| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,352,996 | 5,170,766 | -182,230 | 0.04 | 0.04 | +0.00 | sell |
| VANGUARD GROUP INC | 4,418,610 | 4,176,016 | -242,594 | 0.03 | 0.03 | +0.00 | sell |
| Avoro Capital Advisors LLC | 2,022,222 | 2,606,060 | +583,838 | 10.97 | 12.48 | +1.51 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,398,781 | 2,441,492 | +1,042,711 | 0.10 | 0.21 | +0.11 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,173,392 | 1,909,259 | -264,133 | 1.20 | 1.44 | +0.24 | sell |
| STATE STREET CORP | 1,922,609 | 1,842,411 | -80,198 | 0.03 | 0.03 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 986,478 | 1,281,699 | +295,221 | 0.27 | 0.33 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,249,660 | 1,193,064 | -56,596 | 0.03 | 0.04 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 454,718 | 796,101 | +341,383 | 0.09 | 0.17 | +0.09 | buy |
| ASSETMARK, INC | 645,908 | 634,956 | -10,952 | 0.58 | 0.63 | +0.05 | sell |
| Invesco Ltd. | 637,223 | 608,759 | -28,464 | 0.04 | 0.04 | -0.01 | sell |
| NORGES BANK | 0 | 602,191 | +602,191 | 0.00 | 0.03 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 512,816 | 528,210 | +15,394 | 0.05 | 0.05 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 425,993 | 425,993 | 0 | 2.74 | 2.66 | -0.08 | hold |
| NORTHERN TRUST CORP | 447,018 | 418,427 | -28,591 | 0.02 | 0.03 | +0.00 | sell |
| LSV ASSET MANAGEMENT | 686,710 | 408,065 | -278,645 | 0.64 | 0.43 | -0.20 | sell |
| FMR LLC | 250,331 | 403,830 | +153,499 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 438,804 | 389,275 | -49,529 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 300,931 | 352,086 | +51,155 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 351,455 | 333,629 | -17,826 | 0.03 | 0.03 | +0.00 | sell |
| Swedbank AB | 329,118 | 324,772 | -4,346 | 0.14 | 0.15 | +0.01 | sell |
| BAILLIE GIFFORD & CO | 0 | 323,016 | +323,016 | 0.00 | 0.13 | +0.13 | buy |
| D. E. Shaw & Co., Inc. | 64,711 | 306,971 | +242,260 | 0.02 | 0.11 | +0.09 | buy |
| Pictet Asset Management Holding SA | 321,495 | 306,837 | -14,658 | 0.13 | 0.15 | +0.02 | sell |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 98,137 | 296,320 | +198,183 | 0.07 | 0.24 | +0.17 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 315,305 | 290,613 | -24,692 | 0.45 | 0.48 | +0.03 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 312,948 | 289,926 | -23,022 | 0.02 | 0.02 | +0.00 | sell |
| JPMORGAN CHASE & CO | 247,937 | 262,215 | +14,278 | 0.01 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 269,072 | 258,049 | -11,023 | 0.34 | 0.39 | +0.05 | sell |
| Eversept Partners, LP | 253,220 | 252,592 | -628 | 8.13 | 6.90 | -1.23 | sell |
| Nuveen, LLC | 287,067 | 251,809 | -35,258 | 0.03 | 0.03 | +0.00 | sell |
| Pacer Advisors, Inc. | 339,071 | 241,872 | -97,199 | 0.36 | 0.18 | -0.19 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 109,755 | 228,383 | +118,628 | 0.03 | 0.06 | +0.04 | buy |
| UBS Group AG | 155,404 | 225,849 | +70,445 | 0.01 | 0.02 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 300,495 | 219,023 | -81,472 | 0.09 | 0.08 | -0.02 | sell |
| JANE STREET GROUP, LLC | 47,176 | 216,820 | +169,644 | 0.02 | 0.13 | +0.10 | buy |
| ALLIANCEBERNSTEIN L.P. | 180,402 | 206,543 | +26,141 | 0.02 | 0.03 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 192,844 | 205,131 | +12,287 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 203,193 | 203,351 | +158 | 0.02 | 0.02 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 139,857 | 200,531 | +60,674 | 0.10 | 0.16 | +0.06 | buy |
| CITADEL ADVISORS LLC | 273,982 | 187,164 | -86,818 | 0.09 | 0.06 | -0.03 | sell |
| Point72 Asset Management, L.P. | 99,784 | 186,164 | +86,380 | 0.09 | 0.14 | +0.05 | buy |
| CITIGROUP INC | 551,470 | 184,408 | -367,062 | 0.16 | 0.06 | -0.10 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 173,948 | 181,177 | +7,229 | 0.65 | 0.94 | +0.28 | buy |
| FRANKLIN RESOURCES INC | 62,666 | 181,120 | +118,454 | 0.01 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 199,656 | 173,592 | -26,064 | 0.02 | 0.02 | -0.00 | sell |
| Amundi | 129,985 | 163,194 | +33,209 | 0.02 | 0.02 | +0.00 | buy |
| COMERICA BANK | 157,952 | 161,683 | +3,731 | 0.25 | 0.31 | +0.07 | buy |
| Sofinnova Investments, Inc. | 190,626 | 157,641 | -32,985 | 4.90 | 3.31 | -1.59 | sell |
| SEIZERT CAPITAL PARTNERS, LLC | 146,991 | 145,522 | -1,469 | 2.67 | 3.00 | +0.33 | sell |
| HSBC HOLDINGS PLC | 156,367 | 143,624 | -12,743 | 0.04 | 0.04 | +0.00 | sell |
| Epoch Investment Partners, Inc. | 205,782 | 142,292 | -63,490 | 0.47 | 0.39 | -0.08 | sell |
| Candriam S.C.A. | 123,387 | 127,215 | +3,828 | 0.27 | 0.31 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 119,046 | 124,475 | +5,429 | 0.02 | 0.02 | +0.00 | buy |
| RHUMBLINE ADVISERS | 128,829 | 121,751 | -7,078 | 0.04 | 0.05 | +0.00 | sell |
| Tri Locum Partners LP | 122,187 | 120,921 | -1,266 | 11.77 | 7.65 | -4.12 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 176,787 | 120,802 | -55,985 | 0.15 | 0.10 | -0.04 | sell |
| Swiss National Bank | 123,455 | 117,735 | -5,720 | 0.03 | 0.03 | +0.00 | sell |
| Robeco Institutional Asset Management B.V. | 91,099 | 113,850 | +22,751 | 0.06 | 0.08 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 138,859 | 113,135 | -25,724 | 0.05 | 0.04 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 81,536 | 110,774 | +29,238 | 0.00 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 114,900 | 105,200 | -9,700 | 1.16 | 1.05 | -0.11 | sell |
| Allspring Global Investments Holdings, LLC | 89,809 | 104,785 | +14,976 | 0.06 | 0.08 | +0.02 | buy |
| Polaris Capital Management, LLC | 122,050 | 103,650 | -18,400 | 3.36 | 4.19 | +0.83 | sell |
| AMERIPRISE FINANCIAL INC | 63,381 | 101,042 | +37,661 | 0.01 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 29,599 | 98,304 | +68,705 | 0.02 | 0.07 | +0.05 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 105,767 | 98,158 | -7,609 | 0.02 | 0.02 | +0.00 | sell |
| Retirement Systems of Alabama | 100,273 | 97,268 | -3,005 | 0.14 | 0.15 | +0.01 | sell |
| DekaBank Deutsche Girozentrale | 93,532 | 93,532 | 0 | 0.07 | 0.04 | -0.02 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 94,702 | 92,156 | -2,546 | 0.02 | 0.03 | +0.00 | sell |
| Krensavage Asset Management, LLC | 97,646 | 91,282 | -6,364 | 17.44 | 15.71 | -1.73 | sell |
| WELLS FARGO & COMPANY/MN | 78,121 | 90,940 | +12,819 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 112,846 | 90,925 | -21,921 | 0.02 | 0.02 | +0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 146,663 | 83,356 | -63,307 | 0.04 | 0.02 | -0.01 | sell |
| Gotham Asset Management, LLC | 80,957 | 80,018 | -939 | 0.15 | 0.14 | -0.01 | sell |
| Man Group plc | 63,049 | 79,002 | +15,953 | 0.05 | 0.07 | +0.02 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 208,535 | 69,367 | -139,168 | 0.06 | 0.02 | -0.04 | sell |
| AMERICAN CENTURY COMPANIES INC | 36,129 | 67,957 | +31,828 | 0.01 | 0.02 | +0.01 | buy |
| PFM Health Sciences, LP | 95,650 | 67,743 | -27,907 | 3.42 | 3.34 | -0.08 | sell |
| Bridgewater Associates, LP | 16,065 | 64,595 | +48,530 | 0.03 | 0.11 | +0.09 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 64,537 | +64,537 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 258,577 | 64,073 | -194,504 | 0.09 | 0.02 | -0.06 | sell |
| First Turn Management, LLC | 85,318 | 63,580 | -21,738 | 5.37 | 3.54 | -1.83 | sell |
| ATWOOD & PALMER INC | 63,880 | 63,532 | -348 | 1.57 | 1.76 | +0.19 | sell |
| HRT FINANCIAL LP | 75,638 | 63,397 | -12,241 | 0.12 | 0.10 | -0.02 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,185 | 63,304 | -881 | 0.03 | 0.03 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 62,291 | 61,700 | -591 | 0.02 | 0.02 | +0.00 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 61,742 | 61,143 | -599 | 0.38 | 0.43 | +0.06 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 66,552 | 60,687 | -5,865 | 0.47 | 0.53 | +0.06 | sell |
| Soleus Capital Management, L.P. | 150,000 | 60,000 | -90,000 | 3.36 | 1.24 | -2.12 | sell |
| IEQ CAPITAL, LLC | 12,245 | 58,959 | +46,714 | 0.02 | 0.09 | +0.07 | buy |
| Palo Alto Investors LP | 58,186 | 58,186 | 0 | 4.51 | 3.95 | -0.57 | hold |
| ROYAL BANK OF CANADA | 36,432 | 57,288 | +20,856 | 0.00 | 0.00 | +0.00 | buy |
| Summit Street Capital Management, LLC | 67,153 | 56,872 | -10,281 | 3.86 | 4.36 | +0.49 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 146,898 | 55,934 | -90,964 | 0.12 | 0.05 | -0.07 | sell |
| Caption Management, LLC | 39,519 | 55,081 | +15,562 | 0.96 | 1.18 | +0.22 | buy |
| Russell Investments Group, Ltd. | 42,876 | 54,811 | +11,935 | 0.02 | 0.03 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,323 | 52,012 | +32,689 | 0.02 | 0.05 | +0.04 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 54,808 | 50,872 | -3,936 | 0.04 | 0.05 | +0.00 | sell |
| Zurich Insurance Group Ltd/FI | 0 | 49,498 | +49,498 | 0.00 | 0.17 | +0.17 | buy |