| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LORD, ABBETT & CO. LLC | 4,420,000 | 7,115,000 | +2,695,000 | 0.01 | 0.04 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,011,627 | 3,244,250 | +2,232,623 | 0.00 | 0.04 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,178,878 | 413,137 | +765,741 | 0.10 | 0.10 | 0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 1,816,186 | 2,229,485 | +413,299 | 0.04 | 0.12 | +0.08 | buy |
| Logos Global Management LP | 1,250,000 | 1,625,000 | +375,000 | 5.25 | 15.09 | +9.83 | buy |
| TD ASSET MANAGEMENT INC | 99,640 | 182,040 | +82,400 | 0.00 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 2,493,326 | 2,568,405 | +75,079 | 0.05 | 0.13 | 0.00 | buy |
| Hood River Capital Management LLC | 502,526 | 560,981 | +58,455 | 0.48 | 1.29 | +0.81 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 64,180 | 21,159 | +43,021 | 0.02 | 0.01 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 167,977 | 130,472 | +37,505 | 0.03 | 0.05 | +0.03 | sell |
| ALGERT GLOBAL LLC | 15,450 | 43,820 | +28,370 | 0.02 | 0.15 | 0.00 | buy |
| Erste Asset Management GmbH | 18,450 | 37,450 | +19,000 | 0.01 | 0.05 | +0.04 | buy |
| Rafferty Asset Management, LLC | 246,922 | 263,275 | +16,353 | 0.04 | 0.09 | +0.05 | buy |
| Crestline Management, LP | 20,000 | 34,887 | +14,887 | 0.07 | 0.25 | +0.18 | buy |
| China Universal Asset Management Co., Ltd. | 2,463 | 11,341 | +8,878 | 0.02 | 0.18 | +0.16 | buy |
| GUGGENHEIM CAPITAL LLC | 51,002 | 44,222 | +6,780 | 0.01 | 0.03 | 0.00 | sell |
| CANADA LIFE ASSURANCE Co | 99,979 | 105,192 | +5,213 | 0.01 | 0.02 | +0.01 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 80,443 | 84,705 | +4,262 | 0.02 | 0.06 | 0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 525,283 | 521,172 | +4,111 | 0.01 | 0.03 | 0.00 | sell |
| ProShare Advisors LLC | 20,512 | 23,854 | +3,342 | 0.00 | 0.01 | 0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 9,700 | 11,786 | +2,086 | 0.03 | 0.09 | +0.06 | buy |
| PROFUND ADVISORS LLC | 45,879 | 47,749 | +1,870 | 0.07 | 0.17 | 0.00 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 50,423 | 48,929 | +1,494 | 0.02 | 0.05 | 0.00 | sell |
| E Fund Management Co., Ltd. | 12,681 | 14,085 | +1,404 | 0.03 | 0.07 | +0.05 | buy |
| State of Alaska, Department of Revenue | 59,805 | 60,322 | +517 | 0.02 | 0.06 | 0.00 | buy |
| Veracity Capital LLC | 7,434 | 7,478 | +44 | 0.10 | 0.25 | +0.15 | buy |
| GILDER GAGNON HOWE & CO LLC | 26,533 | 26,345 | -188 | 0.01 | 0.03 | +0.02 | sell |
| VIRTUS ADVISERS, LLC | 2,824 | 2,529 | -295 | 0.05 | 0.13 | +0.08 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 62,102 | 61,629 | -473 | 1.12 | 2.70 | +1.59 | sell |
| PINNACLE ASSOCIATES LTD | 259,329 | 258,358 | -971 | 0.14 | 0.36 | +0.22 | sell |
| Dana Investment Advisors, Inc. | 18,416 | 17,121 | -1,295 | 0.03 | 0.07 | +0.04 | sell |
| EFG Asset Management (North America) Corp. | 35,703 | 32,218 | -3,485 | 0.25 | 0.51 | +0.26 | sell |
| Virtus Investment Advisers, LLC | 8,664 | 4,718 | -3,946 | 0.17 | 0.29 | +0.12 | sell |
| Inspire Investing, LLC | 10,364 | 4,482 | -5,882 | 0.04 | 0.04 | +0.00 | sell |
| Mirador Capital Partners LP | 55,628 | 48,952 | -6,676 | 0.37 | 0.87 | +0.49 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 233,933 | 223,820 | -10,113 | 1.26 | 3.01 | +1.75 | sell |
| Bellevue Group AG | 37,100 | 18,900 | -18,200 | 0.02 | 0.02 | +0.01 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 25,000 | 5,000 | -20,000 | 0.01 | 0.01 | -0.01 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 51,141 | 29,446 | -21,695 | 0.01 | 0.01 | +0.00 | sell |
| THORNBURG INVESTMENT MANAGEMENT INC | 108,166 | 85,199 | -22,967 | 0.05 | 0.10 | +0.05 | sell |
| South Dakota Investment Council | 41,721 | 8,021 | -33,700 | 0.03 | 0.01 | -0.01 | sell |
| Saturn V Capital Management LP | 495,168 | 448,144 | -47,024 | 6.11 | 14.32 | +8.22 | sell |
| RTW INVESTMENTS, LP | 2,574,198 | 2,525,080 | -49,118 | 1.60 | 3.29 | +1.69 | sell |
| Rhenman & Partners Asset Management AB | 200,000 | 149,912 | -50,088 | 0.64 | 1.25 | +0.62 | sell |
| J. Goldman & Co LP | 60,289 | 8,095 | -52,194 | 0.06 | 0.03 | -0.03 | sell |
| MOODY ALDRICH PARTNERS LLC | 94,448 | 29,871 | -64,577 | 0.53 | 0.45 | -0.08 | sell |
| Nantahala Capital Management, LLC | 179,257 | 110,017 | -69,240 | 0.45 | 0.55 | +0.10 | sell |
| Affinity Asset Advisors, LLC | 230,366 | 160,000 | -70,366 | 1.91 | 2.44 | +0.53 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 204,664 | 131,514 | -73,150 | 0.18 | 0.33 | +0.15 | sell |
| DAFNA Capital Management LLC | 479,538 | 400,000 | -79,538 | 4.39 | 8.00 | +3.61 | sell |
| GREAT POINT PARTNERS LLC | 600,000 | 500,000 | -100,000 | 3.22 | 7.11 | +3.90 | sell |
| SECTORAL ASSET MANAGEMENT INC | 118,303 | 7,013 | -111,290 | 0.68 | 0.25 | -0.43 | sell |
| BNP Paribas Asset Management Holding S.A. | 616,478 | 467,078 | -149,400 | 0.06 | 0.11 | +0.05 | sell |
| Candriam S.C.A. | 503,240 | 267,240 | -236,000 | 0.11 | 0.15 | +0.05 | sell |
| Artal Group S.A. | 1,518,831 | 1,214,284 | -304,547 | 1.92 | 3.37 | +1.45 | sell |
| Integral Health Asset Management, LLC | 800,000 | 200,000 | -600,000 | 3.26 | 2.27 | -0.99 | sell |
| PFM Health Sciences, LP | 2,399,545 | 1,757,192 | -642,353 | 3.33 | 8.80 | +5.47 | sell |
| Sofinnova Investments, Inc. | 1,060,164 | 414,207 | -645,957 | 1.97 | 1.93 | -0.04 | sell |
| Nicholas Investment Partners, LP | 942,137 | 102,572 | -839,565 | 2.07 | 1.00 | -1.07 | sell |
| Polar Capital Holdings Plc | 2,654,445 | 1,417,054 | -1,237,391 | 0.58 | 0.73 | +0.15 | sell |