| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,523,128 | 12,094,254 | +571,126 | 0.04 | 0.04 | -0.00 | buy |
| VANGUARD GROUP INC | 11,437,696 | 11,761,605 | +323,909 | 0.01 | 0.01 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 8,138,677 | 9,689,987 | +1,551,310 | 0.28 | 0.31 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 7,509,530 | 7,774,970 | +265,440 | 0.07 | 0.07 | -0.00 | buy |
| STATE STREET CORP | 6,548,536 | 6,458,324 | -90,212 | 0.02 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 4,380,769 | 4,829,423 | +448,654 | 0.02 | 0.02 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,358,343 | 3,164,945 | +806,602 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,738,646 | 2,848,584 | +109,938 | 0.01 | 0.01 | -0.00 | buy |
| RTW INVESTMENTS, LP | 2,721,158 | 2,721,158 | 0 | 2.28 | 2.08 | -0.20 | hold |
| Polar Capital Holdings Plc | 2,454,665 | 2,337,847 | -116,818 | 0.78 | 0.59 | -0.20 | sell |
| Pictet Asset Management Holding SA | 1,768,162 | 2,088,567 | +320,405 | 0.11 | 0.12 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 2,065,991 | 1,896,575 | -169,416 | 2.93 | 2.62 | -0.31 | sell |
| MARSHALL WACE, LLP | 1,678,159 | 1,873,701 | +195,542 | 0.13 | 0.13 | -0.00 | buy |
| PFM Health Sciences, LP | 1,757,192 | 1,757,192 | 0 | 5.19 | 5.32 | +0.13 | hold |
| ALLIANCEBERNSTEIN L.P. | 1,879,161 | 1,661,014 | -218,147 | 0.04 | 0.03 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,500,000 | 1,500,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Vestal Point Capital, LP | 2,075,000 | 1,500,000 | -575,000 | 8.38 | 6.25 | -2.13 | sell |
| NORTHERN TRUST CORP | 1,282,893 | 1,329,654 | +46,761 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 925,682 | 1,321,391 | +395,709 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,111,943 | 1,234,917 | +122,974 | 0.01 | 0.01 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 873,513 | 1,212,886 | +339,373 | 0.23 | 0.29 | +0.06 | buy |
| Melqart Asset Management (UK) Ltd | 1,675,785 | 1,212,258 | -463,527 | 8.52 | 6.29 | -2.24 | sell |
| GOLDMAN SACHS GROUP INC | 1,138,154 | 1,184,789 | +46,635 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 1,105,674 | 1,168,372 | +62,698 | 0.00 | 0.00 | -0.00 | buy |
| BROWN ADVISORY INC | 762,549 | 1,165,991 | +403,442 | 0.05 | 0.08 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 976,329 | 1,143,830 | +167,501 | 0.03 | 0.03 | +0.00 | buy |
| Sarissa Capital Management LP | 1,110,000 | 1,110,000 | 0 | 10.15 | 14.57 | +4.42 | hold |
| Pentwater Capital Management LP | 1,119,000 | 1,100,000 | -19,000 | 1.31 | 1.06 | -0.25 | sell |
| NORGES BANK | 799,664 | 992,637 | +192,973 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 737,637 | 990,796 | +253,159 | 0.83 | 0.84 | +0.02 | buy |
| RP Management, LLC | 980,392 | 980,392 | 0 | 29.71 | 22.73 | -6.97 | hold |
| CITADEL ADVISORS LLC | 858,973 | 937,191 | +78,218 | 0.05 | 0.05 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 853,862 | 911,182 | +57,320 | 9.32 | 8.06 | -1.25 | buy |
| Bank of New York Mellon Corp | 1,068,596 | 907,295 | -161,301 | 0.01 | 0.01 | -0.00 | sell |
| NOMURA HOLDINGS INC | 137,658 | 854,254 | +716,596 | 0.05 | 0.34 | +0.29 | buy |
| ORBIMED ADVISORS LLC | 812,906 | 766,906 | -46,000 | 0.88 | 0.74 | -0.13 | sell |
| Integral Health Asset Management, LLC | 1,000,000 | 750,000 | -250,000 | 5.39 | 4.66 | -0.73 | sell |
| Deep Track Capital, LP | 132,495 | 629,906 | +497,411 | 0.21 | 1.06 | +0.85 | buy |
| TD ASSET MANAGEMENT INC | 360,598 | 561,018 | +200,420 | 0.02 | 0.03 | +0.01 | buy |
| Fisher Asset Management, LLC | 534,520 | 542,284 | +7,764 | 0.01 | 0.01 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 344,134 | 542,135 | +198,001 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 403,561 | 536,447 | +132,886 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 495,398 | 503,091 | +7,693 | 0.01 | 0.01 | -0.00 | buy |
| Checkpoint Capital L.P. | 190,000 | 466,813 | +276,813 | 6.21 | 12.23 | +6.02 | buy |
| Point72 Asset Management, L.P. | 374,848 | 464,010 | +89,162 | 0.07 | 0.09 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 463,431 | 461,836 | -1,595 | 0.05 | 0.04 | -0.00 | sell |
| Logos Global Management LP | 0 | 400,000 | +400,000 | 0.00 | 2.37 | +2.37 | buy |
| DAFNA Capital Management LLC | 398,100 | 398,100 | 0 | 5.15 | 4.97 | -0.19 | hold |
| RHUMBLINE ADVISERS | 379,257 | 378,676 | -581 | 0.02 | 0.02 | -0.00 | sell |
| BARCLAYS PLC | 282,378 | 376,996 | +94,618 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 369,237 | 348,056 | -21,181 | 0.04 | 0.03 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 276,067 | 344,448 | +68,381 | 0.00 | 0.01 | +0.00 | buy |
| Saturn V Capital Management LP | 272,036 | 331,283 | +59,247 | 5.57 | 6.25 | +0.68 | buy |
| AMERICAN CENTURY COMPANIES INC | 331,444 | 328,957 | -2,487 | 0.01 | 0.01 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 384,042 | 328,072 | -55,970 | 0.05 | 0.04 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 474,202 | 316,000 | -158,202 | 4.92 | 5.03 | +0.11 | sell |
| UBS Group AG | 299,604 | 313,559 | +13,955 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 75,139 | 302,213 | +227,074 | 0.01 | 0.05 | +0.03 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 252,811 | 283,482 | +30,671 | 0.19 | 0.19 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 393,579 | 273,082 | -120,497 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 251,942 | 266,756 | +14,814 | 0.00 | 0.00 | -0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 266,700 | 266,700 | 0 | 2.23 | 2.07 | -0.16 | hold |
| TWO SIGMA INVESTMENTS, LP | 58,600 | 258,917 | +200,317 | 0.01 | 0.03 | +0.02 | buy |
| PINNACLE ASSOCIATES LTD | 253,864 | 258,358 | +4,494 | 0.22 | 0.37 | +0.15 | buy |
| Finepoint Capital LP | 256,449 | 256,449 | 0 | 3.94 | 1.65 | -2.30 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 254,148 | 254,148 | 0 | 0.24 | 0.23 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 470,967 | 244,367 | -226,600 | 0.04 | 0.02 | -0.02 | sell |
| COMERICA BANK | 166,180 | 237,022 | +70,842 | 0.04 | 0.05 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 384,924 | 225,021 | -159,903 | 3.40 | 1.94 | -1.46 | sell |
| First Turn Management, LLC | 293,318 | 223,147 | -70,171 | 2.59 | 1.87 | -0.72 | sell |
| Rafferty Asset Management, LLC | 265,069 | 216,826 | -48,243 | 0.05 | 0.04 | -0.01 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 187,633 | 215,798 | +28,165 | 12.81 | 10.19 | -2.63 | buy |
| Swiss National Bank | 195,500 | 215,500 | +20,000 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 173,775 | 214,832 | +41,057 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 214,700 | +214,700 | 0.00 | 0.03 | +0.03 | buy |
| Clearline Capital LP | 207,695 | 207,695 | 0 | 0.98 | 0.97 | -0.01 | hold |
| Rock Springs Capital Management LP | 0 | 206,108 | +206,108 | 0.00 | 0.35 | +0.35 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 126,438 | 203,042 | +76,604 | 0.11 | 0.23 | +0.12 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 157,039 | 201,489 | +44,450 | 0.01 | 0.02 | +0.00 | buy |
| Bank of New York Mellon Corp | 200,000 | 200,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corebridge Financial, Inc. | 204,245 | 199,375 | -4,870 | 0.06 | 0.06 | -0.00 | sell |
| Prosight Management, LP | 230,000 | 192,700 | -37,300 | 3.72 | 2.58 | -1.14 | sell |
| CITIGROUP INC | 131,354 | 189,845 | +58,491 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 179,737 | 183,736 | +3,999 | 0.01 | 0.01 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 197,515 | 180,500 | -17,015 | 1.03 | 0.77 | -0.25 | sell |
| Candriam S.C.A. | 179,200 | 179,200 | 0 | 0.06 | 0.05 | -0.00 | hold |
| LMR Partners LLP | 0 | 174,775 | +174,775 | 0.00 | 0.20 | +0.20 | buy |
| Ikarian Capital, LLC | 170,147 | 170,147 | 0 | 2.88 | 2.79 | -0.09 | hold |
| Legal & General Group Plc | 159,518 | 169,977 | +10,459 | 0.00 | 0.00 | -0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 155,794 | 155,794 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Russell Investments Group, Ltd. | 158,242 | 155,680 | -2,562 | 0.01 | 0.01 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 394,175 | 153,864 | -240,311 | 1.01 | 0.42 | -0.59 | sell |
| NOMURA HOLDINGS INC | 121,954 | 146,966 | +25,012 | 0.04 | 0.06 | +0.02 | buy |
| Retirement Systems of Alabama | 141,516 | 142,930 | +1,414 | 0.03 | 0.03 | -0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 140,601 | 140,911 | +310 | 0.22 | 0.22 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 253,487 | 135,725 | -117,762 | 0.02 | 0.01 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 119,664 | 134,927 | +15,263 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 198,181 | 129,035 | -69,146 | 0.10 | 0.06 | -0.05 | sell |
| Impax Asset Management Group plc | 125,000 | 125,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| MetLife Investment Management, LLC | 122,770 | 123,308 | +538 | 0.04 | 0.04 | -0.00 | buy |