| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 19,080,496 | 17,716,372 | -1,364,124 | 0.64 | 0.71 | +0.07 | sell |
| BlackRock, Inc. | 15,525,747 | 16,395,123 | +869,376 | 0.02 | 0.02 | +0.00 | buy |
| FMR LLC | 13,091,647 | 12,807,752 | -283,895 | 0.04 | 0.04 | +0.00 | sell |
| VANGUARD GROUP INC | 11,856,795 | 12,048,131 | +191,336 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 7,408,561 | 7,937,063 | +528,502 | 0.07 | 0.09 | +0.02 | buy |
| STATE STREET CORP | 5,617,334 | 5,825,295 | +207,961 | 0.01 | 0.01 | +0.00 | buy |
| Deep Track Capital, LP | 4,300,000 | 3,336,998 | -963,002 | 6.60 | 4.84 | -1.76 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,500,000 | 3,150,000 | +1,650,000 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,040,202 | 3,056,017 | +15,815 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 3,061,796 | 2,941,152 | -120,644 | 0.01 | 0.01 | +0.00 | sell |
| RTW INVESTMENTS, LP | 2,721,158 | 2,721,158 | 0 | 1.84 | 1.73 | -0.11 | hold |
| Polar Capital Holdings Plc | 2,782,930 | 2,422,612 | -360,318 | 0.74 | 0.70 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 1,634,723 | 2,371,679 | +736,956 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,366,848 | 1,930,119 | -436,729 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 1,647,725 | 1,648,428 | +703 | 0.43 | 0.41 | -0.02 | buy |
| JPMORGAN CHASE & CO | 1,542,857 | 1,412,797 | -130,060 | 0.01 | 0.01 | +0.00 | sell |
| Integral Health Asset Management, LLC | 1,400,000 | 1,400,000 | 0 | 5.61 | 4.51 | -1.10 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,373,883 | 1,383,437 | +9,554 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,406,832 | 1,380,787 | -26,045 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 1,521,186 | 1,265,301 | -255,885 | 0.01 | 0.00 | -0.00 | sell |
| Capital International Investors | 1,178,780 | 1,178,780 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CITADEL ADVISORS LLC | 1,386,065 | 1,162,937 | -223,128 | 0.06 | 0.05 | -0.01 | sell |
| UBS Group AG | 1,803,251 | 1,131,456 | -671,795 | 0.02 | 0.01 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 1,196,868 | 992,766 | -204,102 | 2.06 | 1.54 | -0.52 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 1,174,448 | 976,892 | -197,556 | 0.03 | 0.03 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 890,445 | 934,642 | +44,197 | 1.47 | 1.60 | +0.13 | buy |
| Bank of New York Mellon Corp | 869,231 | 854,309 | -14,922 | 0.01 | 0.01 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 785,000 | 827,863 | +42,863 | 0.11 | 0.06 | -0.05 | buy |
| Fisher Asset Management, LLC | 761,587 | 822,885 | +61,298 | 0.02 | 0.02 | +0.00 | buy |
| NORGES BANK | 0 | 807,070 | +807,070 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 350,000 | 800,000 | +450,000 | 1.79 | 3.65 | +1.86 | buy |
| Pictet Asset Management Holding SA | 1,145,558 | 757,563 | -387,995 | 0.06 | 0.05 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,017,801 | 753,617 | -264,184 | 0.08 | 0.07 | -0.02 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 1,192,484 | 747,983 | -444,501 | 5.06 | 4.22 | -0.85 | sell |
| BROWN ADVISORY INC | 912,186 | 731,154 | -181,032 | 0.07 | 0.06 | -0.00 | sell |
| Melqart Asset Management (UK) Ltd | 783,774 | 622,898 | -160,876 | 5.75 | 3.96 | -1.79 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 247,465 | 579,862 | +332,397 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 564,547 | 545,805 | -18,742 | 0.01 | 0.01 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 671,780 | 544,010 | -127,770 | 0.03 | 0.03 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 518,921 | 540,166 | +21,245 | 2.82 | 2.57 | -0.26 | buy |
| Qube Research & Technologies Ltd | 9,038 | 537,277 | +528,239 | 0.00 | 0.05 | +0.05 | buy |
| FEDERATED HERMES, INC. | 25,794 | 483,668 | +457,874 | 0.00 | 0.05 | +0.05 | buy |
| Aberdeen Group plc | 927,832 | 483,061 | -444,771 | 0.08 | 0.05 | -0.03 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 170,108 | 479,611 | +309,503 | 0.15 | 0.48 | +0.32 | buy |
| GW&K Investment Management, LLC | 180,670 | 472,363 | +291,693 | 0.09 | 0.26 | +0.17 | buy |
| Foresite Capital Management IV, LLC | 458,295 | 458,295 | 0 | 13.79 | 12.68 | -1.12 | hold |
| AMERICAN CENTURY COMPANIES INC | 429,203 | 443,910 | +14,707 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 235,416 | 412,966 | +177,550 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 409,725 | 409,990 | +265 | 0.01 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 187,969 | 407,253 | +219,284 | 0.31 | 0.77 | +0.46 | buy |
| Sarissa Capital Management LP | 588,357 | 396,357 | -192,000 | 17.93 | 11.30 | -6.63 | sell |
| GILDER GAGNON HOWE & CO LLC | 389,055 | 385,820 | -3,235 | 0.22 | 0.26 | +0.04 | sell |
| DAFNA Capital Management LLC | 394,940 | 370,997 | -23,943 | 5.36 | 5.48 | +0.11 | sell |
| Nuveen, LLC | 370,915 | 369,279 | -1,636 | 0.01 | 0.01 | +0.00 | sell |
| E. Ohman J:or Asset Management AB | 407,037 | 362,962 | -44,075 | 0.53 | 0.54 | +0.01 | sell |
| RHUMBLINE ADVISERS | 385,813 | 356,995 | -28,818 | 0.02 | 0.02 | +0.00 | sell |
| BARCLAYS PLC | 398,075 | 343,458 | -54,617 | 0.01 | 0.01 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 343,144 | +343,144 | 0.00 | 0.24 | +0.24 | buy |
| MARSHALL WACE, LLP | 178,980 | 337,031 | +158,051 | 0.01 | 0.02 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 496,673 | 327,202 | -169,471 | 0.01 | 0.01 | -0.00 | sell |
| First Turn Management, LLC | 254,795 | 325,668 | +70,873 | 2.10 | 2.36 | +0.26 | buy |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 1.27 | +1.27 | buy |
| JANE STREET GROUP, LLC | 0 | 284,125 | +284,125 | 0.00 | 0.02 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 278,429 | 278,429 | 0 | 0.24 | 0.27 | +0.03 | hold |
| TWO SIGMA INVESTMENTS, LP | 0 | 274,017 | +274,017 | 0.00 | 0.03 | +0.03 | buy |
| Catalio Capital Management, LP | 451,581 | 258,381 | -193,200 | 4.59 | 2.90 | -1.69 | sell |
| JANUS HENDERSON GROUP PLC | 49,564 | 256,212 | +206,648 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 513,290 | 236,925 | -276,365 | 0.02 | 0.01 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 238,382 | 235,049 | -3,333 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 342,533 | 225,456 | -117,077 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 219,900 | 224,200 | +4,300 | 0.01 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 234,500 | 205,800 | -28,700 | 0.04 | 0.04 | -0.00 | sell |
| Invesco Ltd. | 157,249 | 204,878 | +47,629 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 300,000 | 200,000 | -100,000 | 0.00 | 0.00 | -0.00 | sell |
| Mirador Capital Partners LP | 197,367 | 198,558 | +1,191 | 1.54 | 1.73 | +0.19 | buy |
| Rosalind Advisors, Inc. | 400,000 | 195,045 | -204,955 | 7.77 | 4.52 | -3.25 | sell |
| PINNACLE ASSOCIATES LTD | 201,490 | 190,999 | -10,491 | 0.15 | 0.16 | +0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 191,897 | 190,807 | -1,090 | 0.01 | 0.01 | +0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 181,050 | 189,513 | +8,463 | 0.13 | 0.16 | +0.03 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 150,399 | 189,401 | +39,002 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 165,564 | 175,804 | +10,240 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 182,131 | 175,350 | -6,781 | 0.06 | 0.06 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 174,700 | +174,700 | 0.00 | 0.02 | +0.02 | buy |
| Ikarian Capital, LLC | 222,674 | 172,672 | -50,002 | 2.48 | 1.42 | -1.06 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 289,967 | 172,067 | -117,900 | 0.02 | 0.02 | -0.00 | sell |
| Legal & General Group Plc | 179,650 | 168,586 | -11,064 | 0.00 | 0.00 | +0.00 | sell |
| Checkpoint Capital L.P. | 37,587 | 166,823 | +129,236 | 0.69 | 3.36 | +2.67 | buy |
| WELLS FARGO & COMPANY/MN | 97,460 | 161,556 | +64,096 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 146,978 | +146,978 | 0.00 | 1.60 | +1.60 | buy |
| Retirement Systems of Alabama | 144,672 | 146,668 | +1,996 | 0.03 | 0.03 | +0.00 | buy |
| Candriam S.C.A. | 0 | 146,631 | +146,631 | 0.00 | 0.05 | +0.05 | buy |
| ROYCE & ASSOCIATES LP | 100,083 | 144,426 | +44,343 | 0.05 | 0.09 | +0.04 | buy |
| Russell Investments Group, Ltd. | 119,890 | 137,690 | +17,800 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 0 | 137,597 | +137,597 | 0.00 | 0.10 | +0.10 | buy |
| FIRST TRUST ADVISORS LP | 0 | 127,524 | +127,524 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 142,417 | 124,749 | -17,668 | 5.17 | 3.92 | -1.25 | sell |
| READYSTATE ASSET MANAGEMENT LP | 142,482 | 122,711 | -19,771 | 0.38 | 0.34 | -0.04 | sell |
| MetLife Investment Management, LLC | 127,590 | 121,910 | -5,680 | 0.03 | 0.04 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 13,603 | 119,221 | +105,618 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 132,930 | 114,564 | -18,366 | 1.79 | 1.87 | +0.08 | sell |