| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Integral Health Asset Management, LLC | 350,000 | 1,300,000 | +950,000 | 1.57 | 3.46 | +1.90 | buy |
| JANUS HENDERSON GROUP PLC | 1,403,091 | 2,229,463 | +826,372 | 0.03 | 0.03 | 0.00 | buy |
| GREAT POINT PARTNERS LLC | 225,912 | 775,585 | +549,673 | 1.19 | 3.28 | +2.09 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 943,431 | 450,394 | +493,037 | 0.09 | 0.03 | 0.00 | sell |
| AMERIPRISE FINANCIAL INC | 2,282,491 | 2,735,338 | +452,847 | 0.02 | 0.02 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 271,312 | 82,083 | +189,229 | 0.04 | 0.01 | -0.03 | sell |
| Hudson Bay Capital Management LP | 467,500 | 626,810 | +159,310 | 0.09 | 0.09 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 352,612 | 460,173 | +107,561 | 0.03 | 0.03 | 0.00 | buy |
| STEMPOINT CAPITAL LP | 173,579 | 272,448 | +98,869 | 1.45 | 1.97 | +0.53 | buy |
| Soleus Capital Management, L.P. | 167,100 | 250,000 | +82,900 | 0.57 | 0.60 | +0.02 | buy |
| Candriam S.C.A. | 310,200 | 390,200 | +80,000 | 0.07 | 0.07 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,359,563 | 1,439,280 | +79,717 | 0.03 | 0.02 | 0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 895,946 | 972,313 | +76,367 | 0.08 | 0.07 | -0.01 | buy |
| Long Focus Capital Management, LLC | 371,649 | 431,649 | +60,000 | 0.38 | 0.60 | +0.22 | buy |
| Hood River Capital Management LLC | 905,819 | 962,501 | +56,682 | 0.77 | 0.58 | -0.19 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 405,000 | 455,000 | +50,000 | 2.39 | 1.63 | -0.76 | buy |
| Artia Global Partners LP | 74,936 | 118,236 | +43,300 | 0.92 | 0.79 | -0.13 | buy |
| AMERICAN CENTURY COMPANIES INC | 662,200 | 702,624 | +40,424 | 0.01 | 0.01 | -0.00 | buy |
| Aberdeen Group plc | 100,000 | 133,499 | +33,499 | 0.01 | 0.01 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 29,500 | 61,718 | +32,218 | 0.51 | 1.09 | +0.57 | buy |
| FIL Ltd | 691,431 | 720,245 | +28,814 | 0.02 | 0.02 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 295,328 | 320,001 | +24,673 | 0.03 | 0.02 | -0.01 | buy |
| Brevan Howard Capital Management LP | 6,461 | 24,573 | +18,112 | 0.00 | 0.01 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 59,724 | 72,538 | +12,814 | 0.35 | 0.34 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 16,551 | 28,569 | +12,018 | 0.10 | 0.10 | -0.00 | buy |
| Exome Asset Management LLC | 61,500 | 71,700 | +10,200 | 1.88 | 1.67 | -0.22 | buy |
| Hennion & Walsh Asset Management, Inc. | 138,035 | 146,912 | +8,877 | 0.24 | 0.21 | -0.03 | buy |
| Rafferty Asset Management, LLC | 321,087 | 329,635 | +8,548 | 0.04 | 0.03 | -0.01 | buy |
| Dana Investment Advisors, Inc. | 15,630 | 23,690 | +8,060 | 0.02 | 0.02 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,763,771 | 10,769,366 | +5,595 | 0.05 | 0.04 | -0.01 | buy |
| Fox Hill Wealth Management | 131,000 | 136,000 | +5,000 | 0.12 | 0.10 | -0.02 | buy |
| AXIOM INVESTORS LLC /DE | 60,027 | 64,051 | +4,024 | 0.02 | 0.02 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 13,400 | 17,304 | +3,904 | 0.04 | 0.03 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 56,727 | 53,507 | +3,220 | 0.13 | 0.11 | 0.00 | sell |
| ProShare Advisors LLC | 32,023 | 35,241 | +3,218 | 0.00 | 0.00 | 0.00 | buy |
| Beacon Financial Advisory LLC | 10,075 | 13,220 | +3,145 | 0.15 | 0.17 | +0.02 | buy |
| MPM BioImpact LLC | 528,150 | 530,794 | +2,644 | 3.83 | 2.32 | -1.51 | buy |
| SECTORAL ASSET MANAGEMENT INC | 13,811 | 16,421 | +2,610 | 0.18 | 0.18 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 11,295 | 13,193 | +1,898 | 0.22 | 0.19 | -0.03 | buy |
| Quarry LP | 3,750 | 4,900 | +1,150 | 0.05 | 0.06 | 0.00 | buy |
| PROFUND ADVISORS LLC | 54,027 | 52,943 | +1,084 | 0.07 | 0.06 | 0.00 | sell |
| Diversified Trust Co | 20,606 | 21,684 | +1,078 | 0.02 | 0.02 | -0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 108,007 | 108,629 | +622 | 0.66 | 0.58 | -0.08 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 290,088 | 290,174 | +86 | 0.27 | 0.23 | -0.04 | buy |
| Compound Planning, Inc. | 29,350 | 29,264 | -86 | 0.13 | 0.07 | -0.05 | sell |
| Ameritas Investment Partners, Inc. | 14,309 | 13,786 | -523 | 0.02 | 0.01 | -0.00 | sell |
| Teza Capital Management LLC | 10,489 | 8,984 | -1,505 | 0.05 | 0.03 | -0.02 | sell |
| E Fund Management Co., Ltd. | 17,178 | 15,577 | -1,601 | 0.03 | 0.03 | -0.01 | sell |
| JENNISON ASSOCIATES LLC | 120,831 | 118,512 | -2,319 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 11,764 | 9,324 | -2,440 | 0.06 | 0.03 | -0.03 | sell |
| OAK RIDGE INVESTMENTS LLC | 87,348 | 84,181 | -3,167 | 0.31 | 0.23 | -0.08 | sell |
| J. Goldman & Co LP | 26,014 | 18,221 | -7,793 | 0.03 | 0.02 | -0.02 | sell |
| Stonegate Investment Group, LLC | 28,000 | 13,000 | -15,000 | 0.00 | 0.00 | -0.00 | sell |
| GW&K Investment Management, LLC | 1,291,772 | 1,269,898 | -21,874 | 0.37 | 0.30 | -0.07 | sell |
| Sonora Investment Management Group, LLC | 6,074,000 | 6,039,000 | -35,000 | 0.52 | 0.50 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 463,532 | 427,178 | -36,354 | 0.01 | 0.01 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 155,504 | 113,616 | -41,888 | 1.49 | 0.86 | -0.62 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 221,270 | 179,332 | -41,938 | 0.40 | 0.28 | -0.12 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 4,256,687 | 4,214,719 | -41,968 | 0.38 | 0.30 | -0.09 | sell |
| Parkman Healthcare Partners LLC | 150,816 | 93,032 | -57,784 | 0.66 | 0.31 | -0.35 | sell |
| Granahan Investment Management, LLC | 202,193 | 133,755 | -68,438 | 0.21 | 0.13 | -0.08 | sell |
| Knights of Columbus Asset Advisors LLC | 228,783 | 117,174 | -111,609 | 0.46 | 0.23 | -0.23 | sell |
| Cinctive Capital Management LP | 175,000 | 60,263 | -114,737 | 0.38 | 0.08 | -0.30 | sell |
| Susquehanna Portfolio Strategies, LLC | 164,496 | 21,419 | -143,077 | 0.09 | 0.01 | -0.08 | sell |
| Octagon Capital Advisors LP | 1,284,000 | 1,140,000 | -144,000 | 6.37 | 3.76 | -2.61 | sell |
| Bellevue Group AG | 2,290,958 | 2,141,843 | -149,115 | 1.09 | 0.89 | -0.20 | sell |
| Vestal Point Capital, LP | 900,000 | 750,000 | -150,000 | 2.95 | 1.68 | -1.27 | sell |
| Cutter Capital Management, LP | 413,499 | 227,337 | -186,162 | 6.13 | 2.38 | -3.75 | sell |
| Polar Capital Holdings Plc | 504,275 | 251,700 | -252,575 | 0.10 | 0.04 | -0.06 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 748,344 | 484,714 | -263,630 | 1.23 | 0.68 | -0.54 | sell |
| EMERALD ADVISERS, LLC | 930,849 | 630,179 | -300,670 | 1.23 | 0.69 | -0.55 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 600,000 | 250,000 | -350,000 | 0.04 | 0.01 | -0.03 | sell |
| First Light Asset Management, LLC | 646,057 | 282,766 | -363,291 | 1.61 | 0.59 | -1.02 | sell |
| Deep Track Capital, LP | 5,350,000 | 4,783,679 | -566,321 | 5.81 | 3.73 | -2.08 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,684,487 | 2,023,000 | -661,487 | 3.76 | 2.04 | -1.72 | sell |
| SAMLYN CAPITAL, LLC | 1,286,868 | 587,634 | -699,234 | 0.79 | 0.27 | -0.53 | sell |
| LOOMIS SAYLES & CO L P | 2,331,505 | 1,491,794 | -839,711 | 0.11 | 0.06 | -0.05 | sell |
| Palo Alto Investors LP | 5,511,721 | 4,423,369 | -1,088,352 | 15.39 | 13.53 | -1.86 | sell |
| T. Rowe Price Investment Management, Inc. | 5,850,606 | 3,451,580 | -2,399,026 | 0.12 | 0.06 | -0.06 | sell |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 9,000,000 | 5,000,000 | -4,000,000 | 1.50 | 0.73 | -0.78 | sell |
| LORD, ABBETT & CO. LLC | 18,718,000 | 8,216,000 | -10,502,000 | 0.08 | 0.03 | -0.05 | sell |