| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Artal Group S.A. | 117,553,284 | 175,099,384 | +57,546,100 | 7.27 | 7.55 | +0.28 | buy |
| FMR LLC | 13,894,062 | 38,687,123 | +24,793,061 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 8,294,950 | +8,294,950 | 0.00 | 0.44 | +0.44 | buy |
| VANGUARD GROUP INC | 6,401,225 | 7,675,125 | +1,273,900 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 3,542,000 | 5,846,100 | +2,304,100 | 0.16 | 0.20 | +0.04 | buy |
| Point72 Asset Management, L.P. | 584,386 | 4,121,191 | +3,536,805 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,389,137 | 3,250,535 | +861,398 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 134,477 | 2,409,456 | +2,274,979 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 2,382,286 | 2,382,286 | 0 | 0.35 | 0.30 | -0.05 | hold |
| STATE STREET CORP | 1,987,510 | 2,313,477 | +325,967 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 2,304,150 | +2,304,150 | 0.00 | 0.39 | +0.39 | buy |
| AMERIPRISE FINANCIAL INC | 1,417,950 | 2,092,710 | +674,760 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 1,875,000 | +1,875,000 | 0.00 | 0.72 | +0.72 | buy |
| PINNACLE ASSOCIATES LTD | 1,747,830 | 1,715,831 | -31,999 | 0.07 | 0.05 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 881,123 | 1,359,148 | +478,025 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 499,172 | 1,190,448 | +691,276 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 866,556 | 997,528 | +130,972 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 686,418 | 738,628 | +52,210 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 534,184 | 597,321 | +63,137 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 960,150 | 571,492 | -388,658 | 0.04 | 0.03 | -0.02 | sell |
| Hennion & Walsh Asset Management, Inc. | 0 | 542,899 | +542,899 | 0.00 | 0.05 | +0.05 | buy |
| Bank of New York Mellon Corp | 292,006 | 401,908 | +109,902 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 156,214 | 373,431 | +217,217 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 219,941 | 273,041 | +53,100 | 0.00 | 0.00 | -0.00 | buy |
| BBR PARTNERS, LLC | 30,000 | 270,000 | +240,000 | 0.01 | 0.04 | +0.03 | buy |
| VIRTUS ADVISERS, LLC | 293,092 | 179,972 | -113,120 | 0.37 | 0.15 | -0.23 | sell |
| UBS Group AG | 166,961 | 161,113 | -5,848 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 134,845 | 152,785 | +17,940 | 0.00 | 0.00 | -0.00 | buy |
| Altium Capital Management LLC | 0 | 121,986 | +121,986 | 0.00 | 0.08 | +0.08 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 105,315 | 117,179 | +11,864 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 114,126 | +114,126 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 95,184 | 101,134 | +5,950 | 0.00 | 0.00 | -0.00 | buy |
| Compagnie Lombard Odier SCmA | 94,000 | 94,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 0 | 84,637 | +84,637 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 49,943 | 76,086 | +26,143 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 40,001 | 70,001 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 89,963 | 61,085 | -28,878 | 0.00 | 0.00 | -0.00 | sell |
| Pathstone Holdings, LLC | 62,725 | 60,038 | -2,687 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 49,818 | 59,743 | +9,925 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 32,862 | 55,182 | +22,320 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 49,100 | 53,080 | +3,980 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 52,174 | 51,451 | -723 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,546 | 49,957 | +14,411 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 31,015 | 45,601 | +14,586 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 31,369 | 45,341 | +13,972 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 46,930 | 42,469 | -4,461 | 0.01 | 0.01 | -0.00 | sell |
| WEDBUSH SECURITIES INC | 41,650 | 40,850 | -800 | 0.00 | 0.00 | -0.00 | sell |
| KWB Wealth | 40,640 | 40,640 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 28,969 | 39,646 | +10,677 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 64,619 | 39,437 | -25,182 | 0.00 | 0.00 | -0.00 | sell |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 35,714 | 35,714 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ProShare Advisors LLC | 33,746 | 34,725 | +979 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 33,733 | 33,702 | -31 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 17,548 | 33,130 | +15,582 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 38,737 | 31,890 | -6,847 | 0.00 | 0.00 | -0.00 | sell |
| Prosperity Financial Group, Inc. | 31,500 | 31,500 | 0 | 0.05 | 0.03 | -0.01 | hold |
| GREAT POINT PARTNERS LLC | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| TIAA TRUST, NATIONAL ASSOCIATION | 27,057 | 27,057 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 0 | 23,531 | +23,531 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 10,534 | 22,759 | +12,225 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 22,512 | 22,512 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SG Americas Securities, LLC | 19,269 | 22,197 | +2,928 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vanguard Personalized Indexing Management, LLC | 15,485 | 19,329 | +3,844 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 189,431 | 19,156 | -170,275 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 59,378 | 18,607 | -40,771 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 18,158 | +18,158 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 17,771 | +17,771 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 18,037 | 16,952 | -1,085 | 0.00 | 0.00 | -0.00 | sell |
| Kestra Advisory Services, LLC | 14,500 | 15,500 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| Cresset Asset Management, LLC | 0 | 15,120 | +15,120 | 0.00 | 0.00 | +0.00 | buy |
| TRUIST FINANCIAL CORP | 13,000 | 13,400 | +400 | 0.00 | 0.00 | -0.00 | buy |
| NORTH STAR ASSET MANAGEMENT INC | 12,550 | 12,550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Coyle Financial Counsel LLC | 12,500 | 12,500 | 0 | 0.01 | 0.01 | 0.00 | hold |
| Pinnacle Wealth Management Advisory Group, LLC | 12,445 | 12,445 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vermillion & White Wealth Management Group, LLC | 12,415 | 12,415 | 0 | 0.02 | 0.02 | -0.01 | hold |
| Chemistry Wealth Management LLC | 12,000 | 12,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Legal & General Group Plc | 8,212 | 11,466 | +3,254 | 0.00 | 0.00 | -0.00 | buy |
| CIBC WORLD MARKET INC. | 0 | 10,980 | +10,980 | 0.00 | 0.00 | +0.00 | buy |
| Berger Financial Group, Inc | 10,929 | 10,929 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CAPTRUST FINANCIAL ADVISORS | 10,811 | 10,865 | +54 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 10,792 | +10,792 | 0.00 | 0.00 | +0.00 | buy |
| Estabrook Capital Management | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| River Wealth Advisors LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LifeSteps Financial, Inc. | 10,000 | 10,000 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 8,867 | 8,867 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,316 | 8,319 | -997 | 0.00 | 0.00 | -0.00 | sell |
| Nordwand Advisors, LLC | 4,000 | 4,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 2,409 | 2,409 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Manchester Capital Management LLC | 0 | 2,380 | +2,380 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 2,200 | 2,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quintet Private Bank (Europe) S.A. | 1,749 | 1,682 | -67 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 1,371 | 1,371 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 434 | 1,369 | +935 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 1,174 | 1,174 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Smartleaf Asset Management LLC | 0 | 726 | +726 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 639 | +639 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avion Wealth | 407 | 407 | 0 | 0.00 | 0.00 | -0.00 | hold |