| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8,973,771 | 9,125,134 | +151,363 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,208,606 | 7,892,799 | -315,807 | 0.04 | 0.05 | +0.01 | sell |
| RTW INVESTMENTS, LP | 7,393,127 | 7,393,127 | 0 | 3.50 | 3.97 | +0.47 | hold |
| ARMISTICE CAPITAL, LLC | 6,962,227 | 7,234,898 | +272,671 | 5.57 | 7.02 | +1.45 | buy |
| Camber Capital Management LP | 3,500,000 | 3,500,000 | 0 | 4.13 | 5.04 | +0.91 | hold |
| STATE STREET CORP | 2,749,340 | 2,899,040 | +149,700 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,981,559 | 1,870,217 | -1,111,342 | 0.05 | 0.04 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,787,780 | 1,798,666 | +10,886 | 0.00 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,715,791 | 1,486,297 | -229,494 | 0.22 | 0.21 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 1,357,638 | 1,419,539 | +61,901 | 0.06 | 0.07 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 1,470,350 | 1,409,014 | -61,336 | 0.01 | 0.02 | +0.00 | sell |
| MORGAN STANLEY | 1,516,757 | 1,158,054 | -358,703 | 0.00 | 0.00 | -0.00 | sell |
| Blackstone Inc. | 1,095,290 | 1,095,290 | 0 | 0.15 | 0.18 | +0.04 | hold |
| FMR LLC | 1,104,099 | 1,057,182 | -46,917 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 791,164 | 822,441 | +31,277 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 658,828 | 706,730 | +47,902 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 700,000 | 0 | 2.18 | 1.86 | -0.32 | hold |
| NORTHERN TRUST CORP | 658,459 | 675,262 | +16,803 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 783,062 | 660,532 | -122,530 | 0.09 | 0.09 | +0.00 | sell |
| Point72 Asset Management, L.P. | 26,700 | 575,860 | +549,160 | 0.00 | 0.07 | +0.07 | buy |
| JPMORGAN CHASE & CO | 680,933 | 562,781 | -118,152 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 606,676 | 559,746 | -46,930 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 818,100 | 538,200 | -279,900 | 0.04 | 0.03 | -0.01 | sell |
| Jefferies Financial Group Inc. | 522,895 | 522,895 | 0 | 0.31 | 0.32 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 499,144 | 493,588 | -5,556 | 0.04 | 0.05 | +0.01 | sell |
| Assenagon Asset Management S.A. | 372,827 | 492,464 | +119,637 | 0.03 | 0.04 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 445,515 | 472,288 | +26,773 | 0.04 | 0.04 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 389,542 | 429,842 | +40,300 | 0.03 | 0.04 | +0.01 | buy |
| Pictet Asset Management Holding SA | 369,990 | 355,069 | -14,921 | 0.01 | 0.01 | +0.00 | sell |
| Squarepoint Ops LLC | 122,890 | 331,707 | +208,817 | 0.01 | 0.04 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 318,173 | 317,297 | -876 | 0.02 | 0.03 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 315,100 | 315,041 | -59 | 0.05 | 0.06 | +0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 310,863 | 314,723 | +3,860 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 0 | 264,469 | +264,469 | 0.00 | 1.27 | +1.27 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 250,000 | -50,000 | 0.02 | 0.02 | -0.00 | sell |
| CITADEL ADVISORS LLC | 270,079 | 239,129 | -30,950 | 0.01 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 341,830 | 238,708 | -103,122 | 0.01 | 0.01 | +0.00 | sell |
| Russell Investments Group, Ltd. | 281,100 | 232,239 | -48,861 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 95,650 | 222,048 | +126,398 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 317,579 | 219,464 | -98,115 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 279,049 | 218,197 | -60,852 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 298,422 | 217,999 | -80,423 | 0.14 | 0.10 | -0.04 | sell |
| BANK OF MONTREAL /CAN/ | 54,982 | 216,344 | +161,362 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 208,302 | 208,302 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Parkman Healthcare Partners LLC | 0 | 195,000 | +195,000 | 0.00 | 0.92 | +0.92 | buy |
| AQR CAPITAL MANAGEMENT LLC | 68,912 | 189,579 | +120,667 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 27,661 | 189,233 | +161,572 | 0.01 | 0.06 | +0.05 | buy |
| Candriam S.C.A. | 0 | 168,220 | +168,220 | 0.00 | 0.04 | +0.04 | buy |
| BARCLAYS PLC | 64,874 | 167,012 | +102,138 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 136,761 | 165,071 | +28,310 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 139,380 | 165,068 | +25,688 | 0.40 | 0.54 | +0.14 | buy |
| PINNACLE ASSOCIATES LTD | 153,904 | 154,204 | +300 | 0.07 | 0.07 | -0.00 | buy |
| Swiss National Bank | 135,665 | 134,865 | -800 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 152,402 | 133,977 | -18,425 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 94,318 | 118,345 | +24,027 | 0.47 | 0.72 | +0.25 | buy |
| RHUMBLINE ADVISERS | 116,396 | 110,771 | -5,625 | 0.00 | 0.00 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 78,599 | 107,882 | +29,283 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 100,460 | 101,263 | +803 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 89,715 | +89,715 | 0.00 | 0.50 | +0.50 | buy |
| Qube Research & Technologies Ltd | 0 | 84,749 | +84,749 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 90,000 | 80,000 | -10,000 | 0.21 | 0.23 | +0.03 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 40,292 | 78,848 | +38,556 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 76,266 | 78,705 | +2,439 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 127,601 | 72,946 | -54,655 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 78,852 | 69,060 | -9,792 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,867 | 65,815 | -2,052 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 59,698 | 65,476 | +5,778 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 62,549 | +62,549 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 478,441 | 60,674 | -417,767 | 0.25 | 0.03 | -0.22 | sell |
| ALPS ADVISORS INC | 59,818 | 58,169 | -1,649 | 0.01 | 0.01 | +0.00 | sell |
| CITIGROUP INC | 31,583 | 57,305 | +25,722 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 53,093 | 56,820 | +3,727 | 0.01 | 0.01 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 47,380 | 54,014 | +6,634 | 0.11 | 0.09 | -0.02 | buy |
| Invesco Ltd. | 282,810 | 53,809 | -229,001 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 51,293 | +51,293 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 38,854 | 49,068 | +10,214 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,738 | 48,860 | -8,878 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 94,285 | 48,029 | -46,256 | 0.07 | 0.03 | -0.03 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 44,771 | +44,771 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 44,007 | 44,007 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 43,796 | 42,992 | -804 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 40,974 | 40,723 | -251 | 0.01 | 0.01 | +0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 39,098 | +39,098 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 54,569 | 38,910 | -15,659 | 0.01 | 0.01 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 53,161 | 38,646 | -14,515 | 0.02 | 0.02 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 37,394 | 36,060 | -1,334 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 31,065 | 32,734 | +1,669 | 0.01 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 33,000 | 31,435 | -1,565 | 0.03 | 0.03 | +0.00 | sell |
| Edgestream Partners, L.P. | 22,080 | 30,383 | +8,303 | 0.03 | 0.05 | +0.02 | buy |
| ALGERT GLOBAL LLC | 28,309 | 28,309 | 0 | 0.03 | 0.03 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 30,837 | 26,649 | -4,188 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 25,875 | 25,875 | 0 | 0.03 | 0.07 | +0.03 | hold |
| GUGGENHEIM CAPITAL LLC | 24,413 | 25,147 | +734 | 0.01 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 22,200 | 24,700 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 29,016 | 24,000 | -5,016 | 0.00 | 0.00 | -0.00 | sell |
| Rathbones Group PLC | 23,735 | 23,500 | -235 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 33,421 | 23,421 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 26,979 | 23,199 | -3,780 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 0 | 22,514 | +22,514 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 4,188 | 22,359 | +18,171 | 0.02 | 0.07 | +0.06 | buy |