| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,399,649 | 5,294,529 | -105,120 | 0.06 | 0.04 | -0.01 | sell |
| Avoro Capital Advisors LLC | 2,630,000 | 2,777,777 | +147,777 | 15.36 | 13.52 | -1.85 | buy |
| STATE STREET CORP | 1,843,963 | 1,898,064 | +54,101 | 0.04 | 0.03 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,787,019 | 1,708,739 | -78,280 | 1.66 | 1.27 | -0.38 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,264,247 | 1,379,025 | -885,222 | 0.25 | 0.13 | -0.12 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,233,029 | 996,598 | -236,431 | 0.05 | 0.03 | -0.02 | sell |
| NORGES BANK | 0 | 694,753 | +694,753 | 0.00 | 0.04 | +0.04 | buy |
| ASSETMARK, INC | 616,050 | 624,068 | +8,018 | 0.74 | 0.58 | -0.16 | buy |
| AQR CAPITAL MANAGEMENT LLC | 826,226 | 546,002 | -280,224 | 0.22 | 0.10 | -0.12 | sell |
| DIMENSIONAL FUND ADVISORS LP | 512,739 | 527,904 | +15,165 | 0.06 | 0.05 | -0.01 | buy |
| FMR LLC | 528,346 | 473,409 | -54,937 | 0.02 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 608,367 | 473,109 | -135,258 | 0.05 | 0.02 | -0.03 | sell |
| BAILLIE GIFFORD & CO | 428,127 | 467,209 | +39,082 | 0.26 | 0.23 | -0.03 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 457,000 | 457,000 | 0 | 3.20 | 2.58 | -0.61 | hold |
| MORGAN STANLEY | 409,288 | 436,699 | +27,411 | 0.01 | 0.01 | -0.00 | buy |
| Vestal Point Capital, LP | 75,000 | 435,000 | +360,000 | 1.24 | 5.51 | +4.26 | buy |
| NORTHERN TRUST CORP | 436,566 | 430,844 | -5,722 | 0.03 | 0.03 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 153,372 | 409,074 | +255,702 | 0.07 | 0.15 | +0.08 | buy |
| FRANKLIN RESOURCES INC | 277,983 | 340,275 | +62,292 | 0.04 | 0.04 | -0.00 | buy |
| Swedbank AB | 327,122 | 322,995 | -4,127 | 0.20 | 0.15 | -0.05 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 300,204 | 318,320 | +18,116 | 0.25 | 0.20 | -0.05 | buy |
| CITADEL ADVISORS LLC | 360,643 | 304,692 | -55,951 | 0.15 | 0.09 | -0.06 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 297,162 | +297,162 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 300,481 | 297,162 | -3,319 | 0.03 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 329,148 | 294,413 | -34,735 | 0.04 | 0.03 | -0.01 | sell |
| Eversept Partners, LP | 264,271 | 287,668 | +23,397 | 10.33 | 8.50 | -1.83 | buy |
| JANE STREET GROUP, LLC | 2,759 | 285,926 | +283,167 | 0.00 | 0.10 | +0.10 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 343,659 | 284,783 | -58,876 | 0.33 | 0.22 | -0.11 | sell |
| JPMORGAN CHASE & CO | 291,621 | 275,358 | -16,263 | 0.01 | 0.01 | -0.00 | sell |
| LSV ASSET MANAGEMENT | 398,665 | 268,370 | -130,295 | 0.51 | 0.26 | -0.25 | sell |
| Pictet Asset Management Holding SA | 309,220 | 267,852 | -41,368 | 0.19 | 0.14 | -0.05 | sell |
| CITIGROUP INC | 235,620 | 262,200 | +26,580 | 0.09 | 0.07 | -0.02 | buy |
| FIRST TRUST ADVISORS LP | 270,578 | 249,056 | -21,522 | 0.11 | 0.08 | -0.04 | sell |
| LORD, ABBETT & CO. LLC | 250,276 | 244,323 | -5,953 | 0.48 | 0.38 | -0.11 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 405,447 | 243,444 | -162,003 | 0.03 | 0.01 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 220,634 | 234,607 | +13,973 | 0.03 | 0.05 | +0.01 | buy |
| Qube Research & Technologies Ltd | 123,441 | 233,639 | +110,198 | 0.10 | 0.14 | +0.04 | buy |
| Soleus Capital Management, L.P. | 187,187 | 225,587 | +38,400 | 4.50 | 4.21 | -0.28 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 280,405 | 220,697 | -59,708 | 0.56 | 0.33 | -0.23 | sell |
| UBS Group AG | 236,729 | 220,616 | -16,113 | 0.02 | 0.02 | -0.01 | sell |
| Amundi | 147,599 | 219,094 | +71,495 | 0.02 | 0.03 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 207,309 | 218,164 | +10,855 | 0.03 | 0.02 | -0.00 | buy |
| Legal & General Group Plc | 186,794 | 207,093 | +20,299 | 0.03 | 0.02 | -0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 252,702 | 206,808 | -45,894 | 1.54 | 1.04 | -0.50 | sell |
| Point72 Asset Management, L.P. | 149,303 | 201,159 | +51,856 | 0.15 | 0.17 | +0.01 | buy |
| Nuveen, LLC | 190,697 | 200,059 | +9,362 | 0.03 | 0.03 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 198,777 | 195,269 | -3,508 | 0.04 | 0.03 | -0.01 | sell |
| Bellevue Group AG | 2,077 | 188,515 | +186,438 | 0.03 | 2.15 | +2.12 | buy |
| BANK OF AMERICA CORP /DE/ | 199,426 | 179,235 | -20,191 | 0.01 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 104,588 | 168,649 | +64,061 | 0.05 | 0.08 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 114,419 | 165,979 | +51,560 | 0.01 | 0.01 | +0.00 | buy |
| FIFTH THIRD BANCORP | 164,978 | 158,184 | -6,794 | 0.18 | 0.14 | -0.04 | sell |
| Pacer Advisors, Inc. | 243,545 | 155,398 | -88,147 | 0.00 | 0.22 | +0.22 | sell |
| Epoch Investment Partners, Inc. | 120,682 | 150,644 | +29,962 | 0.43 | 0.46 | +0.03 | buy |
| Man Group plc | 77,495 | 134,890 | +57,395 | 0.10 | 0.13 | +0.04 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 106,440 | 128,626 | +22,186 | 0.12 | 0.12 | -0.00 | buy |
| HSBC HOLDINGS PLC | 119,235 | 127,125 | +7,890 | 0.04 | 0.03 | -0.01 | buy |
| Deep Track Capital, LP | 0 | 123,616 | +123,616 | 0.00 | 0.99 | +0.99 | buy |
| AMERIPRISE FINANCIAL INC | 91,225 | 123,215 | +31,990 | 0.01 | 0.01 | +0.00 | buy |
| Robeco Institutional Asset Management B.V. | 127,902 | 123,056 | -4,846 | 0.11 | 0.08 | -0.03 | sell |
| RHUMBLINE ADVISERS | 122,486 | 120,078 | -2,408 | 0.06 | 0.05 | -0.01 | sell |
| Bridgewater Associates, LP | 111,169 | 111,326 | +157 | 0.29 | 0.25 | -0.05 | buy |
| Swiss National Bank | 120,055 | 111,255 | -8,800 | 0.04 | 0.03 | -0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 101,692 | 106,561 | +4,869 | 0.03 | 0.03 | -0.00 | buy |
| HRT FINANCIAL LP | 66,842 | 98,864 | +32,022 | 0.10 | 0.10 | -0.00 | buy |
| Allspring Global Investments Holdings, LLC | 146,524 | 96,696 | -49,828 | 0.14 | 0.08 | -0.06 | sell |
| DekaBank Deutsche Girozentrale | 93,532 | 93,532 | 0 | 0.09 | 0.09 | +0.00 | hold |
| SG Americas Securities, LLC | 23,113 | 89,893 | +66,780 | 0.02 | 0.03 | +0.01 | buy |
| AustralianSuper Pty Ltd | 13,691 | 89,590 | +75,899 | 0.04 | 0.21 | +0.17 | buy |
| Retirement Systems of Alabama | 98,378 | 89,496 | -8,882 | 0.19 | 0.15 | -0.05 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 88,289 | 88,696 | +407 | 0.03 | 0.03 | -0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,696 | 88,579 | +58,883 | 0.02 | 0.04 | +0.02 | buy |
| Vinva Investment Management Ltd | 68,608 | 88,369 | +19,761 | 0.50 | 0.32 | -0.18 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 88,637 | 85,496 | -3,141 | 0.03 | 0.03 | -0.01 | sell |
| BOWEN HANES & CO INC | 85,000 | 85,000 | 0 | 1.23 | 1.23 | 0.00 | hold |
| First Turn Management, LLC | 104,726 | 84,932 | -19,794 | 6.94 | 4.92 | -2.01 | sell |
| Assenagon Asset Management S.A. | 47,183 | 84,538 | +37,355 | 0.04 | 0.06 | +0.01 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 83,855 | +83,855 | 0.00 | 0.02 | +0.02 | buy |
| Portolan Capital Management, LLC | 63,435 | 81,518 | +18,083 | 2.00 | 1.65 | -0.35 | buy |
| Gotham Asset Management, LLC | 80,387 | 79,123 | -1,264 | 0.15 | 0.10 | -0.05 | sell |
| SEIZERT CAPITAL PARTNERS, LLC | 104,667 | 76,828 | -27,839 | 2.86 | 1.72 | -1.14 | sell |
| Sofinnova Investments, Inc. | 160,070 | 76,489 | -83,581 | 4.76 | 2.21 | -2.54 | sell |
| WELLS FARGO & COMPANY/MN | 77,138 | 74,303 | -2,835 | 0.01 | 0.01 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 45,631 | 72,306 | +26,675 | 0.02 | 0.03 | +0.01 | buy |
| BARCLAYS PLC | 63,005 | 72,010 | +9,005 | 0.01 | 0.01 | -0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 60,283 | 71,878 | +11,595 | 0.53 | 0.51 | -0.02 | buy |
| Zurich Insurance Group Ltd/FI | 34,828 | 69,927 | +35,099 | 0.16 | 0.26 | +0.10 | buy |
| Krensavage Asset Management, LLC | 84,282 | 69,282 | -15,000 | 19.55 | 14.26 | -5.28 | sell |
| AMERICAN CENTURY COMPANIES INC | 69,368 | 65,953 | -3,415 | 0.02 | 0.02 | -0.01 | sell |
| ROYAL BANK OF CANADA | 59,152 | 62,600 | +3,448 | 0.01 | 0.01 | -0.00 | buy |
| Palo Alto Investors LP | 62,809 | 62,587 | -222 | 5.70 | 4.69 | -1.01 | sell |
| ATWOOD & PALMER INC | 62,436 | 61,479 | -957 | 2.09 | 1.78 | -0.31 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 59,844 | 61,438 | +1,594 | 0.04 | 0.03 | -0.01 | buy |
| Russell Investments Group, Ltd. | 67,551 | 60,345 | -7,206 | 0.04 | 0.03 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 62,008 | 58,580 | -3,428 | 0.02 | 0.02 | -0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 47,576 | 55,173 | +7,597 | 0.01 | 0.01 | -0.00 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 0 | 54,453 | +54,453 | 0.00 | 0.10 | +0.10 | buy |
| AXIOM INVESTORS LLC /DE | 805 | 54,437 | +53,632 | 0.01 | 0.26 | +0.25 | buy |
| Candriam S.C.A. | 63,066 | 53,684 | -9,382 | 0.19 | 0.13 | -0.06 | sell |
| Polaris Capital Management, LLC | 96,650 | 53,450 | -43,200 | 4.69 | 2.73 | -1.96 | sell |