| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 2,325,915 | 2,916,729 | +590,814 | 0.05 | 0.09 | 0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,041,059 | 1,512,645 | +471,586 | 0.39 | 0.74 | +0.36 | buy |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 1,000,000 | +300,000 | 2.09 | 2.82 | +0.73 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 306,756 | 595,000 | +288,244 | 0.02 | 0.06 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 157,349 | 413,023 | +255,674 | 0.01 | 0.02 | 0.00 | buy |
| Parkman Healthcare Partners LLC | 177,368 | 280,314 | +102,946 | 1.07 | 1.69 | +0.63 | buy |
| D. E. Shaw & Co., Inc. | 1,542,292 | 1,445,279 | +97,013 | 0.09 | 0.10 | 0.00 | sell |
| RTW INVESTMENTS, LP | 7,393,127 | 7,483,127 | +90,000 | 5.05 | 5.83 | +0.79 | buy |
| Hillsdale Investment Management Inc. | 170 | 68,056 | +67,886 | 0.00 | 0.18 | +0.18 | buy |
| BNP Paribas Asset Management Holding S.A. | 584,326 | 628,658 | +44,332 | 0.07 | 0.09 | +0.02 | buy |
| Rockefeller Capital Management L.P. | 492,420 | 455,328 | +37,092 | 0.06 | 0.06 | 0.00 | sell |
| SECTOR GAMMA AS | 65,250 | 92,250 | +27,000 | 1.01 | 1.51 | +0.49 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 46,894 | 23,353 | +23,541 | 0.17 | 0.10 | 0.00 | sell |
| Palo Alto Investors LP | 386,413 | 404,196 | +17,783 | 2.70 | 3.92 | +1.22 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 653,100 | 670,200 | +17,100 | 0.05 | 0.06 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 52,616 | 40,725 | +11,891 | 0.10 | 0.09 | 0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 9,400 | 20,450 | +11,050 | 0.00 | 0.01 | 0.00 | buy |
| CIBC WORLD MARKETS CORP | 7,127 | 16,900 | +9,773 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 11,024 | 4,981 | +6,043 | 0.03 | 0.02 | 0.00 | sell |
| MPM BioImpact LLC | 434,767 | 439,977 | +5,210 | 2.79 | 3.85 | +1.07 | buy |
| ProShare Advisors LLC | 25,102 | 20,047 | +5,055 | 0.00 | 0.00 | 0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 19,486 | 16,021 | +3,465 | 0.01 | 0.01 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 23,632 | 26,337 | +2,705 | 0.00 | 0.01 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 5,800 | 8,350 | +2,550 | 0.17 | 0.33 | +0.16 | buy |
| ADAR1 Capital Management, LLC | 48,023 | 50,023 | +2,000 | 0.45 | 0.49 | +0.04 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 1,706 | 2,422 | +716 | 0.02 | 0.03 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,619 | 1,974 | +355 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 16,818 | 17,147 | +329 | 0.02 | 0.02 | +0.00 | buy |
| CHOREO, LLC | 11,961 | 12,047 | +86 | 0.01 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 15,130 | 15,164 | +34 | 0.00 | 0.00 | 0.00 | buy |
| LGL PARTNERS, LLC | 12,016 | 12,000 | -16 | 0.08 | 0.29 | +0.22 | sell |
| E Fund Management Co., Ltd. | 5,520 | 5,334 | -186 | 0.01 | 0.01 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 7,968 | 7,705 | -263 | 0.01 | 0.01 | +0.00 | sell |
| WEST PACES ADVISORS INC. | 500 | 200 | -300 | 0.01 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 16,353 | 15,820 | -533 | 0.07 | 0.08 | +0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 43,475 | 42,509 | -966 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 160,109 | 159,099 | -1,010 | 0.04 | 0.05 | +0.01 | sell |
| GC Wealth Management RIA, LLC | 8,032 | 6,196 | -1,836 | 0.06 | 0.06 | -0.01 | sell |
| Inspire Investing, LLC | 9,127 | 6,882 | -2,245 | 0.05 | 0.04 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 15,038 | 11,792 | -3,246 | 0.02 | 0.02 | -0.00 | sell |
| PROFUND ADVISORS LLC | 16,036 | 12,711 | -3,325 | 0.03 | 0.03 | +0.00 | sell |
| ALPS ADVISORS INC | 62,368 | 57,368 | -5,000 | 0.02 | 0.02 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 130,023 | 124,438 | -5,585 | 0.08 | 0.09 | +0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 65,681 | 60,081 | -5,600 | 0.01 | 0.01 | +0.00 | sell |
| Point72 Hong Kong Ltd | 32,436 | 22,273 | -10,163 | 0.09 | 0.07 | -0.02 | sell |
| Rafferty Asset Management, LLC | 78,032 | 57,067 | -20,965 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 509,204 | 468,554 | -40,650 | 0.00 | 0.00 | +0.00 | sell |
| PDT Partners, LLC | 92,081 | 40,335 | -51,746 | 0.37 | 0.15 | -0.22 | sell |
| ARMISTICE CAPITAL, LLC | 6,378,000 | 5,434,843 | -943,157 | 3.93 | 4.15 | +0.22 | sell |
| Camber Capital Management LP | 3,200,000 | 1,500,000 | -1,700,000 | 3.34 | 2.72 | -0.63 | sell |