| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 3,286,248 | 6,354,022 | +3,067,774 | 0.02 | 0.04 | +0.02 | buy |
| Darwin Global Management, Ltd. | 12,960,538 | 15,397,975 | +2,437,437 | 84.75 | 82.08 | -2.67 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,647,562 | 3,446,944 | +1,799,382 | 0.20 | 0.49 | +0.29 | buy |
| Holocene Advisors, LP | 687,712 | 2,026,422 | +1,338,710 | 0.15 | 0.46 | +0.30 | buy |
| Duquesne Family Office LLC | 593,470 | 1,369,050 | +775,580 | 1.15 | 3.50 | +2.35 | buy |
| Invesco Ltd. | 1,016,090 | 1,791,324 | +775,234 | 0.01 | 0.03 | +0.01 | buy |
| 1832 Asset Management L.P. | 0 | 487,800 | +487,800 | 0.00 | 0.07 | +0.07 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 752,226 | 1,222,627 | +470,401 | 0.01 | 0.02 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 938,551 | 1,406,609 | +468,058 | 0.28 | 0.52 | +0.24 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 458,000 | +458,000 | 0.00 | 0.69 | +0.69 | buy |
| Paradigm Biocapital Advisors LP | 0 | 451,359 | +451,359 | 0.00 | 1.59 | +1.59 | buy |
| MAVERICK CAPITAL LTD | 0 | 425,125 | +425,125 | 0.00 | 0.58 | +0.58 | buy |
| TimesSquare Capital Management, LLC | 684,384 | 1,064,148 | +379,764 | 0.69 | 1.31 | +0.62 | buy |
| BAKER BROS. ADVISORS LP | 5,006,863 | 5,380,626 | +373,763 | 3.69 | 4.54 | +0.85 | buy |
| PERCEPTIVE ADVISORS LLC | 144,000 | 509,300 | +365,300 | 0.28 | 1.38 | +1.10 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 187,016 | 461,663 | +274,647 | 0.01 | 0.03 | +0.02 | buy |
| Deep Track Capital, LP | 0 | 254,751 | +254,751 | 0.00 | 0.63 | +0.63 | buy |
| BANK OF AMERICA CORP /DE/ | 1,107,666 | 1,352,999 | +245,333 | 0.01 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 1,135,393 | 1,377,726 | +242,333 | 0.67 | 0.97 | +0.31 | buy |
| D. E. Shaw & Co., Inc. | 508,787 | 734,880 | +226,093 | 0.04 | 0.07 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,704,410 | 12,923,541 | +219,131 | 0.10 | 0.12 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,087,143 | 4,288,735 | +201,592 | 0.02 | 0.03 | +0.00 | buy |
| Vestal Point Capital, LP | 900,000 | 1,075,000 | +175,000 | 3.68 | 5.86 | +2.17 | buy |
| NWI MANAGEMENT LP | 279,000 | 450,000 | +171,000 | 1.52 | 4.58 | +3.05 | buy |
| Russell Investments Group, Ltd. | 132,154 | 302,996 | +170,842 | 0.01 | 0.03 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 171,289 | 331,459 | +160,170 | 0.10 | 0.24 | +0.15 | buy |
| Artia Global Partners LP | 167,939 | 318,239 | +150,300 | 4.68 | 7.12 | +2.44 | buy |
| Rhenman & Partners Asset Management AB | 61,500 | 185,500 | +124,000 | 0.44 | 1.63 | +1.19 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 435,006 | 557,587 | +122,581 | 0.29 | 0.47 | +0.18 | buy |
| COMERICA BANK | 170,780 | 290,275 | +119,495 | 0.05 | 0.09 | +0.05 | buy |
| READYSTATE ASSET MANAGEMENT LP | 26,190 | 134,569 | +108,379 | 0.08 | 0.52 | +0.44 | buy |
| Tri Locum Partners LP | 0 | 101,859 | +101,859 | 0.00 | 3.99 | +3.99 | buy |
| AMERIPRISE FINANCIAL INC | 2,850,097 | 2,951,622 | +101,525 | 0.05 | 0.06 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 1,445,696 | 1,545,419 | +99,723 | 0.05 | 0.07 | +0.02 | buy |
| Atika Capital Management LLC | 0 | 96,000 | +96,000 | 0.00 | 1.12 | +1.12 | buy |
| Artisan Partners Limited Partnership | 3,126,339 | 3,217,268 | +90,929 | 0.33 | 0.40 | +0.07 | buy |
| Affinity Asset Advisors, LLC | 50,000 | 140,000 | +90,000 | 0.54 | 1.67 | +1.13 | buy |
| ExodusPoint Capital Management, LP | 0 | 87,783 | +87,783 | 0.00 | 0.09 | +0.09 | buy |
| Woodline Partners LP | 162,230 | 248,770 | +86,540 | 0.08 | 0.12 | +0.05 | buy |
| Capital International Investors | 7,116,997 | 7,198,485 | +81,488 | 0.09 | 0.11 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,100,993 | 1,181,675 | +80,682 | 1.38 | 1.80 | +0.41 | buy |
| UBS Group AG | 405,725 | 477,636 | +71,911 | 0.01 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 256,358 | 325,307 | +68,949 | 0.01 | 0.01 | +0.00 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 638,848 | 704,366 | +65,518 | 1.48 | 2.58 | +1.10 | buy |
| ROYAL BANK OF CANADA | 184,072 | 245,262 | +61,190 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 529,049 | 589,399 | +60,350 | 0.06 | 0.09 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,363,561 | 2,423,513 | +59,952 | 0.06 | 0.07 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 812,780 | 872,123 | +59,343 | 0.03 | 0.04 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,546,607 | 1,602,655 | +56,048 | 0.02 | 0.02 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,959,718 | 2,013,329 | +53,611 | 0.15 | 0.17 | +0.02 | buy |
| MOODY ALDRICH PARTNERS LLC | 35,478 | 89,020 | +53,542 | 0.45 | 1.42 | +0.97 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 486,847 | 539,484 | +52,637 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 323,735 | 374,815 | +51,080 | 0.02 | 0.03 | +0.01 | buy |
| VANGUARD GROUP INC | 18,218,973 | 18,268,122 | +49,149 | 0.02 | 0.03 | +0.00 | buy |
| MACQUARIE GROUP LTD | 2,313,159 | 2,362,105 | +48,946 | 0.19 | 0.22 | +0.03 | buy |
| Sofinnova Investments, Inc. | 256,281 | 304,254 | +47,973 | 1.30 | 1.75 | +0.45 | buy |
| Aberdeen Group plc | 289,653 | 336,357 | +46,704 | 0.04 | 0.05 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 363,446 | 408,937 | +45,491 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 160,709 | 205,511 | +44,802 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 182,743 | 223,931 | +41,188 | 1.11 | 1.76 | +0.65 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 317,753 | 355,722 | +37,969 | 0.03 | 0.04 | +0.01 | buy |
| LMR Partners LLP | 0 | 36,928 | +36,928 | 0.00 | 0.06 | +0.06 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 548,867 | 585,428 | +36,561 | 0.04 | 0.05 | +0.01 | buy |
| Walleye Capital LLC | 0 | 34,478 | +34,478 | 0.00 | 0.03 | +0.03 | buy |
| SEI INVESTMENTS CO | 362,616 | 395,979 | +33,363 | 0.03 | 0.04 | +0.01 | buy |
| Hood River Capital Management LLC | 1,525,628 | 1,558,286 | +32,658 | 1.56 | 2.03 | +0.47 | buy |
| SEGALL BRYANT & HAMILL, LLC | 139,045 | 170,859 | +31,814 | 0.13 | 0.20 | +0.07 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 71,227 | 101,979 | +30,752 | 0.05 | 0.08 | +0.03 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 98,460 | 129,187 | +30,727 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 247,443 | 277,549 | +30,106 | 0.02 | 0.02 | -0.00 | buy |
| Neuberger Berman Group LLC | 149,241 | 176,633 | +27,392 | 0.01 | 0.01 | +0.00 | buy |
| Calamos Advisors LLC | 13,376 | 39,301 | +25,925 | 0.00 | 0.01 | +0.01 | buy |
| Patient Square Capital LP | 307,167 | 330,250 | +23,083 | 7.93 | 10.42 | +2.49 | buy |
| CIBC WORLD MARKETS CORP | 16,135 | 38,258 | +22,123 | 0.01 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 21,250 | +21,250 | 0.00 | 0.08 | +0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 350,939 | 372,000 | +21,061 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 32,757 | 51,213 | +18,456 | 0.00 | 0.00 | +0.00 | buy |
| NWAM LLC | 36,096 | 53,789 | +17,693 | 0.15 | 0.35 | +0.20 | buy |
| BlackRock, Inc. | 16,032,944 | 16,048,882 | +15,938 | 0.02 | 0.03 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 423,094 | 438,674 | +15,580 | 0.05 | 0.05 | +0.01 | buy |
| RHUMBLINE ADVISERS | 288,337 | 303,557 | +15,220 | 0.02 | 0.02 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 15,143 | +15,143 | 0.00 | 0.01 | +0.01 | buy |
| TRUIST FINANCIAL CORP | 30,038 | 45,074 | +15,036 | 0.00 | 0.01 | +0.00 | buy |
| Creative Planning | 56,710 | 71,744 | +15,034 | 0.00 | 0.01 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 59,600 | 72,816 | +13,216 | 0.18 | 0.25 | +0.07 | buy |
| Cerity Partners LLC | 18,258 | 31,438 | +13,180 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 12,775 | +12,775 | 0.00 | 0.01 | +0.01 | buy |
| SIH Partners, LLLP | 0 | 11,415 | +11,415 | 0.00 | 0.08 | +0.08 | buy |
| Orion Porfolio Solutions, LLC | 27,762 | 38,735 | +10,973 | 0.02 | 0.03 | +0.01 | buy |
| Cetera Investment Advisers | 10,154 | 20,679 | +10,525 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 662,997 | 672,450 | +9,453 | 0.06 | 0.07 | +0.02 | buy |
| Aster Capital Management (DIFC) Ltd | 20 | 9,271 | +9,251 | 0.00 | 0.14 | +0.14 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 256,355 | 265,477 | +9,122 | 0.01 | 0.01 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 21,325 | 29,862 | +8,537 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 146,722 | 155,177 | +8,455 | 0.01 | 0.02 | +0.00 | buy |
| Pathstone Holdings, LLC | 37,145 | 45,533 | +8,388 | 0.01 | 0.02 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 26,880 | 35,237 | +8,357 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 22,955 | 31,209 | +8,254 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 321,100 | 329,300 | +8,200 | 0.01 | 0.02 | +0.00 | buy |
| MYDA Advisors LLC | 0 | 8,000 | +8,000 | 0.00 | 0.22 | +0.22 | buy |