| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 0 | 4,575,558 | +4,575,558 | 0.00 | 28.63 | +28.63 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,981,460 | 7,509,530 | +3,528,070 | 0.05 | 0.07 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 5,121,589 | 8,138,677 | +3,017,088 | 0.22 | 0.28 | +0.06 | buy |
| STATE STREET CORP | 4,520,358 | 6,548,536 | +2,028,178 | 0.01 | 0.02 | +0.00 | buy |
| VANGUARD GROUP INC | 9,997,076 | 11,437,696 | +1,440,620 | 0.01 | 0.01 | -0.00 | buy |
| RP Management, LLC | 0 | 980,392 | +980,392 | 0.00 | 29.71 | +29.71 | buy |
| Polar Capital Holdings Plc | 1,605,576 | 2,454,665 | +849,089 | 0.59 | 0.78 | +0.19 | buy |
| Sarissa Capital Management LP | 300,000 | 1,110,000 | +810,000 | 3.68 | 10.15 | +6.47 | buy |
| Melqart Asset Management (UK) Ltd | 983,395 | 1,675,785 | +692,390 | 5.13 | 8.52 | +3.40 | buy |
| FMR LLC | 10,901,143 | 11,523,128 | +621,985 | 0.05 | 0.04 | -0.01 | buy |
| Integral Health Asset Management, LLC | 450,000 | 1,000,000 | +550,000 | 3.10 | 5.39 | +2.30 | buy |
| ARMISTICE CAPITAL, LLC | 1,525,688 | 2,065,991 | +540,303 | 2.85 | 2.93 | +0.08 | buy |
| ADAR1 Capital Management, LLC | 319,510 | 853,862 | +534,352 | 6.12 | 9.32 | +3.20 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,247,165 | 2,738,646 | +491,481 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 691,449 | 1,138,154 | +446,705 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 688,104 | 1,111,943 | +423,839 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 560,902 | 858,973 | +298,071 | 0.04 | 0.05 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 276,067 | +276,067 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 202,202 | 474,202 | +272,000 | 2.21 | 4.92 | +2.71 | buy |
| Cutter Capital Management, LP | 0 | 236,900 | +236,900 | 0.00 | 3.91 | +3.91 | buy |
| Opaleye Management Inc. | 0 | 198,500 | +198,500 | 0.00 | 2.46 | +2.46 | buy |
| Woodline Partners LP | 0 | 198,181 | +198,181 | 0.00 | 0.10 | +0.10 | buy |
| RTW INVESTMENTS, LP | 2,525,080 | 2,721,158 | +196,078 | 2.61 | 2.28 | -0.33 | buy |
| Ghisallo Capital Management LLC | 0 | 196,000 | +196,000 | 0.00 | 0.92 | +0.92 | buy |
| JANUS HENDERSON GROUP PLC | 797,372 | 976,329 | +178,957 | 0.03 | 0.03 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,111,440 | 1,282,893 | +171,453 | 0.01 | 0.01 | -0.00 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 83,761 | 252,811 | +169,050 | 0.08 | 0.19 | +0.11 | buy |
| Bank of New York Mellon Corp | 900,054 | 1,068,596 | +168,542 | 0.01 | 0.01 | -0.00 | buy |
| Clearline Capital LP | 48,035 | 207,695 | +159,660 | 0.33 | 0.98 | +0.65 | buy |
| MORGAN STANLEY | 954,858 | 1,105,674 | +150,816 | 0.01 | 0.00 | -0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 116,000 | 266,700 | +150,700 | 1.08 | 2.23 | +1.16 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 775,556 | 925,682 | +150,126 | 0.01 | 0.01 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 731,386 | 873,513 | +142,127 | 0.27 | 0.23 | -0.04 | buy |
| Granahan Investment Management, LLC | 0 | 136,878 | +136,878 | 0.00 | 0.30 | +0.30 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 117,922 | 251,942 | +134,020 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 132,495 | +132,495 | 0.00 | 0.21 | +0.21 | buy |
| NOMURA HOLDINGS INC | 5,745 | 137,658 | +131,913 | 0.00 | 0.05 | +0.04 | buy |
| ORBIMED ADVISORS LLC | 682,700 | 812,906 | +130,206 | 0.88 | 0.88 | -0.00 | buy |
| Aberdeen Group plc | 239,242 | 369,237 | +129,995 | 0.03 | 0.04 | +0.01 | buy |
| SG Americas Securities, LLC | 9,085 | 138,142 | +129,057 | 0.00 | 0.05 | +0.04 | buy |
| Eversept Partners, LP | 0 | 126,877 | +126,877 | 0.00 | 0.53 | +0.53 | buy |
| Rafferty Asset Management, LLC | 139,477 | 265,069 | +125,592 | 0.04 | 0.05 | +0.02 | buy |
| Impax Asset Management Group plc | 0 | 125,000 | +125,000 | 0.00 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,770,065 | 1,879,161 | +109,096 | 0.04 | 0.04 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 365,967 | 470,967 | +105,000 | 0.04 | 0.04 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 281,671 | 384,924 | +103,253 | 3.20 | 3.40 | +0.20 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 36,875 | 126,438 | +89,563 | 0.04 | 0.11 | +0.07 | buy |
| Allspring Global Investments Holdings, LLC | 3,416 | 87,812 | +84,396 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 284,520 | 360,598 | +76,078 | 0.02 | 0.02 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 75,398 | +75,398 | 0.00 | 0.07 | +0.07 | buy |
| RHUMBLINE ADVISERS | 306,639 | 379,257 | +72,618 | 0.02 | 0.02 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 67,076 | 125,271 | +58,195 | 0.22 | 0.16 | -0.06 | buy |
| Silphium Asset Management Ltd | 32,500 | 87,500 | +55,000 | 1.18 | 2.27 | +1.09 | buy |
| Zimmer Partners, LP | 38,600 | 92,200 | +53,600 | 0.06 | 0.10 | +0.04 | buy |
| AMERIPRISE FINANCIAL INC | 294,023 | 344,134 | +50,111 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 131,141 | 179,737 | +48,596 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 45,264 | 92,933 | +47,669 | 0.04 | 0.06 | +0.02 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 15,603 | 62,682 | +47,079 | 0.01 | 0.04 | +0.03 | buy |
| Quinn Opportunity Partners LLC | 46,377 | 90,637 | +44,260 | 0.37 | 0.57 | +0.20 | buy |
| Hood River Capital Management LLC | 696,647 | 737,637 | +40,990 | 1.09 | 0.83 | -0.26 | buy |
| Ensign Peak Advisors, Inc | 424,259 | 463,431 | +39,172 | 0.05 | 0.05 | -0.01 | buy |
| Pentwater Capital Management LP | 1,080,000 | 1,119,000 | +39,000 | 1.24 | 1.31 | +0.07 | buy |
| COMERICA BANK | 130,806 | 166,180 | +35,374 | 0.04 | 0.04 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 43,866 | 76,813 | +32,947 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 116,189 | 148,561 | +32,372 | 0.00 | 0.00 | -0.00 | buy |
| Troluce Capital Advisors LLC | 0 | 30,398 | +30,398 | 0.00 | 0.34 | +0.34 | buy |
| Parallax Volatility Advisers, L.P. | 1,269 | 31,419 | +30,150 | 0.00 | 0.04 | +0.04 | buy |
| BNP Paribas Asset Management Holding S.A. | 354,498 | 384,042 | +29,544 | 0.07 | 0.05 | -0.01 | buy |
| Quantitative Investment Management, LLC | 0 | 28,624 | +28,624 | 0.00 | 0.17 | +0.17 | buy |
| ALGERT GLOBAL LLC | 43,670 | 71,408 | +27,738 | 0.12 | 0.13 | +0.01 | buy |
| Mirador Capital Partners LP | 35,455 | 63,143 | +27,688 | 0.47 | 0.64 | +0.17 | buy |
| PROFUND ADVISORS LLC | 26,521 | 51,921 | +25,400 | 0.07 | 0.10 | +0.03 | buy |
| Ikarian Capital, LLC | 145,147 | 170,147 | +25,000 | 2.77 | 2.88 | +0.11 | buy |
| NEOS Investment Management LLC | 25,590 | 50,067 | +24,477 | 0.11 | 0.11 | +0.00 | buy |
| MetLife Investment Management, LLC | 100,548 | 122,770 | +22,222 | 0.05 | 0.04 | -0.01 | buy |
| Lisanti Capital Growth, LLC | 17,805 | 39,155 | +21,350 | 0.30 | 0.51 | +0.21 | buy |
| Swiss National Bank | 174,200 | 195,500 | +21,300 | 0.01 | 0.01 | -0.00 | buy |
| Concentric Capital Strategies, LP | 40,207 | 60,564 | +20,357 | 0.18 | 0.21 | +0.02 | buy |
| NOMURA HOLDINGS INC | 101,609 | 121,954 | +20,345 | 0.06 | 0.04 | -0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 153,569 | 173,775 | +20,206 | 0.01 | 0.01 | -0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 0 | 18,488 | +18,488 | 0.00 | 0.10 | +0.10 | buy |
| Finepoint Capital LP | 238,046 | 256,449 | +18,403 | 4.28 | 3.94 | -0.34 | buy |
| Retirement Systems of Alabama | 123,132 | 141,516 | +18,384 | 0.03 | 0.03 | -0.00 | buy |
| WINTON GROUP Ltd | 0 | 18,149 | +18,149 | 0.00 | 0.07 | +0.07 | buy |
| FEDERATED HERMES, INC. | 8,568 | 26,098 | +17,530 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 78,002 | 95,366 | +17,364 | 0.00 | 0.00 | -0.00 | buy |
| CenterBook Partners LP | 0 | 16,896 | +16,896 | 0.00 | 0.06 | +0.06 | buy |
| Legal & General Group Plc | 143,126 | 159,518 | +16,392 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 70,957 | 86,819 | +15,862 | 0.01 | 0.01 | -0.00 | buy |
| Edgestream Partners, L.P. | 0 | 15,835 | +15,835 | 0.00 | 0.04 | +0.04 | buy |
| CANADA LIFE ASSURANCE Co | 54,006 | 69,726 | +15,720 | 0.01 | 0.01 | -0.00 | buy |
| Cetera Investment Advisers | 11,954 | 27,320 | +15,366 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,753,646 | 1,768,162 | +14,516 | 0.13 | 0.11 | -0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 3,544 | 17,814 | +14,270 | 0.03 | 0.07 | +0.04 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 126,393 | 140,601 | +14,208 | 0.25 | 0.22 | -0.03 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 13,477 | +13,477 | 0.00 | 0.06 | +0.06 | buy |
| WELLS FARGO & COMPANY/MN | 40,664 | 54,108 | +13,444 | 0.00 | 0.00 | +0.00 | buy |
| Carlson Capital, L.P. | 25,000 | 38,200 | +13,200 | 0.14 | 0.32 | +0.18 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 12,506 | +12,506 | 0.00 | 0.06 | +0.06 | buy |
| Alpine Global Management, LLC | 0 | 12,468 | +12,468 | 0.00 | 0.12 | +0.12 | buy |