| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 19,995,332 | 24,435,632 | +4,440,300 | 0.59 | 0.94 | +0.35 | buy |
| MORGAN STANLEY | 0 | 917,688 | +917,688 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 786,160 | +786,160 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 780,077 | +780,077 | 0.00 | 0.10 | +0.10 | buy |
| AMERIPRISE FINANCIAL INC | 1,214,678 | 1,890,200 | +675,522 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 2,815,034 | 3,043,291 | +228,257 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,126,137 | 2,348,916 | +222,779 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 210,725 | +210,725 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 81,930 | 272,367 | +190,437 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 36,015 | 224,998 | +188,983 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 150,100 | +150,100 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 272,255 | 412,175 | +139,920 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 121,711 | 250,923 | +129,212 | 0.08 | 0.24 | +0.16 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 103,144 | +103,144 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 328,506 | 417,813 | +89,307 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 39,189 | 127,016 | +87,827 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 54,532 | +54,532 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 54,248 | +54,248 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 125,362 | 169,616 | +44,254 | 0.00 | 0.00 | +0.00 | buy |
| KWB Wealth | 0 | 40,640 | +40,640 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 38,268 | +38,268 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 32,119 | +32,119 | 0.00 | 0.01 | +0.01 | buy |
| RPO LLC | 0 | 32,000 | +32,000 | 0.00 | 0.08 | +0.08 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 26,735 | +26,735 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 24,500 | +24,500 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 24,062 | +24,062 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,286 | 28,329 | +22,043 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 26,994 | 43,994 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 16,522 | +16,522 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 1,876,139 | 1,892,319 | +16,180 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 16,054 | +16,054 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 15,173 | +15,173 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 14,400 | +14,400 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 851,921 | 864,175 | +12,254 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 331,323 | 341,077 | +9,754 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 51,937 | 61,182 | +9,245 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 26,374 | 32,187 | +5,813 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 28,049 | 30,982 | +2,933 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 1,611 | +1,611 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 1,371 | +1,371 | 0.00 | 0.00 | +0.00 | buy |
| TRUIST FINANCIAL CORP | 12,000 | 12,500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Management Advisory Group, LLC | 12,135 | 12,445 | +310 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 242 | +242 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 204 | +204 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 10,333 | 10,534 | +201 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 44,618 | 44,636 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 35,714 | 35,714 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Artal Group S.A. | 117,553,284 | 117,553,284 | 0 | 5.59 | 6.13 | +0.55 | hold |
| Ameritas Investment Partners, Inc. | 5,367 | 5,367 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 37,359 | 37,359 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 245,301 | 245,301 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 130,291 | 130,291 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Estabrook Capital Management | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 434 | 434 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 2,382,286 | 2,382,286 | 0 | 0.20 | 0.24 | +0.04 | hold |
| JNBA Financial Advisors | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Compagnie Lombard Odier SCmA | 94,000 | 94,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 49,100 | 49,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avion Wealth | 407 | 407 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LifeSteps Financial, Inc. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Berger Financial Group, Inc | 10,929 | 10,929 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FWL INVESTMENT MANAGEMENT, LLC | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Chemistry Wealth Management LLC | 12,000 | 12,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Quintet Private Bank (Europe) S.A. | 1,928 | 1,928 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Prosperity Financial Group, Inc. | 31,500 | 31,500 | 0 | 0.03 | 0.03 | +0.01 | hold |
| TIAA TRUST, NATIONAL ASSOCIATION | 27,000 | 27,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SYNTAX RESEARCH, INC. | 142 | 142 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 100,691 | 100,691 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 47,101 | 47,101 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 2,200 | 2,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 40,289 | 40,289 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Coppell Advisory Solutions LLC | 113 | 52 | -61 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 184 | 0 | -184 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 46,235 | 46,049 | -186 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 33,876 | 33,670 | -206 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 10,664 | 9,947 | -717 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 16,930 | 15,921 | -1,009 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE TRADING, LLC | 17,414 | 14,018 | -3,396 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 4,595 | 0 | -4,595 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 4,635 | 0 | -4,635 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 39,569 | 34,184 | -5,385 | 0.00 | 0.00 | +0.00 | sell |
| Covestor Ltd | 8,385 | 66 | -8,319 | 0.01 | 0.00 | -0.01 | sell |
| Cambridge Investment Research Advisors, Inc. | 14,239 | 0 | -14,239 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 58,707 | 43,793 | -14,914 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Capital Management LLC | 15,038 | 0 | -15,038 | 0.01 | 0.00 | -0.01 | sell |
| FEDERATED HERMES, INC. | 16,493 | 0 | -16,493 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,787 | 0 | -20,787 | 0.00 | 0.00 | -0.00 | sell |
| Traynor Capital Management, Inc. | 21,909 | 0 | -21,909 | 0.00 | 0.00 | -0.00 | sell |
| Beacon Pointe Advisors, LLC | 22,800 | 0 | -22,800 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 42,487 | 18,220 | -24,267 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 29,470 | 0 | -29,470 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 29,558 | 0 | -29,558 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Middle East FZE | 29,615 | 0 | -29,615 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 30,937 | 0 | -30,937 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 31,372 | 0 | -31,372 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 34,844 | 0 | -34,844 | 0.00 | 0.00 | -0.00 | sell |