| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,333,708 | 5,352,996 | +19,288 | 0.03 | 0.04 | +0.01 | buy |
| VANGUARD GROUP INC | 4,448,848 | 4,418,610 | -30,238 | 0.02 | 0.03 | +0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,119,092 | 2,173,392 | +54,300 | 0.81 | 1.20 | +0.39 | buy |
| Avoro Capital Advisors LLC | 2,370,000 | 2,022,222 | -347,778 | 11.93 | 10.97 | -0.96 | sell |
| STATE STREET CORP | 2,167,511 | 1,922,609 | -244,902 | 0.02 | 0.03 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,442,936 | 1,398,781 | -44,155 | 0.08 | 0.10 | +0.03 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,200,365 | 1,249,660 | +49,295 | 0.02 | 0.03 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,273,161 | 986,478 | -286,683 | 0.30 | 0.27 | -0.04 | sell |
| Darwin Global Management, Ltd. | 0 | 748,550 | +748,550 | 0.00 | 8.83 | +8.83 | buy |
| LSV ASSET MANAGEMENT | 864,623 | 686,710 | -177,913 | 0.58 | 0.64 | +0.05 | sell |
| ASSETMARK, INC | 715,834 | 645,908 | -69,926 | 0.49 | 0.58 | +0.09 | sell |
| Invesco Ltd. | 884,703 | 637,223 | -247,480 | 0.04 | 0.04 | -0.00 | sell |
| CITIGROUP INC | 42,534 | 551,470 | +508,936 | 0.01 | 0.16 | +0.15 | buy |
| DIMENSIONAL FUND ADVISORS LP | 573,734 | 512,816 | -60,918 | 0.04 | 0.05 | +0.01 | sell |
| JANUS HENDERSON GROUP PLC | 281,523 | 454,718 | +173,195 | 0.04 | 0.09 | +0.05 | buy |
| NORTHERN TRUST CORP | 452,219 | 447,018 | -5,201 | 0.02 | 0.02 | +0.01 | sell |
| MORGAN STANLEY | 397,514 | 438,804 | +41,290 | 0.01 | 0.01 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 540,626 | 425,993 | -114,633 | 2.82 | 2.74 | -0.08 | sell |
| Bank of New York Mellon Corp | 362,471 | 351,455 | -11,016 | 0.02 | 0.03 | +0.01 | sell |
| Pacer Advisors, Inc. | 509,737 | 339,071 | -170,666 | 0.37 | 0.36 | -0.01 | sell |
| Swedbank AB | 330,617 | 329,118 | -1,499 | 0.11 | 0.14 | +0.03 | sell |
| Pictet Asset Management Holding SA | 211,417 | 321,495 | +110,078 | 0.06 | 0.13 | +0.07 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 387,046 | 315,305 | -71,741 | 0.41 | 0.45 | +0.04 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 335,885 | 312,948 | -22,937 | 0.02 | 0.02 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 114,502 | 300,931 | +186,429 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 305,512 | 300,495 | -5,017 | 0.07 | 0.09 | +0.02 | sell |
| Nuveen, LLC | 251,299 | 287,067 | +35,768 | 0.02 | 0.03 | +0.01 | buy |
| CITADEL ADVISORS LLC | 141,011 | 273,982 | +132,971 | 0.04 | 0.09 | +0.06 | buy |
| LORD, ABBETT & CO. LLC | 273,687 | 269,072 | -4,615 | 0.25 | 0.34 | +0.08 | sell |
| MILLENNIUM MANAGEMENT LLC | 77,064 | 258,577 | +181,513 | 0.02 | 0.09 | +0.07 | buy |
| Eversept Partners, LP | 59,366 | 253,220 | +193,854 | 1.72 | 8.13 | +6.41 | buy |
| FMR LLC | 424,240 | 250,331 | -173,909 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 242,590 | 247,937 | +5,347 | 0.00 | 0.01 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 339,092 | 208,535 | -130,557 | 0.07 | 0.06 | -0.01 | sell |
| Epoch Investment Partners, Inc. | 291,494 | 205,782 | -85,712 | 0.43 | 0.47 | +0.04 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 285,068 | 203,193 | -81,875 | 0.02 | 0.02 | +0.00 | sell |
| Legal & General Group Plc | 198,519 | 199,656 | +1,137 | 0.01 | 0.02 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 212,726 | 192,844 | -19,882 | 0.00 | 0.01 | +0.00 | sell |
| Sofinnova Investments, Inc. | 118,513 | 190,626 | +72,113 | 2.32 | 4.90 | +2.59 | buy |
| ALLIANCEBERNSTEIN L.P. | 296,071 | 180,402 | -115,669 | 0.03 | 0.02 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 185,477 | 176,787 | -8,690 | 0.12 | 0.15 | +0.03 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,266 | 176,531 | +153,265 | 0.01 | 0.11 | +0.10 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 198,583 | 173,948 | -24,635 | 0.53 | 0.65 | +0.13 | sell |
| COMERICA BANK | 161,980 | 157,952 | -4,028 | 0.18 | 0.25 | +0.07 | sell |
| HSBC HOLDINGS PLC | 184,794 | 156,367 | -28,427 | 0.03 | 0.04 | +0.00 | sell |
| UBS Group AG | 104,114 | 155,404 | +51,290 | 0.01 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 209,794 | 150,000 | -59,794 | 4.16 | 3.36 | -0.80 | sell |
| SEIZERT CAPITAL PARTNERS, LLC | 125,541 | 146,991 | +21,450 | 1.59 | 2.67 | +1.08 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 152,727 | 146,898 | -5,829 | 0.10 | 0.12 | +0.02 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 170,030 | 146,663 | -23,367 | 0.03 | 0.04 | +0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 206,018 | 139,857 | -66,161 | 0.12 | 0.10 | -0.02 | sell |
| TD ASSET MANAGEMENT INC | 132,278 | 138,859 | +6,581 | 0.03 | 0.05 | +0.01 | buy |
| Amundi | 362,826 | 129,985 | -232,841 | 0.04 | 0.02 | -0.02 | sell |
| RHUMBLINE ADVISERS | 129,116 | 128,829 | -287 | 0.03 | 0.04 | +0.01 | sell |
| Swiss National Bank | 129,055 | 123,455 | -5,600 | 0.02 | 0.03 | +0.01 | sell |
| Candriam S.C.A. | 83,211 | 123,387 | +40,176 | 0.14 | 0.27 | +0.13 | buy |
| Tri Locum Partners LP | 0 | 122,187 | +122,187 | 0.00 | 11.77 | +11.77 | buy |
| Polaris Capital Management, LLC | 127,650 | 122,050 | -5,600 | 2.44 | 3.36 | +0.92 | sell |
| DEUTSCHE BANK AG\ | 125,534 | 119,046 | -6,488 | 0.01 | 0.02 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 0 | 114,900 | +114,900 | 0.00 | 1.16 | +1.16 | buy |
| BARCLAYS PLC | 114,760 | 112,846 | -1,914 | 0.01 | 0.02 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 396,655 | 109,755 | -286,900 | 0.07 | 0.03 | -0.05 | sell |
| Schonfeld Strategic Advisors LLC | 2,480 | 108,951 | +106,471 | 0.01 | 0.32 | +0.31 | buy |
| Aware Super Pty Ltd as trustee of Aware Super | 106,484 | 106,484 | 0 | 0.45 | 0.61 | +0.17 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 111,350 | 105,767 | -5,583 | 0.02 | 0.02 | +0.01 | sell |
| Retirement Systems of Alabama | 118,982 | 100,273 | -18,709 | 0.12 | 0.14 | +0.02 | sell |
| Point72 Asset Management, L.P. | 0 | 99,784 | +99,784 | 0.00 | 0.09 | +0.09 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 482,781 | 98,137 | -384,644 | 0.30 | 0.07 | -0.22 | sell |
| AustralianSuper Pty Ltd | 287,845 | 98,000 | -189,845 | 0.42 | 0.19 | -0.22 | sell |
| Krensavage Asset Management, LLC | 101,146 | 97,646 | -3,500 | 15.38 | 17.44 | +2.06 | sell |
| PFM Health Sciences, LP | 36,391 | 95,650 | +59,259 | 0.91 | 3.42 | +2.51 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 100,248 | 94,702 | -5,546 | 0.02 | 0.02 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 93,532 | 93,532 | 0 | 0.05 | 0.07 | +0.02 | hold |
| Robeco Institutional Asset Management B.V. | 234,639 | 91,099 | -143,540 | 0.11 | 0.06 | -0.05 | sell |
| Allspring Global Investments Holdings, LLC | 84,865 | 89,809 | +4,944 | 0.04 | 0.06 | +0.02 | buy |
| First Turn Management, LLC | 0 | 85,318 | +85,318 | 0.00 | 5.37 | +5.37 | buy |
| GOLDMAN SACHS GROUP INC | 148,198 | 81,536 | -66,662 | 0.01 | 0.00 | -0.00 | sell |
| Gotham Asset Management, LLC | 89,403 | 80,957 | -8,446 | 0.15 | 0.15 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 107,726 | 78,121 | -29,605 | 0.01 | 0.01 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 75,638 | +75,638 | 0.00 | 0.12 | +0.12 | buy |
| Andra AP-fonden | 118,400 | 73,800 | -44,600 | 0.47 | 0.40 | -0.08 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 44,895 | 70,097 | +25,202 | 0.01 | 0.02 | +0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 48,479 | 68,889 | +20,410 | 0.15 | 0.29 | +0.13 | buy |
| Kynam Capital Management, LP | 0 | 67,588 | +67,588 | 0.00 | 1.49 | +1.49 | buy |
| CANADA LIFE ASSURANCE Co | 68,569 | 67,157 | -1,412 | 0.03 | 0.04 | +0.01 | sell |
| Summit Street Capital Management, LLC | 80,815 | 67,153 | -13,662 | 3.83 | 3.86 | +0.03 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 95,844 | 66,552 | -29,292 | 0.49 | 0.47 | -0.02 | sell |
| D. E. Shaw & Co., Inc. | 21,608 | 64,711 | +43,103 | 0.01 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,327 | 64,185 | +3,858 | 0.02 | 0.03 | +0.01 | buy |
| ATWOOD & PALMER INC | 63,924 | 63,880 | -44 | 1.15 | 1.57 | +0.42 | sell |
| AMERIPRISE FINANCIAL INC | 59,721 | 63,381 | +3,660 | 0.00 | 0.01 | +0.00 | buy |
| Man Group plc | 104,936 | 63,049 | -41,887 | 0.07 | 0.05 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 142,098 | 62,666 | -79,432 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57,123 | 62,291 | +5,168 | 0.01 | 0.02 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 47,241 | 62,241 | +15,000 | 0.24 | 0.43 | +0.19 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 62,233 | 61,742 | -491 | 0.27 | 0.38 | +0.10 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 110,274 | 61,591 | -48,683 | 0.12 | 0.09 | -0.03 | sell |
| Palo Alto Investors LP | 95,482 | 58,186 | -37,296 | 5.84 | 4.51 | -1.32 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 73,072 | 57,820 | -15,252 | 0.01 | 0.01 | +0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 194,000 | 56,100 | -137,900 | 0.38 | 0.15 | -0.23 | sell |