| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 19,818,301 | 20,445,212 | +626,911 | 0.02 | 0.02 | -0.00 | buy |
| DODGE & COX | 14,561,759 | 14,844,930 | +283,171 | 0.45 | 0.44 | -0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 14,194,005 | 14,190,183 | -3,822 | 0.63 | 0.48 | -0.15 | sell |
| NORGES BANK | 0 | 8,207,954 | +8,207,954 | 0.00 | 0.05 | +0.05 | buy |
| STATE STREET CORP | 7,295,079 | 7,800,959 | +505,880 | 0.01 | 0.01 | -0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 7,062,077 | 7,616,563 | +554,486 | 1.12 | 1.24 | +0.13 | buy |
| Vestal Point Capital, LP | 3,575,000 | 6,025,000 | +2,450,000 | 5.65 | 8.06 | +2.41 | buy |
| AQR CAPITAL MANAGEMENT LLC | 7,676,541 | 5,699,541 | -1,977,000 | 0.20 | 0.11 | -0.08 | sell |
| FMR LLC | 3,567,031 | 4,822,893 | +1,255,862 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 3,802,930 | 4,075,714 | +272,784 | 0.04 | 0.04 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 4,000,000 | +1,000,000 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,819,441 | 3,911,794 | +92,353 | 0.01 | 0.01 | -0.00 | buy |
| Capital Research Global Investors | 3,491,386 | 3,504,387 | +13,001 | 0.03 | 0.03 | -0.00 | buy |
| Deep Track Capital, LP | 1,150,000 | 3,307,481 | +2,157,481 | 1.34 | 2.79 | +1.45 | buy |
| Focus Partners Wealth | 3,348,000 | 3,208,000 | -140,000 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,010,308 | 2,071,816 | -938,492 | 0.13 | 0.08 | -0.05 | sell |
| Assenagon Asset Management S.A. | 1,920,658 | 1,762,086 | -158,572 | 0.17 | 0.13 | -0.04 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 1,616,020 | +1,616,020 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,587,683 | 1,616,020 | +28,337 | 0.01 | 0.01 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 1,672,491 | 1,606,273 | -66,218 | 0.07 | 0.05 | -0.01 | sell |
| NORTHERN TRUST CORP | 1,586,384 | 1,558,104 | -28,280 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 1,321,665 | 1,504,989 | +183,324 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 851,556 | 1,332,836 | +481,280 | 0.57 | 0.80 | +0.23 | buy |
| Swedbank AB | 792,187 | 1,314,787 | +522,600 | 0.05 | 0.06 | +0.02 | buy |
| UBS Group AG | 1,496,852 | 1,286,505 | -210,347 | 0.02 | 0.01 | -0.00 | sell |
| DnB Asset Management AS | 1,221,387 | 1,268,194 | +46,807 | 0.25 | 0.20 | -0.04 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 945,603 | 1,236,446 | +290,843 | 0.09 | 0.10 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 379,596 | 1,201,977 | +822,381 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,173,516 | 1,157,865 | -15,651 | 0.02 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 1,144,892 | 1,155,305 | +10,413 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 4,512,634 | 1,122,408 | -3,390,226 | 0.18 | 0.04 | -0.14 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,362,752 | 1,054,613 | -308,139 | 0.15 | 0.11 | -0.04 | sell |
| ARGA Investment Management, LP | 0 | 1,039,409 | +1,039,409 | 0.00 | 1.52 | +1.52 | buy |
| FRANKLIN RESOURCES INC | 933,879 | 936,044 | +2,165 | 0.01 | 0.01 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 441,444 | 931,864 | +490,420 | 0.03 | 0.05 | +0.02 | buy |
| LSV ASSET MANAGEMENT | 884,800 | 881,700 | -3,100 | 0.11 | 0.09 | -0.02 | sell |
| Hudson Bay Capital Management LP | 974,776 | 825,002 | -149,774 | 0.33 | 0.22 | -0.11 | sell |
| Russell Investments Group, Ltd. | 606,224 | 776,774 | +170,550 | 0.04 | 0.04 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 850,819 | 735,724 | -115,095 | 0.01 | 0.01 | -0.00 | sell |
| FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ | 714,536 | 715,646 | +1,110 | 0.22 | 0.21 | -0.02 | buy |
| LOOMIS SAYLES & CO L P | 713,795 | 713,657 | -138 | 0.05 | 0.05 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 407,379 | 696,784 | +289,405 | 0.09 | 0.15 | +0.06 | buy |
| JPMORGAN CHASE & CO | 557,836 | 694,550 | +136,714 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 705,198 | 689,131 | -16,067 | 0.01 | 0.01 | -0.00 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 686,030 | 687,030 | +1,000 | 0.56 | 0.52 | -0.04 | buy |
| Palo Alto Investors LP | 685,182 | 682,777 | -2,405 | 5.92 | 5.40 | -0.52 | sell |
| Qube Research & Technologies Ltd | 689,721 | 668,835 | -20,886 | 0.06 | 0.04 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 936,951 | 663,163 | -273,788 | 0.00 | 0.00 | -0.00 | sell |
| Eagle Health Investments LP | 505,809 | 624,676 | +118,867 | 6.00 | 5.92 | -0.07 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 103,161 | 601,532 | +498,371 | 0.00 | 0.02 | +0.02 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 547,871 | 583,219 | +35,348 | 9.48 | 7.81 | -1.68 | buy |
| River Road Asset Management, LLC | 917,612 | 542,990 | -374,622 | 0.59 | 0.35 | -0.24 | sell |
| Legal & General Group Plc | 575,186 | 537,468 | -37,718 | 0.01 | 0.01 | -0.00 | sell |
| Krensavage Asset Management, LLC | 524,786 | 524,786 | 0 | 11.59 | 11.41 | -0.19 | hold |
| RHUMBLINE ADVISERS | 522,125 | 516,786 | -5,339 | 0.03 | 0.02 | -0.00 | sell |
| Pacer Advisors, Inc. | 23,643 | 506,545 | +482,902 | 0.00 | 0.08 | +0.08 | buy |
| Invesco Ltd. | 419,411 | 494,604 | +75,193 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 448,768 | 490,189 | +41,421 | 0.02 | 0.01 | -0.00 | buy |
| Jefferies Financial Group Inc. | 468,146 | 466,258 | -1,888 | 0.32 | 0.25 | -0.08 | sell |
| BNP Paribas Asset Management Holding S.A. | 574,945 | 460,559 | -114,386 | 0.04 | 0.03 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,024,871 | 451,871 | -573,000 | 0.09 | 0.04 | -0.05 | sell |
| HOTCHKIS & WILEY CAPITAL MANAGEMENT LLC | 0 | 447,200 | +447,200 | 0.00 | 0.07 | +0.07 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 490,715 | 439,094 | -51,621 | 0.02 | 0.01 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 428,607 | 438,818 | +10,211 | 0.01 | 0.01 | -0.00 | buy |
| Rockefeller Capital Management L.P. | 372,197 | 433,376 | +61,179 | 0.04 | 0.04 | +0.00 | buy |
| Allianz Asset Management GmbH | 400,020 | 418,602 | +18,582 | 0.03 | 0.02 | -0.00 | buy |
| Robeco Institutional Asset Management B.V. | 545,135 | 408,215 | -136,920 | 0.04 | 0.03 | -0.02 | sell |
| TD ASSET MANAGEMENT INC | 0 | 400,000 | +400,000 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,193,661 | 395,382 | -798,279 | 0.07 | 0.02 | -0.05 | sell |
| PRUDENTIAL FINANCIAL INC | 119,961 | 392,811 | +272,850 | 0.01 | 0.02 | +0.02 | buy |
| Soleus Capital Management, L.P. | 650,572 | 375,572 | -275,000 | 1.49 | 0.74 | -0.75 | sell |
| SEI INVESTMENTS CO | 371,000 | 371,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Man Group plc | 309,659 | 367,981 | +58,322 | 0.04 | 0.04 | +0.00 | buy |
| Freestone Grove Partners LP | 606,187 | 364,194 | -241,993 | 0.25 | 0.14 | -0.11 | sell |
| Sofinnova Investments, Inc. | 781,982 | 358,568 | -423,414 | 2.21 | 1.10 | -1.12 | sell |
| Swiss National Bank | 361,100 | 357,000 | -4,100 | 0.01 | 0.01 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 325,851 | 350,397 | +24,546 | 0.03 | 0.03 | +0.00 | buy |
| EASTERLY INVESTMENT PARTNERS LLC | 246,929 | 329,387 | +82,458 | 1.06 | 0.96 | -0.10 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 139,900 | 328,550 | +188,650 | 1.36 | 2.69 | +1.33 | buy |
| DIADEMA PARTNERS LP | 148,229 | 312,846 | +164,617 | 3.46 | 6.32 | +2.86 | buy |
| HSBC HOLDINGS PLC | 148,182 | 307,543 | +159,361 | 0.00 | 0.01 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 181,882 | 307,103 | +125,221 | 0.01 | 0.01 | +0.00 | buy |
| SECTOR GAMMA AS | 239,918 | 294,918 | +55,000 | 3.20 | 3.66 | +0.46 | buy |
| Rhenman & Partners Asset Management AB | 207,000 | 290,500 | +83,500 | 1.44 | 1.57 | +0.13 | buy |
| SYSTEMATIC FINANCIAL MANAGEMENT LP | 255,354 | 290,249 | +34,895 | 0.33 | 0.33 | +0.00 | buy |
| Walleye Capital LLC | 364,246 | 288,233 | -76,013 | 0.13 | 0.08 | -0.05 | sell |
| ALLIANCEBERNSTEIN L.P. | 248,157 | 283,400 | +35,243 | 0.00 | 0.01 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 280,330 | 280,330 | 0 | 0.03 | 0.03 | +0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 331,373 | 279,274 | -52,099 | 0.01 | 0.00 | -0.00 | sell |
| Bridgewater Associates, LP | 206,911 | 274,911 | +68,000 | 0.05 | 0.06 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 31,809 | 273,562 | +241,753 | 0.03 | 0.25 | +0.22 | buy |
| C WorldWide Group Holding A/S | 267,851 | 267,851 | 0 | 0.32 | 0.37 | +0.04 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 176,275 | 265,654 | +89,379 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 173,859 | 265,169 | +91,310 | 0.65 | 1.02 | +0.37 | buy |
| Amundi | 188,536 | 259,782 | +71,246 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 251,480 | 250,230 | -1,250 | 0.01 | 0.01 | -0.00 | sell |
| Eversept Partners, LP | 207,768 | 249,607 | +41,839 | 0.77 | 0.78 | +0.01 | buy |
| Distillate Capital Partners LLC | 0 | 248,916 | +248,916 | 0.00 | 0.74 | +0.74 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 104,659 | 248,224 | +143,565 | 0.33 | 0.69 | +0.36 | buy |
| Jump Financial, LLC | 3,548 | 245,390 | +241,842 | 0.00 | 0.13 | +0.12 | buy |