| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 2,500,000 | 3,073,853 | +573,853 | 4.41 | 4.00 | -0.41 | buy |
| Hood River Capital Management LLC | 989,248 | 1,256,580 | +267,332 | 0.69 | 0.86 | +0.17 | buy |
| Polar Capital Holdings Plc | 2,196,721 | 2,455,737 | +259,016 | 0.58 | 0.60 | +0.02 | buy |
| Vestal Point Capital, LP | 2,350,000 | 2,590,531 | +240,531 | 6.55 | 7.43 | +0.88 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 149,433 | 345,598 | +196,165 | 0.01 | 0.02 | +0.01 | buy |
| Fisher Asset Management, LLC | 616,492 | 793,458 | +176,966 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 450,513 | 602,421 | +151,908 | 0.04 | 0.05 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 254,148 | 382,696 | +128,548 | 0.22 | 0.31 | +0.09 | buy |
| Catalio Capital Management, LP | 457,587 | 585,812 | +128,225 | 4.71 | 5.84 | +1.13 | buy |
| Integral Health Asset Management, LLC | 1,000,000 | 1,100,000 | +100,000 | 4.16 | 4.90 | +0.74 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,841,338 | 2,937,484 | +96,146 | 0.01 | 0.01 | 0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 60,975 | 148,169 | +87,194 | 0.12 | 0.30 | +0.18 | buy |
| Woodline Partners LP | 126,201 | 212,303 | +86,102 | 0.04 | 0.06 | +0.02 | buy |
| Capital International Investors | 1,096,164 | 1,168,110 | +71,946 | 0.01 | 0.01 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 83,576 | 149,648 | +66,072 | 0.99 | 1.92 | +0.93 | buy |
| ALGERT GLOBAL LLC | 58,680 | 116,320 | +57,640 | 0.07 | 0.12 | 0.00 | buy |
| Zimmer Partners, LP | 38,000 | 82,132 | +44,132 | 0.03 | 0.06 | +0.03 | buy |
| Exome Asset Management LLC | 65,883 | 103,483 | +37,600 | 2.33 | 3.73 | +1.39 | buy |
| Mirador Capital Partners LP | 65,636 | 99,125 | +33,489 | 0.56 | 0.70 | +0.14 | buy |
| BNP Paribas Asset Management Holding S.A. | 489,362 | 522,468 | +33,106 | 0.06 | 0.06 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,024,417 | 1,057,146 | +32,729 | 0.02 | 0.03 | 0.00 | buy |
| HighVista Strategies LLC | 14,261 | 44,749 | +30,488 | 0.25 | 0.69 | +0.44 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,279,990 | 1,310,336 | +30,346 | 0.26 | 0.26 | -0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 50,273 | 67,261 | +16,988 | 0.02 | 0.03 | +0.01 | buy |
| J. Safra Sarasin Holding AG | 13,027 | 27,791 | +14,764 | 0.01 | 0.02 | +0.01 | buy |
| CIBC WORLD MARKETS CORP | 10,696 | 25,361 | +14,665 | 0.00 | 0.01 | +0.01 | buy |
| Quinn Opportunity Partners LLC | 115,939 | 129,939 | +14,000 | 0.37 | 0.36 | -0.01 | buy |
| RHUMBLINE ADVISERS | 383,883 | 373,855 | +10,028 | 0.02 | 0.01 | 0.00 | sell |
| GREAT POINT PARTNERS LLC | 360,000 | 370,000 | +10,000 | 7.98 | 7.88 | -0.10 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 20,206 | 28,554 | +8,348 | 0.08 | 0.12 | +0.04 | buy |
| ProShare Advisors LLC | 43,299 | 35,115 | +8,184 | 0.00 | 0.00 | 0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 45,130 | 53,113 | +7,983 | 0.09 | 0.10 | 0.00 | buy |
| Bayforest Capital Ltd | 1,689 | 7,372 | +5,683 | 0.10 | 0.13 | +0.03 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 150,343 | 155,737 | +5,394 | 0.21 | 0.21 | -0.00 | buy |
| WINTON GROUP Ltd | 19,005 | 24,255 | +5,250 | 0.06 | 0.06 | -0.00 | buy |
| Allostery Investments LP | 65,000 | 70,000 | +5,000 | 6.00 | 4.06 | -1.94 | buy |
| Kazazian Asset Management, LLC | 5,236 | 9,796 | +4,560 | 0.19 | 0.32 | +0.13 | buy |
| ONTARIO TEACHERS PENSION PLAN BOARD | 10,758 | 14,943 | +4,185 | 0.01 | 0.01 | +0.00 | buy |
| CERTUITY, LLC | 5,204 | 9,204 | +4,000 | 0.03 | 0.04 | +0.01 | buy |
| Corebridge Financial, Inc. | 189,540 | 185,551 | +3,989 | 0.05 | 0.05 | 0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,658 | 74,918 | +3,260 | 0.01 | 0.01 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 11,892 | 14,862 | +2,970 | 0.01 | 0.01 | +0.00 | buy |
| Qsemble Capital Management, LP | 5,545 | 7,843 | +2,298 | 0.03 | 0.03 | -0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 14,864 | 17,096 | +2,232 | 0.05 | 0.06 | +0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 26,064 | 28,210 | +2,146 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 11,744 | 13,783 | +2,039 | 0.03 | 0.03 | -0.00 | buy |
| Cynosure Group, LLC | 5,800 | 7,788 | +1,988 | 0.04 | 0.04 | +0.00 | buy |
| GABELLI FUNDS LLC | 5,000 | 6,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 1,751 | 3,094 | +1,343 | 0.01 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 9,213 | 10,434 | +1,221 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 104,718 | 103,512 | +1,206 | 0.01 | 0.01 | -0.00 | sell |
| CI INVESTMENTS INC. | 2,988 | 1,859 | +1,129 | 0.00 | 0.00 | 0.00 | sell |
| YOUSIF CAPITAL MANAGEMENT, LLC | 42,786 | 41,660 | +1,126 | 0.02 | 0.02 | 0.00 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 59,085 | 59,841 | +756 | 1.38 | 1.31 | -0.07 | buy |
| GUGGENHEIM CAPITAL LLC | 35,988 | 36,703 | +715 | 0.01 | 0.01 | 0.00 | buy |
| HARVEST MANAGEMENT LLC | 11,200 | 11,744 | +544 | 0.25 | 0.21 | -0.05 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,478 | 3,021 | +543 | 0.00 | 0.00 | +0.00 | buy |
| HARVEY CAPITAL MANAGEMENT INC | 22,105 | 22,580 | +475 | 0.24 | 0.24 | -0.01 | buy |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 27,900 | 28,200 | +300 | 0.01 | 0.01 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 319,281 | 319,533 | +252 | 0.00 | 0.00 | -0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 33,589 | 33,826 | +237 | 0.01 | 0.01 | -0.00 | buy |
| Retirement Systems of Alabama | 143,495 | 143,637 | +142 | 0.03 | 0.02 | -0.00 | buy |
| Dana Investment Advisors, Inc. | 16,863 | 17,003 | +140 | 0.03 | 0.02 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 6,423 | 6,506 | +83 | 0.01 | 0.01 | -0.00 | buy |
| High Note Wealth, LLC | 31 | 79 | +48 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 8,504 | 8,551 | +47 | 0.04 | 0.04 | -0.00 | buy |
| NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC | 26,228 | 26,239 | +11 | 0.03 | 0.02 | -0.01 | buy |
| MEEDER ASSET MANAGEMENT INC | 76 | 52 | -24 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 5,128 | 5,051 | -77 | 0.04 | 0.03 | -0.01 | sell |
| Ameritas Investment Partners, Inc. | 35,595 | 34,892 | -703 | 0.06 | 0.05 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 25,023 | 23,751 | -1,272 | 0.11 | 0.09 | -0.02 | sell |
| PROFUND ADVISORS LLC | 35,713 | 34,035 | -1,678 | 0.06 | 0.06 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 71,500 | 69,543 | -1,957 | 0.05 | 0.04 | -0.00 | sell |
| Swiss National Bank | 219,800 | 217,200 | -2,600 | 0.01 | 0.01 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 83,862 | 80,359 | -3,503 | 0.54 | 0.54 | -0.00 | sell |
| FNY Investment Advisers, LLC | 14,545 | 10,855 | -3,690 | 0.35 | 0.27 | -0.09 | sell |
| EntryPoint Capital, LLC | 10,923 | 6,840 | -4,083 | 0.22 | 0.13 | -0.09 | sell |
| SECTORAL ASSET MANAGEMENT INC | 24,500 | 18,068 | -6,432 | 0.77 | 0.57 | -0.20 | sell |
| Bellevue Group AG | 10,941 | 3,741 | -7,200 | 0.01 | 0.00 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 153,021 | 144,961 | -8,060 | 1.30 | 1.34 | +0.04 | sell |
| Finepoint Capital LP | 318,448 | 309,948 | -8,500 | 0.91 | 0.95 | +0.04 | sell |
| Redmile Group, LLC | 92,598 | 82,098 | -10,500 | 0.30 | 0.31 | +0.01 | sell |
| NEOS Investment Management LLC | 47,383 | 32,588 | -14,795 | 0.05 | 0.02 | -0.03 | sell |
| TEMA ETFS LLC | 47,383 | 32,588 | -14,795 | 0.93 | 0.39 | -0.53 | sell |
| PINNACLE ASSOCIATES LTD | 285,532 | 270,435 | -15,097 | 0.18 | 0.16 | -0.02 | sell |
| Rafferty Asset Management, LLC | 167,935 | 149,507 | -18,428 | 0.03 | 0.03 | -0.00 | sell |
| THORNBURG INVESTMENT MANAGEMENT INC | 281,862 | 260,893 | -20,969 | 0.18 | 0.15 | -0.03 | sell |
| ADAR1 Capital Management, LLC | 414,209 | 390,729 | -23,480 | 4.02 | 3.02 | -0.99 | sell |
| Candriam S.C.A. | 170,560 | 145,191 | -25,369 | 0.05 | 0.04 | -0.01 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 182,126 | 150,908 | -31,218 | 100.00 | 4.26 | -95.74 | sell |
| Rhenman & Partners Asset Management AB | 149,250 | 104,250 | -45,000 | 0.72 | 0.48 | -0.24 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 129,389 | 72,992 | -56,397 | 5.35 | 3.50 | -1.85 | sell |
| ORBIMED ADVISORS LLC | 1,584,005 | 1,509,205 | -74,800 | 1.55 | 1.46 | -0.09 | sell |
| Alyeska Investment Group, L.P. | 150,000 | 75,000 | -75,000 | 0.03 | 0.01 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 524,634 | 446,828 | -77,806 | 0.02 | 0.02 | -0.01 | sell |
| LMR Partners LLP | 103,346 | 20,000 | -83,346 | 0.08 | 0.02 | -0.07 | sell |
| Melqart Asset Management (UK) Ltd | 1,136,434 | 999,447 | -136,987 | 6.45 | 5.24 | -1.22 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 329,136 | 161,285 | -167,851 | 1.87 | 1.34 | -0.54 | sell |
| Sarissa Capital Management LP | 833,799 | 600,000 | -233,799 | 12.15 | 15.59 | +3.44 | sell |
| ARMISTICE CAPITAL, LLC | 1,312,000 | 1,023,390 | -288,610 | 0.84 | 0.62 | -0.23 | sell |