| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 3,333,333 | 4,999,999 | +1,666,666 | 2.16 | 3.82 | +1.66 | buy |
| Capital Research Global Investors | 770,999 | 1,686,625 | +915,626 | 0.01 | 0.02 | +0.01 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,087,591 | 1,603,442 | +515,851 | 0.24 | 0.41 | +0.17 | buy |
| ARMISTICE CAPITAL, LLC | 764,538 | 1,201,342 | +436,804 | 0.90 | 1.25 | +0.36 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 39,817 | 219,987 | +180,170 | 0.42 | 2.44 | +2.03 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 135,464 | 279,769 | +144,305 | 0.43 | 0.84 | +0.40 | buy |
| Rock Springs Capital Management LP | 45,364 | 187,980 | +142,616 | 0.18 | 0.78 | +0.61 | buy |
| RTW INVESTMENTS, LP | 2,721,158 | 2,862,003 | +140,845 | 1.78 | 2.08 | +0.30 | buy |
| Nicholas Investment Partners, LP | 69,845 | 209,071 | +139,226 | 0.33 | 1.00 | +0.67 | buy |
| Candriam S.C.A. | 335,208 | 443,066 | +107,858 | 0.11 | 0.17 | +0.06 | buy |
| Alyeska Investment Group, L.P. | 150,000 | 250,000 | +100,000 | 0.03 | 0.05 | +0.03 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 479,098 | 564,398 | +85,300 | 0.52 | 0.64 | +0.12 | buy |
| SEGALL BRYANT & HAMILL, LLC | 180,200 | 257,063 | +76,863 | 0.17 | 0.26 | +0.09 | buy |
| SummitTX Capital, L.P. | 49,711 | 112,893 | +63,182 | 0.10 | 0.25 | +0.15 | buy |
| Calamos Advisors LLC | 21,627 | 51,443 | +29,816 | 0.01 | 0.01 | +0.01 | buy |
| PINNACLE ASSOCIATES LTD | 177,062 | 202,440 | +25,378 | 0.15 | 0.19 | +0.04 | buy |
| HighVista Strategies LLC | 58,643 | 78,003 | +19,360 | 1.07 | 1.52 | +0.45 | buy |
| OAK RIDGE INVESTMENTS LLC | 15,902 | 32,518 | +16,616 | 0.07 | 0.16 | +0.09 | buy |
| Legato Capital Management LLC | 11,334 | 26,239 | +14,905 | 0.07 | 0.19 | +0.12 | buy |
| TEMA ETFS LLC | 8,162 | 22,413 | +14,251 | 0.04 | 0.06 | +0.03 | buy |
| Bellevue Group AG | 8,841 | 19,007 | +10,166 | 0.01 | 0.03 | +0.02 | buy |
| J. Safra Sarasin Holding AG | 8,634 | 18,211 | +9,577 | 0.01 | 0.02 | +0.01 | buy |
| Capital World Investors | 242,041 | 248,815 | +6,774 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 12,007 | 18,002 | +5,995 | 0.02 | 0.04 | +0.02 | buy |
| Dana Investment Advisors, Inc. | 15,761 | 20,734 | +4,973 | 0.03 | 0.05 | +0.02 | buy |
| E. Ohman J:or Asset Management AB | 300,762 | 304,611 | +3,849 | 0.52 | 0.60 | +0.08 | buy |
| NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC | 27,391 | 30,541 | +3,150 | 0.03 | 0.03 | +0.00 | buy |
| Yorktown Management & Research Co Inc | 4,750 | 7,750 | +3,000 | 0.26 | 0.40 | +0.14 | buy |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 29,400 | 31,800 | +2,400 | 0.01 | 0.01 | +0.00 | buy |
| Fifth Third Wealth Advisors LLC | 3,324 | 5,154 | +1,830 | 0.01 | 0.01 | +0.00 | buy |
| HARVEST MANAGEMENT LLC | 11,000 | 12,400 | +1,400 | 0.35 | 0.42 | +0.06 | buy |
| Abel Hall, LLC | 4,050 | 5,283 | +1,233 | 0.06 | 0.08 | +0.02 | buy |
| INTRUST BANK NA | 5,140 | 6,334 | +1,194 | 0.03 | 0.04 | +0.01 | buy |
| Pier Capital, LLC | 69,583 | 70,665 | +1,082 | 0.76 | 0.80 | +0.04 | buy |
| SECURIAN ASSET MANAGEMENT, INC | 9,012 | 10,012 | +1,000 | 0.02 | 0.03 | +0.01 | buy |
| PRAXIS INVESTMENT MANAGEMENT INC | 3,853 | 4,328 | +475 | 0.02 | 0.02 | +0.00 | buy |
| LVW Advisors, LLC | 3,982 | 4,234 | +252 | 0.03 | 0.03 | +0.01 | buy |
| Ellsworth Advisors, LLC | 12,730 | 12,858 | +128 | 0.16 | 0.17 | +0.02 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 239 | 319 | +80 | 0.01 | 0.01 | +0.00 | buy |
| W.G. Shaheen & Associates DBA Whitney & Co | 3,240 | 3,253 | +13 | 0.02 | 0.02 | +0.00 | buy |
| Veracity Capital LLC | 7,414 | 7,419 | +5 | 0.17 | 0.17 | -0.00 | buy |
| First Bank & Trust | 6,394 | 6,392 | -2 | 0.07 | 0.08 | +0.01 | sell |
| MEEDER ASSET MANAGEMENT INC | 142 | 46 | -96 | 0.00 | 0.00 | -0.00 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 56,738 | 56,589 | -149 | 1.56 | 1.67 | +0.11 | sell |
| Gallagher Fiduciary Advisors, LLC | 11,577 | 11,322 | -255 | 0.03 | 0.03 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 21,856 | 21,577 | -279 | 0.11 | 0.11 | +0.00 | sell |
| Mirador Capital Partners LP | 202,673 | 202,370 | -303 | 1.89 | 2.11 | +0.22 | sell |
| AMI ASSET MANAGEMENT CORP | 14,816 | 14,261 | -555 | 0.06 | 0.07 | +0.01 | sell |
| GREAT LAKES ADVISORS, LLC | 24,981 | 23,002 | -1,979 | 0.01 | 0.01 | +0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 103,626 | 100,019 | -3,607 | 0.25 | 0.28 | +0.02 | sell |
| FNY Investment Advisers, LLC | 9,030 | 2,000 | -7,030 | 0.26 | 0.06 | -0.20 | sell |
| MOODY ALDRICH PARTNERS LLC | 36,945 | 28,963 | -7,982 | 0.44 | 0.44 | +0.00 | sell |
| Retirement Systems of Alabama | 149,891 | 140,426 | -9,465 | 0.03 | 0.04 | +0.00 | sell |
| Quinn Opportunity Partners LLC | 16,000 | 5,000 | -11,000 | 0.05 | 0.02 | -0.04 | sell |
| BAMCO INC /NY/ | 23,000 | 10,000 | -13,000 | 0.00 | 0.00 | -0.00 | sell |
| Granahan Investment Management, LLC | 72,464 | 40,247 | -32,217 | 0.23 | 0.12 | -0.11 | sell |
| Capital International Investors | 1,338,803 | 1,305,848 | -32,955 | 0.02 | 0.02 | +0.00 | sell |
| DAFNA Capital Management LLC | 217,497 | 171,998 | -45,499 | 3.26 | 2.79 | -0.47 | sell |
| THORNBURG INVESTMENT MANAGEMENT INC | 83,190 | 31,133 | -52,057 | 0.06 | 0.03 | -0.03 | sell |