| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 12,062,212 | 12,151,276 | +89,064 | 0.01 | 0.01 | +0.00 | buy |
| INGALLS & SNYDER LLC | 7,195,060 | 7,608,716 | +413,656 | 9.23 | 10.89 | +1.66 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 5,758,528 | 5,682,783 | -75,745 | 0.31 | 0.36 | +0.05 | sell |
| Parallel Advisors, LLC | 3,879,141 | 3,977,404 | +98,263 | 2.47 | 2.89 | +0.41 | buy |
| STATE STREET CORP | 2,986,056 | 3,200,946 | +214,890 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,414,640 | 3,190,192 | +775,552 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,668,918 | 2,713,519 | +44,601 | 0.01 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 693,317 | 2,173,376 | +1,480,059 | 0.02 | 0.06 | +0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,620,333 | 1,553,135 | -67,198 | 0.01 | 0.01 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 156,764 | 1,500,000 | +1,343,236 | 0.27 | 3.07 | +2.80 | buy |
| UBS Group AG | 414,851 | 1,363,668 | +948,817 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 169,667 | 1,181,348 | +1,011,681 | 0.00 | 0.04 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,062,101 | 1,119,959 | +57,858 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,592,059 | 1,018,845 | -573,214 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 0 | 985,700 | +985,700 | 0.00 | 3.07 | +3.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 27,959 | 945,884 | +917,925 | 0.00 | 0.03 | +0.03 | buy |
| Cerity Partners LLC | 755,295 | 731,689 | -23,606 | 0.04 | 0.04 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 430,976 | 725,822 | +294,846 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 674,759 | +674,759 | 0.00 | 3.92 | +3.92 | buy |
| NORTHERN TRUST CORP | 629,075 | 643,158 | +14,083 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 816,996 | 628,384 | -188,612 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 88,437 | 558,747 | +470,310 | 0.00 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 581,656 | 543,757 | -37,899 | 0.00 | 0.00 | +0.00 | sell |
| Boston Trust Walden Corp | 527,626 | 462,606 | -65,020 | 0.14 | 0.15 | +0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 444,092 | 455,248 | +11,156 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 209,071 | 427,645 | +218,574 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 34,129 | 421,067 | +386,938 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 887,861 | 406,205 | -481,656 | 0.02 | 0.01 | -0.01 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 324,027 | 334,875 | +10,848 | 0.04 | 0.04 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 124,400 | 324,901 | +200,501 | 0.00 | 0.01 | +0.01 | buy |
| FAS Wealth Partners, Inc. | 310,018 | 322,370 | +12,352 | 0.70 | 0.81 | +0.11 | buy |
| FRANKLIN RESOURCES INC | 468,178 | 305,211 | -162,967 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 209,733 | 304,615 | +94,882 | 0.15 | 0.26 | +0.11 | buy |
| Soleus Capital Management, L.P. | 0 | 285,531 | +285,531 | 0.00 | 0.47 | +0.47 | buy |
| Voleon Capital Management LP | 0 | 262,223 | +262,223 | 0.00 | 0.23 | +0.23 | buy |
| Caption Management, LLC | 0 | 260,000 | +260,000 | 0.00 | 0.50 | +0.50 | buy |
| CITADEL ADVISORS LLC | 863,052 | 254,220 | -608,832 | 0.02 | 0.01 | -0.01 | sell |
| Boxer Capital Management, LLC | 0 | 250,000 | +250,000 | 0.00 | 1.32 | +1.32 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 230,731 | +230,731 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 245,009 | 219,680 | -25,329 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 205,102 | 217,468 | +12,366 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 507,967 | 214,572 | -293,395 | 0.03 | 0.02 | -0.02 | sell |
| AMERIPRISE FINANCIAL INC | 411,170 | 212,074 | -199,096 | 0.00 | 0.00 | -0.00 | sell |
| Pacer Advisors, Inc. | 426,353 | 210,964 | -215,389 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 232,739 | 205,558 | -27,181 | 0.25 | 0.26 | +0.01 | sell |
| JPMORGAN CHASE & CO | 834,449 | 200,953 | -633,496 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 76,417 | 194,041 | +117,624 | 0.02 | 0.06 | +0.03 | buy |
| Nuveen, LLC | 186,525 | 191,904 | +5,379 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 186,688 | 190,698 | +4,010 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 186,965 | 186,965 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EMERALD MUTUAL FUND ADVISERS TRUST | 194,349 | 179,607 | -14,742 | 0.33 | 0.35 | +0.02 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 177,147 | +177,147 | 0.00 | 0.11 | +0.11 | buy |
| BARCLAYS PLC | 31,163 | 172,078 | +140,915 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 153,257 | 164,074 | +10,817 | 0.00 | 0.00 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 160,964 | 159,550 | -1,414 | 0.00 | 0.00 | +0.00 | sell |
| Propel Bio Management, LLC | 0 | 147,828 | +147,828 | 0.00 | 3.80 | +3.80 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 27,626 | 139,257 | +111,631 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 166,562 | 135,430 | -31,132 | 0.06 | 0.05 | -0.00 | sell |
| LPL Financial LLC | 34,727 | 134,309 | +99,582 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 97,660 | 126,429 | +28,769 | 0.03 | 0.05 | +0.01 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 31,500 | 126,000 | +94,500 | 0.26 | 1.10 | +0.83 | buy |
| Rockefeller Capital Management L.P. | 65,797 | 123,497 | +57,700 | 0.00 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 221,444 | 117,954 | -103,490 | 0.02 | 0.01 | -0.01 | sell |
| Livforsakringsbolaget Skandia, Omsesidigt | 77,800 | 114,100 | +36,300 | 0.13 | 0.06 | -0.07 | buy |
| BANK OF AMERICA CORP /DE/ | 83,658 | 111,736 | +28,078 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 90,037 | 110,829 | +20,792 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 106,147 | +106,147 | 0.00 | 0.04 | +0.04 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 104,132 | +104,132 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 118,617 | 103,521 | -15,096 | 0.01 | 0.01 | +0.00 | sell |
| Empowered Funds, LLC | 0 | 97,295 | +97,295 | 0.00 | 0.03 | +0.03 | buy |
| KBC Group NV | 5,311 | 94,767 | +89,456 | 0.00 | 0.01 | +0.01 | buy |
| BROWN CAPITAL MANAGEMENT LLC | 138,191 | 93,693 | -44,498 | 0.39 | 0.54 | +0.14 | sell |
| PRUDENTIAL FINANCIAL INC | 84,684 | 92,534 | +7,850 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 89,905 | 89,152 | -753 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 384,246 | 86,590 | -297,656 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 101,022 | 80,018 | -21,004 | 0.01 | 0.00 | -0.00 | sell |
| ASSETMARK, INC | 82,098 | 79,943 | -2,155 | 0.01 | 0.01 | +0.00 | sell |
| Man Group plc | 90,708 | 77,604 | -13,104 | 0.01 | 0.01 | +0.00 | sell |
| BESSEMER GROUP INC | 76,521 | 76,617 | +96 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 81,878 | 76,342 | -5,536 | 0.00 | 0.01 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 42,654 | 75,474 | +32,820 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 198,528 | 72,853 | -125,675 | 0.02 | 0.01 | -0.01 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 72,407 | 72,407 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 56,550 | 71,781 | +15,231 | 0.00 | 0.01 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 109,337 | 69,515 | -39,822 | 0.11 | 0.09 | -0.02 | sell |
| Edgestream Partners, L.P. | 0 | 69,217 | +69,217 | 0.00 | 0.09 | +0.09 | buy |
| Stanley-Laman Group, Ltd. | 33,311 | 68,625 | +35,314 | 0.15 | 0.34 | +0.19 | buy |
| S&T BANK/PA | 93,272 | 68,087 | -25,185 | 1.03 | 1.02 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 149,845 | 67,972 | -81,873 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 57,273 | 64,988 | +7,715 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 64,327 | 62,487 | -1,840 | 0.00 | 0.00 | +0.00 | sell |
| Linden Thomas Advisory Services, LLC | 63,210 | 61,250 | -1,960 | 0.22 | 0.24 | +0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 60,411 | 59,470 | -941 | 0.00 | 0.01 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 52,069 | 59,446 | +7,377 | 0.02 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 56,181 | +56,181 | 0.00 | 0.00 | +0.00 | buy |
| Bridge City Capital, LLC | 29,535 | 54,874 | +25,339 | 0.30 | 0.61 | +0.31 | buy |
| State of Alaska, Department of Revenue | 56,312 | 54,856 | -1,456 | 0.02 | 0.02 | +0.00 | sell |
| BOKF, NA | 30,496 | 53,892 | +23,396 | 0.02 | 0.03 | +0.02 | buy |
| F/m Investments LLC | 65,894 | 51,152 | -14,742 | 0.09 | 0.14 | +0.05 | sell |
| Rock Springs Capital Management LP | 50,250 | 50,250 | 0 | 0.09 | 0.12 | +0.03 | hold |