| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FIRST TRUST ADVISORS LP | 693,317 | 2,173,376 | +1,480,059 | 0.02 | 0.06 | +0.05 | buy |
| TANG CAPITAL MANAGEMENT LLC | 156,764 | 1,500,000 | +1,343,236 | 0.27 | 3.07 | +2.80 | buy |
| D. E. Shaw & Co., Inc. | 169,667 | 1,181,348 | +1,011,681 | 0.00 | 0.04 | +0.03 | buy |
| MPM BioImpact LLC | 0 | 985,700 | +985,700 | 0.00 | 3.07 | +3.07 | buy |
| UBS Group AG | 414,851 | 1,363,668 | +948,817 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 27,959 | 945,884 | +917,925 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 2,414,640 | 3,190,192 | +775,552 | 0.00 | 0.01 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 674,759 | +674,759 | 0.00 | 3.92 | +3.92 | buy |
| MILLENNIUM MANAGEMENT LLC | 88,437 | 558,747 | +470,310 | 0.00 | 0.02 | +0.01 | buy |
| INGALLS & SNYDER LLC | 7,195,060 | 7,608,716 | +413,656 | 9.23 | 10.89 | +1.66 | buy |
| CITIGROUP INC | 34,129 | 421,067 | +386,938 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 430,976 | 725,822 | +294,846 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 285,531 | +285,531 | 0.00 | 0.47 | +0.47 | buy |
| Voleon Capital Management LP | 0 | 262,223 | +262,223 | 0.00 | 0.23 | +0.23 | buy |
| Caption Management, LLC | 0 | 260,000 | +260,000 | 0.00 | 0.50 | +0.50 | buy |
| Boxer Capital Management, LLC | 0 | 250,000 | +250,000 | 0.00 | 1.32 | +1.32 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 230,731 | +230,731 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 209,071 | 427,645 | +218,574 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 2,986,056 | 3,200,946 | +214,890 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 124,400 | 324,901 | +200,501 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 177,147 | +177,147 | 0.00 | 0.11 | +0.11 | buy |
| Propel Bio Management, LLC | 0 | 147,828 | +147,828 | 0.00 | 3.80 | +3.80 | buy |
| BARCLAYS PLC | 31,163 | 172,078 | +140,915 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 76,417 | 194,041 | +117,624 | 0.02 | 0.06 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 27,626 | 139,257 | +111,631 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 106,147 | +106,147 | 0.00 | 0.04 | +0.04 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 104,132 | +104,132 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 34,727 | 134,309 | +99,582 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 3,879,141 | 3,977,404 | +98,263 | 2.47 | 2.89 | +0.41 | buy |
| Empowered Funds, LLC | 0 | 97,295 | +97,295 | 0.00 | 0.03 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 209,733 | 304,615 | +94,882 | 0.15 | 0.26 | +0.11 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 31,500 | 126,000 | +94,500 | 0.26 | 1.10 | +0.83 | buy |
| KBC Group NV | 5,311 | 94,767 | +89,456 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 12,062,212 | 12,151,276 | +89,064 | 0.01 | 0.01 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 69,217 | +69,217 | 0.00 | 0.09 | +0.09 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,062,101 | 1,119,959 | +57,858 | 0.01 | 0.01 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 65,797 | 123,497 | +57,700 | 0.00 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 56,181 | +56,181 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.12 | +0.12 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 0 | 48,636 | +48,636 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,668,918 | 2,713,519 | +44,601 | 0.01 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 39,186 | +39,186 | 0.00 | 0.05 | +0.05 | buy |
| Simplify Asset Management Inc. | 0 | 37,763 | +37,763 | 0.00 | 0.02 | +0.02 | buy |
| Livforsakringsbolaget Skandia, Omsesidigt | 77,800 | 114,100 | +36,300 | 0.13 | 0.06 | -0.07 | buy |
| Stanley-Laman Group, Ltd. | 33,311 | 68,625 | +35,314 | 0.15 | 0.34 | +0.19 | buy |
| Quadrature Capital Ltd | 0 | 34,192 | +34,192 | 0.00 | 0.02 | +0.02 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 33,519 | +33,519 | 0.00 | 0.08 | +0.08 | buy |
| FIFTH THIRD BANCORP | 3,794 | 37,242 | +33,448 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 42,654 | 75,474 | +32,820 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 29,900 | +29,900 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 97,660 | 126,429 | +28,769 | 0.03 | 0.05 | +0.01 | buy |
| Jump Financial, LLC | 18,216 | 46,848 | +28,632 | 0.01 | 0.03 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 83,658 | 111,736 | +28,078 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 27,200 | +27,200 | 0.00 | 0.01 | +0.01 | buy |
| Bridge City Capital, LLC | 29,535 | 54,874 | +25,339 | 0.30 | 0.61 | +0.31 | buy |
| BOKF, NA | 30,496 | 53,892 | +23,396 | 0.02 | 0.03 | +0.02 | buy |
| Quantitative Investment Management, LLC | 0 | 23,375 | +23,375 | 0.00 | 0.10 | +0.10 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 21,763 | +21,763 | 0.00 | 0.05 | +0.05 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 21,449 | +21,449 | 0.00 | 0.08 | +0.08 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 90,037 | 110,829 | +20,792 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,624 | 22,060 | +20,436 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Wealth, LLC | 8,341 | 27,887 | +19,546 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 19,524 | +19,524 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 7,068 | 25,916 | +18,848 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 18,692 | +18,692 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 16,499 | +16,499 | 0.00 | 0.03 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 56,550 | 71,781 | +15,231 | 0.00 | 0.01 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 9,422 | 23,795 | +14,373 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 629,075 | 643,158 | +14,083 | 0.00 | 0.00 | +0.00 | buy |
| Patten Group, Inc. | 0 | 12,879 | +12,879 | 0.00 | 0.09 | +0.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 205,102 | 217,468 | +12,366 | 0.00 | 0.00 | +0.00 | buy |
| FAS Wealth Partners, Inc. | 310,018 | 322,370 | +12,352 | 0.70 | 0.81 | +0.11 | buy |
| Amundi | 0 | 11,392 | +11,392 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 444,092 | 455,248 | +11,156 | 0.01 | 0.01 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 324,027 | 334,875 | +10,848 | 0.04 | 0.04 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 153,257 | 164,074 | +10,817 | 0.00 | 0.00 | +0.00 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 10,188 | +10,188 | 0.00 | 0.04 | +0.04 | buy |
| Perbak Capital Partners LLP | 0 | 9,709 | +9,709 | 0.00 | 0.10 | +0.10 | buy |
| Tidal Investments LLC | 12,495 | 22,179 | +9,684 | 0.00 | 0.00 | +0.00 | buy |
| Summit Trail Advisors, LLC | 0 | 9,660 | +9,660 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 9,174 | +9,174 | 0.00 | 0.01 | +0.01 | buy |
| Cambridge Investment Research Advisors, Inc. | 33,745 | 42,754 | +9,009 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 8,716 | +8,716 | 0.00 | 0.03 | +0.03 | buy |
| INCEPTIONR LLC | 0 | 8,612 | +8,612 | 0.00 | 0.08 | +0.08 | buy |
| NewEdge Advisors, LLC | 1,132 | 9,364 | +8,232 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 22,000 | 30,000 | +8,000 | 0.22 | 0.24 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 0 | 8,000 | +8,000 | 0.00 | 0.02 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 84,684 | 92,534 | +7,850 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 57,273 | 64,988 | +7,715 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 52,069 | 59,446 | +7,377 | 0.02 | 0.02 | +0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 6,653 | +6,653 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,532 | 16,044 | +6,512 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 1,238 | 7,559 | +6,321 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 6,248 | +6,248 | 0.00 | 0.00 | +0.00 | buy |
| Waldron Private Wealth LLC | 0 | 5,614 | +5,614 | 0.00 | 0.01 | +0.01 | buy |
| Formidable Asset Management, LLC | 6,231 | 11,681 | +5,450 | 0.03 | 0.07 | +0.04 | buy |
| COMMERCE BANK | 0 | 5,426 | +5,426 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 186,525 | 191,904 | +5,379 | 0.00 | 0.00 | +0.00 | buy |
| WHITTIER TRUST CO | 402 | 5,402 | +5,000 | 0.00 | 0.00 | +0.00 | buy |