| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Artal Group S.A. | 136,180,481 | 136,180,481 | 0 | 8.98 | 8.59 | -0.39 | hold |
| FMR LLC | 49,867,042 | 51,970,455 | +2,103,413 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 38,918,903 | 38,918,903 | 0 | 3.06 | 1.27 | -1.79 | hold |
| BlackRock, Inc. | 10,133,014 | 10,333,158 | +200,144 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 8,091,098 | 9,881,728 | +1,790,630 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 1,230,050 | 8,988,421 | +7,758,371 | 0.01 | 0.02 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 1,882,600 | 7,558,621 | +5,676,021 | 0.02 | 0.04 | +0.01 | buy |
| Nantahala Capital Management, LLC | 2,304,150 | 6,604,150 | +4,300,000 | 0.30 | 0.34 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,523,971 | 3,521,255 | -2,716 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 2,471,215 | 2,718,248 | +247,033 | 0.00 | 0.00 | -0.00 | buy |
| NEA Management Company, LLC | 2,382,286 | 2,382,286 | 0 | 0.20 | 0.10 | -0.10 | hold |
| Ikarian Capital, LLC | 0 | 1,550,000 | +1,550,000 | 0.00 | 0.33 | +0.33 | buy |
| PINNACLE ASSOCIATES LTD | 1,730,821 | 1,425,292 | -305,529 | 0.05 | 0.01 | -0.03 | sell |
| NORTHERN TRUST CORP | 1,144,031 | 1,308,651 | +164,620 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,417,295 | 1,191,091 | -226,204 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 731,138 | 863,255 | +132,117 | 0.05 | 0.03 | -0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 850,268 | +750,268 | 0.01 | 0.04 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 732,747 | 747,996 | +15,249 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 139,992 | 686,117 | +546,125 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,501 | 550,891 | +463,390 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 401,291 | 540,207 | +138,916 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 480,822 | +480,822 | 0.00 | 0.01 | +0.01 | buy |
| BBR PARTNERS, LLC | 470,000 | 470,000 | 0 | 0.06 | 0.02 | -0.03 | hold |
| Swiss National Bank | 317,500 | 426,600 | +109,100 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 179,972 | 425,269 | +245,297 | 0.13 | 0.13 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 120,387 | 353,508 | +233,121 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 66,043 | 315,659 | +249,616 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 314,780 | 314,919 | +139 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 314,404 | +314,404 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 273,041 | 246,121 | -26,920 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 193,873 | 243,316 | +49,443 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,211,924 | 229,376 | -982,548 | 0.02 | 0.00 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 150,300 | 195,215 | +44,915 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 145,939 | 153,151 | +7,212 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 51,997 | 112,853 | +60,856 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 111,403 | 111,403 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Compagnie Lombard Odier SCmA | 100,000 | 110,000 | +10,000 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 89,745 | 106,786 | +17,041 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 65,074 | 104,494 | +39,420 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 108,734 | 101,148 | -7,586 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 22,512 | 96,512 | +74,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 96,083 | +96,083 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 88,982 | +88,982 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 89,700 | 87,617 | -2,083 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 117,179 | 77,502 | -39,677 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 69,527 | 76,650 | +7,123 | 0.01 | 0.01 | -0.01 | buy |
| BANK OF MONTREAL /CAN/ | 70,001 | 70,000 | -1 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 62,958 | 65,782 | +2,824 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 40,800 | 65,415 | +24,615 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 76,086 | 64,966 | -11,120 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 46,840 | 62,976 | +16,136 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 61,391 | 57,082 | -4,309 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 63,035 | 57,007 | -6,028 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 73,440 | 56,689 | -16,751 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 46,090 | 55,308 | +9,218 | 0.00 | 0.00 | -0.00 | buy |
| Pathstone Holdings, LLC | 58,959 | 54,051 | -4,908 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 51,141 | +51,141 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 43,056 | 49,460 | +6,404 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 46,013 | 46,013 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RPO LLC | 0 | 44,242 | +44,242 | 0.00 | 0.04 | +0.04 | buy |
| Bayesian Capital Management, LP | 0 | 42,000 | +42,000 | 0.00 | 0.00 | +0.00 | buy |
| WEDBUSH SECURITIES INC | 40,850 | 40,850 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KWB Wealth | 40,640 | 40,640 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 38,418 | 38,418 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 35,714 | 35,714 | 0 | 0.01 | 0.00 | -0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 33,702 | 33,702 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kestra Advisory Services, LLC | 15,500 | 31,500 | +16,000 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 48,048 | 29,646 | -18,402 | 0.00 | 0.00 | -0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 0 | 23,613 | +23,613 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 19,922 | 23,223 | +3,301 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 44,307 | 20,859 | -23,448 | 0.00 | 0.00 | -0.00 | sell |
| TIAA TRUST, NATIONAL ASSOCIATION | 27,057 | 20,000 | -7,057 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 31,853 | 19,704 | -12,149 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,432 | 15,034 | +2,602 | 0.00 | 0.00 | -0.00 | buy |
| TRUIST FINANCIAL CORP | 13,400 | 14,000 | +600 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 13,502 | +13,502 | 0.00 | 0.00 | +0.00 | buy |
| Vermillion & White Wealth Management Group, LLC | 13,415 | 13,415 | 0 | 0.02 | 0.01 | -0.01 | hold |
| CAPTRUST FINANCIAL ADVISORS | 11,350 | 13,358 | +2,008 | 0.00 | 0.00 | -0.00 | buy |
| Pinnacle Wealth Management Advisory Group, LLC | 12,445 | 12,445 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 5,971 | 12,155 | +6,184 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 13,074 | 12,046 | -1,028 | 0.00 | 0.00 | -0.00 | sell |
| Chemistry Wealth Management LLC | 12,000 | 12,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTH STAR ASSET MANAGEMENT INC | 12,550 | 11,500 | -1,050 | 0.00 | 0.00 | -0.00 | sell |
| Berger Financial Group, Inc | 10,929 | 10,929 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC WORLD MARKETS CORP | 0 | 10,744 | +10,744 | 0.00 | 0.00 | +0.00 | buy |
| Estabrook Capital Management | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 8,867 | 8,867 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nordwand Advisors, LLC | 4,000 | 4,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 272 | 2,477 | +2,205 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,409 | 2,409 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Manchester Capital Management LLC | 2,380 | 2,380 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quintet Private Bank (Europe) S.A. | 1,928 | 1,928 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 0 | 1,624 | +1,624 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 1,369 | 1,369 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Optiver Holding B.V. | 0 | 1,200 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 100 | 1,131 | +1,031 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SJS Investment Consulting Inc. | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |