| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 12,960,538 | 15,397,975 | +2,437,437 | 84.75 | 82.08 | -2.67 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,647,562 | 3,446,944 | +1,799,382 | 0.20 | 0.49 | +0.29 | buy |
| Holocene Advisors, LP | 687,712 | 2,026,422 | +1,338,710 | 0.15 | 0.45 | +0.30 | buy |
| Duquesne Family Office LLC | 593,470 | 1,369,050 | +775,580 | 1.10 | 3.41 | +2.31 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 938,551 | 1,406,609 | +468,058 | 0.28 | 0.52 | +0.24 | buy |
| TimesSquare Capital Management, LLC | 684,384 | 1,064,148 | +379,764 | 100.00 | 100.00 | 0.00 | buy |
| BAKER BROS. ADVISORS LP | 5,006,863 | 5,380,626 | +373,763 | 3.69 | 4.54 | +0.85 | buy |
| PERCEPTIVE ADVISORS LLC | 144,000 | 509,300 | +365,300 | 0.27 | 1.37 | +1.10 | buy |
| GW&K Investment Management, LLC | 1,135,393 | 1,377,726 | +242,333 | 0.67 | 0.97 | +0.31 | buy |
| D. E. Shaw & Co., Inc. | 508,787 | 734,880 | +226,093 | 0.04 | 0.07 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,704,410 | 12,923,541 | +219,131 | 0.10 | 0.12 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,087,143 | 4,288,735 | +201,592 | 0.02 | 0.03 | 0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 593,996 | 406,903 | +187,093 | 0.10 | 0.07 | 0.00 | sell |
| Vestal Point Capital, LP | 900,000 | 1,075,000 | +175,000 | 3.68 | 5.86 | +2.17 | buy |
| NWI MANAGEMENT LP | 279,000 | 450,000 | +171,000 | 0.85 | 4.51 | +3.66 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 171,289 | 331,459 | +160,170 | 0.10 | 0.24 | +0.15 | buy |
| Artia Global Partners LP | 167,939 | 318,239 | +150,300 | 4.68 | 7.12 | +2.44 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 268,063 | 127,495 | +140,568 | 0.02 | 0.01 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 61,500 | 185,500 | +124,000 | 0.44 | 1.63 | +1.19 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 435,006 | 557,587 | +122,581 | 0.29 | 0.47 | +0.18 | buy |
| READYSTATE ASSET MANAGEMENT LP | 26,190 | 134,569 | +108,379 | 0.08 | 0.52 | +0.44 | buy |
| AMERIPRISE FINANCIAL INC | 2,850,097 | 2,951,622 | +101,525 | 0.05 | 0.06 | +0.01 | buy |
| Artisan Partners Limited Partnership | 3,126,339 | 3,217,268 | +90,929 | 0.32 | 0.40 | +0.07 | buy |
| Affinity Asset Advisors, LLC | 50,000 | 140,000 | +90,000 | 0.54 | 1.67 | +1.13 | buy |
| Woodline Partners LP | 162,230 | 248,770 | +86,540 | 0.08 | 0.12 | +0.05 | buy |
| Capital International Investors | 7,116,997 | 7,198,485 | +81,488 | 0.09 | 0.11 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,100,993 | 1,181,675 | +80,682 | 1.38 | 1.80 | +0.41 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 638,848 | 704,366 | +65,518 | 0.84 | 1.38 | +0.54 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,817,643 | 1,755,373 | +62,270 | 0.07 | 0.08 | 0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 812,780 | 872,123 | +59,343 | 0.03 | 0.04 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 35,478 | 89,020 | +53,542 | 0.45 | 1.42 | +0.97 | buy |
| Sofinnova Investments, Inc. | 256,281 | 304,254 | +47,973 | 1.29 | 1.52 | +0.23 | buy |
| Aberdeen Group plc | 289,653 | 336,357 | +46,704 | 0.04 | 0.05 | +0.01 | buy |
| Nicholas Investment Partners, LP | 182,743 | 223,931 | +41,188 | 1.11 | 1.76 | +0.65 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 317,753 | 355,722 | +37,969 | 0.03 | 0.04 | +0.01 | buy |
| Hood River Capital Management LLC | 1,525,628 | 1,558,286 | +32,658 | 1.56 | 2.03 | +0.47 | buy |
| SEGALL BRYANT & HAMILL, LLC | 139,045 | 170,859 | +31,814 | 0.13 | 0.20 | +0.07 | buy |
| ALGERT GLOBAL LLC | 75,754 | 44,424 | +31,330 | 0.12 | 0.08 | 0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 71,227 | 101,979 | +30,752 | 0.05 | 0.09 | +0.04 | buy |
| Calamos Advisors LLC | 13,376 | 39,301 | +25,925 | 0.00 | 0.01 | +0.01 | buy |
| Patient Square Capital LP | 307,167 | 330,250 | +23,083 | 7.93 | 10.42 | +2.49 | buy |
| CIBC WORLD MARKETS CORP | 16,135 | 38,258 | +22,123 | 0.01 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 699,006 | 679,191 | +19,815 | 0.05 | 0.06 | 0.00 | sell |
| NWAM LLC | 36,096 | 53,789 | +17,693 | 0.15 | 0.35 | +0.20 | buy |
| Allspring Global Investments Holdings, LLC | 423,094 | 438,674 | +15,580 | 0.05 | 0.06 | 0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 31,600 | 16,065 | +15,535 | 0.01 | 0.01 | 0.00 | sell |
| RHUMBLINE ADVISERS | 288,337 | 303,557 | +15,220 | 0.02 | 0.02 | 0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 59,600 | 72,816 | +13,216 | 0.18 | 0.25 | 0.00 | buy |
| ProShare Advisors LLC | 56,991 | 45,489 | +11,502 | 0.01 | 0.01 | 0.00 | sell |
| Orion Porfolio Solutions, LLC | 27,762 | 38,735 | +10,973 | 0.02 | 0.03 | 0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 146,722 | 155,177 | +8,455 | 0.01 | 0.02 | 0.00 | buy |
| Swiss National Bank | 321,100 | 329,300 | +8,200 | 0.02 | 0.02 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 7,371 | 15,230 | +7,859 | 0.34 | 0.90 | +0.56 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 21,084 | 27,789 | +6,705 | 62.80 | 1.49 | -61.31 | buy |
| CenterBook Partners LP | 9,391 | 15,991 | +6,600 | 0.04 | 0.08 | +0.04 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 14,482 | 19,935 | +5,453 | 0.01 | 0.02 | 0.00 | buy |
| Bayforest Capital Ltd | 1,987 | 7,054 | +5,067 | 0.17 | 0.23 | +0.06 | buy |
| JANUS HENDERSON GROUP PLC | 5,404,000 | 5,409,000 | +5,000 | 0.01 | 0.01 | 0.00 | buy |
| Legato Capital Management LLC | 36,871 | 41,857 | +4,986 | 0.33 | 0.43 | +0.10 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 153,343 | 157,698 | +4,355 | 0.01 | 0.02 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 105,313 | 109,489 | +4,176 | 0.02 | 0.02 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 9,205 | 12,084 | +2,879 | 0.00 | 0.00 | 0.00 | buy |
| Parkman Healthcare Partners LLC | 35,668 | 37,901 | +2,233 | 0.33 | 0.34 | +0.02 | buy |
| Candriam S.C.A. | 453,520 | 455,408 | +1,888 | 0.18 | 0.22 | +0.04 | buy |
| Avior Wealth Management, LLC | 2,278 | 4,151 | +1,873 | 0.01 | 0.01 | +0.01 | buy |
| CI INVESTMENTS INC. | 4,396 | 2,836 | +1,560 | 0.00 | 0.00 | 0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 410,577 | 409,114 | +1,463 | 0.03 | 0.03 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 104,800 | 106,074 | +1,274 | 7.28 | 9.38 | +2.11 | buy |
| Corebridge Financial, Inc. | 85,719 | 84,466 | +1,253 | 0.03 | 0.04 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 26,615 | 25,427 | +1,188 | 0.15 | 0.16 | 0.00 | sell |
| COLDSTREAM CAPITAL MANAGEMENT INC | 3,551 | 4,731 | +1,180 | 0.01 | 0.01 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 34,342 | 35,446 | +1,104 | 0.02 | 0.03 | 0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 52,780 | 53,860 | +1,080 | 0.13 | 0.14 | +0.02 | buy |
| Abel Hall, LLC | 3,333 | 4,271 | +938 | 0.15 | 0.20 | +0.05 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 17,875 | 18,804 | +929 | 0.01 | 0.01 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 48,897 | 49,784 | +887 | 0.07 | 0.07 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,756 | 4,581 | +825 | 0.01 | 0.01 | +0.00 | buy |
| STRS OHIO | 24,900 | 25,700 | +800 | 0.01 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 12,858 | 13,643 | +785 | 0.04 | 0.05 | +0.01 | buy |
| EntryPoint Capital, LLC | 3,252 | 3,997 | +745 | 0.09 | 0.14 | +0.05 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 8,781 | 8,280 | +501 | 0.00 | 0.00 | +0.00 | sell |
| Northwest & Ethical Investments L.P. | 1,050 | 1,500 | +450 | 0.00 | 0.00 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 10,556 | 10,135 | +421 | 0.03 | 0.04 | 0.00 | sell |
| INTRUST BANK NA | 5,566 | 5,882 | +316 | 0.04 | 0.04 | +0.01 | buy |
| Simplify Asset Management Inc. | 20,520 | 20,630 | +110 | 0.10 | 0.07 | -0.03 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,476 | 43,574 | +98 | 0.01 | 0.01 | 0.00 | buy |
| COMMERCE BANK | 6,758 | 6,851 | +93 | 0.00 | 0.00 | 0.00 | buy |
| CIBC Asset Management Inc | 4,685 | 4,777 | +92 | 0.00 | 0.00 | 0.00 | buy |
| Values First Advisors, Inc. | 5,199 | 5,237 | +38 | 0.20 | 0.23 | +0.04 | buy |
| Global IMC LLC | 61,489 | 61,508 | +19 | 0.76 | 1.28 | +0.52 | buy |
| MONTAG A & ASSOCIATES INC | 500 | 517 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Principia Wealth Advisory, LLC | 5 | 4 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Financial Advocates Investment Management | 4,846 | 4,836 | -10 | 0.02 | 0.03 | +0.01 | sell |
| MEEDER ASSET MANAGEMENT INC | 62 | 44 | -18 | 0.00 | 0.00 | -0.00 | sell |
| ELEVATION POINT WEALTH PARTNERS, LLC | 3,434 | 3,397 | -37 | 0.02 | 0.02 | +0.00 | sell |
| V-Square Quantitative Management LLC | 659 | 620 | -39 | 0.01 | 0.01 | +0.00 | sell |
| Meeder Advisory Services, Inc. | 3,547 | 3,507 | -40 | 0.02 | 0.02 | +0.00 | sell |
| RWC Asset Management LLP | 3,485 | 3,420 | -65 | 0.01 | 0.01 | +0.00 | sell |
| PITCAIRN CO | 6,020 | 5,935 | -85 | 0.02 | 0.03 | +0.00 | sell |
| Boussard & Gavaudan Investment Management LLP | 25,700 | 25,500 | -200 | 4.65 | 9.47 | +4.82 | sell |