| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,267,511 | 13,091,647 | +1,824,136 | 0.02 | 0.04 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 17,602,440 | 19,080,496 | +1,478,056 | 0.37 | 0.64 | +0.27 | buy |
| Woodline Partners LP | 212,303 | 1,647,725 | +1,435,422 | 0.04 | 0.43 | +0.39 | buy |
| Deep Track Capital, LP | 3,650,000 | 4,300,000 | +650,000 | 3.88 | 6.60 | +2.72 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,865,977 | 2,366,848 | +500,871 | 0.01 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 471,482 | +471,482 | 0.00 | 0.06 | +0.06 | buy |
| Foresite Capital Management IV, LLC | 0 | 458,295 | +458,295 | 0.00 | 13.79 | +13.79 | buy |
| BANK OF AMERICA CORP /DE/ | 2,645,568 | 3,061,796 | +416,228 | 0.01 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 1,118,080 | 1,521,186 | +403,106 | 0.00 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 1,000,000 | 1,400,000 | +400,000 | 3.09 | 5.61 | +2.52 | buy |
| GOLDMAN SACHS GROUP INC | 1,273,983 | 1,634,723 | +360,740 | 0.01 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 350,000 | +350,000 | 0.00 | 1.79 | +1.79 | buy |
| Frazier Life Sciences Management, L.P. | 554,731 | 890,445 | +335,714 | 0.73 | 1.47 | +0.73 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 720,814 | 1,017,801 | +296,987 | 0.04 | 0.08 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 10,167 | 289,967 | +279,800 | 0.00 | 0.02 | +0.02 | buy |
| First Turn Management, LLC | 0 | 254,795 | +254,795 | 0.00 | 2.10 | +2.10 | buy |
| JPMORGAN CHASE & CO | 1,317,414 | 1,542,857 | +225,443 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 344,966 | 564,547 | +219,581 | 0.00 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 211,000 | +211,000 | 0.00 | 1.68 | +1.68 | buy |
| Handelsbanken Fonder AB | 32,300 | 234,500 | +202,200 | 0.00 | 0.04 | +0.04 | buy |
| Boxer Capital Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 3.50 | +3.50 | buy |
| GILDER GAGNON HOWE & CO LLC | 191,115 | 389,055 | +197,940 | 0.07 | 0.22 | +0.15 | buy |
| GW&K Investment Management, LLC | 0 | 180,670 | +180,670 | 0.00 | 0.09 | +0.09 | buy |
| AQR CAPITAL MANAGEMENT LLC | 347,739 | 513,290 | +165,551 | 0.01 | 0.02 | +0.01 | buy |
| MARSHALL WACE, LLP | 21,225 | 178,980 | +157,755 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 104,250 | 255,250 | +151,000 | 0.44 | 1.55 | +1.12 | buy |
| Nantahala Capital Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.51 | +0.51 | buy |
| Aquatic Capital Management LLC | 5,497 | 135,869 | +130,372 | 0.00 | 0.14 | +0.13 | buy |
| TD ASSET MANAGEMENT INC | 544,292 | 671,780 | +127,488 | 0.02 | 0.03 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 39,389 | 149,957 | +110,568 | 0.01 | 0.03 | +0.03 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 1,082,563 | 1,192,484 | +109,921 | 4.23 | 5.06 | +0.84 | buy |
| BNP Paribas Asset Management Holding S.A. | 676,280 | 785,000 | +108,720 | 0.05 | 0.11 | +0.06 | buy |
| Cinctive Capital Management LP | 0 | 105,641 | +105,641 | 0.00 | 0.29 | +0.29 | buy |
| ROYCE & ASSOCIATES LP | 0 | 100,083 | +100,083 | 0.00 | 0.05 | +0.05 | buy |
| Bank of New York Mellon Corp | 200,000 | 300,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 100,000 | +100,000 | 0.00 | 2.74 | +2.74 | buy |
| SEGALL BRYANT & HAMILL, LLC | 83,770 | 181,050 | +97,280 | 0.04 | 0.13 | +0.09 | buy |
| CITADEL ADVISORS LLC | 1,298,609 | 1,386,065 | +87,456 | 0.04 | 0.06 | +0.02 | buy |
| Squarepoint Ops LLC | 18,398 | 105,180 | +86,782 | 0.00 | 0.01 | +0.01 | buy |
| NOMURA HOLDINGS INC | 23,310 | 107,253 | +83,943 | 0.01 | 0.03 | +0.02 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 82,460 | +82,460 | 0.00 | 0.86 | +0.86 | buy |
| Quinn Opportunity Partners LLC | 194,939 | 273,661 | +78,722 | 0.55 | 1.10 | +0.54 | buy |
| Monaco Asset Management SAM | 42,500 | 120,000 | +77,500 | 0.53 | 2.46 | +1.92 | buy |
| HighVista Strategies LLC | 68,652 | 132,930 | +64,278 | 0.83 | 1.79 | +0.96 | buy |
| Weiss Asset Management LP | 0 | 64,163 | +64,163 | 0.00 | 0.05 | +0.05 | buy |
| Nuveen, LLC | 307,499 | 370,915 | +63,416 | 0.00 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 62,117 | +62,117 | 0.00 | 0.26 | +0.26 | buy |
| Resolute Capital Asset Partners LLC | 0 | 60,000 | +60,000 | 0.00 | 1.72 | +1.72 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 54,828 | +54,828 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 0 | 53,550 | +53,550 | 0.00 | 0.12 | +0.12 | buy |
| Mirador Capital Partners LP | 144,347 | 197,367 | +53,020 | 0.77 | 1.54 | +0.76 | buy |
| Lisanti Capital Growth, LLC | 0 | 49,070 | +49,070 | 0.00 | 0.66 | +0.66 | buy |
| OSAIC HOLDINGS, INC. | 5,913 | 54,733 | +48,820 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,994,445 | 3,040,202 | +45,757 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 8,048 | 51,397 | +43,349 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 41,004 | +41,004 | 0.00 | 0.05 | +0.05 | buy |
| Philadelphia Financial Management of San Francisco, LLC | 0 | 39,523 | +39,523 | 0.00 | 0.44 | +0.44 | buy |
| Creative Planning | 48,062 | 87,310 | +39,248 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 38,000 | +38,000 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 0 | 37,587 | +37,587 | 0.00 | 0.69 | +0.69 | buy |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 0 | 37,478 | +37,478 | 0.00 | 0.33 | +0.33 | buy |
| RAYMOND JAMES FINANCIAL INC | 5,449 | 42,208 | +36,759 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 30,504 | +30,504 | 0.00 | 0.01 | +0.01 | buy |
| Knott David M Jr | 0 | 30,000 | +30,000 | 0.00 | 0.69 | +0.69 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 29,467 | 59,068 | +29,601 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 28,437 | +28,437 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 733,680 | 761,587 | +27,907 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,379,191 | 1,406,832 | +27,641 | 0.01 | 0.01 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 17,746 | 44,626 | +26,880 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 115,817 | 142,417 | +26,600 | 3.16 | 5.17 | +2.01 | buy |
| MACQUARIE GROUP LTD | 83,872 | 110,260 | +26,388 | 0.00 | 0.01 | +0.00 | buy |
| GABELLI FUNDS LLC | 8,410 | 34,759 | +26,349 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 24,732 | +24,732 | 0.00 | 0.03 | +0.03 | buy |
| BAMCO INC /NY/ | 0 | 24,500 | +24,500 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 24,418 | +24,418 | 0.00 | 0.02 | +0.02 | buy |
| Hudson Bay Capital Management LP | 157,786 | 182,131 | +24,345 | 0.03 | 0.06 | +0.03 | buy |
| ROYAL BANK OF CANADA | 45,891 | 68,193 | +22,302 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 143,813 | 165,564 | +21,751 | 0.00 | 0.00 | +0.00 | buy |
| SANDERS MORRIS HARRIS LLC | 0 | 21,505 | +21,505 | 0.00 | 0.16 | +0.16 | buy |
| Invesco Ltd. | 136,312 | 157,249 | +20,937 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 10,000 | 30,000 | +20,000 | 0.33 | 1.24 | +0.92 | buy |
| DIMENSIONAL FUND ADVISORS LP | 32,086 | 51,259 | +19,173 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 17,603 | +17,603 | 0.00 | 0.11 | +0.11 | buy |
| PRUDENTIAL FINANCIAL INC | 26,221 | 43,326 | +17,105 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,357,117 | 1,373,883 | +16,766 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 175,279 | 191,897 | +16,618 | 0.01 | 0.01 | +0.00 | buy |
| Vident Advisory, LLC | 0 | 16,221 | +16,221 | 0.00 | 0.01 | +0.01 | buy |
| Pacer Advisors, Inc. | 0 | 15,740 | +15,740 | 0.00 | 0.00 | +0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 0 | 15,283 | +15,283 | 0.00 | 0.05 | +0.05 | buy |
| Susquehanna Portfolio Strategies, LLC | 264,329 | 278,429 | +14,100 | 0.19 | 0.24 | +0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 40,762 | 54,644 | +13,882 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 24,678 | 38,278 | +13,600 | 0.00 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 56,405 | 68,772 | +12,367 | 0.00 | 0.00 | +0.00 | buy |
| Atria Investments, Inc | 0 | 12,147 | +12,147 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 12,094 | +12,094 | 0.00 | 0.01 | +0.01 | buy |
| Lighthouse Investment Partners, LLC | 35,000 | 47,000 | +12,000 | 0.05 | 0.09 | +0.04 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 72,879 | 84,719 | +11,840 | 0.03 | 0.06 | +0.03 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 11,799 | +11,799 | 0.00 | 0.10 | +0.10 | buy |
| Gallagher Fiduciary Advisors, LLC | 0 | 11,791 | +11,791 | 0.00 | 0.02 | +0.02 | buy |
| Bayforest Capital Ltd | 0 | 11,747 | +11,747 | 0.00 | 0.31 | +0.31 | buy |