,549 | 1,221,387 | -138,162 | 0.28 | 0.25 | -0.04 | sell |
| Point72 Asset Management, L.P. | 438,817 | 1,199,206 | +760,389 | 0.04 | 0.12 | +0.08 | buy |
| Pictet Asset Management Holding SA | 1,283,622 | 1,193,661 | -89,961 | 0.07 | 0.07 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 1,465,198 | 1,173,516 | -291,682 | 0.02 | 0.02 | -0.00 | sell |
| Deep Track Capital, LP | 2,300,000 | 1,150,000 | -1,150,000 | 3.12 | 1.34 | -1.78 | sell |
| Bank of New York Mellon Corp | 1,230,254 | 1,144,892 | -85,362 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,324,971 | 1,024,871 | -300,100 | 0.12 | 0.09 | -0.03 | sell |
| Hudson Bay Capital Management LP | 670,002 | 974,776 | +304,774 | 0.23 | 0.33 | +0.10 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 1,048,841 | 945,603 | -103,238 | 0.11 | 0.09 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 864,512 | 936,951 | +72,439 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 95,101 | 933,879 | +838,778 | 0.00 | 0.01 | +0.01 | buy |
| River Road Asset Management, LLC | 906,366 | 917,612 | +11,246 | 0.59 | 0.59 | -0.00 | buy |
| LSV ASSET MANAGEMENT | 882,200 | 884,800 | +2,600 | 0.11 | 0.11 | -0.01 | buy |
| JANUS HENDERSON GROUP PLC | 276,330 | 857,010 | +580,680 | 0.01 | 0.02 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 851,556 | +851,556 | 0.00 | 0.57 | +0.57 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 638,725 | 850,819 | +212,094 | 0.01 | 0.01 | +0.00 | buy |
| Swedbank AB | 796,737 | 792,187 | -4,550 | 0.05 | 0.05 | +0.00 | sell |
| Sofinnova Investments, Inc. | 697,133 | 781,982 | +84,849 | 1.79 | 2.21 | +0.43 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 785,095 | 716,523 | -68,572 | 0.01 | 0.01 | -0.00 | sell |
| FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ | 713,979 | 714,536 | +557 | 0.23 | 0.22 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 711,771 | 713,795 | +2,024 | 0.05 | 0.05 | +0.00 | buy |
| Nuveen, LLC | 679,649 | 705,198 | +25,549 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 1,436,639 | 689,721 | -746,918 | 0.12 | 0.06 | -0.07 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 664,530 | 686,030 | +21,500 | 0.56 | 0.56 | -0.00 | buy |
| Palo Alto Investors LP | 746,256 | 685,182 | -61,074 | 6.17 | 5.92 | -0.25 | sell |
| Novo Holdings A/S | 660,000 | 660,000 | 0 | 3.05 | 3.02 | -0.03 | hold |
| Soleus Capital Management, L.P. | 1,320,000 | 650,572 | -669,428 | 3.33 | 1.49 | -1.84 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 794,652 | 627,699 | -166,953 | 0.08 | 0.07 | -0.02 | sell |
| Russell Investments Group, Ltd. | 850,781 | 606,224 | -244,557 | 0.06 | 0.04 | -0.02 | sell |
| Freestone Grove Partners LP | 491,902 | 606,187 | +114,285 | 0.21 | 0.25 | +0.04 | buy |
| Legal & General Group Plc | 603,581 | 575,186 | -28,395 | 0.01 | 0.01 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 529,937 | 574,945 | +45,008 | 0.04 | 0.04 | +0.00 | buy |
| JPMORGAN CHASE & CO | 460,005 | 557,836 | +97,831 | 0.00 | 0.00 | +0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 411,880 | 547,871 | +135,991 | 7.68 | 9.48 | +1.80 | buy |
| Robeco Institutional Asset Management B.V. | 766,432 | 545,135 | -221,297 | 0.06 | 0.04 | -0.02 | sell |
| Krensavage Asset Management, LLC | 524,786 | 524,786 | 0 | 11.02 | 11.59 | +0.58 | hold |
| RHUMBLINE ADVISERS | 513,248 | 522,125 | +8,877 | 0.02 | 0.03 | +0.00 | buy |
| Eagle Health Investments LP | 366,812 | 505,809 | +138,997 | 4.79 | 6.00 | +1.21 | buy |
| BRAIDWELL LP | 601,520 | 497,020 | -104,500 | 1.14 | 0.94 | -0.21 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 527,507 | 490,715 | -36,792 | 0.02 | 0.02 | -0.00 | sell |
| Jefferies Financial Group Inc. | 467,018 | 468,146 | +1,128 | 0.23 | 0.32 | +0.10 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 436,024 | 448,768 | +12,744 | 0.02 | 0.02 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 375,067 | 441,444 | +66,377 | 0.03 | 0.03 | +0.00 | buy |
| Rubric Capital Management LP | 0 | 440,560 | +440,560 | 0.00 | 0.30 | +0.30 | buy |
| Engineers Gate Manager LP | 374,814 | 436,860 | +62,046 | 0.26 | 0.31 | +0.04 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 413,058 | 428,607 | +15,549 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 457,604 | 419,411 | -38,193 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 687,658 | 411,302 | -276,356 | 0.01 | 0.01 | -0.01 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 1,111,698 | 407,379 | -704,319 | 0.20 | 0.09 | -0.11 | sell |
| IEQ CAPITAL, LLC | 358,056 | 401,610 | +43,554 | 0.06 | 0.11 | +0.04 | buy |
| Allianz Asset Management GmbH | 362,119 | 400,020 | +37,901 | 0.02 | 0.03 | +0.00 | buy |
| CITIGROUP INC | 176,226 | 393,895 | +217,669 | 0.01 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 454,912 | 379,596 | -75,316 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 361,571 | 372,197 | +10,626 | 0.04 | 0.04 | -0.00 | buy |
| SEI INVESTMENTS CO | 371,000 | 371,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Walleye Capital LLC | 222,467 | 364,246 | +141,779 | 0.08 | 0.13 | +0.05 | buy |
| Swiss National Bank | 359,600 | 361,100 | +1,500 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 1,828,344 | 359,702 | -1,468,642 | 0.22 | 0.04 | -0.18 | sell |
| RAYMOND JAMES FINANCIAL INC | 211,298 | 331,373 | +120,075 | 0.00 | 0.01 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 287,713 | 325,851 | +38,138 | 0.03 | 0.03 | +0.00 | buy |
| LMR Partners LLP | 19,178 | 324,939 | +305,761 | 0.01 | 0.17 | +0.16 | buy |
| Man Group plc | 361,495 | 309,659 | -51,836 | 0.04 | 0.04 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 1,004,029 | 282,460 | -721,569 | 0.05 | 0.01 | -0.03 | sell |
| DekaBank Deutsche Girozentrale | 280,330 | 280,330 | 0 | 0.04 | 0.03 | -0.02 | hold |
| Mariner, LLC | 174,284 | 268,901 | +94,617 | 0.01 | 0.02 | +0.01 | buy |
| C WorldWide Group Holding A/S | 267,851 | 267,851 | 0 | 0.28 | 0.32 | +0.05 | hold |
| Cerity Partners LLC | 263,128 | 263,389 | +261 | 0.02 | 0.02 | -0.00 | buy |
| SYSTEMATIC FINANCIAL MANAGEMENT LP | 254,400 | 255,354 | +954 | 0.36 | 0.33 | -0.03 | buy |
| SEI INVESTMENTS CO | 276,603 | 251,480 | -25,123 | 0.02 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 264,916 | 248,157 | -16,759 | 0.00 | 0.00 | -0.00 | sell |
| Motley Fool Wealth Management, LLC | 330,853 | 247,877 | -82,976 | 1.52 | 1.58 | +0.06 | sell |
| EASTERLY INVESTMENT PARTNERS LLC | 123,044 | 246,929 | +123,885 | 0.45 | 1.06 | +0.61 | buy |
| SECTOR GAMMA AS | 198,505 | 239,918 | +41,413 | 2.69 | 3.20 | +0.51 | buy |
| Retirement Systems of Alabama | 230,568 | 235,522 | +4,954 | 0.04 | 0.04 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 584,300 | 229,600 | -354,700 | 0.02 | 0.01 | -0.01 | sell |
| M&G Plc | 224,143 | 226,541 | +2,398 | 0.07 | 0.07 | -0.00 | buy |