| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 9,125,134 | 9,178,822 | +53,688 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 7,983,213 | 7,898,801 | -84,412 | 0.01 | 0.01 | +0.00 | sell |
| RTW INVESTMENTS, LP | 7,393,127 | 7,393,127 | 0 | 3.97 | 5.05 | +1.08 | hold |
| ARMISTICE CAPITAL, LLC | 7,234,898 | 6,378,000 | -856,898 | 7.02 | 6.70 | -0.32 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 7,892,799 | 4,787,123 | -3,105,676 | 0.05 | 0.04 | -0.01 | sell |
| TORONTO DOMINION BANK | 0 | 3,286,729 | +3,286,729 | 0.00 | 0.28 | +0.28 | buy |
| Camber Capital Management LP | 3,500,000 | 3,200,000 | -300,000 | 5.04 | 5.65 | +0.61 | sell |
| STATE STREET CORP | 2,899,040 | 2,707,996 | -191,044 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 1,870,217 | 2,325,915 | +455,698 | 0.04 | 0.05 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,798,666 | 1,797,016 | -1,650 | 0.01 | 0.01 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 1,419,539 | 1,542,292 | +122,753 | 0.07 | 0.08 | +0.01 | buy |
| Point72 Asset Management, L.P. | 575,860 | 1,443,362 | +867,502 | 0.07 | 0.18 | +0.10 | buy |
| FRANKLIN RESOURCES INC | 1,409,014 | 1,278,188 | -130,826 | 0.02 | 0.02 | +0.00 | sell |
| MORGAN STANLEY | 1,158,054 | 1,073,817 | -84,237 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 165,071 | 1,071,051 | +905,980 | 0.00 | 0.01 | +0.01 | buy |
| Blackstone Inc. | 1,095,290 | 1,059,574 | -35,716 | 0.18 | 0.23 | +0.04 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 1,041,059 | +1,041,059 | 0.00 | 0.39 | +0.39 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,486,297 | 826,519 | -659,778 | 0.21 | 0.13 | -0.08 | sell |
| FMR LLC | 1,057,182 | 820,044 | -237,138 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 822,441 | 764,625 | -57,816 | 0.01 | 0.01 | +0.00 | sell |
| Pictet Asset Management Holding SA | 355,069 | 736,388 | +381,319 | 0.01 | 0.04 | +0.02 | buy |
| NORTHERN TRUST CORP | 675,262 | 727,976 | +52,714 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 700,000 | 0 | 1.86 | 2.09 | +0.24 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 706,730 | 685,709 | -21,021 | 0.01 | 0.01 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 538,200 | 653,100 | +114,900 | 0.03 | 0.04 | +0.01 | buy |
| JPMORGAN CHASE & CO | 562,781 | 649,269 | +86,488 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 472,288 | 584,326 | +112,038 | 0.04 | 0.07 | +0.02 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 660,532 | 568,364 | -92,168 | 0.09 | 0.09 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 559,746 | 509,204 | -50,542 | 0.00 | 0.00 | +0.00 | sell |
| Rockefeller Capital Management L.P. | 493,588 | 492,420 | -1,168 | 0.05 | 0.06 | +0.01 | sell |
| CITADEL ADVISORS LLC | 239,129 | 458,015 | +218,886 | 0.01 | 0.02 | +0.01 | buy |
| Assenagon Asset Management S.A. | 492,464 | 439,670 | -52,794 | 0.04 | 0.04 | -0.00 | sell |
| MPM BioImpact LLC | 89,715 | 434,767 | +345,052 | 0.50 | 2.79 | +2.29 | buy |
| Palo Alto Investors LP | 264,469 | 386,413 | +121,944 | 1.27 | 2.70 | +1.43 | buy |
| ALLIANCEBERNSTEIN L.P. | 222,048 | 361,644 | +139,596 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 429,842 | 360,442 | -69,400 | 0.04 | 0.04 | +0.00 | sell |
| Trexquant Investment LP | 217,999 | 313,417 | +95,418 | 0.10 | 0.17 | +0.06 | buy |
| PANAGORA ASSET MANAGEMENT INC | 315,041 | 312,016 | -3,025 | 0.06 | 0.07 | +0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 219,464 | 309,423 | +89,959 | 0.01 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 250,000 | 306,756 | +56,756 | 0.02 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 314,723 | 256,536 | -58,187 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 84,749 | 230,131 | +145,382 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 218,197 | 216,882 | -1,315 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 208,302 | 208,302 | 0 | 0.01 | 0.02 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 78,848 | 192,481 | +113,633 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 195,000 | 177,368 | -17,632 | 0.92 | 1.07 | +0.14 | sell |
| TWO SIGMA INVESTMENTS, LP | 317,297 | 173,352 | -143,945 | 0.03 | 0.02 | -0.01 | sell |
| Russell Investments Group, Ltd. | 232,239 | 170,697 | -61,542 | 0.01 | 0.01 | -0.00 | sell |
| JANE STREET GROUP, LLC | 238,708 | 165,918 | -72,790 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 167,012 | 163,848 | -3,164 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 133,977 | 160,251 | +26,274 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 168,220 | 160,109 | -8,111 | 0.04 | 0.04 | +0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 189,579 | 157,349 | -32,230 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 0 | 155,883 | +155,883 | 0.00 | 0.05 | +0.05 | buy |
| Cubist Systematic Strategies, LLC | 60,674 | 141,410 | +80,736 | 0.03 | 0.10 | +0.07 | buy |
| Swiss National Bank | 134,865 | 136,265 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 107,882 | 133,763 | +25,881 | 0.00 | 0.01 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 154,204 | 130,023 | -24,181 | 0.07 | 0.08 | +0.01 | sell |
| Schonfeld Strategic Advisors LLC | 189,233 | 122,280 | -66,953 | 0.06 | 0.03 | -0.02 | sell |
| RHUMBLINE ADVISERS | 110,771 | 112,401 | +1,630 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 53,809 | 111,391 | +57,582 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 110,004 | +110,004 | 0.00 | 0.05 | +0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 105,050 | +105,050 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,142 | 101,669 | +79,527 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 57,305 | 99,164 | +41,859 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 49,068 | 94,378 | +45,310 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 165,068 | 92,081 | -72,987 | 0.54 | 0.37 | -0.17 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 48,860 | 83,273 | +34,413 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 78,705 | 80,628 | +1,923 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 101,263 | 78,032 | -23,231 | 0.01 | 0.01 | -0.00 | sell |
| Aquatic Capital Management LLC | 10,300 | 69,869 | +59,569 | 0.01 | 0.09 | +0.08 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 65,476 | 65,681 | +205 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,815 | 65,254 | -561 | 0.00 | 0.00 | +0.00 | sell |
| SECTOR GAMMA AS | 0 | 65,250 | +65,250 | 0.00 | 1.01 | +1.01 | buy |
| Jump Financial, LLC | 0 | 62,809 | +62,809 | 0.00 | 0.06 | +0.06 | buy |
| ALPS ADVISORS INC | 58,169 | 62,368 | +4,199 | 0.01 | 0.02 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 36,060 | 60,150 | +24,090 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 56,820 | 53,332 | -3,488 | 0.01 | 0.01 | +0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 54,014 | 52,616 | -1,398 | 0.09 | 0.10 | +0.02 | sell |
| ADAR1 Capital Management, LLC | 20,000 | 48,023 | +28,023 | 0.12 | 0.45 | +0.32 | buy |
| FEDERATED HERMES, INC. | 0 | 47,828 | +47,828 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 38,646 | 47,151 | +8,505 | 0.02 | 0.02 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 31,435 | 46,894 | +15,459 | 0.03 | 0.05 | +0.02 | buy |
| MetLife Investment Management, LLC | 44,007 | 46,588 | +2,581 | 0.01 | 0.01 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 11,578 | 45,647 | +34,069 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 44,771 | 43,475 | -1,296 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 69,060 | 42,934 | -26,126 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 32,734 | 41,886 | +9,152 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 42,992 | 41,574 | -1,418 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 26,649 | 38,148 | +11,499 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 40,723 | 37,864 | -2,859 | 0.01 | 0.01 | +0.00 | sell |
| Engineers Gate Manager LP | 48,029 | 36,293 | -11,736 | 0.03 | 0.03 | -0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 18,001 | 35,295 | +17,294 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 331,707 | 33,971 | -297,736 | 0.04 | 0.00 | -0.04 | sell |
| Point72 Hong Kong Ltd | 11,402 | 32,436 | +21,034 | 0.03 | 0.09 | +0.06 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 31,670 | +31,670 | 0.00 | 0.02 | +0.02 | buy |
| ProShare Advisors LLC | 18,938 | 25,102 | +6,164 | 0.00 | 0.00 | +0.00 | buy |
| SPX Gestao de Recursos Ltda | 0 | 25,000 | +25,000 | 0.00 | 0.17 | +0.17 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 18,806 | 24,140 | +5,334 | 0.01 | 0.01 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 24,000 | 24,000 | 0 | 0.00 | 0.00 | +0.00 | hold |