| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 9,955,251 | 17,602,440 | +7,647,189 | 0.26 | 0.37 | +0.10 | buy |
| FMR LLC | 10,316,131 | 11,267,511 | +951,380 | 0.03 | 0.02 | -0.01 | buy |
| UBS Group AG | 2,134,219 | 3,070,665 | +936,446 | 0.02 | 0.02 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 161,285 | 1,082,563 | +921,278 | 1.34 | 4.23 | +2.89 | buy |
| Deep Track Capital, LP | 3,073,853 | 3,650,000 | +576,147 | 4.00 | 3.88 | -0.12 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 629,911 | 1,184,805 | +554,894 | 0.01 | 0.02 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 554,731 | +554,731 | 0.00 | 0.73 | +0.73 | buy |
| Rosalind Advisors, Inc. | 0 | 400,000 | +400,000 | 0.00 | 6.40 | +6.40 | buy |
| Vestal Point Capital, LP | 2,590,531 | 2,975,000 | +384,469 | 7.43 | 5.18 | -2.26 | buy |
| Polar Capital Holdings Plc | 2,455,737 | 2,798,401 | +342,664 | 0.60 | 0.48 | -0.12 | buy |
| AQR CAPITAL MANAGEMENT LLC | 19,994 | 347,739 | +327,745 | 0.00 | 0.01 | +0.01 | buy |
| Melqart Asset Management (UK) Ltd | 999,447 | 1,326,719 | +327,272 | 5.43 | 6.26 | +0.84 | buy |
| Aberdeen Group plc | 602,421 | 922,929 | +320,508 | 0.05 | 0.05 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,023,390 | 1,312,349 | +288,959 | 1.10 | 1.64 | +0.54 | buy |
| STATE STREET CORP | 6,085,001 | 6,372,753 | +287,752 | 0.01 | 0.01 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 264,329 | +264,329 | 0.00 | 0.19 | +0.19 | buy |
| ADAR1 Capital Management, LLC | 390,729 | 582,147 | +191,418 | 3.02 | 3.12 | +0.10 | buy |
| BARCLAYS PLC | 309,492 | 492,814 | +183,322 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 144,961 | 326,718 | +181,757 | 1.44 | 2.82 | +1.39 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 539,110 | 720,814 | +181,704 | 0.04 | 0.04 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 319,533 | 497,602 | +178,069 | 0.00 | 0.01 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 14,862 | 191,115 | +176,253 | 0.01 | 0.07 | +0.06 | buy |
| Ensign Peak Advisors, Inc | 31,796 | 203,946 | +172,150 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 287,901 | 458,677 | +170,776 | 0.01 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 522,468 | 676,280 | +153,812 | 0.06 | 0.05 | -0.00 | buy |
| Jump Financial, LLC | 0 | 151,290 | +151,290 | 0.00 | 0.06 | +0.06 | buy |
| CITADEL ADVISORS LLC | 1,150,514 | 1,298,609 | +148,095 | 0.05 | 0.04 | -0.01 | buy |
| VANGUARD GROUP INC | 11,849,547 | 11,983,838 | +134,291 | 0.01 | 0.01 | -0.00 | buy |
| GROUP ONE TRADING LLC | 204,512 | 333,282 | +128,770 | 0.34 | 0.36 | +0.02 | buy |
| BlackRock, Inc. | 15,563,778 | 15,677,867 | +114,089 | 0.01 | 0.01 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 308,896 | 416,253 | +107,357 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,011,745 | 1,118,080 | +106,335 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 49,438 | 151,841 | +102,403 | 0.00 | 0.01 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 55,264 | 154,381 | +99,117 | 0.03 | 0.06 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 446,828 | 544,292 | +97,464 | 0.02 | 0.02 | -0.00 | buy |
| Ikarian Capital, LLC | 149,982 | 233,464 | +83,482 | 1.96 | 2.55 | +0.59 | buy |
| Pentwater Capital Management LP | 220,000 | 300,000 | +80,000 | 0.12 | 0.13 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 329,231 | 407,037 | +77,806 | 0.35 | 0.33 | -0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 361,388 | 432,731 | +71,343 | 0.01 | 0.01 | -0.00 | buy |
| Quinn Opportunity Partners LLC | 129,939 | 194,939 | +65,000 | 0.37 | 0.55 | +0.19 | buy |
| ALPS ADVISORS INC | 0 | 64,392 | +64,392 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,937,484 | 2,994,445 | +56,961 | 0.01 | 0.01 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 237,598 | 290,245 | +52,647 | 0.01 | 0.01 | +0.00 | buy |
| Mirador Capital Partners LP | 99,125 | 144,347 | +45,222 | 0.70 | 0.77 | +0.08 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,312,857 | 1,357,117 | +44,260 | 0.01 | 0.01 | -0.00 | buy |
| Monaco Asset Management SAM | 0 | 42,500 | +42,500 | 0.00 | 0.53 | +0.53 | buy |
| J. Safra Sarasin Holding AG | 27,791 | 68,190 | +40,399 | 0.02 | 0.04 | +0.02 | buy |
| Zweig-DiMenna Associates LLC | 0 | 35,600 | +35,600 | 0.00 | 0.12 | +0.12 | buy |
| Lighthouse Investment Partners, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.05 | +0.05 | buy |
| J. Goldman & Co LP | 0 | 33,636 | +33,636 | 0.00 | 0.03 | +0.03 | buy |
| HighVista Strategies LLC | 44,749 | 68,652 | +23,903 | 0.69 | 0.83 | +0.14 | buy |
| Rafferty Asset Management, LLC | 149,507 | 171,581 | +22,074 | 0.03 | 0.02 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 73,966 | 95,350 | +21,384 | 0.00 | 0.00 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 41,032 | 61,783 | +20,751 | 0.01 | 0.01 | +0.00 | buy |
| Tejara Capital Ltd | 0 | 18,300 | +18,300 | 0.00 | 0.28 | +0.28 | buy |
| CW Advisors, LLC | 28,000 | 46,130 | +18,130 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 21,576 | 38,114 | +16,538 | 0.00 | 0.00 | -0.00 | buy |
| Erste Asset Management GmbH | 60,450 | 76,950 | +16,500 | 0.03 | 0.02 | -0.01 | buy |
| RHUMBLINE ADVISERS | 373,855 | 389,940 | +16,085 | 0.01 | 0.01 | -0.00 | buy |
| Catalio Capital Management, LP | 585,812 | 601,439 | +15,627 | 5.84 | 4.17 | -1.67 | buy |
| Creative Planning | 33,577 | 48,062 | +14,485 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 69,543 | 83,770 | +14,227 | 0.04 | 0.04 | -0.00 | buy |
| ONTARIO TEACHERS PENSION PLAN BOARD | 14,943 | 29,135 | +14,192 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 128,691 | 142,602 | +13,911 | 0.00 | 0.00 | -0.00 | buy |
| Carlson Capital, L.P. | 7,500 | 20,500 | +13,000 | 0.17 | 0.39 | +0.22 | buy |
| WOLVERINE TRADING, LLC | 13,066 | 25,808 | +12,742 | 0.02 | 0.02 | +0.00 | buy |
| Exome Asset Management LLC | 103,483 | 115,817 | +12,334 | 3.73 | 3.16 | -0.57 | buy |
| Trexquant Investment LP | 0 | 10,894 | +10,894 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 147,263 | 157,786 | +10,523 | 0.04 | 0.03 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 69,032 | 78,544 | +9,512 | 0.00 | 0.00 | -0.00 | buy |
| MACQUARIE GROUP LTD | 74,406 | 83,872 | +9,466 | 0.00 | 0.00 | -0.00 | buy |
| FIFTH LANE CAPITAL, LP | 0 | 9,000 | +9,000 | 0.00 | 0.36 | +0.36 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 167,684 | 175,279 | +7,595 | 0.01 | 0.01 | -0.00 | buy |
| NORGES BANK | 1,176,919 | 1,184,072 | +7,153 | 0.01 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28,554 | 35,501 | +6,947 | 0.12 | 0.11 | -0.00 | buy |
| Summit Trail Advisors, LLC | 0 | 6,755 | +6,755 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 13,302 | 19,084 | +5,782 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 24,321 | 29,467 | +5,146 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 13,783 | 18,919 | +5,136 | 0.03 | 0.03 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 5,107 | +5,107 | 0.00 | 0.05 | +0.05 | buy |
| Tidal Investments LLC | 8,338 | 13,333 | +4,995 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 14,861 | 19,778 | +4,917 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 117,220 | 121,822 | +4,602 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 34,035 | 38,448 | +4,413 | 0.06 | 0.05 | -0.01 | buy |
| WINTON GROUP Ltd | 24,255 | 28,159 | +3,904 | 0.06 | 0.05 | -0.01 | buy |
| Legal & General Group Plc | 177,881 | 181,737 | +3,856 | 0.00 | 0.00 | -0.00 | buy |
| Inspire Investing, LLC | 8,551 | 11,888 | +3,337 | 0.04 | 0.04 | +0.00 | buy |
| Bank of New York Mellon Corp | 870,968 | 874,303 | +3,335 | 0.01 | 0.01 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 35,567 | 38,567 | +3,000 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 29,261 | 32,255 | +2,994 | 0.00 | 0.00 | -0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 155,737 | 158,528 | +2,791 | 0.21 | 0.16 | -0.05 | buy |
| Cynosure Group, LLC | 7,788 | 10,372 | +2,584 | 0.04 | 0.04 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 8,535 | 11,086 | +2,551 | 0.01 | 0.01 | -0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 28,210 | 30,684 | +2,474 | 0.01 | 0.01 | -0.00 | buy |
| Shay Capital LLC | 5,051 | 7,500 | +2,449 | 0.06 | 0.06 | -0.00 | buy |
| Retirement Systems of Alabama | 143,637 | 145,967 | +2,330 | 0.02 | 0.02 | -0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 77,895 | 79,964 | +2,069 | 0.01 | 0.01 | -0.00 | buy |
| FNY Investment Advisers, LLC | 10,855 | 12,895 | +2,040 | 0.27 | 0.18 | -0.09 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 6,488 | 8,476 | +1,988 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 130,022 | 131,954 | +1,932 | 0.03 | 0.03 | -0.00 | buy |