| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8,847,467 | 8,288,999 | -558,468 | 0.01 | 0.01 | +0.00 | sell |
| RTW INVESTMENTS, LP | 7,746,415 | 7,746,415 | 0 | 5.39 | 5.86 | +0.47 | hold |
| BlackRock, Inc. | 7,480,432 | 7,130,807 | -349,625 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 4,694,138 | 4,918,619 | +224,481 | 0.04 | 0.05 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 3,175,015 | 3,773,556 | +598,541 | 0.08 | 0.11 | +0.03 | buy |
| ARMISTICE CAPITAL, LLC | 4,735,464 | 3,277,272 | -1,458,192 | 8.77 | 6.31 | -2.45 | sell |
| TORONTO DOMINION BANK | 2,445,958 | 3,246,525 | +800,567 | 0.26 | 0.39 | +0.13 | buy |
| STATE STREET CORP | 2,996,454 | 3,134,783 | +138,329 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 2,437,697 | 2,174,608 | -263,089 | 0.12 | 0.11 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,934,593 | 1,950,878 | +16,285 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 920,493 | 1,731,025 | +810,532 | 0.04 | 0.09 | +0.05 | buy |
| FMR LLC | 1,718,287 | 1,611,775 | -106,512 | 0.00 | 0.01 | +0.00 | sell |
| Jefferies Financial Group Inc. | 0 | 1,584,678 | +1,584,678 | 0.00 | 0.89 | +0.89 | buy |
| BANK OF AMERICA CORP /DE/ | 1,381,408 | 1,517,036 | +135,628 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,500,000 | +400,000 | 2.72 | 3.54 | +0.83 | buy |
| Pictet Asset Management Holding SA | 1,041,431 | 1,407,974 | +366,543 | 0.05 | 0.08 | +0.03 | buy |
| Point72 Asset Management, L.P. | 0 | 1,220,642 | +1,220,642 | 0.00 | 0.16 | +0.16 | buy |
| FRANKLIN RESOURCES INC | 1,274,760 | 1,157,034 | -117,726 | 0.02 | 0.02 | +0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,059,026 | 1,131,749 | +72,723 | 0.41 | 0.50 | +0.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 384,402 | 1,056,481 | +672,079 | 0.02 | 0.05 | +0.03 | buy |
| Hood River Capital Management LLC | 636,502 | 995,782 | +359,280 | 0.43 | 0.72 | +0.29 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 963,300 | 927,300 | -36,000 | 0.06 | 0.08 | +0.01 | sell |
| GOLDMAN SACHS GROUP INC | 775,753 | 876,409 | +100,656 | 0.01 | 0.01 | +0.00 | buy |
| Palo Alto Investors LP | 406,469 | 862,613 | +456,144 | 4.22 | 9.80 | +5.57 | buy |
| BNP Paribas Asset Management Holding S.A. | 789,494 | 800,878 | +11,384 | 0.09 | 0.13 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 527,404 | 773,178 | +245,774 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 739,191 | 737,569 | -1,622 | 0.00 | 0.01 | +0.00 | sell |
| Nuveen, LLC | 968,892 | 721,202 | -247,690 | 0.01 | 0.01 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 707,704 | 702,758 | -4,946 | 0.01 | 0.01 | +0.00 | sell |
| Pacer Advisors, Inc. | 740,817 | 503,966 | -236,851 | 0.09 | 0.08 | -0.01 | sell |
| JPMORGAN CHASE & CO | 601,560 | 490,934 | -110,626 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 463,079 | 473,758 | +10,679 | 0.05 | 0.06 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 453,602 | 458,330 | +4,728 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 578,950 | 452,209 | -126,741 | 0.01 | 0.01 | -0.00 | sell |
| MPM BioImpact LLC | 438,477 | 438,477 | 0 | 3.71 | 4.41 | +0.69 | hold |
| Qube Research & Technologies Ltd | 338,163 | 430,934 | +92,771 | 0.02 | 0.04 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,692 | 424,999 | +383,307 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 1,163,339 | 419,417 | -743,922 | 0.00 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 384,447 | 378,053 | -6,394 | 0.06 | 0.07 | +0.01 | sell |
| Boston Partners | 0 | 361,664 | +361,664 | 0.00 | 0.02 | +0.02 | buy |
| PANAGORA ASSET MANAGEMENT INC | 286,057 | 348,366 | +62,309 | 0.06 | 0.09 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 537,116 | 331,256 | -205,860 | 0.02 | 0.01 | -0.01 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 34,000 | 323,548 | +289,548 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 303,234 | 313,057 | +9,823 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 605,905 | 291,000 | -314,905 | 0.05 | 0.03 | -0.02 | sell |
| Ensign Peak Advisors, Inc | 268,217 | 288,767 | +20,550 | 0.02 | 0.03 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 260,492 | 284,891 | +24,399 | 0.01 | 0.02 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 280,551 | +280,551 | 0.00 | 3.48 | +3.48 | buy |
| Bank of New York Mellon Corp | 266,171 | 273,076 | +6,905 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 671,513 | 265,181 | -406,332 | 0.07 | 0.03 | -0.04 | sell |
| Russell Investments Group, Ltd. | 131,749 | 247,493 | +115,744 | 0.01 | 0.02 | +0.01 | buy |
| Legal & General Group Plc | 222,837 | 241,342 | +18,505 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 279,812 | 239,649 | -40,163 | 0.01 | 0.01 | -0.00 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 207,889 | 237,124 | +29,235 | 0.01 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 181,643 | 202,363 | +20,720 | 1.03 | 1.36 | +0.34 | buy |
| MACKENZIE FINANCIAL CORP | 26,286 | 201,792 | +175,506 | 0.00 | 0.02 | +0.01 | buy |
| Boxer Capital Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 3.91 | +3.91 | buy |
| Sofinnova Investments, Inc. | 375,939 | 186,932 | -189,007 | 1.25 | 0.70 | -0.55 | sell |
| HSBC HOLDINGS PLC | 30,010 | 178,499 | +148,489 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 243,601 | 159,596 | -84,005 | 0.04 | 0.03 | -0.01 | sell |
| MARSHALL WACE, LLP | 537,776 | 157,739 | -380,037 | 0.03 | 0.01 | -0.02 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 147,065 | +147,065 | 0.00 | 0.02 | +0.02 | buy |
| Candriam S.C.A. | 148,595 | 146,265 | -2,330 | 0.04 | 0.05 | +0.01 | sell |
| Swiss National Bank | 135,565 | 138,265 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 124,340 | 132,101 | +7,761 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 4,680 | 130,097 | +125,417 | 0.00 | 0.03 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 229,672 | 129,898 | -99,774 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 125,322 | 121,855 | -3,467 | 0.00 | 0.01 | +0.00 | sell |
| SECTOR GAMMA AS | 92,250 | 118,112 | +25,862 | 1.47 | 1.80 | +0.32 | buy |
| RHUMBLINE ADVISERS | 118,539 | 113,904 | -4,635 | 0.00 | 0.01 | +0.00 | sell |
| GROUP ONE TRADING LLC | 7,615 | 113,271 | +105,656 | 0.01 | 0.21 | +0.20 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 110,631 | +110,631 | 0.00 | 0.17 | +0.17 | buy |
| Assenagon Asset Management S.A. | 631,622 | 107,648 | -523,974 | 0.05 | 0.01 | -0.04 | sell |
| Woodline Partners LP | 0 | 105,605 | +105,605 | 0.00 | 0.03 | +0.03 | buy |
| SummitTX Capital, L.P. | 13,908 | 102,734 | +88,826 | 0.03 | 0.26 | +0.23 | buy |
| Rafferty Asset Management, LLC | 97,629 | 101,001 | +3,372 | 0.02 | 0.02 | +0.00 | buy |
| JANE STREET GROUP, LLC | 49,221 | 100,206 | +50,985 | 0.00 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 272,339 | 98,879 | -173,460 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 95,925 | +95,925 | 0.00 | 0.01 | +0.01 | buy |
| Cinctive Capital Management LP | 0 | 95,308 | +95,308 | 0.00 | 0.29 | +0.29 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 126,120 | 95,005 | -31,115 | 0.06 | 0.05 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 91,970 | 92,017 | +47 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 107,756 | 91,136 | -16,620 | 0.19 | 0.17 | -0.03 | sell |
| PINNACLE ASSOCIATES LTD | 92,508 | 88,592 | -3,916 | 0.07 | 0.07 | +0.01 | sell |
| PRUDENTIAL FINANCIAL INC | 84,250 | 87,440 | +3,190 | 0.01 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 85,721 | 83,125 | -2,596 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 135,056 | 79,888 | -55,168 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 72,177 | 76,113 | +3,936 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 73,458 | +73,458 | 0.00 | 0.06 | +0.06 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 54,000 | 67,677 | +13,677 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,524 | 64,527 | +3 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 63,069 | 63,069 | 0 | 0.12 | 0.08 | -0.04 | hold |
| HUSSMAN STRATEGIC ADVISORS, INC. | 63,000 | 63,000 | 0 | 0.70 | 0.84 | +0.13 | hold |
| Point72 Europe (London) LLP | 0 | 62,407 | +62,407 | 0.00 | 0.21 | +0.21 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 48,859 | 58,785 | +9,926 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 69,068 | 58,341 | -10,727 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 60,250 | 54,592 | -5,658 | 0.01 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 43,937 | 51,443 | +7,506 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 48,767 | 49,600 | +833 | 0.10 | 0.24 | +0.14 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 45,909 | 47,447 | +1,538 | 0.01 | 0.01 | +0.00 | buy |