| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Boxer Capital Management, LLC | 0 | 560,000 | +560,000 | 0.00 | 0.59 | +0.59 | buy |
| Ikarian Capital, LLC | 0 | 396,201 | +396,201 | 0.00 | 0.91 | +0.91 | buy |
| Dauntless Investment Group, LLC | 79,832 | 354,208 | +274,376 | 1.67 | 8.65 | +6.98 | buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 142,469 | 414,958 | +272,489 | 0.02 | 0.07 | +0.05 | buy |
| Ensign Peak Advisors, Inc | 0 | 110,778 | +110,778 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 101,376 | +101,376 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 85,000 | +85,000 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 81,090 | +81,090 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 68,491 | +68,491 | 0.00 | 0.03 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 0 | 61,550 | +61,550 | 0.00 | 0.04 | +0.04 | buy |
| JANE STREET GROUP, LLC | 0 | 57,140 | +57,140 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 50,616 | +50,616 | 0.00 | 0.00 | +0.00 | buy |
| COOPERMAN LEON G | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| MARSHALL WACE, LLP | 0 | 44,231 | +44,231 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 23,999 | 56,999 | +33,000 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 31,186 | +31,186 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,081 | 30,090 | +29,009 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 28,509 | +28,509 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 14,975 | +14,975 | 0.00 | 0.00 | +0.00 | buy |
| UNITED BANK | 0 | 12,851 | +12,851 | 0.00 | 0.02 | +0.02 | buy |
| RAYMOND JAMES FINANCIAL INC | 15,749 | 22,599 | +6,850 | 0.00 | 0.00 | +0.00 | buy |
| Laird Norton Wetherby Trust Company, LLC | 12,400 | 12,900 | +500 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,568 | 1,926 | +358 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 200,000 | 200,300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 87 | +87 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 345,179 | 345,179 | 0 | 2.26 | 3.70 | +1.44 | hold |
| Rockefeller Capital Management L.P. | 12,700 | 12,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bleichroeder LP | 400,000 | 400,000 | 0 | 0.51 | 1.01 | +0.49 | hold |
| RHUMBLINE ADVISERS | 1,402 | 1,296 | -106 | 0.00 | 0.00 | +0.00 | sell |
| Westside Investment Management, Inc. | 50,425 | 47,585 | -2,840 | 0.06 | 0.09 | +0.03 | sell |
| OSAIC HOLDINGS, INC. | 8,744 | 0 | -8,744 | 0.00 | 0.00 | -0.00 | sell |
| FNY Investment Advisers, LLC | 10,000 | 0 | -10,000 | 0.03 | 0.00 | -0.03 | sell |
| Qube Research & Technologies Ltd | 10,608 | 0 | -10,608 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 34,340 | 0 | -34,340 | 0.00 | 0.00 | -0.00 | sell |
| Sequoia Financial Advisors, LLC | 60,000 | 20,003 | -39,997 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 135,315 | 0 | -135,315 | 0.63 | 0.00 | -0.63 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 193,114 | 0 | -193,114 | 0.00 | 0.00 | -0.00 | sell |