| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 26,700 | 575,860 | +549,160 | 0.00 | 0.07 | +0.07 | buy |
| ARMISTICE CAPITAL, LLC | 6,962,227 | 7,234,898 | +272,671 | 5.57 | 7.02 | +1.45 | buy |
| Palo Alto Investors LP | 0 | 264,469 | +264,469 | 0.00 | 1.27 | +1.27 | buy |
| Squarepoint Ops LLC | 122,890 | 331,707 | +208,817 | 0.01 | 0.04 | +0.03 | buy |
| Parkman Healthcare Partners LLC | 0 | 195,000 | +195,000 | 0.00 | 0.92 | +0.92 | buy |
| Candriam S.C.A. | 0 | 168,220 | +168,220 | 0.00 | 0.04 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 27,661 | 189,233 | +161,572 | 0.01 | 0.06 | +0.05 | buy |
| BANK OF MONTREAL /CAN/ | 54,982 | 216,344 | +161,362 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 8,973,771 | 9,125,134 | +151,363 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,749,340 | 2,899,040 | +149,700 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 95,650 | 222,048 | +126,398 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 68,912 | 189,579 | +120,667 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 372,827 | 492,464 | +119,637 | 0.03 | 0.04 | +0.01 | buy |
| BARCLAYS PLC | 64,874 | 167,012 | +102,138 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 89,715 | +89,715 | 0.00 | 0.50 | +0.50 | buy |
| Qube Research & Technologies Ltd | 0 | 84,749 | +84,749 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 62,549 | +62,549 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,357,638 | 1,419,539 | +61,901 | 0.06 | 0.07 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 51,293 | +51,293 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 658,828 | 706,730 | +47,902 | 0.00 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 44,771 | +44,771 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 389,542 | 429,842 | +40,300 | 0.03 | 0.04 | +0.01 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 39,098 | +39,098 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 40,292 | 78,848 | +38,556 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 791,164 | 822,441 | +31,277 | 0.00 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 78,599 | 107,882 | +29,283 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 136,761 | 165,071 | +28,310 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 445,515 | 472,288 | +26,773 | 0.04 | 0.04 | +0.01 | buy |
| CITIGROUP INC | 31,583 | 57,305 | +25,722 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 139,380 | 165,068 | +25,688 | 0.40 | 0.54 | +0.14 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 94,318 | 118,345 | +24,027 | 0.47 | 0.72 | +0.25 | buy |
| SG Americas Securities, LLC | 0 | 22,514 | +22,514 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.12 | +0.12 | buy |
| STRS OHIO | 2,000 | 21,200 | +19,200 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 18,806 | +18,806 | 0.00 | 0.01 | +0.01 | buy |
| AlphaQuest LLC | 4,188 | 22,359 | +18,171 | 0.02 | 0.07 | +0.06 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 542 | 18,001 | +17,459 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 658,459 | 675,262 | +16,803 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 12,944 | +12,944 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,787,780 | 1,798,666 | +10,886 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 38,854 | 49,068 | +10,214 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 8,682 | +8,682 | 0.00 | 0.08 | +0.08 | buy |
| Edgestream Partners, L.P. | 22,080 | 30,383 | +8,303 | 0.03 | 0.05 | +0.02 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 6,645 | +6,645 | 0.00 | 0.03 | +0.03 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 47,380 | 54,014 | +6,634 | 0.11 | 0.09 | -0.02 | buy |
| E Fund Management Co., Ltd. | 0 | 6,506 | +6,506 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,185 | 22,142 | +5,957 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 5,950 | +5,950 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,012 | 14,795 | +5,783 | 0.04 | 0.06 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 59,698 | 65,476 | +5,778 | 0.00 | 0.01 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 5,510 | +5,510 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 5,488 | +5,488 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 4,055 | 8,836 | +4,781 | 0.06 | 0.19 | +0.13 | buy |
| ProShare Advisors LLC | 14,387 | 18,938 | +4,551 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 10,805 | 15,130 | +4,325 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 310,863 | 314,723 | +3,860 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 53,093 | 56,820 | +3,727 | 0.01 | 0.01 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 4,300 | 7,600 | +3,300 | 0.05 | 0.17 | +0.11 | buy |
| Handelsbanken Fonder AB | 22,200 | 24,700 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 76,266 | 78,705 | +2,439 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 15,139 | 17,314 | +2,175 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 591 | 2,687 | +2,096 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 18,918 | 20,967 | +2,049 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 31,065 | 32,734 | +1,669 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 19,358 | 20,746 | +1,388 | 0.02 | 0.03 | +0.01 | buy |
| ROYAL BANK OF CANADA | 7,213 | 8,419 | +1,206 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14,529 | 15,413 | +884 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 10,128 | 10,944 | +816 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 100,460 | 101,263 | +803 | 0.01 | 0.01 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 24,413 | 25,147 | +734 | 0.01 | 0.01 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 16 | 594 | +578 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 19,301 | 19,876 | +575 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,179 | 7,715 | +536 | 0.01 | 0.01 | +0.00 | buy |
| KBC Group NV | 1,728 | 2,232 | +504 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,290 | 2,782 | +492 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 9,369 | 9,809 | +440 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 373 | +373 | 0.00 | 0.00 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 153,904 | 154,204 | +300 | 0.07 | 0.07 | -0.00 | buy |
| CHOREO, LLC | 11,426 | 11,721 | +295 | 0.01 | 0.01 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 167 | +167 | 0.00 | 0.00 | +0.00 | buy |
| Elequin Capital, LP | 0 | 165 | +165 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 111 | 237 | +126 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 85 | +85 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 773 | 827 | +54 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 40 | 80 | +40 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorNet Financial, Inc | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| Hemington Wealth Management | 0 | 23 | +23 | 0.00 | 0.00 | 0.00 | buy |
| AVANTAX ADVISORY SERVICES, INC. | 9,088 | 9,104 | +16 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 1,928 | 1,943 | +15 | 0.00 | 0.00 | +0.00 | buy |
| JFS WEALTH ADVISORS, LLC | 13 | 26 | +13 | 0.00 | 0.00 | +0.00 | buy |
| LGL PARTNERS, LLC | 12,000 | 12,010 | +10 | 0.05 | 0.06 | +0.01 | buy |
| EverSource Wealth Advisors, LLC | 61 | 71 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 5 | 15 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| DiNuzzo Private Wealth, Inc. | 6 | 9 | +3 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 0 | 0 | 0.05 | 0.06 | +0.00 | hold |
| CANADA LIFE ASSURANCE Co | 20,038 | 20,038 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ARISTEIA CAPITAL, L.L.C. | 0 | 0 | 0 | 0.00 | 0.15 | +0.15 | hold |
| STEELHEAD PARTNERS LLC | 0 | 0 | 0 | 1.00 | 1.02 | +0.02 | hold |