| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BANK OF AMERICA CORP /DE/ | 266,771 | 4,777,628 | +4,510,857 | 0.00 | 0.03 | +0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 2,229,485 | 5,121,589 | +2,892,104 | 0.12 | 0.22 | +0.10 | buy |
| Vestal Point Capital, LP | 50,000 | 2,150,000 | +2,100,000 | 0.44 | 12.47 | +12.02 | buy |
| MARSHALL WACE, LLP | 626,087 | 2,556,803 | +1,930,716 | 0.10 | 0.30 | +0.20 | buy |
| ALLIANCEBERNSTEIN L.P. | 122,247 | 1,770,065 | +1,647,818 | 0.00 | 0.04 | +0.04 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 1,525,688 | +1,525,688 | 0.00 | 2.85 | +2.85 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.01 | +0.01 | buy |
| Pentwater Capital Management LP | 0 | 1,080,000 | +1,080,000 | 0.00 | 1.24 | +1.24 | buy |
| Melqart Asset Management (UK) Ltd | 0 | 983,395 | +983,395 | 0.00 | 5.13 | +5.13 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 760,319 | +760,319 | 0.00 | 0.19 | +0.19 | buy |
| BROWN ADVISORY INC | 0 | 759,534 | +759,534 | 0.00 | 0.07 | +0.07 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 731,386 | +731,386 | 0.00 | 0.27 | +0.27 | buy |
| ORBIMED ADVISORS LLC | 0 | 682,700 | +682,700 | 0.00 | 0.88 | +0.88 | buy |
| Laurion Capital Management LP | 0 | 519,918 | +519,918 | 0.00 | 1.01 | +1.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 56,300 | 465,498 | +409,198 | 0.28 | 1.16 | +0.88 | buy |
| JPMORGAN CHASE & CO | 284,400 | 688,104 | +403,704 | 0.00 | 0.00 | +0.00 | buy |
| HAP Trading, LLC | 0 | 395,529 | +395,529 | 0.00 | 8.59 | +8.59 | buy |
| HRT FINANCIAL LP | 42,917 | 430,821 | +387,904 | 0.03 | 0.19 | +0.16 | buy |
| Pictet Asset Management Holding SA | 1,372,244 | 1,753,646 | +381,402 | 0.13 | 0.13 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 35,967 | 365,967 | +330,000 | 0.00 | 0.04 | +0.04 | buy |
| Sarissa Capital Management LP | 0 | 300,000 | +300,000 | 0.00 | 3.68 | +3.68 | buy |
| Iron Triangle Partners LP | 0 | 300,000 | +300,000 | 0.00 | 2.18 | +2.18 | buy |
| BARCLAYS PLC | 464,723 | 762,247 | +297,524 | 0.02 | 0.02 | +0.00 | buy |
| CITADEL ADVISORS LLC | 272,593 | 560,902 | +288,309 | 0.02 | 0.04 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 413,137 | 675,062 | +261,925 | 0.10 | 0.12 | +0.03 | buy |
| NORGES BANK | 722,229 | 982,761 | +260,532 | 0.01 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 200,000 | 450,000 | +250,000 | 2.41 | 3.10 | +0.69 | buy |
| Hudson Bay Capital Management LP | 0 | 247,566 | +247,566 | 0.00 | 0.15 | +0.15 | buy |
| Prosight Management, LP | 0 | 245,000 | +245,000 | 0.00 | 4.78 | +4.78 | buy |
| ADAR1 Capital Management, LLC | 92,082 | 319,510 | +227,428 | 3.44 | 6.12 | +2.68 | buy |
| Candriam S.C.A. | 267,240 | 493,029 | +225,789 | 0.15 | 0.22 | +0.07 | buy |
| JANE STREET GROUP, LLC | 88,581 | 307,567 | +218,986 | 0.01 | 0.03 | +0.02 | buy |
| Point72 Asset Management, L.P. | 157,100 | 364,709 | +207,609 | 0.04 | 0.07 | +0.03 | buy |
| Polar Capital Holdings Plc | 1,417,054 | 1,605,576 | +188,522 | 0.73 | 0.59 | -0.14 | buy |
| SIMPLEX TRADING, LLC | 0 | 178,309 | +178,309 | 0.00 | 0.36 | +0.36 | buy |
| Avidity Partners Management LP | 0 | 166,000 | +166,000 | 0.00 | 0.41 | +0.41 | buy |
| Verition Fund Management LLC | 0 | 162,319 | +162,319 | 0.00 | 0.11 | +0.11 | buy |
| Redmile Group, LLC | 0 | 161,600 | +161,600 | 0.00 | 0.42 | +0.42 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,090,125 | 2,247,165 | +157,040 | 0.02 | 0.01 | -0.00 | buy |
| KRYGER CAPITAL Ltd | 0 | 146,838 | +146,838 | 0.00 | 1.92 | +1.92 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 111,147 | 253,487 | +142,340 | 0.01 | 0.02 | +0.01 | buy |
| Hood River Capital Management LLC | 560,981 | 696,647 | +135,666 | 1.29 | 1.09 | -0.20 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 29,446 | 155,794 | +126,348 | 0.01 | 0.05 | +0.04 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 50,900 | 176,072 | +125,172 | 0.02 | 0.04 | +0.03 | buy |
| Retirement Systems of Alabama | 0 | 123,132 | +123,132 | 0.00 | 0.03 | +0.03 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 344,484 | 461,018 | +116,534 | 6.55 | 4.98 | -1.57 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 0 | 116,000 | +116,000 | 0.00 | 1.08 | +1.08 | buy |
| Ikarian Capital, LLC | 30,000 | 145,147 | +115,147 | 0.69 | 2.77 | +2.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 4,062 | 116,189 | +112,127 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 130,260 | 239,242 | +108,982 | 0.02 | 0.03 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 183,598 | 287,567 | +103,969 | 0.02 | 0.02 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 182,040 | 284,520 | +102,480 | 0.01 | 0.02 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 101,609 | +101,609 | 0.00 | 0.06 | +0.06 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 177,603 | 278,915 | +101,312 | 10.58 | 12.93 | +2.35 | buy |
| Decheng Capital LLC | 0 | 94,043 | +94,043 | 0.00 | 0.88 | +0.88 | buy |
| Polar Asset Management Partners Inc. | 0 | 92,300 | +92,300 | 0.00 | 0.17 | +0.17 | buy |
| EMERALD ADVISERS, LLC | 0 | 91,561 | +91,561 | 0.00 | 0.26 | +0.26 | buy |
| COMERICA BANK | 45,839 | 130,806 | +84,967 | 0.02 | 0.04 | +0.02 | buy |
| Octagon Capital Advisors LP | 116,000 | 194,000 | +78,000 | 1.55 | 1.65 | +0.10 | buy |
| Invesco Ltd. | 1,242,980 | 1,317,538 | +74,558 | 0.02 | 0.02 | -0.00 | buy |
| Man Group plc | 8,287 | 82,644 | +74,357 | 0.00 | 0.02 | +0.01 | buy |
| FORA Capital, LLC | 9,648 | 82,776 | +73,128 | 0.07 | 0.48 | +0.41 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 72,080 | +72,080 | 0.00 | 0.26 | +0.26 | buy |
| Walleye Capital LLC | 37,663 | 105,662 | +67,999 | 0.04 | 0.08 | +0.04 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 67,076 | +67,076 | 0.00 | 0.22 | +0.22 | buy |
| MACQUARIE GROUP LTD | 41,984 | 101,044 | +59,060 | 0.00 | 0.01 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 0 | 57,893 | +57,893 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 223,820 | 281,671 | +57,851 | 3.47 | 3.20 | -0.27 | buy |
| Artia Global Partners LP | 32,113 | 89,525 | +57,412 | 1.06 | 1.54 | +0.48 | buy |
| NORTHERN TRUST CORP | 1,055,977 | 1,111,440 | +55,463 | 0.02 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 99,410 | 153,569 | +54,159 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 42,732 | 95,879 | +53,147 | 0.12 | 0.19 | +0.06 | buy |
| MetLife Investment Management, LLC | 49,088 | 100,548 | +51,460 | 0.03 | 0.05 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.98 | +0.98 | buy |
| Clearline Capital LP | 0 | 48,035 | +48,035 | 0.00 | 0.33 | +0.33 | buy |
| Rhenman & Partners Asset Management AB | 149,912 | 197,515 | +47,603 | 1.25 | 1.31 | +0.06 | buy |
| BRIDGER MANAGEMENT, LLC | 22,510 | 69,110 | +46,600 | 0.72 | 2.18 | +1.46 | buy |
| SANDLER CAPITAL MANAGEMENT | 0 | 46,000 | +46,000 | 0.00 | 0.39 | +0.39 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 43,866 | +43,866 | 0.00 | 0.01 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 29,871 | 72,897 | +43,026 | 0.45 | 0.87 | +0.42 | buy |
| ExodusPoint Capital Management, LP | 3,134 | 45,264 | +42,130 | 0.00 | 0.04 | +0.04 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 17,162 | 58,437 | +41,275 | 0.02 | 0.04 | +0.03 | buy |
| Concentric Capital Strategies, LP | 0 | 40,207 | +40,207 | 0.00 | 0.18 | +0.18 | buy |
| TUDOR INVESTMENT CORP ET AL | 35,727 | 75,736 | +40,009 | 0.04 | 0.06 | +0.02 | buy |
| Murchinson Ltd. | 69,439 | 108,795 | +39,356 | 1.01 | 0.85 | -0.16 | buy |
| Zimmer Partners, LP | 0 | 38,600 | +38,600 | 0.00 | 0.06 | +0.06 | buy |
| Quinn Opportunity Partners LLC | 8,000 | 46,377 | +38,377 | 0.08 | 0.37 | +0.29 | buy |
| FIRST TRUST ADVISORS LP | 0 | 37,949 | +37,949 | 0.00 | 0.00 | +0.00 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 36,875 | +36,875 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 0 | 36,554 | +36,554 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 3,964 | 39,614 | +35,650 | 0.00 | 0.02 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 7,013 | 42,583 | +35,570 | 0.25 | 1.17 | +0.92 | buy |
| BIT Capital GmbH | 0 | 30,144 | +30,144 | 0.00 | 0.19 | +0.19 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 5,000 | 35,000 | +30,000 | 0.01 | 0.05 | +0.04 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 26,300 | +26,300 | 0.00 | 0.84 | +0.84 | buy |
| Squarepoint Ops LLC | 0 | 25,700 | +25,700 | 0.00 | 0.01 | +0.01 | buy |
| Carlson Capital, L.P. | 0 | 25,000 | +25,000 | 0.00 | 0.14 | +0.14 | buy |
| RHUMBLINE ADVISERS | 281,842 | 306,639 | +24,797 | 0.02 | 0.02 | -0.00 | buy |
| UBS Group AG | 274,308 | 298,744 | +24,436 | 0.01 | 0.01 | -0.00 | buy |