| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ALLIANCEBERNSTEIN L.P. | 419,579 | 8,624,132 | +8,204,553 | 0.01 | 0.18 | +0.17 | buy |
| NORGES BANK | 0 | 7,282,743 | +7,282,743 | 0.00 | 0.05 | +0.05 | buy |
| Amundi | 0 | 6,000,000 | +6,000,000 | 0.00 | 0.20 | +0.20 | buy |
| Invesco Ltd. | 4,629,139 | 8,762,189 | +4,133,050 | 0.05 | 0.07 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 79,272 | 3,073,575 | +2,994,303 | 0.00 | 0.04 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 444,631 | 3,102,789 | +2,658,158 | 0.02 | 0.11 | +0.09 | buy |
| TD ASSET MANAGEMENT INC | 0 | 2,230,000 | +2,230,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 2,050,000 | +2,050,000 | 0.00 | 0.00 | +0.00 | buy |
| Fosun International Ltd | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.43 | +0.43 | buy |
| D. E. Shaw & Co., Inc. | 2,203,487 | 3,938,568 | +1,735,081 | 0.12 | 0.20 | +0.08 | buy |
| Castle Hook Partners LP | 604,265 | 2,251,011 | +1,646,746 | 0.62 | 2.15 | +1.53 | buy |
| BNP Paribas Asset Management Holding S.A. | 314,968 | 1,863,891 | +1,548,923 | 0.05 | 0.14 | +0.09 | buy |
| J. Stern & Co. LLP | 72,332 | 1,601,973 | +1,529,641 | 0.37 | 0.14 | -0.23 | buy |
| ANGELO GORDON & CO., L.P. | 3,000,000 | 4,500,000 | +1,500,000 | 0.33 | 0.39 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 2,849,261 | 4,329,213 | +1,479,952 | 0.06 | 0.09 | +0.03 | buy |
| Squarepoint Ops LLC | 1,086,094 | 2,527,448 | +1,441,354 | 0.16 | 0.34 | +0.18 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 207,000 | 1,587,550 | +1,380,550 | 0.02 | 0.16 | +0.14 | buy |
| AMERIPRISE FINANCIAL INC | 808,714 | 2,128,251 | +1,319,537 | 0.01 | 0.03 | +0.02 | buy |
| Soleus Capital Management, L.P. | 0 | 1,297,094 | +1,297,094 | 0.00 | 3.65 | +3.65 | buy |
| STATE STREET CORP | 16,855,113 | 18,093,554 | +1,238,441 | 0.04 | 0.04 | +0.00 | buy |
| Neuberger Berman Group LLC | 1,105,730 | 2,340,199 | +1,234,469 | 0.05 | 0.12 | +0.06 | buy |
| BlackRock, Inc. | 38,821,843 | 39,848,377 | +1,026,534 | 0.05 | 0.04 | -0.00 | buy |
| Pacer Advisors, Inc. | 60,129 | 982,779 | +922,650 | 0.01 | 0.10 | +0.09 | buy |
| Intermede Investment Partners Ltd | 0 | 909,307 | +909,307 | 0.00 | 2.48 | +2.48 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 397,218 | 1,269,961 | +872,743 | 0.02 | 0.05 | +0.03 | buy |
| Russell Investments Group, Ltd. | 256,312 | 1,013,489 | +757,177 | 0.02 | 0.07 | +0.05 | buy |
| Allianz Asset Management GmbH | 103,317 | 852,472 | +749,155 | 0.01 | 0.06 | +0.06 | buy |
| MORGAN STANLEY | 4,352,808 | 5,072,646 | +719,838 | 0.02 | 0.02 | +0.00 | buy |
| Vestal Point Capital, LP | 650,000 | 1,275,000 | +625,000 | 1.98 | 3.10 | +1.12 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 841,564 | 1,444,796 | +603,232 | 0.07 | 0.15 | +0.07 | buy |
| Employees Retirement System of Texas | 0 | 570,600 | +570,600 | 0.00 | 0.31 | +0.31 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 527,492 | +527,492 | 0.00 | 0.54 | +0.54 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 7,482,531 | 7,999,057 | +516,526 | 0.11 | 0.11 | +0.00 | buy |
| BANK OF NOVA SCOTIA | 504,913 | 1,010,210 | +505,297 | 0.06 | 0.10 | +0.04 | buy |
| Integral Health Asset Management, LLC | 0 | 500,000 | +500,000 | 0.00 | 1.68 | +1.68 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 474,310 | +474,310 | 0.00 | 0.49 | +0.49 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,444,566 | 1,871,705 | +427,139 | 0.02 | 0.03 | +0.01 | buy |
| Tri Locum Partners LP | 0 | 421,600 | +421,600 | 0.00 | 3.63 | +3.63 | buy |
| Parkman Healthcare Partners LLC | 171,628 | 587,475 | +415,847 | 1.27 | 3.71 | +2.44 | buy |
| Assenagon Asset Management S.A. | 828,759 | 1,226,449 | +397,690 | 0.08 | 0.12 | +0.04 | buy |
| SG Americas Securities, LLC | 147,742 | 541,058 | +393,316 | 0.04 | 0.05 | +0.01 | buy |
| Man Group plc | 583,690 | 962,592 | +378,902 | 0.08 | 0.12 | +0.05 | buy |
| TWO SIGMA ADVISERS, LP | 386,276 | 748,076 | +361,800 | 0.05 | 0.10 | +0.04 | buy |
| CI INVESTMENTS INC. | 548,132 | 885,716 | +337,584 | 0.13 | 0.26 | +0.12 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 179,938 | 516,606 | +336,668 | 0.02 | 0.05 | +0.03 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 323,052 | +323,052 | 0.00 | 0.52 | +0.52 | buy |
| INCOME RESEARCH & MANAGEMENT | 5,781,000 | 6,101,000 | +320,000 | 2.58 | 2.95 | +0.37 | buy |
| GOLDMAN SACHS GROUP INC | 2,130,300 | 2,437,847 | +307,547 | 0.02 | 0.02 | +0.00 | buy |
| Quantinno Capital Management LP | 106,033 | 406,997 | +300,964 | 0.02 | 0.05 | +0.03 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 204,933 | 505,073 | +300,140 | 0.02 | 0.06 | +0.03 | buy |
| Voleon Capital Management LP | 252,318 | 537,272 | +284,954 | 0.41 | 0.77 | +0.35 | buy |
| FRANKLIN RESOURCES INC | 2,446,081 | 2,682,761 | +236,680 | 0.04 | 0.04 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,607,196 | 1,838,608 | +231,412 | 0.08 | 0.08 | -0.01 | buy |
| PFM Health Sciences, LP | 0 | 227,357 | +227,357 | 0.00 | 1.53 | +1.53 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 225,758 | +225,758 | 0.00 | 0.27 | +0.27 | buy |
| CIBC Private Wealth Group LLC | 2,907,801 | 3,128,114 | +220,313 | 0.33 | 0.35 | +0.02 | buy |
| State of Tennessee, Department of Treasury | 44,395 | 248,954 | +204,559 | 0.01 | 0.06 | +0.05 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 1,620,404 | 1,811,734 | +191,330 | 0.37 | 0.42 | +0.05 | buy |
| CITIGROUP INC | 655,191 | 846,003 | +190,812 | 0.03 | 0.04 | +0.01 | buy |
| ProShare Advisors LLC | 494,147 | 684,608 | +190,461 | 0.07 | 0.08 | +0.01 | buy |
| Stephens Investment Management Group LLC | 861,100 | 1,042,801 | +181,701 | 0.75 | 0.90 | +0.15 | buy |
| Trexquant Investment LP | 69,092 | 249,727 | +180,635 | 0.05 | 0.15 | +0.10 | buy |
| Casdin Capital, LLC | 0 | 175,000 | +175,000 | 0.00 | 0.72 | +0.72 | buy |
| Candriam S.C.A. | 244,363 | 418,460 | +174,097 | 0.09 | 0.14 | +0.05 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0 | 171,573 | +171,573 | 0.00 | 0.03 | +0.03 | buy |
| DnB Asset Management AS | 1,098,544 | 1,269,391 | +170,847 | 0.28 | 0.29 | +0.02 | buy |
| ING GROEP NV | 504,940 | 673,692 | +168,752 | 0.18 | 0.27 | +0.09 | buy |
| FORSTA AP-FONDEN | 99,100 | 255,300 | +156,200 | 0.04 | 0.10 | +0.06 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 659,718 | 808,951 | +149,233 | 0.03 | 0.04 | +0.00 | buy |
| ASSETMARK, INC | 1,362 | 143,618 | +142,256 | 0.00 | 0.02 | +0.02 | buy |
| IEQ CAPITAL, LLC | 6,252 | 145,248 | +138,996 | 0.00 | 0.03 | +0.03 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 116,329 | 254,315 | +137,986 | 0.01 | 0.01 | +0.01 | buy |
| Andra AP-fonden | 92,800 | 225,600 | +132,800 | 0.08 | 0.18 | +0.11 | buy |
| JUPITER ASSET MANAGEMENT LTD | 51,661 | 183,265 | +131,604 | 0.03 | 0.10 | +0.07 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 82,716 | 212,220 | +129,504 | 0.05 | 0.13 | +0.08 | buy |
| OMERS ADMINISTRATION Corp | 29,196 | 157,201 | +128,005 | 0.01 | 0.07 | +0.06 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 530,928 | 657,819 | +126,891 | 1.08 | 1.34 | +0.26 | buy |
| Walleye Capital LLC | 798,740 | 924,662 | +125,922 | 0.44 | 0.35 | -0.09 | buy |
| MML INVESTORS SERVICES, LLC | 32,195 | 156,181 | +123,986 | 0.01 | 0.03 | +0.02 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 0 | 112,346 | +112,346 | 0.00 | 0.03 | +0.03 | buy |
| Quadrature Capital Ltd | 0 | 109,985 | +109,985 | 0.00 | 0.07 | +0.07 | buy |
| MACKENZIE FINANCIAL CORP | 1,105,644 | 1,211,964 | +106,320 | 0.09 | 0.10 | +0.01 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 137,405 | 239,205 | +101,800 | 0.07 | 0.12 | +0.05 | buy |
| Walleye Trading LLC | 82,751 | 183,401 | +100,650 | 0.09 | 0.20 | +0.11 | buy |
| ExodusPoint Capital Management, LP | 35,814 | 134,054 | +98,240 | 0.03 | 0.10 | +0.07 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 23,828 | 119,173 | +95,345 | 0.00 | 0.01 | +0.01 | buy |
| SIRIOS CAPITAL MANAGEMENT L P | 340,170 | 430,948 | +90,778 | 2.98 | 3.56 | +0.58 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 244,654 | 335,284 | +90,630 | 0.16 | 0.21 | +0.05 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 288,063 | 377,806 | +89,743 | 0.08 | 0.10 | +0.02 | buy |
| Corient Private Wealth LLC | 36,286 | 123,754 | +87,468 | 0.00 | 0.01 | +0.01 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 209,535 | 289,945 | +80,410 | 0.03 | 0.03 | +0.01 | buy |
| Mediolanum International Funds Ltd | 114,722 | 186,907 | +72,185 | 0.08 | 0.13 | +0.05 | buy |
| Gotham Asset Management, LLC | 13,554 | 82,253 | +68,699 | 0.00 | 0.02 | +0.02 | buy |
| HighTower Advisors, LLC | 53,446 | 121,697 | +68,251 | 0.00 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 199,460 | 262,911 | +63,451 | 0.15 | 0.21 | +0.05 | buy |
| OneDigital Investment Advisors LLC | 78,708 | 142,039 | +63,331 | 0.05 | 0.09 | +0.04 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 10,467 | 72,544 | +62,077 | 0.02 | 0.10 | +0.09 | buy |
| Bellevue Group AG | 786,118 | 847,405 | +61,287 | 1.10 | 1.07 | -0.03 | buy |
| BRIDGER MANAGEMENT, LLC | 42,000 | 101,893 | +59,893 | 1.52 | 4.35 | +2.83 | buy |
| Motley Fool Wealth Management, LLC | 218,000 | 276,495 | +58,495 | 0.99 | 1.42 | +0.43 | buy |