| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NORGES BANK | 0 | 694,753 | +694,753 | 0.00 | 0.04 | +0.04 | buy |
| Vestal Point Capital, LP | 75,000 | 435,000 | +360,000 | 1.24 | 5.51 | +4.26 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 297,162 | +297,162 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 2,759 | 285,926 | +283,167 | 0.00 | 0.10 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 153,372 | 409,074 | +255,702 | 0.07 | 0.15 | +0.08 | buy |
| Bellevue Group AG | 2,077 | 188,515 | +186,438 | 0.03 | 2.15 | +2.12 | buy |
| Avoro Capital Advisors LLC | 2,630,000 | 2,777,777 | +147,777 | 15.36 | 13.52 | -1.85 | buy |
| Deep Track Capital, LP | 0 | 123,616 | +123,616 | 0.00 | 0.99 | +0.99 | buy |
| Qube Research & Technologies Ltd | 123,441 | 233,639 | +110,198 | 0.10 | 0.14 | +0.04 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 83,855 | +83,855 | 0.00 | 0.02 | +0.02 | buy |
| AustralianSuper Pty Ltd | 13,691 | 89,590 | +75,899 | 0.04 | 0.21 | +0.17 | buy |
| Amundi | 147,599 | 219,094 | +71,495 | 0.02 | 0.03 | +0.00 | buy |
| SG Americas Securities, LLC | 23,113 | 89,893 | +66,780 | 0.02 | 0.03 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 104,588 | 168,649 | +64,061 | 0.05 | 0.08 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 277,983 | 340,275 | +62,292 | 0.04 | 0.04 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,696 | 88,579 | +58,883 | 0.02 | 0.04 | +0.02 | buy |
| Man Group plc | 77,495 | 134,890 | +57,395 | 0.10 | 0.13 | +0.04 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 0 | 54,453 | +54,453 | 0.00 | 0.10 | +0.10 | buy |
| STATE STREET CORP | 1,843,963 | 1,898,064 | +54,101 | 0.04 | 0.03 | -0.01 | buy |
| AXIOM INVESTORS LLC /DE | 805 | 54,437 | +53,632 | 0.01 | 0.26 | +0.25 | buy |
| Point72 Asset Management, L.P. | 149,303 | 201,159 | +51,856 | 0.15 | 0.17 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 114,419 | 165,979 | +51,560 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 48,656 | +48,656 | 0.00 | 0.05 | +0.05 | buy |
| BAILLIE GIFFORD & CO | 428,127 | 467,209 | +39,082 | 0.26 | 0.23 | -0.03 | buy |
| Soleus Capital Management, L.P. | 187,187 | 225,587 | +38,400 | 4.50 | 4.21 | -0.28 | buy |
| Assenagon Asset Management S.A. | 47,183 | 84,538 | +37,355 | 0.04 | 0.06 | +0.01 | buy |
| Patient Square Capital LP | 0 | 37,120 | +37,120 | 0.00 | 3.12 | +3.12 | buy |
| Zurich Insurance Group Ltd/FI | 34,828 | 69,927 | +35,099 | 0.16 | 0.26 | +0.10 | buy |
| HRT FINANCIAL LP | 66,842 | 98,864 | +32,022 | 0.10 | 0.10 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 91,225 | 123,215 | +31,990 | 0.01 | 0.01 | +0.00 | buy |
| Epoch Investment Partners, Inc. | 120,682 | 150,644 | +29,962 | 0.43 | 0.46 | +0.03 | buy |
| MORGAN STANLEY | 409,288 | 436,699 | +27,411 | 0.01 | 0.01 | -0.00 | buy |
| Distillate Capital Partners LLC | 0 | 26,967 | +26,967 | 0.00 | 0.76 | +0.76 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 45,631 | 72,306 | +26,675 | 0.02 | 0.03 | +0.01 | buy |
| CITIGROUP INC | 235,620 | 262,200 | +26,580 | 0.09 | 0.07 | -0.02 | buy |
| DIADEMA PARTNERS LP | 27,303 | 52,989 | +25,686 | 6.69 | 10.14 | +3.45 | buy |
| Eversept Partners, LP | 264,271 | 287,668 | +23,397 | 10.33 | 8.50 | -1.83 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 106,440 | 128,626 | +22,186 | 0.12 | 0.12 | -0.00 | buy |
| Legal & General Group Plc | 186,794 | 207,093 | +20,299 | 0.03 | 0.02 | -0.00 | buy |
| Vinva Investment Management Ltd | 68,608 | 88,369 | +19,761 | 0.50 | 0.32 | -0.18 | buy |
| Woodline Partners LP | 3,477 | 23,074 | +19,597 | 0.01 | 0.04 | +0.03 | buy |
| ING GROEP NV | 0 | 18,800 | +18,800 | 0.00 | 0.05 | +0.05 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 300,204 | 318,320 | +18,116 | 0.25 | 0.20 | -0.05 | buy |
| Portolan Capital Management, LLC | 63,435 | 81,518 | +18,083 | 2.00 | 1.65 | -0.35 | buy |
| ASR Vermogensbeheer N.V. | 1,221 | 19,047 | +17,826 | 0.01 | 0.11 | +0.10 | buy |
| Illinois Municipal Retirement Fund | 22,269 | 39,042 | +16,773 | 0.17 | 0.24 | +0.07 | buy |
| Achmea Investment Management B.V. | 21,876 | 38,530 | +16,654 | 0.34 | 0.52 | +0.18 | buy |
| Empowered Funds, LLC | 20,784 | 36,800 | +16,016 | 0.08 | 0.11 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 512,739 | 527,904 | +15,165 | 0.06 | 0.05 | -0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 14,271 | +14,271 | 0.00 | 0.15 | +0.15 | buy |
| ALLIANCEBERNSTEIN L.P. | 220,634 | 234,607 | +13,973 | 0.03 | 0.05 | +0.01 | buy |
| Quadrature Capital Ltd | 3,544 | 17,356 | +13,812 | 0.03 | 0.08 | +0.06 | buy |
| NATIXIS | 1,175 | 14,571 | +13,396 | 0.00 | 0.04 | +0.03 | buy |
| XTX Topco Ltd | 0 | 13,055 | +13,055 | 0.00 | 0.09 | +0.09 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 12,667 | +12,667 | 0.00 | 0.03 | +0.03 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 60,283 | 71,878 | +11,595 | 0.53 | 0.51 | -0.02 | buy |
| Inspire Investing, LLC | 1,934 | 13,399 | +11,465 | 0.11 | 0.30 | +0.19 | buy |
| MACKENZIE FINANCIAL CORP | 4,679 | 15,849 | +11,170 | 0.00 | 0.01 | +0.01 | buy |
| Simplify Asset Management Inc. | 34,251 | 45,411 | +11,160 | 0.31 | 0.35 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 207,309 | 218,164 | +10,855 | 0.03 | 0.02 | -0.00 | buy |
| Rokos Capital Management LLP | 0 | 10,634 | +10,634 | 0.00 | 0.07 | +0.07 | buy |
| Aquatic Capital Management LLC | 0 | 10,212 | +10,212 | 0.00 | 0.19 | +0.19 | buy |
| PFM Health Sciences, LP | 39,805 | 49,991 | +10,186 | 2.48 | 2.35 | -0.13 | buy |
| Nuveen, LLC | 190,697 | 200,059 | +9,362 | 0.03 | 0.03 | -0.00 | buy |
| Apollon Wealth Management, LLC | 13,288 | 22,585 | +9,297 | 0.13 | 0.15 | +0.02 | buy |
| Edgestream Partners, L.P. | 0 | 9,178 | +9,178 | 0.00 | 0.15 | +0.15 | buy |
| BARCLAYS PLC | 63,005 | 72,010 | +9,005 | 0.01 | 0.01 | -0.00 | buy |
| Allianz Asset Management GmbH | 37,748 | 46,376 | +8,628 | 0.03 | 0.02 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 20,744 | 29,102 | +8,358 | 0.12 | 0.14 | +0.02 | buy |
| Headlands Technologies LLC | 0 | 8,228 | +8,228 | 0.00 | 0.47 | +0.47 | buy |
| Massar Capital Management, LP | 0 | 8,055 | +8,055 | 0.00 | 1.50 | +1.50 | buy |
| ASSETMARK, INC | 616,050 | 624,068 | +8,018 | 0.74 | 0.58 | -0.16 | buy |
| HSBC HOLDINGS PLC | 119,235 | 127,125 | +7,890 | 0.04 | 0.03 | -0.01 | buy |
| MEEDER ASSET MANAGEMENT INC | 1,503 | 9,236 | +7,733 | 0.05 | 0.26 | +0.20 | buy |
| RAYMOND JAMES FINANCIAL INC | 47,576 | 55,173 | +7,597 | 0.01 | 0.01 | -0.00 | buy |
| Virtu Financial LLC | 0 | 7,555 | +7,555 | 0.00 | 0.13 | +0.13 | buy |
| Persistent Asset Partners Ltd | 6,902 | 13,981 | +7,079 | 1.59 | 2.39 | +0.80 | buy |
| Campbell & CO Investment Adviser LLC | 6,434 | 13,309 | +6,875 | 0.22 | 0.38 | +0.16 | buy |
| Creative Planning | 22,075 | 28,934 | +6,859 | 0.01 | 0.01 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 4,529 | 10,752 | +6,223 | 0.00 | 0.01 | +0.00 | buy |
| Quantinno Capital Management LP | 21,135 | 27,122 | +5,987 | 0.02 | 0.02 | -0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 6,629 | 12,597 | +5,968 | 0.04 | 0.05 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 5,854 | +5,854 | 0.00 | 0.57 | +0.57 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 3,631 | 9,328 | +5,697 | 0.31 | 0.59 | +0.27 | buy |
| Arax Advisory Partners | 681 | 6,216 | +5,535 | 0.01 | 0.02 | +0.01 | buy |
| Livforsakringsbolaget Skandia, Omsesidigt | 30,900 | 36,400 | +5,500 | 0.71 | 0.63 | -0.08 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 101,692 | 106,561 | +4,869 | 0.03 | 0.03 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 4,658 | +4,658 | 0.00 | 0.03 | +0.03 | buy |
| Voleon Capital Management LP | 3,105 | 7,649 | +4,544 | 0.04 | 0.08 | +0.04 | buy |
| Brevan Howard Capital Management LP | 0 | 4,174 | +4,174 | 0.00 | 0.03 | +0.03 | buy |
| Vestcor Inc | 9,298 | 13,447 | +4,149 | 0.15 | 0.18 | +0.03 | buy |
| CANADA LIFE ASSURANCE Co | 35,536 | 39,673 | +4,137 | 0.04 | 0.03 | -0.00 | buy |
| Broadleaf Partners, LLC | 8,984 | 13,117 | +4,133 | 1.24 | 1.38 | +0.13 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 48,964 | 53,037 | +4,073 | 0.26 | 0.21 | -0.05 | buy |
| HUNTINGTON NATIONAL BANK | 49 | 4,074 | +4,025 | 0.00 | 0.01 | +0.01 | buy |
| AUGUSTINE ASSET MANAGEMENT INC | 5,973 | 9,892 | +3,919 | 0.80 | 1.09 | +0.29 | buy |
| CIBC Asset Management Inc | 2,465 | 6,285 | +3,820 | 0.00 | 0.01 | +0.00 | buy |
| STRS OHIO | 27,614 | 31,411 | +3,797 | 0.06 | 0.06 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 3,675 | +3,675 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 3,668 | +3,668 | 0.00 | 0.01 | +0.01 | buy |