| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 10,901,143 | 11,523,128 | +621,985 | 0.05 | 0.04 | -0.01 | buy |
| VANGUARD GROUP INC | 9,997,076 | 11,437,696 | +1,440,620 | 0.01 | 0.01 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 5,121,589 | 8,138,677 | +3,017,088 | 0.22 | 0.28 | +0.06 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,981,460 | 7,509,530 | +3,528,070 | 0.05 | 0.07 | +0.02 | buy |
| STATE STREET CORP | 4,520,358 | 6,548,536 | +2,028,178 | 0.01 | 0.02 | +0.00 | buy |
| Darwin Global Management, Ltd. | 0 | 4,575,558 | +4,575,558 | 0.00 | 28.63 | +28.63 | buy |
| BANK OF AMERICA CORP /DE/ | 4,777,628 | 4,380,769 | -396,859 | 0.03 | 0.02 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,247,165 | 2,738,646 | +491,481 | 0.01 | 0.01 | -0.00 | buy |
| RTW INVESTMENTS, LP | 2,525,080 | 2,721,158 | +196,078 | 2.61 | 2.28 | -0.33 | buy |
| Polar Capital Holdings Plc | 1,605,576 | 2,454,665 | +849,089 | 0.59 | 0.78 | +0.19 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,930,948 | 2,358,343 | -572,605 | 0.03 | 0.02 | -0.01 | sell |
| Vestal Point Capital, LP | 2,150,000 | 2,075,000 | -75,000 | 12.47 | 8.38 | -4.08 | sell |
| ARMISTICE CAPITAL, LLC | 1,525,688 | 2,065,991 | +540,303 | 2.85 | 2.93 | +0.08 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,770,065 | 1,879,161 | +109,096 | 0.04 | 0.04 | -0.01 | buy |
| Pictet Asset Management Holding SA | 1,753,646 | 1,768,162 | +14,516 | 0.13 | 0.11 | -0.02 | buy |
| PFM Health Sciences, LP | 1,757,192 | 1,757,192 | 0 | 6.13 | 5.19 | -0.94 | hold |
| MARSHALL WACE, LLP | 2,556,803 | 1,678,159 | -878,644 | 0.30 | 0.13 | -0.17 | sell |
| Melqart Asset Management (UK) Ltd | 983,395 | 1,675,785 | +692,390 | 5.13 | 8.52 | +3.40 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,500,000 | 1,500,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NORTHERN TRUST CORP | 1,111,440 | 1,282,893 | +171,453 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 691,449 | 1,138,154 | +446,705 | 0.01 | 0.01 | +0.00 | buy |
| Pentwater Capital Management LP | 1,080,000 | 1,119,000 | +39,000 | 1.24 | 1.31 | +0.07 | buy |
| JPMORGAN CHASE & CO | 688,104 | 1,111,943 | +423,839 | 0.00 | 0.01 | +0.00 | buy |
| Sarissa Capital Management LP | 300,000 | 1,110,000 | +810,000 | 3.68 | 10.15 | +6.47 | buy |
| MORGAN STANLEY | 954,858 | 1,105,674 | +150,816 | 0.01 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 900,054 | 1,068,596 | +168,542 | 0.01 | 0.01 | -0.00 | buy |
| Integral Health Asset Management, LLC | 450,000 | 1,000,000 | +550,000 | 3.10 | 5.39 | +2.30 | buy |
| RP Management, LLC | 0 | 980,392 | +980,392 | 0.00 | 29.71 | +29.71 | buy |
| JANUS HENDERSON GROUP PLC | 797,372 | 976,329 | +178,957 | 0.03 | 0.03 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 775,556 | 925,682 | +150,126 | 0.01 | 0.01 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 731,386 | 873,513 | +142,127 | 0.27 | 0.23 | -0.04 | buy |
| CITADEL ADVISORS LLC | 560,902 | 858,973 | +298,071 | 0.04 | 0.05 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 319,510 | 853,862 | +534,352 | 6.12 | 9.32 | +3.20 | buy |
| ORBIMED ADVISORS LLC | 682,700 | 812,906 | +130,206 | 0.88 | 0.88 | -0.00 | buy |
| NORGES BANK | 982,761 | 799,664 | -183,097 | 0.01 | 0.01 | -0.00 | sell |
| BROWN ADVISORY INC | 759,534 | 762,549 | +3,015 | 0.07 | 0.05 | -0.02 | buy |
| Hood River Capital Management LLC | 696,647 | 737,637 | +40,990 | 1.09 | 0.83 | -0.26 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 675,062 | 601,367 | -73,695 | 0.12 | 0.08 | -0.04 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 760,319 | 555,110 | -205,209 | 0.19 | 0.11 | -0.08 | sell |
| Fisher Asset Management, LLC | 538,797 | 534,520 | -4,277 | 0.02 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 1,317,538 | 495,398 | -822,140 | 0.02 | 0.01 | -0.01 | sell |
| Artal Group S.A. | 506,584 | 494,421 | -12,163 | 0.92 | 0.69 | -0.23 | sell |
| GREAT POINT PARTNERS LLC | 202,202 | 474,202 | +272,000 | 2.21 | 4.92 | +2.71 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 365,967 | 470,967 | +105,000 | 0.04 | 0.04 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 424,259 | 463,431 | +39,172 | 0.05 | 0.05 | -0.01 | buy |
| FRANKLIN RESOURCES INC | 565,296 | 403,561 | -161,735 | 0.01 | 0.01 | -0.01 | sell |
| DAFNA Capital Management LLC | 398,100 | 398,100 | 0 | 6.35 | 5.15 | -1.20 | hold |
| READYSTATE ASSET MANAGEMENT LP | 465,498 | 394,175 | -71,323 | 1.16 | 1.01 | -0.15 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 431,556 | 393,579 | -37,977 | 0.02 | 0.01 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 281,671 | 384,924 | +103,253 | 3.20 | 3.40 | +0.20 | buy |
| BNP Paribas Asset Management Holding S.A. | 354,498 | 384,042 | +29,544 | 0.07 | 0.05 | -0.01 | buy |
| RHUMBLINE ADVISERS | 306,639 | 379,257 | +72,618 | 0.02 | 0.02 | -0.00 | buy |
| Point72 Asset Management, L.P. | 364,709 | 374,848 | +10,139 | 0.07 | 0.07 | -0.01 | buy |
| Aberdeen Group plc | 239,242 | 369,237 | +129,995 | 0.03 | 0.04 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 284,520 | 360,598 | +76,078 | 0.02 | 0.02 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 294,023 | 344,134 | +50,111 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 415,854 | 331,444 | -84,410 | 0.02 | 0.01 | -0.01 | sell |
| UBS Group AG | 298,744 | 299,604 | +860 | 0.01 | 0.00 | -0.00 | buy |
| First Turn Management, LLC | 430,349 | 293,318 | -137,031 | 4.51 | 2.59 | -1.93 | sell |
| BARCLAYS PLC | 762,247 | 282,378 | -479,869 | 0.02 | 0.01 | -0.02 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 276,067 | +276,067 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 263,701 | 272,036 | +8,335 | 7.41 | 5.57 | -1.84 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 116,000 | 266,700 | +150,700 | 1.08 | 2.23 | +1.16 | buy |
| Rafferty Asset Management, LLC | 139,477 | 265,069 | +125,592 | 0.04 | 0.05 | +0.02 | buy |
| JANE STREET GROUP, LLC | 307,567 | 265,002 | -42,565 | 0.03 | 0.02 | -0.01 | sell |
| Finepoint Capital LP | 238,046 | 256,449 | +18,403 | 4.28 | 3.94 | -0.34 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 254,148 | 254,148 | 0 | 0.28 | 0.24 | -0.04 | hold |
| PINNACLE ASSOCIATES LTD | 257,167 | 253,864 | -3,303 | 0.28 | 0.22 | -0.07 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 253,487 | 253,487 | 0 | 0.02 | 0.02 | -0.01 | hold |
| THORNBURG INVESTMENT MANAGEMENT INC | 83,761 | 252,811 | +169,050 | 0.08 | 0.19 | +0.11 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 117,922 | 251,942 | +134,020 | 0.00 | 0.00 | +0.00 | buy |
| Cutter Capital Management, LP | 0 | 236,900 | +236,900 | 0.00 | 3.91 | +3.91 | buy |
| Prosight Management, LP | 245,000 | 230,000 | -15,000 | 4.78 | 3.72 | -1.05 | sell |
| Clearline Capital LP | 48,035 | 207,695 | +159,660 | 0.33 | 0.98 | +0.65 | buy |
| Bank of New York Mellon Corp | 200,000 | 200,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Opaleye Management Inc. | 0 | 198,500 | +198,500 | 0.00 | 2.46 | +2.46 | buy |
| Woodline Partners LP | 0 | 198,181 | +198,181 | 0.00 | 0.10 | +0.10 | buy |
| Rhenman & Partners Asset Management AB | 197,515 | 197,515 | 0 | 1.31 | 1.03 | -0.29 | hold |
| Ghisallo Capital Management LLC | 0 | 196,000 | +196,000 | 0.00 | 0.92 | +0.92 | buy |
| Swiss National Bank | 174,200 | 195,500 | +21,300 | 0.01 | 0.01 | -0.00 | buy |
| Checkpoint Capital L.P. | 190,000 | 190,000 | 0 | 8.90 | 6.21 | -2.70 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 278,915 | 187,633 | -91,282 | 12.93 | 12.81 | -0.11 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 131,141 | 179,737 | +48,596 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 493,029 | 179,200 | -313,829 | 0.22 | 0.06 | -0.16 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 153,569 | 173,775 | +20,206 | 0.01 | 0.01 | -0.00 | buy |
| Ikarian Capital, LLC | 145,147 | 170,147 | +25,000 | 2.77 | 2.88 | +0.11 | buy |
| COMERICA BANK | 130,806 | 166,180 | +35,374 | 0.04 | 0.04 | -0.00 | buy |
| Legal & General Group Plc | 143,126 | 159,518 | +16,392 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 245,641 | 158,242 | -87,399 | 0.03 | 0.01 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 576,477 | 157,039 | -419,438 | 0.06 | 0.01 | -0.05 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 155,794 | 155,794 | 0 | 0.05 | 0.04 | -0.01 | hold |
| DIMENSIONAL FUND ADVISORS LP | 116,189 | 148,561 | +32,372 | 0.00 | 0.00 | -0.00 | buy |
| Retirement Systems of Alabama | 123,132 | 141,516 | +18,384 | 0.03 | 0.03 | -0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 126,393 | 140,601 | +14,208 | 0.25 | 0.22 | -0.03 | buy |
| SG Americas Securities, LLC | 9,085 | 138,142 | +129,057 | 0.00 | 0.05 | +0.04 | buy |
| NOMURA HOLDINGS INC | 5,745 | 137,658 | +131,913 | 0.00 | 0.05 | +0.04 | buy |
| Granahan Investment Management, LLC | 0 | 136,878 | +136,878 | 0.00 | 0.30 | +0.30 | buy |
| Deep Track Capital, LP | 0 | 132,495 | +132,495 | 0.00 | 0.21 | +0.21 | buy |
| CITIGROUP INC | 164,199 | 131,354 | -32,845 | 0.01 | 0.01 | -0.01 | sell |
| Eversept Partners, LP | 0 | 126,877 | +126,877 | 0.00 | 0.53 | +0.53 | buy |