| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 30,615,000 | +30,615,000 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 14,125,521 | 14,509,235 | +383,714 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,763,771 | 10,769,366 | +5,595 | 0.04 | 0.04 | -0.01 | buy |
| FMR LLC | 5,091,614 | 9,318,894 | +4,227,280 | 0.01 | 0.02 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 18,718,000 | 8,216,000 | -10,502,000 | 0.08 | 0.03 | -0.05 | sell |
| Sonora Investment Management Group, LLC | 6,074,000 | 6,039,000 | -35,000 | 0.52 | 0.50 | -0.03 | sell |
| STATE STREET CORP | 5,929,933 | 5,905,127 | -24,806 | 0.01 | 0.01 | -0.00 | sell |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 9,000,000 | 5,000,000 | -4,000,000 | 1.50 | 0.73 | -0.78 | sell |
| Deep Track Capital, LP | 5,350,000 | 4,783,679 | -566,321 | 5.81 | 3.73 | -2.08 | sell |
| Palo Alto Investors LP | 5,511,721 | 4,423,369 | -1,088,352 | 15.39 | 13.53 | -1.86 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 4,256,687 | 4,214,719 | -41,968 | 0.38 | 0.30 | -0.09 | sell |
| MACQUARIE GROUP LTD | 4,651,492 | 3,899,504 | -751,988 | 0.17 | 0.12 | -0.05 | sell |
| FRANKLIN RESOURCES INC | 3,396,727 | 3,567,013 | +170,286 | 0.05 | 0.03 | -0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 5,850,606 | 3,451,580 | -2,399,026 | 0.12 | 0.06 | -0.06 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,069,378 | 3,163,751 | +94,373 | 0.01 | 0.01 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,282,491 | 2,735,338 | +452,847 | 0.02 | 0.02 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,403,091 | 2,229,463 | +826,372 | 0.03 | 0.03 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,147,902 | 2,146,479 | -1,423 | 0.03 | 0.02 | -0.01 | sell |
| Bellevue Group AG | 2,290,958 | 2,141,843 | -149,115 | 1.09 | 0.89 | -0.20 | sell |
| Bank of New York Mellon Corp | 2,356,862 | 2,051,311 | -305,551 | 0.01 | 0.01 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,684,487 | 2,023,000 | -661,487 | 3.80 | 2.32 | -1.49 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,975,000 | 1,975,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RTW INVESTMENTS, LP | 1,865,108 | 1,865,108 | 0 | 0.90 | 0.75 | -0.16 | hold |
| Capital International Investors | 0 | 1,620,814 | +1,620,814 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 1,453,025 | 1,588,541 | +135,516 | 0.01 | 0.01 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,961,801 | 1,530,008 | -431,793 | 0.07 | 0.05 | -0.02 | sell |
| LOOMIS SAYLES & CO L P | 2,331,505 | 1,491,794 | -839,711 | 0.11 | 0.06 | -0.05 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 1,359,563 | 1,439,280 | +79,717 | 0.03 | 0.02 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 95,932 | 1,437,174 | +1,341,242 | 0.00 | 0.04 | +0.04 | buy |
| Novo Holdings A/S | 1,339,304 | 1,339,304 | 0 | 2.56 | 2.51 | -0.06 | hold |
| NORTHERN TRUST CORP | 1,372,245 | 1,336,797 | -35,448 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 1,439,769 | 1,330,048 | -109,721 | 0.09 | 0.06 | -0.03 | sell |
| Integral Health Asset Management, LLC | 350,000 | 1,300,000 | +950,000 | 1.57 | 3.46 | +1.90 | buy |
| GW&K Investment Management, LLC | 1,291,772 | 1,269,898 | -21,874 | 0.37 | 0.30 | -0.07 | sell |
| BNP Paribas Asset Management Holding S.A. | 0 | 1,250,000 | +1,250,000 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 284,520 | 1,211,560 | +927,040 | 0.03 | 0.09 | +0.06 | buy |
| Octagon Capital Advisors LP | 1,284,000 | 1,140,000 | -144,000 | 6.37 | 3.76 | -2.61 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,128,436 | 1,126,767 | -1,669 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,043,831 | 996,128 | -47,703 | 0.00 | 0.00 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 895,946 | 972,313 | +76,367 | 0.08 | 0.07 | -0.01 | buy |
| Hood River Capital Management LLC | 905,819 | 962,501 | +56,682 | 0.77 | 0.58 | -0.19 | buy |
| MORGAN STANLEY | 1,534,747 | 939,603 | -595,144 | 0.00 | 0.00 | -0.00 | sell |
| Clearbridge Investments, LLC | 0 | 930,409 | +930,409 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 1,046,214 | 927,563 | -118,651 | 0.03 | 0.02 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 225,912 | 775,585 | +549,673 | 1.19 | 3.28 | +2.09 | buy |
| GOLDMAN SACHS GROUP INC | 761,772 | 753,610 | -8,162 | 0.01 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 900,000 | 750,000 | -150,000 | 2.95 | 1.68 | -1.27 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 747,331 | +747,331 | 0.00 | 0.19 | +0.19 | buy |
| FIL Ltd | 691,431 | 720,245 | +28,814 | 0.02 | 0.02 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 629,200 | 716,400 | +87,200 | 0.05 | 0.05 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 662,200 | 702,624 | +40,424 | 0.01 | 0.01 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 635,185 | 635,185 | 0 | 0.32 | 0.27 | -0.05 | hold |
| EMERALD ADVISERS, LLC | 930,849 | 630,179 | -300,670 | 1.23 | 0.69 | -0.55 | sell |
| Hudson Bay Capital Management LP | 467,500 | 626,810 | +159,310 | 0.13 | 0.15 | +0.02 | buy |
| SAMLYN CAPITAL, LLC | 1,286,868 | 587,634 | -699,234 | 0.87 | 0.28 | -0.59 | sell |
| Cormorant Asset Management, LP | 575,000 | 575,000 | 0 | 0.85 | 0.69 | -0.17 | hold |
| Sonora Investment Management Group, LLC | 540,000 | 540,000 | 0 | 0.05 | 0.05 | -0.00 | hold |
| MPM BioImpact LLC | 528,150 | 530,794 | +2,644 | 3.83 | 2.32 | -1.51 | buy |
| PANAGORA ASSET MANAGEMENT INC | 429,003 | 514,829 | +85,826 | 0.07 | 0.07 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 748,344 | 484,714 | -263,630 | 1.23 | 0.68 | -0.54 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 504,237 | 472,006 | -32,231 | 0.02 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 352,612 | 460,173 | +107,561 | 0.03 | 0.03 | +0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 405,000 | 455,000 | +50,000 | 2.39 | 1.63 | -0.76 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 943,431 | 450,394 | -493,037 | 0.08 | 0.03 | -0.05 | sell |
| Long Focus Capital Management, LLC | 371,649 | 431,649 | +60,000 | 1.49 | 1.35 | -0.14 | buy |
| TD ASSET MANAGEMENT INC | 463,532 | 427,178 | -36,354 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 407,570 | 407,025 | -545 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 400,000 | 400,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Candriam S.C.A. | 310,200 | 390,200 | +80,000 | 0.07 | 0.07 | +0.00 | buy |
| UBS Group AG | 300,181 | 381,063 | +80,882 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 79,374 | 369,918 | +290,544 | 0.02 | 0.08 | +0.06 | buy |
| C WorldWide Group Holding A/S | 343,110 | 343,110 | 0 | 0.14 | 0.11 | -0.04 | hold |
| BAKER BROS. ADVISORS LP | 343,000 | 343,000 | 0 | 0.12 | 0.12 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 70,010 | 341,574 | +271,564 | 0.00 | 0.02 | +0.01 | buy |
| Rafferty Asset Management, LLC | 321,087 | 329,635 | +8,548 | 0.04 | 0.03 | -0.01 | buy |
| CITIGROUP INC | 143,281 | 326,566 | +183,285 | 0.01 | 0.01 | +0.00 | buy |
| Bleichroeder LP | 325,000 | 325,000 | 0 | 2.24 | 2.20 | -0.04 | hold |
| WCM INVESTMENT MANAGEMENT, LLC | 295,328 | 320,001 | +24,673 | 0.03 | 0.02 | -0.01 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 290,088 | 290,174 | +86 | 0.27 | 0.23 | -0.04 | buy |
| JPMORGAN CHASE & CO | 382,494 | 289,531 | -92,963 | 0.00 | 0.00 | -0.00 | sell |
| AXA S.A. | 352,046 | 288,599 | -63,447 | 0.04 | 0.02 | -0.01 | sell |
| First Light Asset Management, LLC | 646,057 | 282,766 | -363,291 | 1.61 | 0.59 | -1.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,605,001 | 276,618 | -1,328,383 | 0.05 | 0.01 | -0.04 | sell |
| STEMPOINT CAPITAL LP | 173,579 | 272,448 | +98,869 | 1.45 | 1.97 | +0.53 | buy |
| JANE STREET GROUP, LLC | 112,974 | 270,973 | +157,999 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 269,200 | 268,400 | -800 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 164,232 | 254,560 | +90,328 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 504,275 | 251,700 | -252,575 | 0.10 | 0.04 | -0.06 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 600,000 | 250,000 | -350,000 | 0.04 | 0.01 | -0.03 | sell |
| Soleus Capital Management, L.P. | 167,100 | 250,000 | +82,900 | 0.57 | 0.60 | +0.02 | buy |
| Ally Bridge Group (NY) LLC | 0 | 250,000 | +250,000 | 0.00 | 3.77 | +3.77 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 221,572 | 239,984 | +18,412 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 212,035 | 232,681 | +20,646 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 334,529 | 227,936 | -106,593 | 0.01 | 0.00 | -0.00 | sell |
| Cutter Capital Management, LP | 413,499 | 227,337 | -186,162 | 6.13 | 2.38 | -3.75 | sell |
| RHUMBLINE ADVISERS | 203,696 | 207,662 | +3,966 | 0.01 | 0.01 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 200,000 | +200,000 | 0.00 | 0.03 | +0.03 | buy |
| Walleye Capital LLC | 118,411 | 191,142 | +72,731 | 0.05 | 0.06 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 191,305 | 190,717 | -588 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 221,270 | 179,332 | -41,938 | 0.40 | 0.28 | -0.12 | sell |