| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 17,716,372 | 17,523,840 | -192,532 | 0.71 | 0.80 | +0.08 | sell |
| BlackRock, Inc. | 16,395,123 | 16,548,011 | +152,888 | 0.02 | 0.02 | +0.00 | buy |
| FMR LLC | 12,807,752 | 10,723,140 | -2,084,612 | 0.04 | 0.04 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 7,937,063 | 8,009,489 | +72,426 | 0.09 | 0.10 | +0.01 | buy |
| STATE STREET CORP | 5,825,295 | 5,745,193 | -80,102 | 0.01 | 0.01 | +0.00 | sell |
| Avoro Capital Advisors LLC | 0 | 3,333,333 | +3,333,333 | 0.00 | 2.16 | +2.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,056,017 | 3,215,415 | +159,398 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 2,941,152 | 3,125,436 | +184,284 | 0.01 | 0.02 | +0.00 | buy |
| RTW INVESTMENTS, LP | 2,721,158 | 2,721,158 | 0 | 1.73 | 1.78 | +0.05 | hold |
| BNP Paribas Asset Management Holding S.A. | 3,150,000 | 2,500,000 | -650,000 | 0.01 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 2,371,679 | 2,205,758 | -165,921 | 0.02 | 0.02 | -0.00 | sell |
| UBS Group AG | 1,131,456 | 2,077,277 | +945,821 | 0.01 | 0.02 | +0.01 | buy |
| Polar Capital Holdings Plc | 2,422,612 | 1,661,248 | -761,364 | 0.70 | 0.48 | -0.23 | sell |
| Integral Health Asset Management, LLC | 1,400,000 | 1,600,000 | +200,000 | 4.51 | 5.58 | +1.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,930,119 | 1,584,321 | -345,798 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 1,265,301 | 1,505,075 | +239,774 | 0.00 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,480,857 | +1,480,857 | 0.00 | 1.99 | +1.99 | buy |
| NORTHERN TRUST CORP | 1,380,787 | 1,441,634 | +60,847 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,383,437 | 1,397,045 | +13,608 | 0.01 | 0.01 | +0.00 | buy |
| Deep Track Capital, LP | 3,336,998 | 1,374,320 | -1,962,678 | 4.84 | 1.87 | -2.97 | sell |
| Capital International Investors | 1,178,780 | 1,338,803 | +160,023 | 0.01 | 0.02 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 934,642 | 1,159,879 | +225,237 | 1.60 | 1.97 | +0.37 | buy |
| CITADEL ADVISORS LLC | 1,162,937 | 1,099,858 | -63,079 | 0.05 | 0.05 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 976,892 | 1,093,485 | +116,593 | 0.03 | 0.04 | +0.01 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0 | 1,087,591 | +1,087,591 | 0.00 | 0.24 | +0.24 | buy |
| Bank of New York Mellon Corp | 854,309 | 1,006,185 | +151,876 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 1,648,428 | 1,000,428 | -648,000 | 0.41 | 0.25 | -0.16 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 992,545 | +992,545 | 0.00 | 0.13 | +0.13 | buy |
| JPMORGAN CHASE & CO | 1,412,797 | 903,805 | -508,992 | 0.01 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 753,617 | 898,951 | +145,334 | 0.07 | 0.08 | +0.01 | buy |
| Logos Global Management LP | 300,000 | 875,000 | +575,000 | 1.27 | 2.97 | +1.70 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 579,862 | 854,374 | +274,512 | 0.02 | 0.04 | +0.01 | buy |
| Melqart Asset Management (UK) Ltd | 622,898 | 843,949 | +221,051 | 3.96 | 5.48 | +1.52 | buy |
| Qube Research & Technologies Ltd | 537,277 | 779,446 | +242,169 | 0.05 | 0.07 | +0.02 | buy |
| Capital Research Global Investors | 0 | 770,999 | +770,999 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 822,885 | 768,264 | -54,621 | 0.02 | 0.02 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 992,766 | 764,538 | -228,228 | 1.54 | 1.66 | +0.12 | sell |
| Pictet Asset Management Holding SA | 757,563 | 750,953 | -6,610 | 0.05 | 0.05 | +0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 827,863 | 714,344 | -113,519 | 0.06 | 0.05 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 119,221 | 706,631 | +587,410 | 0.01 | 0.04 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 800,000 | 700,483 | -99,517 | 3.65 | 2.71 | -0.94 | sell |
| FEDERATED HERMES, INC. | 483,668 | 699,453 | +215,785 | 0.05 | 0.07 | +0.02 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 747,983 | 660,310 | -87,673 | 4.22 | 3.69 | -0.53 | sell |
| MARSHALL WACE, LLP | 337,031 | 656,608 | +319,577 | 0.02 | 0.05 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 540,166 | 632,556 | +92,390 | 2.57 | 2.51 | -0.06 | buy |
| Point72 Asset Management, L.P. | 0 | 626,102 | +626,102 | 0.00 | 0.07 | +0.07 | buy |
| BROWN ADVISORY INC | 731,154 | 614,655 | -116,499 | 0.06 | 0.07 | +0.00 | sell |
| Siren, L.L.C. | 0 | 613,952 | +613,952 | 0.00 | 1.12 | +1.12 | buy |
| Foresite Capital Management IV, LLC | 458,295 | 503,295 | +45,000 | 12.68 | 13.99 | +1.32 | buy |
| MPM BioImpact LLC | 0 | 500,000 | +500,000 | 0.00 | 2.54 | +2.54 | buy |
| GW&K Investment Management, LLC | 472,363 | 494,619 | +22,256 | 0.26 | 0.29 | +0.03 | buy |
| Invesco Ltd. | 204,878 | 484,980 | +280,102 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 483,061 | 483,274 | +213 | 0.05 | 0.05 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 479,611 | 479,098 | -513 | 0.48 | 0.52 | +0.05 | sell |
| ALLIANCEBERNSTEIN L.P. | 412,966 | 459,087 | +46,121 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 443,910 | 443,957 | +47 | 0.01 | 0.02 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 544,010 | 420,846 | -123,164 | 0.03 | 0.02 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 409,990 | 409,784 | -206 | 0.01 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 356,995 | 369,575 | +12,580 | 0.02 | 0.02 | +0.00 | buy |
| GROUP ONE TRADING LLC | 407,253 | 363,997 | -43,256 | 0.77 | 0.79 | +0.03 | sell |
| Nuveen, LLC | 369,279 | 351,809 | -17,470 | 0.01 | 0.01 | +0.00 | sell |
| Candriam S.C.A. | 146,631 | 335,208 | +188,577 | 0.05 | 0.11 | +0.07 | buy |
| GILDER GAGNON HOWE & CO LLC | 385,820 | 330,989 | -54,831 | 0.26 | 0.26 | +0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 327,202 | 311,649 | -15,553 | 0.01 | 0.01 | +0.00 | sell |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 308,000 | +308,000 | 0.03 | 0.03 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 545,805 | 302,802 | -243,003 | 0.01 | 0.00 | -0.00 | sell |
| E. Ohman J:or Asset Management AB | 362,962 | 300,762 | -62,200 | 0.54 | 0.52 | -0.01 | sell |
| Vestal Point Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 0.55 | +0.55 | buy |
| TWO SIGMA INVESTMENTS, LP | 274,017 | 285,008 | +10,991 | 0.03 | 0.02 | -0.01 | buy |
| First Turn Management, LLC | 325,668 | 283,700 | -41,968 | 2.36 | 2.09 | -0.28 | sell |
| Ikarian Capital, LLC | 172,672 | 283,572 | +110,900 | 1.42 | 2.67 | +1.25 | buy |
| JANUS HENDERSON GROUP PLC | 256,212 | 282,121 | +25,909 | 0.01 | 0.01 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 278,429 | 278,429 | 0 | 0.27 | 0.27 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 65,592 | 259,459 | +193,867 | 0.00 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 102,101 | 249,243 | +147,142 | 0.00 | 0.01 | +0.01 | buy |
| Handelsbanken Fonder AB | 205,800 | 247,300 | +41,500 | 0.04 | 0.05 | +0.01 | buy |
| Caption Management, LLC | 27,999 | 245,000 | +217,001 | 0.08 | 0.77 | +0.69 | buy |
| Capital World Investors | 0 | 242,041 | +242,041 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 235,049 | 240,632 | +5,583 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 224,200 | 229,800 | +5,600 | 0.01 | 0.01 | +0.00 | buy |
| Sarissa Capital Management LP | 396,357 | 228,623 | -167,734 | 11.30 | 9.56 | -1.74 | sell |
| HSBC HOLDINGS PLC | 3,696 | 221,999 | +218,303 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 370,997 | 217,497 | -153,500 | 5.48 | 3.26 | -2.21 | sell |
| Freestone Grove Partners LP | 0 | 216,769 | +216,769 | 0.00 | 0.10 | +0.10 | buy |
| Catalio Capital Management, LP | 258,381 | 215,501 | -42,880 | 2.90 | 2.97 | +0.07 | sell |
| Mirador Capital Partners LP | 198,558 | 202,673 | +4,115 | 1.73 | 1.89 | +0.16 | buy |
| Bank of New York Mellon Corp | 200,000 | 200,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EMERALD ADVISERS, LLC | 0 | 198,811 | +198,811 | 0.00 | 0.41 | +0.41 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 189,401 | 198,530 | +9,129 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 175,804 | 187,138 | +11,334 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 189,513 | 183,391 | -6,122 | 0.16 | 0.12 | -0.04 | sell |
| SEGALL BRYANT & HAMILL, LLC | 189,513 | 180,200 | -9,313 | 0.16 | 0.12 | -0.04 | sell |
| Checkpoint Capital L.P. | 166,823 | 180,000 | +13,177 | 3.36 | 4.26 | +0.90 | buy |
| PINNACLE ASSOCIATES LTD | 190,999 | 177,062 | -13,937 | 0.16 | 0.15 | -0.01 | sell |
| Russell Investments Group, Ltd. | 137,690 | 174,029 | +36,339 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 190,807 | 167,124 | -23,683 | 0.01 | 0.01 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 236,925 | 156,544 | -80,381 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 168,586 | 151,021 | -17,565 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 0 | 150,000 | +150,000 | 0.00 | 0.03 | +0.03 | buy |
| Retirement Systems of Alabama | 146,668 | 149,891 | +3,223 | 0.03 | 0.03 | +0.00 | buy |