| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 820,044 | 2,013,562 | +1,193,518 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 741,002 | +741,002 | 0.00 | 0.05 | +0.05 | buy |
| CITADEL ADVISORS LLC | 458,015 | 1,167,621 | +709,606 | 0.02 | 0.06 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,787,123 | 5,419,172 | +632,049 | 0.04 | 0.05 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 2,325,915 | 2,916,729 | +590,814 | 0.05 | 0.09 | +0.03 | buy |
| Sofinnova Investments, Inc. | 0 | 579,339 | +579,339 | 0.00 | 2.23 | +2.23 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,041,059 | 1,512,645 | +471,586 | 0.39 | 0.74 | +0.36 | buy |
| DIMENSIONAL FUND ADVISORS LP | 105,050 | 561,839 | +456,789 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 736,388 | 1,042,458 | +306,070 | 0.04 | 0.06 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 1,000,000 | +300,000 | 2.09 | 2.82 | +0.73 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 306,756 | 595,000 | +288,244 | 0.02 | 0.06 | +0.03 | buy |
| Man Group plc | 0 | 260,860 | +260,860 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 256,536 | 516,127 | +259,591 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 157,349 | 413,023 | +255,674 | 0.01 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 94,378 | 341,724 | +247,346 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 99,164 | 305,817 | +206,653 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 111,391 | 310,329 | +198,938 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,071,051 | 1,269,647 | +198,596 | 0.01 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 174,088 | +174,088 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 23,500 | 162,300 | +138,800 | 0.00 | 0.01 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 127,193 | +127,193 | 0.00 | 0.12 | +0.12 | buy |
| Legal & General Group Plc | 80,628 | 192,844 | +112,216 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 177,368 | 280,314 | +102,946 | 1.07 | 1.69 | +0.63 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.56 | +0.56 | buy |
| RTW INVESTMENTS, LP | 7,393,127 | 7,483,127 | +90,000 | 5.05 | 5.83 | +0.79 | buy |
| Hood River Capital Management LLC | 0 | 84,372 | +84,372 | 0.00 | 0.07 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,797,016 | 1,873,886 | +76,870 | 0.01 | 0.01 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 170 | 68,056 | +67,886 | 0.00 | 0.18 | +0.18 | buy |
| Qube Research & Technologies Ltd | 230,131 | 296,567 | +66,436 | 0.02 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 208,302 | 274,267 | +65,965 | 0.02 | 0.03 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 60,389 | +60,389 | 0.00 | 0.64 | +0.64 | buy |
| PRUDENTIAL FINANCIAL INC | 5,620 | 62,190 | +56,570 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 584,326 | 628,658 | +44,332 | 0.07 | 0.09 | +0.02 | buy |
| Empowered Funds, LLC | 0 | 39,228 | +39,228 | 0.00 | 0.03 | +0.03 | buy |
| IEQ CAPITAL, LLC | 5,091 | 43,895 | +38,804 | 0.00 | 0.02 | +0.02 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 108,345 | 144,710 | +36,365 | 0.01 | 0.01 | +0.01 | buy |
| Neo Ivy Capital Management | 0 | 36,246 | +36,246 | 0.00 | 0.59 | +0.59 | buy |
| FEDERATED HERMES, INC. | 47,828 | 75,345 | +27,517 | 0.00 | 0.01 | +0.00 | buy |
| SECTOR GAMMA AS | 65,250 | 92,250 | +27,000 | 1.01 | 1.51 | +0.49 | buy |
| Engineers Gate Manager LP | 36,293 | 60,976 | +24,683 | 0.03 | 0.05 | +0.02 | buy |
| XTX Topco Ltd | 13,223 | 35,987 | +22,764 | 0.05 | 0.09 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 160,251 | 178,755 | +18,504 | 0.00 | 0.00 | +0.00 | buy |
| CSS LLC/IL | 0 | 17,857 | +17,857 | 0.00 | 0.06 | +0.06 | buy |
| Palo Alto Investors LP | 386,413 | 404,196 | +17,783 | 2.70 | 3.92 | +1.22 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 653,100 | 670,200 | +17,100 | 0.04 | 0.05 | +0.01 | buy |
| NORTHERN TRUST CORP | 727,976 | 744,011 | +16,035 | 0.00 | 0.01 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 24,140 | 39,307 | +15,167 | 0.01 | 0.02 | +0.01 | buy |
| CWM, LLC | 3,617 | 17,756 | +14,139 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 12,680 | +12,680 | 0.00 | 0.01 | +0.01 | buy |
| Cerity Partners LLC | 0 | 12,581 | +12,581 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 11,670 | +11,670 | 0.00 | 0.00 | +0.00 | buy |
| Ellsworth Advisors, LLC | 0 | 11,529 | +11,529 | 0.00 | 0.15 | +0.15 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 9,400 | 20,450 | +11,050 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 10,287 | +10,287 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 7,127 | 16,900 | +9,773 | 0.00 | 0.01 | +0.00 | buy |
| Savant Capital, LLC | 4,648 | 13,768 | +9,120 | 0.00 | 0.01 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 8,196 | +8,196 | 0.00 | 0.01 | +0.01 | buy |
| Bayforest Capital Ltd | 0 | 8,153 | +8,153 | 0.00 | 0.18 | +0.18 | buy |
| FIRST TRUST ADVISORS LP | 133,763 | 141,748 | +7,985 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 19,016 | 26,969 | +7,953 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 7,583 | +7,583 | 0.00 | 0.11 | +0.11 | buy |
| RAYMOND JAMES FINANCIAL INC | 48,728 | 56,027 | +7,299 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 9,637 | 16,709 | +7,072 | 0.06 | 0.04 | -0.03 | buy |
| Harvest Investment Services, LLC | 0 | 7,037 | +7,037 | 0.00 | 0.10 | +0.10 | buy |
| Pallas Capital Advisors LLC | 0 | 6,925 | +6,925 | 0.00 | 0.01 | +0.01 | buy |
| Mach-1 Financial Group, LLC | 0 | 6,893 | +6,893 | 0.00 | 0.11 | +0.11 | buy |
| BANQUE PICTET & CIE SA | 0 | 6,705 | +6,705 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 6,247 | +6,247 | 0.00 | 0.09 | +0.09 | buy |
| SEI INVESTMENTS CO | 5,274 | 11,264 | +5,990 | 0.00 | 0.00 | +0.00 | buy |
| Capula Management Ltd | 0 | 5,882 | +5,882 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 5,721 | +5,721 | 0.00 | 0.01 | +0.01 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 5,382 | +5,382 | 0.00 | 0.13 | +0.13 | buy |
| MPM BioImpact LLC | 434,767 | 439,977 | +5,210 | 2.79 | 3.85 | +1.07 | buy |
| SG Americas Securities, LLC | 0 | 5,187 | +5,187 | 0.00 | 0.00 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 5,076 | +5,076 | 0.00 | 0.00 | +0.00 | buy |
| SIH Partners, LLLP | 0 | 4,962 | +4,962 | 0.00 | 0.02 | +0.02 | buy |
| Gotham Asset Management, LLC | 0 | 4,800 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 4,492 | +4,492 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 101,669 | 106,067 | +4,398 | 0.01 | 0.01 | +0.00 | buy |
| SteelPeak Wealth, LLC | 0 | 4,250 | +4,250 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 31,670 | 35,828 | +4,158 | 0.02 | 0.03 | +0.01 | buy |
| Merit Financial Group, LLC | 0 | 4,028 | +4,028 | 0.00 | 0.00 | +0.00 | buy |
| SYON CAPITAL LLC | 0 | 4,020 | +4,020 | 0.00 | 0.02 | +0.02 | buy |
| Cladis Investment Advisory, LLC | 0 | 4,000 | +4,000 | 0.00 | 0.15 | +0.15 | buy |
| MACKENZIE FINANCIAL CORP | 22,776 | 26,092 | +3,316 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 12,060 | 15,220 | +3,160 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 23,632 | 26,337 | +2,705 | 0.00 | 0.01 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 5,800 | 8,350 | +2,550 | 0.17 | 0.33 | +0.16 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 35,295 | 37,435 | +2,140 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 48,023 | 50,023 | +2,000 | 0.45 | 0.49 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,421 | 25,421 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 14,998 | 16,725 | +1,727 | 0.02 | 0.03 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,574 | 43,160 | +1,586 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 16,468 | 17,711 | +1,243 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 38,148 | 39,355 | +1,207 | 0.00 | 0.00 | +0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 1,195 | +1,195 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1,082 | 1,807 | +725 | 0.01 | 0.01 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 1,706 | 2,422 | +716 | 0.02 | 0.03 | +0.01 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 707 | +707 | 0.00 | 0.00 | +0.00 | buy |