| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,170,766 | 5,399,649 | +228,883 | 0.04 | 0.06 | +0.01 | buy |
| Avoro Capital Advisors LLC | 2,606,060 | 2,630,000 | +23,940 | 12.48 | 15.36 | +2.88 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,441,492 | 2,264,247 | -177,245 | 0.21 | 0.25 | +0.04 | sell |
| STATE STREET CORP | 1,842,411 | 1,843,963 | +1,552 | 0.03 | 0.04 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,909,259 | 1,787,019 | -122,240 | 1.44 | 1.66 | +0.21 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,193,064 | 1,233,029 | +39,965 | 0.04 | 0.05 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 796,101 | 866,930 | +70,829 | 0.17 | 0.25 | +0.07 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,281,699 | 826,226 | -455,473 | 0.33 | 0.22 | -0.10 | sell |
| ASSETMARK, INC | 634,956 | 616,050 | -18,906 | 0.63 | 0.74 | +0.11 | sell |
| Invesco Ltd. | 608,759 | 608,367 | -392 | 0.04 | 0.05 | +0.01 | sell |
| FMR LLC | 403,830 | 528,346 | +124,516 | 0.01 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 528,210 | 512,739 | -15,471 | 0.05 | 0.06 | +0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 425,993 | 457,000 | +31,007 | 2.66 | 3.20 | +0.54 | buy |
| NORTHERN TRUST CORP | 418,427 | 436,566 | +18,139 | 0.03 | 0.03 | +0.01 | buy |
| BAILLIE GIFFORD & CO | 323,016 | 428,127 | +105,111 | 0.13 | 0.26 | +0.13 | buy |
| MORGAN STANLEY | 389,275 | 409,288 | +20,013 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 352,086 | 405,447 | +53,361 | 0.02 | 0.03 | +0.01 | buy |
| LSV ASSET MANAGEMENT | 408,065 | 398,665 | -9,400 | 0.43 | 0.51 | +0.08 | sell |
| CITADEL ADVISORS LLC | 187,164 | 360,643 | +173,479 | 0.06 | 0.15 | +0.09 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 296,320 | 343,659 | +47,339 | 0.24 | 0.33 | +0.08 | buy |
| Bank of New York Mellon Corp | 333,629 | 329,148 | -4,481 | 0.03 | 0.04 | +0.01 | sell |
| Swedbank AB | 324,772 | 327,122 | +2,350 | 0.15 | 0.20 | +0.05 | buy |
| Pictet Asset Management Holding SA | 306,837 | 309,220 | +2,383 | 0.15 | 0.19 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 289,926 | 300,481 | +10,555 | 0.02 | 0.03 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 200,531 | 300,204 | +99,673 | 0.16 | 0.25 | +0.09 | buy |
| JPMORGAN CHASE & CO | 262,215 | 291,621 | +29,406 | 0.01 | 0.01 | +0.00 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 290,613 | 280,405 | -10,208 | 0.48 | 0.56 | +0.08 | sell |
| FRANKLIN RESOURCES INC | 181,120 | 277,983 | +96,863 | 0.02 | 0.04 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 219,023 | 270,578 | +51,555 | 0.08 | 0.11 | +0.04 | buy |
| Eversept Partners, LP | 252,592 | 264,271 | +11,679 | 6.90 | 10.33 | +3.43 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 181,177 | 252,702 | +71,525 | 0.94 | 1.54 | +0.60 | buy |
| LORD, ABBETT & CO. LLC | 258,049 | 250,276 | -7,773 | 0.39 | 0.48 | +0.10 | sell |
| Pacer Advisors, Inc. | 241,872 | 243,545 | +1,673 | 0.18 | 0.00 | -0.18 | buy |
| UBS Group AG | 225,849 | 236,729 | +10,880 | 0.02 | 0.02 | +0.00 | buy |
| CITIGROUP INC | 184,408 | 235,620 | +51,212 | 0.06 | 0.09 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 206,543 | 220,634 | +14,091 | 0.03 | 0.03 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 203,351 | 207,309 | +3,958 | 0.02 | 0.03 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 205,131 | 199,426 | -5,705 | 0.01 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 124,475 | 198,777 | +74,302 | 0.02 | 0.04 | +0.02 | buy |
| Nuveen, LLC | 251,809 | 190,697 | -61,112 | 0.03 | 0.03 | -0.00 | sell |
| Soleus Capital Management, L.P. | 60,000 | 187,187 | +127,187 | 1.24 | 4.50 | +3.26 | buy |
| Legal & General Group Plc | 173,592 | 186,794 | +13,202 | 0.02 | 0.03 | +0.01 | buy |
| FIFTH THIRD BANCORP | 459 | 164,978 | +164,519 | 0.00 | 0.18 | +0.18 | buy |
| Sofinnova Investments, Inc. | 157,641 | 160,070 | +2,429 | 3.31 | 4.76 | +1.44 | buy |
| MILLENNIUM MANAGEMENT LLC | 64,073 | 153,372 | +89,299 | 0.02 | 0.07 | +0.05 | buy |
| Point72 Asset Management, L.P. | 186,164 | 149,303 | -36,861 | 0.14 | 0.15 | +0.01 | sell |
| Amundi | 163,194 | 147,599 | -15,595 | 0.02 | 0.02 | +0.00 | sell |
| Allspring Global Investments Holdings, LLC | 104,785 | 146,524 | +41,739 | 0.08 | 0.14 | +0.06 | buy |
| Robeco Institutional Asset Management B.V. | 113,850 | 127,902 | +14,052 | 0.08 | 0.11 | +0.03 | buy |
| Qube Research & Technologies Ltd | 98,304 | 123,441 | +25,137 | 0.07 | 0.10 | +0.04 | buy |
| RHUMBLINE ADVISERS | 121,751 | 122,486 | +735 | 0.05 | 0.06 | +0.01 | buy |
| Epoch Investment Partners, Inc. | 142,292 | 120,682 | -21,610 | 0.39 | 0.43 | +0.04 | sell |
| Swiss National Bank | 117,735 | 120,055 | +2,320 | 0.03 | 0.04 | +0.01 | buy |
| HSBC HOLDINGS PLC | 143,624 | 119,235 | -24,389 | 0.04 | 0.04 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 110,774 | 114,419 | +3,645 | 0.01 | 0.01 | +0.00 | buy |
| Bridgewater Associates, LP | 64,595 | 111,169 | +46,574 | 0.11 | 0.29 | +0.18 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 120,802 | 106,440 | -14,362 | 0.10 | 0.12 | +0.02 | sell |
| First Turn Management, LLC | 63,580 | 104,726 | +41,146 | 3.54 | 6.94 | +3.40 | buy |
| SEIZERT CAPITAL PARTNERS, LLC | 145,522 | 104,667 | -40,855 | 3.00 | 2.86 | -0.14 | sell |
| TD ASSET MANAGEMENT INC | 113,135 | 104,588 | -8,547 | 0.04 | 0.05 | +0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 98,158 | 101,692 | +3,534 | 0.02 | 0.03 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 306,971 | 99,106 | -207,865 | 0.11 | 0.05 | -0.07 | sell |
| Retirement Systems of Alabama | 97,268 | 98,378 | +1,110 | 0.15 | 0.19 | +0.04 | buy |
| Polaris Capital Management, LLC | 103,650 | 96,650 | -7,000 | 4.19 | 4.69 | +0.50 | sell |
| DekaBank Deutsche Girozentrale | 93,532 | 93,532 | 0 | 0.04 | 0.09 | +0.05 | hold |
| AMERIPRISE FINANCIAL INC | 101,042 | 91,225 | -9,817 | 0.01 | 0.01 | +0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 92,156 | 88,637 | -3,519 | 0.03 | 0.03 | +0.01 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 83,356 | 88,289 | +4,933 | 0.02 | 0.03 | +0.01 | buy |
| BOWEN HANES & CO INC | 0 | 85,000 | +85,000 | 0.00 | 1.23 | +1.23 | buy |
| Krensavage Asset Management, LLC | 91,282 | 84,282 | -7,000 | 15.71 | 19.55 | +3.84 | sell |
| Gotham Asset Management, LLC | 80,018 | 80,387 | +369 | 0.14 | 0.15 | +0.00 | buy |
| Logos Global Management LP | 0 | 80,000 | +80,000 | 0.00 | 2.44 | +2.44 | buy |
| Man Group plc | 79,002 | 77,495 | -1,507 | 0.07 | 0.10 | +0.02 | sell |
| WELLS FARGO & COMPANY/MN | 90,940 | 77,138 | -13,802 | 0.01 | 0.01 | +0.00 | sell |
| MARSHALL WACE, LLP | 0 | 75,977 | +75,977 | 0.00 | 0.05 | +0.05 | buy |
| Vestal Point Capital, LP | 0 | 75,000 | +75,000 | 0.00 | 1.24 | +1.24 | buy |
| Caption Management, LLC | 55,081 | 74,445 | +19,364 | 1.18 | 2.10 | +0.92 | buy |
| BNP Paribas Asset Management Holding S.A. | 64,537 | 72,715 | +8,178 | 0.04 | 0.05 | +0.01 | buy |
| Aware Super Pty Ltd as trustee of Aware Super | 106,484 | 72,530 | -33,954 | 0.61 | 0.65 | +0.04 | sell |
| Tri Locum Partners LP | 120,921 | 70,370 | -50,551 | 7.65 | 5.86 | -1.79 | sell |
| AMERICAN CENTURY COMPANIES INC | 67,957 | 69,368 | +1,411 | 0.02 | 0.02 | +0.00 | buy |
| Vinva Investment Management Ltd | 48,959 | 68,608 | +19,649 | 0.30 | 0.50 | +0.20 | buy |
| Russell Investments Group, Ltd. | 54,811 | 67,551 | +12,740 | 0.03 | 0.04 | +0.01 | buy |
| HRT FINANCIAL LP | 63,397 | 66,842 | +3,445 | 0.10 | 0.10 | +0.00 | buy |
| Portolan Capital Management, LLC | 36,753 | 63,435 | +26,682 | 0.96 | 2.00 | +1.04 | buy |
| Candriam S.C.A. | 127,215 | 63,066 | -64,149 | 0.31 | 0.19 | -0.11 | sell |
| BARCLAYS PLC | 90,925 | 63,005 | -27,920 | 0.02 | 0.01 | -0.00 | sell |
| Palo Alto Investors LP | 58,186 | 62,809 | +4,623 | 3.95 | 5.70 | +1.75 | buy |
| ATWOOD & PALMER INC | 63,532 | 62,436 | -1,096 | 1.76 | 2.09 | +0.33 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 42,156 | 62,008 | +19,852 | 0.01 | 0.02 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 228,383 | 60,541 | -167,842 | 0.06 | 0.02 | -0.04 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 61,143 | 60,283 | -860 | 0.43 | 0.53 | +0.10 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 63,304 | 59,844 | -3,460 | 0.03 | 0.04 | +0.01 | sell |
| ROYAL BANK OF CANADA | 57,288 | 59,152 | +1,864 | 0.00 | 0.01 | +0.00 | buy |
| Summit Street Capital Management, LLC | 56,872 | 56,872 | 0 | 4.36 | 4.77 | +0.41 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 61,700 | 56,361 | -5,339 | 0.02 | 0.03 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 52,012 | 54,824 | +2,812 | 0.05 | 0.07 | +0.02 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 60,687 | 54,673 | -6,014 | 0.53 | 0.60 | +0.07 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 0 | 50,000 | +50,000 | 0.00 | 4.52 | +4.52 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 50,872 | 49,334 | -1,538 | 0.05 | 0.06 | +0.01 | sell |