| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 17,602,440 | 19,080,496 | +1,478,056 | 0.37 | 0.64 | +0.27 | buy |
| BlackRock, Inc. | 15,677,867 | 15,525,747 | -152,120 | 0.01 | 0.02 | +0.01 | sell |
| FMR LLC | 11,267,511 | 13,091,647 | +1,824,136 | 0.02 | 0.04 | +0.02 | buy |
| VANGUARD GROUP INC | 11,983,838 | 11,856,795 | -127,043 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 7,827,679 | 7,408,561 | -419,118 | 0.05 | 0.07 | +0.02 | sell |
| STATE STREET CORP | 6,372,753 | 5,617,334 | -755,419 | 0.01 | 0.01 | +0.00 | sell |
| Deep Track Capital, LP | 3,650,000 | 4,300,000 | +650,000 | 3.88 | 6.60 | +2.72 | buy |
| BANK OF AMERICA CORP /DE/ | 2,645,568 | 3,061,796 | +416,228 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,994,445 | 3,040,202 | +45,757 | 0.01 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 2,798,401 | 2,782,930 | -15,471 | 0.48 | 0.74 | +0.25 | sell |
| RTW INVESTMENTS, LP | 2,721,158 | 2,721,158 | 0 | 1.28 | 1.84 | +0.56 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,865,977 | 2,366,848 | +500,871 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 3,070,665 | 1,803,251 | -1,267,414 | 0.02 | 0.02 | -0.00 | sell |
| Woodline Partners LP | 212,303 | 1,647,725 | +1,435,422 | 0.04 | 0.43 | +0.39 | buy |
| GOLDMAN SACHS GROUP INC | 1,273,983 | 1,634,723 | +360,740 | 0.01 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 1,317,414 | 1,542,857 | +225,443 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,118,080 | 1,521,186 | +403,106 | 0.00 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,500,000 | 1,500,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| NORTHERN TRUST CORP | 1,379,191 | 1,406,832 | +27,641 | 0.01 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 1,000,000 | 1,400,000 | +400,000 | 3.09 | 5.61 | +2.52 | buy |
| CITADEL ADVISORS LLC | 1,298,609 | 1,386,065 | +87,456 | 0.04 | 0.06 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,357,117 | 1,373,883 | +16,766 | 0.01 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,312,349 | 1,196,868 | -115,481 | 1.64 | 2.06 | +0.42 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 1,082,563 | 1,192,484 | +109,921 | 4.23 | 5.06 | +0.84 | buy |
| Capital International Investors | 1,168,110 | 1,178,780 | +10,670 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,184,805 | 1,174,448 | -10,357 | 0.02 | 0.03 | +0.01 | sell |
| Pictet Asset Management Holding SA | 1,546,391 | 1,145,558 | -400,833 | 0.05 | 0.06 | +0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 720,814 | 1,017,801 | +296,987 | 0.04 | 0.08 | +0.05 | buy |
| Aberdeen Group plc | 922,929 | 927,832 | +4,903 | 0.05 | 0.08 | +0.03 | buy |
| BROWN ADVISORY INC | 995,299 | 912,186 | -83,113 | 0.04 | 0.07 | +0.02 | sell |
| Frazier Life Sciences Management, L.P. | 554,731 | 890,445 | +335,714 | 0.73 | 1.47 | +0.73 | buy |
| Bank of New York Mellon Corp | 874,303 | 869,231 | -5,072 | 0.01 | 0.01 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 676,280 | 785,000 | +108,720 | 0.05 | 0.11 | +0.06 | buy |
| Melqart Asset Management (UK) Ltd | 1,326,719 | 783,774 | -542,945 | 6.26 | 5.75 | -0.52 | sell |
| Fisher Asset Management, LLC | 733,680 | 761,587 | +27,907 | 0.01 | 0.02 | +0.01 | buy |
| Vestal Point Capital, LP | 2,975,000 | 725,000 | -2,250,000 | 5.18 | 1.81 | -3.37 | sell |
| TD ASSET MANAGEMENT INC | 544,292 | 671,780 | +127,488 | 0.02 | 0.03 | +0.01 | buy |
| Sarissa Capital Management LP | 588,357 | 588,357 | 0 | 12.59 | 17.93 | +5.33 | hold |
| AMERIPRISE FINANCIAL INC | 344,966 | 564,547 | +219,581 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 582,147 | 518,921 | -63,226 | 3.12 | 2.82 | -0.30 | sell |
| AQR CAPITAL MANAGEMENT LLC | 347,739 | 513,290 | +165,551 | 0.01 | 0.02 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 497,602 | 496,673 | -929 | 0.01 | 0.01 | +0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 471,482 | +471,482 | 0.00 | 0.06 | +0.06 | buy |
| Foresite Capital Management IV, LLC | 0 | 458,295 | +458,295 | 0.00 | 13.79 | +13.79 | buy |
| Catalio Capital Management, LP | 601,439 | 451,581 | -149,858 | 4.17 | 4.59 | +0.42 | sell |
| AMERICAN CENTURY COMPANIES INC | 432,731 | 429,203 | -3,528 | 0.01 | 0.01 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 402,789 | 409,725 | +6,936 | 0.00 | 0.01 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 407,037 | 407,037 | 0 | 0.33 | 0.53 | +0.19 | hold |
| Rosalind Advisors, Inc. | 400,000 | 400,000 | 0 | 6.40 | 7.77 | +1.37 | hold |
| BARCLAYS PLC | 492,814 | 398,075 | -94,739 | 0.01 | 0.01 | +0.00 | sell |
| DAFNA Capital Management LLC | 398,100 | 394,940 | -3,160 | 3.63 | 5.36 | +1.73 | sell |
| GILDER GAGNON HOWE & CO LLC | 191,115 | 389,055 | +197,940 | 0.07 | 0.22 | +0.15 | buy |
| RHUMBLINE ADVISERS | 389,940 | 385,813 | -4,127 | 0.01 | 0.02 | +0.01 | sell |
| Nuveen, LLC | 307,499 | 370,915 | +63,416 | 0.00 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 350,000 | +350,000 | 0.00 | 1.79 | +1.79 | buy |
| MILLENNIUM MANAGEMENT LLC | 458,677 | 342,533 | -116,144 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 200,000 | 300,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| Pentwater Capital Management LP | 300,000 | 300,000 | 0 | 0.13 | 0.15 | +0.02 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 10,167 | 289,967 | +279,800 | 0.00 | 0.02 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 264,329 | 278,429 | +14,100 | 0.19 | 0.24 | +0.05 | buy |
| Quinn Opportunity Partners LLC | 194,939 | 273,661 | +78,722 | 0.55 | 1.10 | +0.54 | buy |
| Rhenman & Partners Asset Management AB | 104,250 | 255,250 | +151,000 | 0.44 | 1.55 | +1.12 | buy |
| First Turn Management, LLC | 0 | 254,795 | +254,795 | 0.00 | 2.10 | +2.10 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 290,245 | 247,465 | -42,780 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 416,253 | 238,382 | -177,871 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,385,953 | 235,416 | -1,150,537 | 0.01 | 0.00 | -0.01 | sell |
| Handelsbanken Fonder AB | 32,300 | 234,500 | +202,200 | 0.00 | 0.04 | +0.04 | buy |
| Ikarian Capital, LLC | 233,464 | 222,674 | -10,790 | 2.55 | 2.48 | -0.08 | sell |
| Swiss National Bank | 216,200 | 219,900 | +3,700 | 0.00 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 211,000 | +211,000 | 0.00 | 1.68 | +1.68 | buy |
| PINNACLE ASSOCIATES LTD | 208,527 | 201,490 | -7,037 | 0.10 | 0.15 | +0.05 | sell |
| Boxer Capital Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 3.50 | +3.50 | buy |
| Mirador Capital Partners LP | 144,347 | 197,367 | +53,020 | 0.77 | 1.54 | +0.76 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 175,279 | 191,897 | +16,618 | 0.01 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 333,282 | 187,969 | -145,313 | 0.36 | 0.31 | -0.05 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 310,891 | 186,883 | -124,008 | 0.01 | 0.01 | -0.00 | sell |
| Hudson Bay Capital Management LP | 157,786 | 182,131 | +24,345 | 0.03 | 0.06 | +0.03 | buy |
| SEGALL BRYANT & HAMILL, LLC | 83,770 | 181,050 | +97,280 | 0.04 | 0.13 | +0.09 | buy |
| GW&K Investment Management, LLC | 0 | 180,670 | +180,670 | 0.00 | 0.09 | +0.09 | buy |
| Legal & General Group Plc | 181,737 | 179,650 | -2,087 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 21,225 | 178,980 | +157,755 | 0.00 | 0.01 | +0.01 | buy |
| Impax Asset Management Group plc | 175,000 | 175,000 | 0 | 0.03 | 0.06 | +0.02 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 249,500 | 170,108 | -79,392 | 0.14 | 0.15 | +0.01 | sell |
| DEUTSCHE BANK AG\ | 143,813 | 165,564 | +21,751 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 326,718 | 161,517 | -165,201 | 2.82 | 2.11 | -0.72 | sell |
| Invesco Ltd. | 136,312 | 157,249 | +20,937 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 158,528 | 154,449 | -4,079 | 0.16 | 0.26 | +0.10 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 142,602 | 150,399 | +7,797 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 150,000 | 150,000 | 0 | 3.22 | 3.44 | +0.22 | hold |
| Nantahala Capital Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.51 | +0.51 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 39,389 | 149,957 | +110,568 | 0.01 | 0.03 | +0.03 | buy |
| Retirement Systems of Alabama | 145,967 | 144,672 | -1,295 | 0.02 | 0.03 | +0.01 | sell |
| READYSTATE ASSET MANAGEMENT LP | 132,218 | 142,482 | +10,264 | 0.18 | 0.38 | +0.20 | buy |
| Exome Asset Management LLC | 115,817 | 142,417 | +26,600 | 3.16 | 5.17 | +2.01 | buy |
| Aquatic Capital Management LLC | 5,497 | 135,869 | +130,372 | 0.00 | 0.14 | +0.13 | buy |
| HighVista Strategies LLC | 68,652 | 132,930 | +64,278 | 0.83 | 1.79 | +0.96 | buy |
| MetLife Investment Management, LLC | 131,954 | 127,590 | -4,364 | 0.03 | 0.03 | +0.01 | sell |
| Monaco Asset Management SAM | 42,500 | 120,000 | +77,500 | 0.53 | 2.46 | +1.92 | buy |
| Russell Investments Group, Ltd. | 151,841 | 119,890 | -31,951 | 0.01 | 0.01 | +0.00 | sell |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 114,500 | 114,500 | 0 | 0.01 | 0.01 | +0.00 | hold |