| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 9,955,251 | 17,602,440 | +7,647,189 | 0.26 | 0.37 | +0.10 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 161,285 | 1,082,563 | +921,278 | 1.34 | 4.23 | +2.89 | buy |
| Deep Track Capital, LP | 3,073,853 | 3,650,000 | +576,147 | 4.00 | 3.88 | -0.12 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 629,911 | 1,184,805 | +554,894 | 0.01 | 0.02 | 0.00 | buy |
| Vestal Point Capital, LP | 2,590,531 | 2,975,000 | +384,469 | 7.43 | 5.18 | -2.26 | buy |
| Polar Capital Holdings Plc | 2,455,737 | 2,798,401 | +342,664 | 0.60 | 0.48 | -0.12 | buy |
| Melqart Asset Management (UK) Ltd | 999,447 | 1,326,719 | +327,272 | 5.24 | 6.26 | +1.03 | buy |
| Aberdeen Group plc | 602,421 | 922,929 | +320,508 | 0.05 | 0.05 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,023,390 | 1,312,349 | +288,959 | 0.62 | 0.75 | +0.13 | buy |
| ADAR1 Capital Management, LLC | 390,729 | 582,147 | +191,418 | 3.02 | 3.12 | +0.10 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 144,961 | 326,718 | +181,757 | 1.34 | 2.53 | +1.19 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 319,533 | 497,602 | +178,069 | 0.00 | 0.01 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 14,862 | 191,115 | +176,253 | 0.01 | 0.07 | +0.06 | buy |
| TD ASSET MANAGEMENT INC | 446,828 | 544,292 | +97,464 | 0.02 | 0.02 | -0.00 | buy |
| Ikarian Capital, LLC | 149,982 | 233,464 | +83,482 | 1.96 | 2.55 | +0.59 | buy |
| Pentwater Capital Management LP | 220,000 | 300,000 | +80,000 | 0.07 | 0.06 | -0.01 | buy |
| E. Ohman J:or Asset Management AB | 329,231 | 407,037 | +77,806 | 0.35 | 0.33 | -0.02 | buy |
| Quinn Opportunity Partners LLC | 129,939 | 194,939 | +65,000 | 0.36 | 0.54 | +0.18 | buy |
| ALGERT GLOBAL LLC | 116,320 | 60,390 | +55,930 | 0.12 | 0.04 | 0.00 | sell |
| Mirador Capital Partners LP | 99,125 | 144,347 | +45,222 | 0.70 | 0.77 | +0.08 | buy |
| J. Safra Sarasin Holding AG | 27,791 | 68,190 | +40,399 | 0.02 | 0.04 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 345,598 | 310,891 | +34,707 | 0.02 | 0.01 | -0.01 | sell |
| HighVista Strategies LLC | 44,749 | 68,652 | +23,903 | 0.69 | 0.83 | +0.14 | buy |
| Rafferty Asset Management, LLC | 149,507 | 171,581 | +22,074 | 0.03 | 0.02 | -0.01 | buy |
| Erste Asset Management GmbH | 60,450 | 76,950 | +16,500 | 0.03 | 0.02 | -0.01 | buy |
| RHUMBLINE ADVISERS | 373,855 | 389,940 | +16,085 | 0.01 | 0.01 | 0.00 | buy |
| Catalio Capital Management, LP | 585,812 | 601,439 | +15,627 | 5.84 | 4.17 | -1.67 | buy |
| SEGALL BRYANT & HAMILL, LLC | 69,543 | 83,770 | +14,227 | 0.04 | 0.04 | -0.00 | buy |
| ONTARIO TEACHERS PENSION PLAN BOARD | 14,943 | 29,135 | +14,192 | 0.01 | 0.02 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 67,261 | 53,223 | +14,038 | 0.03 | 0.02 | -0.01 | sell |
| Carlson Capital, L.P. | 7,500 | 20,500 | +13,000 | 0.12 | 0.28 | +0.16 | buy |
| Exome Asset Management LLC | 103,483 | 115,817 | +12,334 | 3.73 | 3.16 | -0.57 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28,554 | 35,501 | +6,947 | 0.09 | 0.11 | +0.03 | buy |
| E Fund Management Co., Ltd. | 13,783 | 18,919 | +5,136 | 0.03 | 0.03 | +0.00 | buy |
| PROFUND ADVISORS LLC | 34,035 | 38,448 | +4,413 | 0.06 | 0.05 | -0.01 | buy |
| WINTON GROUP Ltd | 24,255 | 28,159 | +3,904 | 0.06 | 0.05 | -0.01 | buy |
| Inspire Investing, LLC | 8,551 | 11,888 | +3,337 | 0.04 | 0.04 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 155,737 | 158,528 | +2,791 | 0.21 | 0.16 | -0.05 | buy |
| Cynosure Group, LLC | 7,788 | 10,372 | +2,584 | 0.04 | 0.04 | -0.00 | buy |
| Shay Capital LLC | 5,051 | 7,500 | +2,449 | 0.03 | 0.03 | -0.00 | buy |
| Retirement Systems of Alabama | 143,637 | 145,967 | +2,330 | 0.02 | 0.02 | -0.01 | buy |
| FNY Investment Advisers, LLC | 10,855 | 12,895 | +2,040 | 0.27 | 0.18 | 0.00 | buy |
| ProShare Advisors LLC | 35,115 | 33,710 | +1,405 | 0.00 | 0.00 | 0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 36,703 | 37,912 | +1,209 | 0.01 | 0.01 | 0.00 | buy |
| DnB Asset Management AS | 10,434 | 11,455 | +1,021 | 0.00 | 0.00 | -0.00 | buy |
| J.Safra Asset Management Corp | 3,094 | 3,687 | +593 | 0.01 | 0.01 | -0.00 | buy |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 28,200 | 28,700 | +500 | 0.01 | 0.00 | -0.00 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 41,660 | 41,177 | +483 | 0.02 | 0.02 | 0.00 | sell |
| NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC | 26,239 | 26,666 | +427 | 0.02 | 0.01 | -0.00 | buy |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | 24,015 | 24,415 | +400 | 0.02 | 0.01 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 34,892 | 35,147 | +255 | 0.05 | 0.04 | -0.01 | buy |
| Nebula Research & Development LLC | 12,165 | 12,411 | +246 | 0.05 | 0.03 | -0.01 | buy |
| Optiver Holding B.V. | 822 | 1,066 | +244 | 0.00 | 0.00 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 23,751 | 23,987 | +236 | 0.09 | 0.07 | -0.01 | buy |
| SECURIAN ASSET MANAGEMENT, INC | 8,921 | 9,095 | +174 | 0.01 | 0.01 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 6,506 | 6,671 | +165 | 0.01 | 0.01 | -0.00 | buy |
| Hughes Financial Services, LLC | 11 | 32 | +21 | 0.00 | 0.00 | +0.00 | buy |
| First Bank & Trust | 6,425 | 6,304 | -121 | 0.05 | 0.04 | -0.01 | sell |
| EntryPoint Capital, LLC | 6,840 | 6,586 | -254 | 0.13 | 0.11 | -0.02 | sell |
| Dana Investment Advisors, Inc. | 17,003 | 16,602 | -401 | 0.02 | 0.02 | -0.01 | sell |
| Virtus Investment Advisers, LLC | 3,270 | 2,832 | -438 | 0.04 | 0.03 | -0.00 | sell |
| BANQUE PICTET & CIE SA | 8,203 | 7,688 | -515 | 0.00 | 0.00 | -0.00 | sell |
| HARVEY CAPITAL MANAGEMENT INC | 22,580 | 21,930 | -650 | 0.24 | 0.17 | -0.06 | sell |
| OAK RIDGE INVESTMENTS LLC | 17,096 | 16,251 | -845 | 0.06 | 0.04 | -0.02 | sell |
| HARVEST MANAGEMENT LLC | 11,744 | 10,744 | -1,000 | 0.21 | 0.15 | -0.06 | sell |
| GREAT LAKES ADVISORS, LLC | 33,826 | 32,729 | -1,097 | 0.01 | 0.01 | -0.00 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 59,841 | 57,516 | -2,325 | 1.31 | 0.92 | -0.39 | sell |
| Edgestream Partners, L.P. | 18,216 | 15,275 | -2,941 | 0.02 | 0.01 | -0.01 | sell |
| EFG Asset Management (North America) Corp. | 80,359 | 76,257 | -4,102 | 0.54 | 0.36 | -0.18 | sell |
| Zimmer Partners, LP | 82,132 | 76,500 | -5,632 | 0.06 | 0.05 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 18,068 | 11,723 | -6,345 | 0.57 | 0.26 | -0.31 | sell |
| NEOS Investment Management LLC | 32,588 | 23,996 | -8,592 | 0.02 | 0.01 | -0.02 | sell |
| TEMA ETFS LLC | 32,588 | 23,996 | -8,592 | 0.39 | 0.21 | -0.18 | sell |
| CIBC WORLD MARKETS CORP | 25,361 | 14,394 | -10,967 | 0.01 | 0.00 | -0.01 | sell |
| Sarissa Capital Management LP | 600,000 | 588,357 | -11,643 | 15.59 | 12.59 | -3.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 72,992 | 61,103 | -11,889 | 3.50 | 2.52 | -0.98 | sell |
| READYSTATE ASSET MANAGEMENT LP | 148,169 | 132,218 | -15,951 | 0.30 | 0.18 | -0.12 | sell |
| Fisher Asset Management, LLC | 793,458 | 733,680 | -59,778 | 0.01 | 0.01 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 270,435 | 208,527 | -61,908 | 0.16 | 0.10 | -0.06 | sell |
| Allostery Investments LP | 70,000 | 5,000 | -65,000 | 4.06 | 2.10 | -1.95 | sell |
| Integral Health Asset Management, LLC | 1,100,000 | 1,000,000 | -100,000 | 4.90 | 3.09 | -1.81 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 150,908 | 39,389 | -111,519 | 4.26 | 0.01 | -4.25 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,993,896 | 1,865,977 | -127,919 | 0.01 | 0.01 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 382,696 | 249,500 | -133,196 | 0.31 | 0.14 | -0.16 | sell |
| Clearline Capital LP | 166,477 | 6,817 | -159,660 | 0.40 | 0.01 | -0.39 | sell |
| THORNBURG INVESTMENT MANAGEMENT INC | 260,893 | 72,879 | -188,014 | 0.15 | 0.03 | -0.12 | sell |
| GREAT POINT PARTNERS LLC | 370,000 | 150,000 | -220,000 | 7.88 | 3.22 | -4.65 | sell |
| ORBIMED ADVISORS LLC | 1,509,205 | 1,077,000 | -432,205 | 1.46 | 0.89 | -0.56 | sell |