| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 0 | 3,333,333 | +3,333,333 | 0.00 | 2.16 | +2.16 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,480,857 | +1,480,857 | 0.00 | 1.99 | +1.99 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0 | 1,087,591 | +1,087,591 | 0.00 | 0.24 | +0.24 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 992,545 | +992,545 | 0.00 | 0.13 | +0.13 | buy |
| UBS Group AG | 1,131,456 | 2,077,277 | +945,821 | 0.01 | 0.02 | +0.01 | buy |
| Capital Research Global Investors | 0 | 770,999 | +770,999 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 626,102 | +626,102 | 0.00 | 0.07 | +0.07 | buy |
| Siren, L.L.C. | 0 | 613,952 | +613,952 | 0.00 | 1.12 | +1.12 | buy |
| D. E. Shaw & Co., Inc. | 119,221 | 706,631 | +587,410 | 0.01 | 0.04 | +0.03 | buy |
| Logos Global Management LP | 300,000 | 875,000 | +575,000 | 1.27 | 2.97 | +1.70 | buy |
| MPM BioImpact LLC | 0 | 500,000 | +500,000 | 0.00 | 2.54 | +2.54 | buy |
| MARSHALL WACE, LLP | 337,031 | 656,608 | +319,577 | 0.02 | 0.05 | +0.03 | buy |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 308,000 | +308,000 | 0.03 | 0.03 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 0.55 | +0.55 | buy |
| Invesco Ltd. | 204,878 | 484,980 | +280,102 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 579,862 | 854,374 | +274,512 | 0.02 | 0.04 | +0.01 | buy |
| Qube Research & Technologies Ltd | 537,277 | 779,446 | +242,169 | 0.05 | 0.07 | +0.02 | buy |
| Capital World Investors | 0 | 242,041 | +242,041 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,265,301 | 1,505,075 | +239,774 | 0.00 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 934,642 | 1,159,879 | +225,237 | 1.60 | 1.97 | +0.37 | buy |
| Melqart Asset Management (UK) Ltd | 622,898 | 843,949 | +221,051 | 3.96 | 5.48 | +1.52 | buy |
| HSBC HOLDINGS PLC | 3,696 | 221,999 | +218,303 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 27,999 | 245,000 | +217,001 | 0.08 | 0.77 | +0.69 | buy |
| Freestone Grove Partners LP | 0 | 216,769 | +216,769 | 0.00 | 0.10 | +0.10 | buy |
| FEDERATED HERMES, INC. | 483,668 | 699,453 | +215,785 | 0.05 | 0.07 | +0.02 | buy |
| Integral Health Asset Management, LLC | 1,400,000 | 1,600,000 | +200,000 | 4.51 | 5.58 | +1.07 | buy |
| EMERALD ADVISERS, LLC | 0 | 198,811 | +198,811 | 0.00 | 0.41 | +0.41 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 65,592 | 259,459 | +193,867 | 0.00 | 0.02 | +0.01 | buy |
| Candriam S.C.A. | 146,631 | 335,208 | +188,577 | 0.05 | 0.11 | +0.07 | buy |
| BANK OF AMERICA CORP /DE/ | 2,941,152 | 3,125,436 | +184,284 | 0.01 | 0.02 | +0.00 | buy |
| Capital International Investors | 1,178,780 | 1,338,803 | +160,023 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,056,017 | 3,215,415 | +159,398 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 16,395,123 | 16,548,011 | +152,888 | 0.02 | 0.02 | +0.00 | buy |
| Bank of New York Mellon Corp | 854,309 | 1,006,185 | +151,876 | 0.01 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 150,000 | +150,000 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 102,101 | 249,243 | +147,142 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 753,617 | 898,951 | +145,334 | 0.07 | 0.08 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 135,464 | +135,464 | 0.00 | 0.43 | +0.43 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 976,892 | 1,093,485 | +116,593 | 0.03 | 0.04 | +0.01 | buy |
| Ikarian Capital, LLC | 172,672 | 283,572 | +110,900 | 1.42 | 2.67 | +1.25 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 101,565 | +101,565 | 0.00 | 0.05 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 540,166 | 632,556 | +92,390 | 2.57 | 2.51 | -0.06 | buy |
| Sofinnova Investments, Inc. | 0 | 91,791 | +91,791 | 0.00 | 0.30 | +0.30 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 7,937,063 | 8,009,489 | +72,426 | 0.09 | 0.10 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 71,203 | +71,203 | 0.00 | 0.55 | +0.55 | buy |
| Pier Capital, LLC | 0 | 69,583 | +69,583 | 0.00 | 0.76 | +0.76 | buy |
| ALGERT GLOBAL LLC | 51,310 | 117,120 | +65,810 | 0.05 | 0.12 | +0.07 | buy |
| NORTHERN TRUST CORP | 1,380,787 | 1,441,634 | +60,847 | 0.01 | 0.01 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 49,711 | +49,711 | 0.00 | 0.10 | +0.10 | buy |
| Trexquant Investment LP | 0 | 48,190 | +48,190 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 56,453 | 104,445 | +47,992 | 0.09 | 0.16 | +0.07 | buy |
| ALLIANCEBERNSTEIN L.P. | 412,966 | 459,087 | +46,121 | 0.01 | 0.01 | +0.00 | buy |
| Foresite Capital Management IV, LLC | 458,295 | 503,295 | +45,000 | 12.68 | 13.99 | +1.32 | buy |
| Handelsbanken Fonder AB | 205,800 | 247,300 | +41,500 | 0.04 | 0.05 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 53,929 | 94,503 | +40,574 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 36,900 | +36,900 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 137,690 | 174,029 | +36,339 | 0.01 | 0.01 | +0.00 | buy |
| Palo Alto Investors LP | 0 | 32,195 | +32,195 | 0.00 | 0.32 | +0.32 | buy |
| F/m Investments LLC | 0 | 29,588 | +29,588 | 0.00 | 0.13 | +0.13 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107,324 | 136,599 | +29,275 | 0.01 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 6,562 | 35,062 | +28,500 | 0.02 | 0.15 | +0.13 | buy |
| FIFTH THIRD BANCORP | 1,090 | 28,728 | +27,638 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 256,212 | 282,121 | +25,909 | 0.01 | 0.01 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 5,568 | 31,216 | +25,648 | 0.08 | 0.53 | +0.45 | buy |
| Monashee Investment Management LLC | 75,000 | 100,000 | +25,000 | 2.69 | 3.59 | +0.90 | buy |
| Impax Asset Management Group plc | 100,000 | 125,000 | +25,000 | 0.04 | 0.06 | +0.02 | buy |
| BAMCO INC /NY/ | 0 | 23,000 | +23,000 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 472,363 | 494,619 | +22,256 | 0.26 | 0.29 | +0.03 | buy |
| Daiwa Securities Group Inc. | 351 | 22,200 | +21,849 | 0.00 | 0.00 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 21,627 | +21,627 | 0.00 | 0.01 | +0.01 | buy |
| SANDERS MORRIS HARRIS LLC | 0 | 21,505 | +21,505 | 0.00 | 0.22 | +0.22 | buy |
| ALLSTATE CORP | 0 | 21,490 | +21,490 | 0.00 | 0.02 | +0.02 | buy |
| Atom Investors LP | 0 | 20,350 | +20,350 | 0.00 | 0.10 | +0.10 | buy |
| FIRST TRUST ADVISORS LP | 127,524 | 145,890 | +18,366 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 18,300 | +18,300 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 18,113 | +18,113 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 42,035 | 59,425 | +17,390 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 16,914 | +16,914 | 0.00 | 0.10 | +0.10 | buy |
| Artia Global Partners LP | 0 | 16,300 | +16,300 | 0.00 | 0.24 | +0.24 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 16,059 | +16,059 | 0.00 | 0.01 | +0.01 | buy |
| INCEPTIONR LLC | 0 | 15,974 | +15,974 | 0.00 | 0.25 | +0.25 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,383,437 | 1,397,045 | +13,608 | 0.01 | 0.01 | +0.00 | buy |
| Checkpoint Capital L.P. | 166,823 | 180,000 | +13,177 | 3.36 | 4.26 | +0.90 | buy |
| Ellsworth Advisors, LLC | 0 | 12,730 | +12,730 | 0.00 | 0.16 | +0.16 | buy |
| RHUMBLINE ADVISERS | 356,995 | 369,575 | +12,580 | 0.02 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 175,804 | 187,138 | +11,334 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 274,017 | 285,008 | +10,991 | 0.03 | 0.02 | -0.01 | buy |
| Creative Planning | 96,939 | 107,760 | +10,821 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 6,773 | 17,078 | +10,305 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,978 | 15,118 | +10,140 | 0.01 | 0.03 | +0.02 | buy |
| Rock Springs Capital Management LP | 35,853 | 45,364 | +9,511 | 0.12 | 0.18 | +0.06 | buy |
| NVWM, LLC | 0 | 9,217 | +9,217 | 0.00 | 0.14 | +0.14 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 36,414 | 45,573 | +9,159 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 189,401 | 198,530 | +9,129 | 0.01 | 0.01 | +0.00 | buy |
| CenterBook Partners LP | 0 | 7,864 | +7,864 | 0.00 | 0.03 | +0.03 | buy |
| NATIXIS ADVISORS, LLC | 26,250 | 33,716 | +7,466 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 195 | 7,548 | +7,353 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 2,230 | 9,191 | +6,961 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 47,971 | 54,444 | +6,473 | 0.00 | 0.00 | +0.00 | buy |
| SIG BROKERAGE, LP | 0 | 6,011 | +6,011 | 0.00 | 0.11 | +0.11 | buy |