| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 7,130,807 | 12,779,065 | +5,648,258 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 8,288,999 | 8,803,203 | +514,204 | 0.01 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 7,746,415 | 7,746,415 | 0 | 5.86 | 5.89 | +0.04 | hold |
| JANUS HENDERSON GROUP PLC | 3,773,556 | 4,851,332 | +1,077,776 | 0.11 | 0.17 | +0.06 | buy |
| STATE STREET CORP | 3,134,783 | 4,206,126 | +1,071,343 | 0.01 | 0.01 | +0.00 | buy |
| TORONTO DOMINION BANK | 3,246,525 | 4,138,215 | +891,690 | 0.39 | 0.55 | +0.17 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,918,619 | 3,867,380 | -1,051,239 | 0.05 | 0.05 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 3,277,272 | 2,801,869 | -475,403 | 6.31 | 5.21 | -1.10 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,950,878 | 2,016,062 | +65,184 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 2,174,608 | 1,744,991 | -429,617 | 0.11 | 0.10 | -0.01 | sell |
| FMR LLC | 1,611,775 | 1,681,216 | +69,441 | 0.01 | 0.01 | +0.00 | buy |
| Jefferies Financial Group Inc. | 1,584,678 | 1,658,481 | +73,803 | 0.89 | 1.03 | +0.14 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | 1,500,000 | 0 | 3.54 | 5.63 | +2.08 | hold |
| BANK OF AMERICA CORP /DE/ | 1,517,036 | 1,431,557 | -85,479 | 0.01 | 0.01 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 1,157,034 | 1,286,685 | +129,651 | 0.02 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 1,731,025 | 1,154,455 | -576,570 | 0.09 | 0.06 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,131,749 | 1,136,188 | +4,439 | 0.50 | 0.59 | +0.09 | buy |
| Point72 Asset Management, L.P. | 1,220,642 | 1,128,551 | -92,091 | 0.16 | 0.13 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 876,409 | 1,023,091 | +146,682 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 995,782 | 1,003,075 | +7,293 | 0.72 | 0.84 | +0.11 | buy |
| Pictet Asset Management Holding SA | 1,407,974 | 978,957 | -429,017 | 0.08 | 0.07 | -0.01 | sell |
| UBS Group AG | 452,209 | 964,658 | +512,449 | 0.01 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 419,417 | 905,192 | +485,775 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 862,613 | 903,916 | +41,303 | 9.80 | 9.56 | -0.24 | buy |
| SG Americas Securities, LLC | 130,097 | 894,461 | +764,364 | 0.03 | 0.09 | +0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 20,147 | 828,662 | +808,515 | 0.00 | 0.04 | +0.04 | buy |
| NORTHERN TRUST CORP | 737,569 | 769,420 | +31,851 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 702,758 | 734,933 | +32,175 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 721,202 | 699,190 | -22,012 | 0.01 | 0.01 | +0.00 | sell |
| Avoro Capital Advisors LLC | 0 | 685,000 | +685,000 | 0.00 | 0.51 | +0.51 | buy |
| BNP Paribas Asset Management Holding S.A. | 800,878 | 647,585 | -153,293 | 0.13 | 0.06 | -0.07 | sell |
| LORD, ABBETT & CO. LLC | 378,053 | 627,106 | +249,053 | 0.07 | 0.15 | +0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 773,178 | 627,092 | -146,086 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 927,300 | 607,589 | -319,711 | 0.08 | 0.07 | -0.00 | sell |
| Woodline Partners LP | 105,605 | 571,553 | +465,948 | 0.03 | 0.17 | +0.14 | buy |
| Bank of New York Mellon Corp | 273,076 | 514,680 | +241,604 | 0.00 | 0.01 | +0.00 | buy |
| Boston Partners | 361,664 | 487,977 | +126,313 | 0.02 | 0.04 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 67,677 | 478,897 | +411,220 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 458,330 | 460,114 | +1,784 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 313,057 | 434,285 | +121,228 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 438,477 | 430,013 | -8,464 | 4.41 | 3.74 | -0.67 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 424,999 | 426,506 | +1,507 | 0.02 | 0.03 | +0.01 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 323,548 | 406,410 | +82,862 | 0.01 | 0.02 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 473,758 | 405,536 | -68,222 | 0.06 | 0.06 | -0.00 | sell |
| Legal & General Group Plc | 241,342 | 366,265 | +124,923 | 0.00 | 0.01 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 0 | 361,159 | +361,159 | 0.00 | 0.22 | +0.22 | buy |
| PANAGORA ASSET MANAGEMENT INC | 348,366 | 359,837 | +11,471 | 0.09 | 0.10 | +0.01 | buy |
| JPMORGAN CHASE & CO | 490,934 | 356,041 | -134,893 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 331,256 | 341,927 | +10,671 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 284,891 | 339,146 | +54,255 | 0.02 | 0.03 | +0.01 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 324,636 | +324,636 | 0.00 | 0.08 | +0.08 | buy |
| Ensign Peak Advisors, Inc | 288,767 | 280,572 | -8,195 | 0.03 | 0.04 | +0.01 | sell |
| Russell Investments Group, Ltd. | 247,493 | 270,748 | +23,255 | 0.02 | 0.02 | +0.01 | buy |
| Empowered Funds, LLC | 43,705 | 250,412 | +206,707 | 0.03 | 0.15 | +0.12 | buy |
| MARSHALL WACE, LLP | 157,739 | 247,746 | +90,007 | 0.01 | 0.02 | +0.01 | buy |
| MACKENZIE FINANCIAL CORP | 201,792 | 236,909 | +35,117 | 0.02 | 0.02 | +0.01 | buy |
| Pacer Advisors, Inc. | 503,966 | 235,653 | -268,313 | 0.08 | 0.03 | -0.05 | sell |
| DEUTSCHE BANK AG\ | 79,888 | 231,268 | +151,380 | 0.00 | 0.01 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 237,124 | 220,847 | -16,277 | 0.01 | 0.01 | +0.00 | sell |
| BARCLAYS PLC | 239,649 | 220,196 | -19,453 | 0.01 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 113,904 | 207,950 | +94,046 | 0.01 | 0.01 | +0.01 | buy |
| Boxer Capital Management, LLC | 200,000 | 200,000 | 0 | 3.91 | 3.33 | -0.59 | hold |
| PRUDENTIAL FINANCIAL INC | 87,440 | 183,185 | +95,745 | 0.01 | 0.02 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 202,363 | 160,179 | -42,184 | 1.36 | 1.16 | -0.21 | sell |
| BI Asset Management Fondsmaeglerselskab A/S | 95,005 | 159,477 | +64,472 | 0.05 | 0.11 | +0.05 | buy |
| FIRST TRUST ADVISORS LP | 121,855 | 155,596 | +33,741 | 0.01 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 132,101 | 151,401 | +19,300 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 10,630 | 147,584 | +136,954 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 138,265 | 141,065 | +2,800 | 0.00 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 291,000 | 141,000 | -150,000 | 0.03 | 0.02 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 129,898 | 131,893 | +1,995 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 280,551 | 118,657 | -161,894 | 3.48 | 1.17 | -2.32 | sell |
| FEDERATED HERMES, INC. | 14,816 | 112,566 | +97,750 | 0.00 | 0.01 | +0.01 | buy |
| Neuberger Berman Group LLC | 3,607 | 111,590 | +107,983 | 0.00 | 0.01 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 147,065 | 110,267 | -36,798 | 0.02 | 0.02 | -0.00 | sell |
| CASTLEARK MANAGEMENT LLC | 0 | 96,860 | +96,860 | 0.00 | 0.22 | +0.22 | buy |
| ALLIANCEBERNSTEIN L.P. | 92,017 | 94,308 | +2,291 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 58,341 | 92,089 | +33,748 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 51,443 | 86,921 | +35,478 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 83,125 | 85,998 | +2,873 | 0.00 | 0.00 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 88,592 | 83,431 | -5,161 | 0.07 | 0.08 | +0.01 | sell |
| ROYCE & ASSOCIATES LP | 32,779 | 80,794 | +48,015 | 0.02 | 0.06 | +0.04 | buy |
| Rafferty Asset Management, LLC | 101,001 | 78,507 | -22,494 | 0.02 | 0.02 | +0.00 | sell |
| CANADA LIFE ASSURANCE Co | 33,984 | 78,150 | +44,166 | 0.00 | 0.01 | +0.01 | buy |
| Abacus FCF Advisors LLC | 0 | 75,757 | +75,757 | 0.00 | 0.75 | +0.75 | buy |
| Hillsdale Investment Management Inc. | 91,136 | 75,706 | -15,430 | 0.17 | 0.16 | -0.01 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 75,400 | +75,400 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 34,122 | 72,597 | +38,475 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 72,307 | +72,307 | 0.00 | 0.02 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 71,735 | +71,735 | 0.00 | 0.61 | +0.61 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 24,150 | 69,504 | +45,354 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,527 | 68,293 | +3,766 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 11,782 | 67,064 | +55,282 | 0.00 | 0.02 | +0.01 | buy |
| SECTOR GAMMA AS | 118,112 | 61,923 | -56,189 | 1.80 | 1.07 | -0.73 | sell |
| Rock Springs Capital Management LP | 0 | 61,879 | +61,879 | 0.00 | 0.24 | +0.24 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 76,113 | 56,571 | -19,542 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 55,169 | +55,169 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 107,648 | 54,170 | -53,478 | 0.01 | 0.01 | -0.00 | sell |
| NORGES BANK | 0 | 53,807 | +53,807 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 37,462 | 50,431 | +12,969 | 0.03 | 0.05 | +0.02 | buy |