| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8,607,372 | 8,847,467 | +240,095 | 0.01 | 0.01 | -0.00 | buy |
| RTW INVESTMENTS, LP | 7,483,127 | 7,746,415 | +263,288 | 5.83 | 5.39 | -0.44 | buy |
| BlackRock, Inc. | 7,768,217 | 7,480,432 | -287,785 | 0.01 | 0.01 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 5,434,843 | 4,735,464 | -699,379 | 7.40 | 8.77 | +1.37 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 5,419,172 | 4,694,138 | -725,034 | 0.05 | 0.04 | -0.01 | sell |
| JANUS HENDERSON GROUP PLC | 2,916,729 | 3,175,015 | +258,286 | 0.09 | 0.08 | -0.01 | buy |
| STATE STREET CORP | 2,454,896 | 2,996,454 | +541,558 | 0.01 | 0.01 | +0.00 | buy |
| TORONTO DOMINION BANK | 2,613,196 | 2,445,958 | -167,238 | 0.34 | 0.26 | -0.08 | sell |
| D. E. Shaw & Co., Inc. | 1,445,279 | 2,437,697 | +992,418 | 0.09 | 0.12 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,873,886 | 1,934,593 | +60,707 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 2,013,562 | 1,718,287 | -295,275 | 0.01 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 516,127 | 1,381,408 | +865,281 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,273,008 | 1,274,760 | +1,752 | 0.02 | 0.02 | -0.00 | buy |
| MORGAN STANLEY | 949,434 | 1,163,339 | +213,905 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 1,100,000 | +100,000 | 2.82 | 2.72 | -0.10 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,512,645 | 1,059,026 | -453,619 | 0.74 | 0.41 | -0.33 | sell |
| Pictet Asset Management Holding SA | 1,042,458 | 1,041,431 | -1,027 | 0.06 | 0.05 | -0.01 | sell |
| Nuveen, LLC | 1,009,168 | 968,892 | -40,276 | 0.02 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 670,200 | 963,300 | +293,100 | 0.05 | 0.06 | +0.01 | buy |
| CITADEL ADVISORS LLC | 1,167,621 | 920,493 | -247,128 | 0.06 | 0.04 | -0.02 | sell |
| BNP Paribas Asset Management Holding S.A. | 628,658 | 789,494 | +160,836 | 0.09 | 0.09 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 602,665 | 775,753 | +173,088 | 0.01 | 0.01 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 740,817 | +740,817 | 0.00 | 0.09 | +0.09 | buy |
| NORTHERN TRUST CORP | 744,011 | 739,191 | -4,820 | 0.01 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 662,074 | 707,704 | +45,630 | 0.01 | 0.01 | -0.00 | buy |
| Man Group plc | 260,860 | 671,513 | +410,653 | 0.04 | 0.07 | +0.03 | buy |
| Hood River Capital Management LLC | 84,372 | 636,502 | +552,130 | 0.07 | 0.43 | +0.36 | buy |
| Assenagon Asset Management S.A. | 337,960 | 631,622 | +293,662 | 0.03 | 0.05 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 595,000 | 605,905 | +10,905 | 0.06 | 0.05 | -0.01 | buy |
| JPMORGAN CHASE & CO | 603,482 | 601,560 | -1,922 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 1,269,647 | 578,950 | -690,697 | 0.01 | 0.01 | -0.01 | sell |
| MARSHALL WACE, LLP | 741,002 | 537,776 | -203,226 | 0.05 | 0.03 | -0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 413,023 | 537,116 | +124,093 | 0.02 | 0.02 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 561,839 | 527,404 | -34,435 | 0.01 | 0.01 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 455,328 | 463,079 | +7,751 | 0.06 | 0.05 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 468,554 | 453,602 | -14,952 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 439,977 | 438,477 | -1,500 | 3.85 | 3.71 | -0.14 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 106,067 | 431,730 | +325,663 | 0.01 | 0.03 | +0.02 | buy |
| Palo Alto Investors LP | 404,196 | 406,469 | +2,273 | 3.92 | 4.22 | +0.30 | buy |
| LORD, ABBETT & CO. LLC | 0 | 384,447 | +384,447 | 0.00 | 0.06 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 224,839 | 384,402 | +159,563 | 0.01 | 0.02 | +0.01 | buy |
| Sofinnova Investments, Inc. | 579,339 | 375,939 | -203,400 | 2.23 | 1.25 | -0.98 | sell |
| Qube Research & Technologies Ltd | 296,567 | 338,163 | +41,596 | 0.02 | 0.02 | -0.00 | buy |
| Invesco Ltd. | 310,329 | 303,234 | -7,095 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 305,817 | 288,536 | -17,281 | 0.01 | 0.01 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 311,777 | 286,057 | -25,720 | 0.08 | 0.06 | -0.02 | sell |
| BARCLAYS PLC | 132,339 | 279,812 | +147,473 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 193,799 | 272,774 | +78,975 | 0.11 | 0.15 | +0.04 | buy |
| ROYAL BANK OF CANADA | 1,836 | 272,339 | +270,503 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 274,267 | 268,217 | -6,050 | 0.03 | 0.02 | -0.00 | sell |
| Bank of New York Mellon Corp | 216,443 | 266,171 | +49,728 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 112,131 | 260,492 | +148,361 | 0.01 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 460,428 | 243,601 | -216,827 | 0.09 | 0.04 | -0.04 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 178,755 | 229,672 | +50,917 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 192,844 | 222,837 | +29,993 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 162,300 | 211,000 | +48,700 | 0.01 | 0.01 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 207,889 | +207,889 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 10,681 | 181,978 | +171,297 | 0.00 | 0.02 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 280,314 | 181,643 | -98,671 | 1.69 | 1.03 | -0.67 | sell |
| Candriam S.C.A. | 159,099 | 148,595 | -10,504 | 0.05 | 0.04 | -0.01 | sell |
| Swiss National Bank | 134,565 | 135,565 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 341,724 | 135,056 | -206,668 | 0.01 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 13,644 | 131,749 | +118,105 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 37,435 | 127,793 | +90,358 | 0.01 | 0.01 | +0.01 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 1,195 | 126,120 | +124,925 | 0.00 | 0.06 | +0.06 | buy |
| FIRST TRUST ADVISORS LP | 141,748 | 125,322 | -16,426 | 0.01 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 144,710 | 124,340 | -20,370 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 111,813 | 118,539 | +6,726 | 0.01 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 35,403 | 115,408 | +80,005 | 0.01 | 0.03 | +0.02 | buy |
| Hillsdale Investment Management Inc. | 68,056 | 107,756 | +39,700 | 0.18 | 0.19 | +0.02 | buy |
| Rafferty Asset Management, LLC | 57,067 | 97,629 | +40,562 | 0.01 | 0.02 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 124,438 | 92,508 | -31,930 | 0.09 | 0.07 | -0.03 | sell |
| SECTOR GAMMA AS | 92,250 | 92,250 | 0 | 1.51 | 1.47 | -0.03 | hold |
| ALLIANCEBERNSTEIN L.P. | 133,283 | 91,970 | -41,313 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 56,027 | 85,721 | +29,694 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 62,190 | 84,250 | +22,060 | 0.00 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 9,262 | 72,177 | +62,915 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 11,264 | 69,068 | +57,804 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,425 | 64,524 | +99 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 16,709 | 63,069 | +46,360 | 0.04 | 0.12 | +0.08 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 21,000 | 63,000 | +42,000 | 0.26 | 0.70 | +0.44 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 60,081 | 60,250 | +169 | 0.01 | 0.01 | -0.00 | buy |
| IEQ CAPITAL, LLC | 43,895 | 60,106 | +16,211 | 0.02 | 0.02 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 189,442 | 59,742 | -129,700 | 0.02 | 0.01 | -0.02 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 5,840 | 54,000 | +48,160 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 51,606 | +51,606 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 80,100 | 50,851 | -29,249 | 0.01 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 50,387 | +50,387 | 0.00 | 0.03 | +0.03 | buy |
| ROYCE & ASSOCIATES LP | 0 | 50,237 | +50,237 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 158,630 | 49,221 | -109,409 | 0.01 | 0.00 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 66,772 | 48,859 | -17,913 | 0.01 | 0.01 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 40,725 | 48,767 | +8,042 | 0.09 | 0.10 | +0.01 | buy |
| MetLife Investment Management, LLC | 44,354 | 46,331 | +1,977 | 0.01 | 0.01 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 0 | 46,104 | +46,104 | 0.00 | 0.02 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 15,164 | 45,909 | +30,745 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 45,641 | +45,641 | 0.00 | 0.02 | +0.02 | buy |
| J. Goldman & Co LP | 0 | 44,058 | +44,058 | 0.00 | 0.07 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 39,355 | 43,937 | +4,582 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 56,253 | 43,844 | -12,409 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 42,509 | 43,041 | +532 | 0.00 | 0.00 | -0.00 | buy |