| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,870,217 | 2,325,915 | +455,698 | 0.04 | 0.05 | 0.00 | buy |
| MPM BioImpact LLC | 89,715 | 434,767 | +345,052 | 0.50 | 2.79 | +2.29 | buy |
| TWO SIGMA INVESTMENTS, LP | 317,297 | 173,352 | +143,945 | 0.03 | 0.02 | 0.00 | sell |
| D. E. Shaw & Co., Inc. | 1,419,539 | 1,542,292 | +122,753 | 0.08 | 0.09 | 0.00 | buy |
| Palo Alto Investors LP | 264,469 | 386,413 | +121,944 | 1.27 | 2.70 | +1.43 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 538,200 | 653,100 | +114,900 | 0.03 | 0.05 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 472,288 | 584,326 | +112,038 | 0.04 | 0.07 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 250,000 | 306,756 | +56,756 | 0.02 | 0.02 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 189,579 | 157,349 | +32,230 | 0.01 | 0.01 | 0.00 | sell |
| ADAR1 Capital Management, LLC | 20,000 | 48,023 | +28,023 | 0.12 | 0.45 | +0.32 | buy |
| Point72 Hong Kong Ltd | 11,402 | 32,436 | +21,034 | 0.03 | 0.09 | +0.06 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 31,435 | 46,894 | +15,459 | 0.09 | 0.17 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 38,910 | 23,632 | +15,278 | 0.01 | 0.00 | -0.00 | sell |
| Apollon Wealth Management, LLC | 17,678 | 8,839 | +8,839 | 0.02 | 0.01 | 0.00 | sell |
| ProShare Advisors LLC | 18,938 | 25,102 | +6,164 | 0.00 | 0.00 | 0.00 | buy |
| PROFUND ADVISORS LLC | 20,746 | 16,036 | +4,710 | 0.03 | 0.03 | 0.00 | sell |
| ALPS ADVISORS INC | 58,169 | 62,368 | +4,199 | 0.01 | 0.02 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 6,645 | 9,637 | +2,992 | 0.03 | 0.06 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 13,829 | 11,024 | +2,805 | 0.03 | 0.03 | 0.00 | sell |
| Diversified Trust Co | 15,240 | 16,818 | +1,578 | 0.01 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,795 | 16,353 | +1,558 | 0.06 | 0.07 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 54,014 | 52,616 | +1,398 | 0.09 | 0.10 | 0.00 | sell |
| Rockefeller Capital Management L.P. | 493,588 | 492,420 | +1,168 | 0.05 | 0.06 | 0.00 | sell |
| CHOREO, LLC | 11,721 | 11,961 | +240 | 0.01 | 0.01 | +0.00 | buy |
| LGL PARTNERS, LLC | 12,010 | 12,016 | +6 | 0.06 | 0.08 | +0.02 | buy |
| Elequin Capital, LP | 165 | 2 | -163 | 0.00 | 0.00 | -0.00 | sell |
| Vise Technologies, Inc. | 10,887 | 10,215 | -672 | 0.05 | 0.04 | -0.01 | sell |
| E Fund Management Co., Ltd. | 6,506 | 5,520 | -986 | 0.01 | 0.01 | +0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 44,771 | 43,475 | -1,296 | 0.00 | 0.00 | +0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 16,492 | 15,038 | -1,454 | 0.01 | 0.02 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 8,925 | 7,383 | -1,542 | 0.15 | 0.14 | -0.02 | sell |
| INCEPTIONR LLC | 8,682 | 7,115 | -1,567 | 0.08 | 0.07 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 7,600 | 5,800 | -1,800 | 0.17 | 0.17 | +0.01 | sell |
| Inspire Investing, LLC | 11,039 | 9,127 | -1,912 | 0.04 | 0.05 | +0.00 | sell |
| Candriam S.C.A. | 168,220 | 160,109 | -8,111 | 0.04 | 0.04 | +0.01 | sell |
| Parkman Healthcare Partners LLC | 195,000 | 177,368 | -17,632 | 0.92 | 1.07 | +0.14 | sell |
| Rafferty Asset Management, LLC | 101,263 | 78,032 | -23,231 | 0.01 | 0.01 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 154,204 | 130,023 | -24,181 | 0.07 | 0.08 | +0.01 | sell |
| Blackstone Inc. | 1,095,290 | 1,059,574 | -35,716 | 0.18 | 0.22 | +0.04 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 559,746 | 509,204 | -50,542 | 0.00 | 0.00 | +0.00 | sell |
| PDT Partners, LLC | 165,068 | 92,081 | -72,987 | 0.54 | 0.37 | -0.17 | sell |
| Camber Capital Management LP | 3,500,000 | 3,200,000 | -300,000 | 4.12 | 3.34 | -0.78 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,486,297 | 826,519 | -659,778 | 0.21 | 0.13 | -0.08 | sell |
| ARMISTICE CAPITAL, LLC | 7,234,898 | 6,378,000 | -856,898 | 4.29 | 3.93 | -0.37 | sell |