| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| D. E. Shaw & Co., Inc. | 1,445,279 | 2,437,697 | +992,418 | 0.10 | 0.13 | 0.00 | buy |
| Hood River Capital Management LLC | 84,372 | 636,502 | +552,130 | 0.07 | 0.43 | +0.36 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 670,200 | 963,300 | +293,100 | 0.06 | 0.07 | +0.01 | buy |
| RTW INVESTMENTS, LP | 7,483,127 | 7,746,415 | +263,288 | 5.83 | 5.39 | -0.44 | buy |
| JANUS HENDERSON GROUP PLC | 2,916,729 | 3,175,015 | +258,286 | 0.09 | 0.08 | 0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 1,195 | 126,120 | +124,925 | 0.00 | 0.06 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 413,023 | 537,116 | +124,093 | 0.02 | 0.02 | 0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 1,100,000 | +100,000 | 2.82 | 2.72 | -0.10 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 162,300 | 211,000 | +48,700 | 0.01 | 0.01 | 0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 21,000 | 63,000 | +42,000 | 0.26 | 0.70 | +0.44 | buy |
| Qube Research & Technologies Ltd | 296,567 | 338,163 | +41,596 | 0.03 | 0.03 | 0.00 | buy |
| Rafferty Asset Management, LLC | 57,067 | 97,629 | +40,562 | 0.01 | 0.02 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 68,056 | 107,756 | +39,700 | 0.18 | 0.19 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 15,164 | 45,909 | +30,745 | 0.00 | 0.01 | 0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 4,981 | 27,832 | +22,851 | 0.02 | 0.04 | 0.00 | buy |
| ALPS ADVISORS INC | 57,368 | 42,709 | +14,659 | 0.02 | 0.01 | 0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 20,450 | 31,650 | +11,200 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 595,000 | 605,905 | +10,905 | 0.06 | 0.05 | -0.01 | buy |
| Bayforest Capital Ltd | 8,153 | 18,779 | +10,626 | 0.18 | 0.40 | +0.22 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 23,353 | 14,548 | +8,805 | 0.10 | 0.04 | 0.00 | sell |
| PROFUND ADVISORS LLC | 12,711 | 20,842 | +8,131 | 0.03 | 0.04 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 40,725 | 48,767 | +8,042 | 0.09 | 0.10 | 0.00 | buy |
| Entropy Technologies, LP | 4,492 | 12,478 | +7,986 | 0.02 | 0.05 | +0.03 | buy |
| Rockefeller Capital Management L.P. | 455,328 | 463,079 | +7,751 | 0.06 | 0.06 | 0.00 | buy |
| E Fund Management Co., Ltd. | 5,334 | 10,898 | +5,564 | 0.01 | 0.03 | +0.01 | buy |
| LGL PARTNERS, LLC | 12,000 | 16,000 | +4,000 | 0.29 | 0.36 | +0.06 | buy |
| Empowered Funds, LLC | 39,228 | 42,507 | +3,279 | 0.03 | 0.02 | -0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 16,021 | 18,338 | +2,317 | 0.01 | 0.01 | 0.00 | buy |
| Palo Alto Investors LP | 404,196 | 406,469 | +2,273 | 3.92 | 4.22 | +0.30 | buy |
| SteelPeak Wealth, LLC | 4,250 | 6,100 | +1,850 | 0.01 | 0.01 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 5,382 | 7,028 | +1,646 | 0.13 | 0.15 | +0.02 | buy |
| Capula Management Ltd | 5,882 | 7,126 | +1,244 | 0.00 | 0.00 | +0.00 | buy |
| Cladis Investment Advisory, LLC | 4,000 | 5,200 | +1,200 | 0.15 | 0.16 | +0.01 | buy |
| ProShare Advisors LLC | 20,047 | 18,898 | +1,149 | 0.00 | 0.00 | 0.00 | sell |
| Virtus Investment Advisers, LLC | 7,583 | 8,717 | +1,134 | 0.11 | 0.14 | +0.04 | buy |
| Inspire Investing, LLC | 6,882 | 7,943 | +1,061 | 0.04 | 0.04 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 42,509 | 43,041 | +532 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,705 | 7,936 | +231 | 0.01 | 0.01 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 8,350 | 8,535 | +185 | 0.33 | 0.28 | -0.06 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 60,081 | 60,250 | +169 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,820 | 15,918 | +98 | 0.08 | 0.07 | -0.00 | buy |
| CHOREO, LLC | 12,047 | 11,691 | -356 | 0.01 | 0.01 | -0.00 | sell |
| BANQUE PICTET & CIE SA | 6,705 | 6,283 | -422 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 11,792 | 10,903 | -889 | 0.02 | 0.01 | -0.00 | sell |
| Diversified Trust Co | 17,147 | 15,833 | -1,314 | 0.02 | 0.02 | -0.00 | sell |
| MPM BioImpact LLC | 439,977 | 438,477 | -1,500 | 3.85 | 3.71 | -0.14 | sell |
| Pallas Capital Advisors LLC | 6,925 | 4,203 | -2,722 | 0.01 | 0.01 | -0.01 | sell |
| Quadrature Capital Ltd | 12,680 | 9,582 | -3,098 | 0.01 | 0.01 | -0.01 | sell |
| SummitTX Capital, L.P. | 20,749 | 13,908 | -6,841 | 0.05 | 0.03 | -0.02 | sell |
| CIBC WORLD MARKETS CORP | 16,900 | 9,577 | -7,323 | 0.01 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 159,099 | 148,595 | -10,504 | 0.05 | 0.04 | -0.01 | sell |
| Neo Ivy Capital Management | 36,246 | 23,067 | -13,179 | 0.59 | 0.36 | -0.23 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 35,828 | 21,887 | -13,941 | 0.03 | 0.03 | +0.00 | sell |
| PDT Partners, LLC | 40,335 | 25,684 | -14,651 | 0.15 | 0.07 | -0.08 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 468,554 | 453,602 | -14,952 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Hong Kong Ltd | 22,273 | 5,000 | -17,273 | 0.07 | 0.02 | -0.06 | sell |
| PINNACLE ASSOCIATES LTD | 124,438 | 92,508 | -31,930 | 0.09 | 0.07 | -0.03 | sell |
| Parkman Healthcare Partners LLC | 280,314 | 181,643 | -98,671 | 1.69 | 1.03 | -0.67 | sell |
| Sofinnova Investments, Inc. | 579,339 | 375,939 | -203,400 | 1.93 | 1.12 | -0.81 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,512,645 | 1,059,026 | -453,619 | 0.74 | 0.41 | -0.33 | sell |
| ARMISTICE CAPITAL, LLC | 5,434,843 | 4,735,464 | -699,379 | 4.15 | 3.99 | -0.16 | sell |