| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 16,548,011 | 20,094,362 | +3,546,351 | 0.02 | 0.03 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 17,523,840 | 18,718,498 | +1,194,658 | 0.80 | 1.05 | +0.25 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,009,489 | 6,931,770 | -1,077,719 | 0.10 | 0.10 | +0.00 | sell |
| STATE STREET CORP | 5,745,193 | 6,494,233 | +749,040 | 0.01 | 0.02 | +0.00 | buy |
| FMR LLC | 10,723,140 | 5,031,782 | -5,691,358 | 0.04 | 0.02 | -0.02 | sell |
| Avoro Capital Advisors LLC | 3,333,333 | 4,999,999 | +1,666,666 | 2.16 | 3.82 | +1.66 | buy |
| BANK OF AMERICA CORP /DE/ | 3,125,436 | 4,635,709 | +1,510,273 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,215,415 | 3,712,501 | +497,086 | 0.01 | 0.02 | +0.00 | buy |
| RTW INVESTMENTS, LP | 2,721,158 | 2,862,003 | +140,845 | 1.78 | 2.08 | +0.30 | buy |
| Polar Capital Holdings Plc | 1,661,248 | 2,253,649 | +592,401 | 0.48 | 0.54 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,584,321 | 1,958,946 | +374,625 | 0.01 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,205,758 | 1,761,588 | -444,170 | 0.02 | 0.02 | -0.00 | sell |
| Capital Research Global Investors | 770,999 | 1,686,625 | +915,626 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,441,634 | 1,647,345 | +205,711 | 0.01 | 0.02 | +0.00 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,087,591 | 1,603,442 | +515,851 | 0.24 | 0.41 | +0.17 | buy |
| Integral Health Asset Management, LLC | 1,600,000 | 1,600,000 | 0 | 5.58 | 5.59 | +0.01 | hold |
| JPMORGAN CHASE & CO | 903,805 | 1,588,895 | +685,090 | 0.00 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 626,102 | 1,587,712 | +961,610 | 0.07 | 0.21 | +0.13 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,565,781 | +1,565,781 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,397,045 | 1,565,781 | +168,736 | 0.01 | 0.02 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 898,951 | 1,549,458 | +650,507 | 0.08 | 0.12 | +0.04 | buy |
| MORGAN STANLEY | 1,505,075 | 1,510,318 | +5,243 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,093,485 | 1,311,664 | +218,179 | 0.04 | 0.05 | +0.02 | buy |
| Capital International Investors | 1,338,803 | 1,305,848 | -32,955 | 0.02 | 0.02 | +0.00 | sell |
| Invesco Ltd. | 484,980 | 1,235,323 | +750,343 | 0.00 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 764,538 | 1,201,342 | +436,804 | 1.66 | 2.83 | +1.17 | buy |
| UBS Group AG | 2,077,277 | 1,171,287 | -905,990 | 0.02 | 0.02 | -0.01 | sell |
| Pictet Asset Management Holding SA | 750,953 | 1,160,463 | +409,510 | 0.05 | 0.09 | +0.04 | buy |
| Frazier Life Sciences Management, L.P. | 1,159,879 | 1,159,879 | 0 | 1.97 | 2.15 | +0.18 | hold |
| Bank of New York Mellon Corp | 1,006,185 | 1,150,697 | +144,512 | 0.01 | 0.02 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 1,144,579 | +1,144,579 | 0.00 | 0.22 | +0.22 | buy |
| Woodline Partners LP | 1,000,428 | 1,100,708 | +100,280 | 0.25 | 0.29 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 706,631 | 1,048,103 | +341,472 | 0.04 | 0.06 | +0.02 | buy |
| NORGES BANK | 0 | 1,015,522 | +1,015,522 | 0.00 | 0.01 | +0.01 | buy |
| GW&K Investment Management, LLC | 494,619 | 916,107 | +421,488 | 0.29 | 0.61 | +0.32 | buy |
| FRANKLIN RESOURCES INC | 409,784 | 891,087 | +481,303 | 0.01 | 0.02 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 714,344 | 827,810 | +113,466 | 0.05 | 0.07 | +0.02 | buy |
| Melqart Asset Management (UK) Ltd | 843,949 | 767,525 | -76,424 | 5.48 | 6.22 | +0.74 | sell |
| Siren, L.L.C. | 613,952 | 758,952 | +145,000 | 1.12 | 1.31 | +0.19 | buy |
| Fisher Asset Management, LLC | 768,264 | 743,697 | -24,567 | 0.02 | 0.02 | +0.00 | sell |
| Foresite Capital Management IV, LLC | 503,295 | 714,695 | +211,400 | 13.99 | 20.98 | +6.99 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 992,545 | 711,676 | -280,869 | 0.13 | 0.11 | -0.02 | sell |
| Deep Track Capital, LP | 1,374,320 | 700,000 | -674,320 | 1.87 | 0.88 | -0.99 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 854,374 | 689,077 | -165,297 | 0.04 | 0.03 | -0.01 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 660,310 | 660,310 | 0 | 3.69 | 3.08 | -0.61 | hold |
| CITADEL ADVISORS LLC | 1,099,858 | 640,945 | -458,913 | 0.05 | 0.03 | -0.02 | sell |
| Qube Research & Technologies Ltd | 779,446 | 572,535 | -206,911 | 0.07 | 0.05 | -0.02 | sell |
| BROWN ADVISORY INC | 614,655 | 570,664 | -43,991 | 0.07 | 0.08 | +0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 479,098 | 564,398 | +85,300 | 0.52 | 0.64 | +0.12 | buy |
| Affinity Asset Advisors, LLC | 700,483 | 550,000 | -150,483 | 2.71 | 2.29 | -0.42 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 311,649 | 549,348 | +237,699 | 0.01 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 699,453 | 538,022 | -161,431 | 0.07 | 0.07 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 459,087 | 535,993 | +76,906 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 283,700 | 527,412 | +243,712 | 2.09 | 4.81 | +2.72 | buy |
| AMERICAN CENTURY COMPANIES INC | 443,957 | 518,398 | +74,441 | 0.02 | 0.02 | +0.00 | buy |
| Checkpoint Capital L.P. | 180,000 | 475,000 | +295,000 | 4.26 | 10.38 | +6.12 | buy |
| Hood River Capital Management LLC | 0 | 469,273 | +469,273 | 0.00 | 0.29 | +0.29 | buy |
| EMERALD ADVISERS, LLC | 198,811 | 457,956 | +259,145 | 0.41 | 0.92 | +0.50 | buy |
| ADAR1 Capital Management, LLC | 632,556 | 457,907 | -174,649 | 2.51 | 1.83 | -0.67 | sell |
| AMERIPRISE FINANCIAL INC | 302,802 | 454,851 | +152,049 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 656,608 | 451,467 | -205,141 | 0.05 | 0.03 | -0.01 | sell |
| Nuveen, LLC | 351,809 | 447,185 | +95,376 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 335,208 | 443,066 | +107,858 | 0.11 | 0.17 | +0.06 | buy |
| RHUMBLINE ADVISERS | 369,575 | 421,799 | +52,224 | 0.02 | 0.03 | +0.01 | buy |
| Handelsbanken Fonder AB | 247,300 | 405,000 | +157,700 | 0.05 | 0.10 | +0.04 | buy |
| GILDER GAGNON HOWE & CO LLC | 330,989 | 400,245 | +69,256 | 0.26 | 0.35 | +0.09 | buy |
| TD ASSET MANAGEMENT INC | 420,846 | 385,130 | -35,716 | 0.02 | 0.03 | +0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 259,459 | 368,698 | +109,239 | 0.02 | 0.03 | +0.01 | buy |
| CITIGROUP INC | 249,243 | 322,932 | +73,689 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 285,008 | 317,411 | +32,403 | 0.02 | 0.02 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 300,762 | 304,611 | +3,849 | 0.52 | 0.60 | +0.08 | buy |
| Russell Investments Group, Ltd. | 174,029 | 300,024 | +125,995 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 14,612 | 285,688 | +271,076 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 135,464 | 279,769 | +144,305 | 0.43 | 0.84 | +0.40 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 240,632 | 273,031 | +32,399 | 0.00 | 0.00 | +0.00 | buy |
| Polaris Capital Management, LLC | 0 | 266,900 | +266,900 | 0.00 | 2.14 | +2.14 | buy |
| SEGALL BRYANT & HAMILL, LLC | 183,391 | 257,063 | +73,672 | 0.12 | 0.26 | +0.14 | buy |
| Alyeska Investment Group, L.P. | 150,000 | 250,000 | +100,000 | 0.03 | 0.05 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 52,227 | 249,259 | +197,032 | 0.03 | 0.20 | +0.16 | buy |
| Capital World Investors | 242,041 | 248,815 | +6,774 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 239,728 | +239,728 | 0.00 | 0.10 | +0.10 | buy |
| Sarissa Capital Management LP | 228,623 | 228,623 | 0 | 9.56 | 10.95 | +1.39 | hold |
| Swiss National Bank | 229,800 | 222,400 | -7,400 | 0.01 | 0.01 | +0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 39,817 | 219,987 | +180,170 | 0.45 | 2.68 | +2.23 | buy |
| DEUTSCHE BANK AG\ | 187,138 | 216,540 | +29,402 | 0.00 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 59,425 | 214,535 | +155,110 | 0.00 | 0.02 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 0 | 211,267 | +211,267 | 0.00 | 0.09 | +0.09 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 198,530 | 211,052 | +12,522 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 69,845 | 209,071 | +139,226 | 0.33 | 1.00 | +0.67 | buy |
| PINNACLE ASSOCIATES LTD | 177,062 | 202,440 | +25,378 | 0.15 | 0.19 | +0.04 | buy |
| Mirador Capital Partners LP | 202,673 | 202,370 | -303 | 1.89 | 2.11 | +0.22 | sell |
| Bank of New York Mellon Corp | 200,000 | 200,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tri Locum Partners LP | 0 | 194,000 | +194,000 | 0.00 | 2.03 | +2.03 | buy |
| PFM Health Sciences, LP | 0 | 191,686 | +191,686 | 0.00 | 1.42 | +1.42 | buy |
| Rock Springs Capital Management LP | 45,364 | 187,980 | +142,616 | 0.18 | 0.78 | +0.61 | buy |
| DAFNA Capital Management LLC | 217,497 | 171,998 | -45,499 | 3.26 | 2.79 | -0.47 | sell |
| Ghisallo Capital Management LLC | 0 | 170,000 | +170,000 | 0.00 | 0.28 | +0.28 | buy |
| Impax Asset Management Group plc | 125,000 | 165,000 | +40,000 | 0.06 | 0.09 | +0.03 | buy |
| Legal & General Group Plc | 151,021 | 164,688 | +13,667 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 156,544 | 161,903 | +5,359 | 0.00 | 0.00 | +0.00 | buy |