| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 23,199,512 | 24,150,499 | +950,987 | 0.27 | 0.25 | -0.02 | buy |
| Darwin Global Management, Ltd. | 20,933,277 | 16,805,184 | -4,128,093 | 73.78 | 68.33 | -5.45 | sell |
| BlackRock, Inc. | 15,065,052 | 16,678,146 | +1,613,094 | 0.04 | 0.05 | +0.00 | buy |
| FMR LLC | 9,927,936 | 13,160,167 | +3,232,231 | 0.09 | 0.11 | +0.03 | buy |
| BAKER BROS. ADVISORS LP | 6,592,746 | 7,421,111 | +828,365 | 6.72 | 6.97 | +0.25 | buy |
| Artisan Partners Limited Partnership | 4,843,749 | 6,527,301 | +1,683,552 | 1.29 | 1.74 | +0.45 | buy |
| D. E. Shaw & Co., Inc. | 4,350,995 | 5,625,825 | +1,274,830 | 0.58 | 0.72 | +0.15 | buy |
| Capital International Investors | 5,151,671 | 5,595,194 | +443,523 | 0.14 | 0.21 | +0.07 | buy |
| STATE STREET CORP | 5,201,744 | 5,551,699 | +349,955 | 0.03 | 0.03 | +0.00 | buy |
| RTW INVESTMENTS, LP | 4,842,879 | 4,842,880 | +1 | 8.44 | 7.88 | -0.56 | buy |
| Invesco Ltd. | 4,791,481 | 4,523,921 | -267,560 | 0.10 | 0.09 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 4,299,052 | 4,450,389 | +151,337 | 0.05 | 0.05 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,039,466 | 3,092,807 | -946,659 | 0.08 | 0.06 | -0.02 | sell |
| AMERIPRISE FINANCIAL INC | 1,968,857 | 3,057,718 | +1,088,861 | 0.08 | 0.12 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 2,755,536 | 2,617,251 | -138,285 | 0.12 | 0.10 | -0.01 | sell |
| CITADEL ADVISORS LLC | 1,157,295 | 2,182,571 | +1,025,276 | 0.14 | 0.25 | +0.12 | buy |
| Orbis Allan Gray Ltd | 4,179,957 | 1,872,824 | -2,307,133 | 3.05 | 1.29 | -1.76 | sell |
| UBS Group AG | 1,867,635 | 1,737,481 | -130,154 | 0.06 | 0.05 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 1,725,681 | 1,502,281 | -223,400 | 0.02 | 0.02 | -0.00 | sell |
| Integral Health Asset Management, LLC | 1,250,000 | 1,500,000 | +250,000 | 11.03 | 12.98 | +1.95 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 432,521 | 1,468,459 | +1,035,938 | 0.31 | 1.01 | +0.69 | buy |
| SEI INVESTMENTS CO | 890,170 | 1,395,794 | +505,624 | 0.15 | 0.21 | +0.06 | buy |
| Capital World Investors | 0 | 1,362,291 | +1,362,291 | 0.00 | 0.03 | +0.03 | buy |
| MORGAN STANLEY | 1,631,906 | 1,331,542 | -300,364 | 0.02 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,238,438 | 1,294,000 | +55,562 | 0.03 | 0.03 | +0.00 | buy |
| Castle Hook Partners LP | 1,253,568 | 1,269,754 | +16,186 | 3.14 | 4.20 | +1.06 | buy |
| Bank of New York Mellon Corp | 1,390,042 | 1,262,749 | -127,293 | 0.04 | 0.04 | -0.00 | sell |
| Paradigm Biocapital Advisors LP | 0 | 1,254,488 | +1,254,488 | 0.00 | 4.19 | +4.19 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 943,306 | 1,215,025 | +271,719 | 0.03 | 0.04 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,311,654 | 1,157,786 | -153,868 | 0.16 | 0.14 | -0.02 | sell |
| Duquesne Family Office LLC | 1,481,752 | 1,154,090 | -327,662 | 6.11 | 6.43 | +0.31 | sell |
| Pictet Asset Management Holding SA | 958,963 | 1,102,248 | +143,285 | 0.16 | 0.19 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,027,355 | 1,069,390 | +42,035 | 0.03 | 0.03 | -0.00 | buy |
| Fiera Capital Corp | 992,892 | 1,021,970 | +29,078 | 0.55 | 0.57 | +0.02 | buy |
| NWI MANAGEMENT LP | 988,460 | 1,014,000 | +25,540 | 10.51 | 10.14 | -0.37 | buy |
| GOLDMAN SACHS GROUP INC | 1,244,913 | 942,646 | -302,267 | 0.03 | 0.02 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 185,090 | 925,799 | +740,709 | 0.02 | 0.08 | +0.06 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 771,358 | 916,464 | +145,106 | 0.07 | 0.08 | +0.01 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,221,096 | 902,666 | -318,430 | 0.59 | 0.49 | -0.10 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 900,000 | +600,000 | 0.08 | 0.23 | +0.15 | buy |
| FIL Ltd | 838,509 | 828,947 | -9,562 | 0.11 | 0.11 | -0.00 | sell |
| Amundi | 916,998 | 804,977 | -112,021 | 0.04 | 0.04 | -0.01 | sell |
| Legal & General Group Plc | 540,313 | 787,079 | +246,766 | 0.02 | 0.03 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 779,254 | 775,148 | -4,106 | 0.04 | 0.04 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 642,719 | 688,734 | +46,015 | 0.04 | 0.04 | +0.00 | buy |
| Hood River Capital Management LLC | 637,577 | 688,554 | +50,977 | 1.22 | 1.13 | -0.09 | buy |
| AQR CAPITAL MANAGEMENT LLC | 468,260 | 675,485 | +207,225 | 0.04 | 0.05 | +0.01 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 909,080 | 653,445 | -255,635 | 4.45 | 4.94 | +0.49 | sell |
| Clearbridge Investments, LLC | 819,011 | 643,435 | -175,576 | 0.11 | 0.09 | -0.02 | sell |
| Artia Global Partners LP | 682,212 | 628,712 | -53,500 | 19.08 | 23.18 | +4.10 | sell |
| Swiss National Bank | 579,112 | 625,912 | +46,800 | 0.06 | 0.06 | -0.00 | buy |
| GW&K Investment Management, LLC | 482,670 | 623,048 | +140,378 | 0.73 | 0.90 | +0.17 | buy |
| JENNISON ASSOCIATES LLC | 562,296 | 604,694 | +42,398 | 0.06 | 0.07 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 915,419 | 604,600 | -310,819 | 0.10 | 0.07 | -0.04 | sell |
| WELLS FARGO & COMPANY/MN | 586,651 | 597,384 | +10,733 | 0.02 | 0.02 | -0.00 | buy |
| TimesSquare Capital Management, LLC | 490,506 | 584,798 | +94,292 | 1.29 | 1.62 | +0.34 | buy |
| DEUTSCHE BANK AG\ | 590,030 | 562,474 | -27,556 | 0.03 | 0.03 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 483,589 | 546,310 | +62,721 | 1.31 | 1.48 | +0.16 | buy |
| FEDERATED HERMES, INC. | 632,298 | 538,257 | -94,041 | 0.18 | 0.14 | -0.04 | sell |
| Nuveen, LLC | 650,404 | 534,750 | -115,654 | 0.03 | 0.02 | -0.01 | sell |
| ROYAL BANK OF CANADA | 506,811 | 523,101 | +16,290 | 0.02 | 0.02 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 435,442 | 501,282 | +65,840 | 0.04 | 0.05 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 382,202 | 499,756 | +117,554 | 0.12 | 0.15 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 450,000 | 480,000 | +30,000 | 5.63 | 4.60 | -1.02 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 284,844 | 469,561 | +184,717 | 0.53 | 0.79 | +0.26 | buy |
| BNP Paribas Asset Management Holding S.A. | 328,328 | 467,753 | +139,425 | 0.07 | 0.09 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 800,555 | 419,304 | -381,251 | 0.06 | 0.03 | -0.03 | sell |
| SAMLYN CAPITAL, LLC | 369,575 | 417,205 | +47,630 | 1.03 | 1.17 | +0.15 | buy |
| Palo Alto Investors LP | 489,482 | 415,269 | -74,213 | 11.86 | 10.39 | -1.47 | sell |
| Candriam S.C.A. | 401,042 | 401,735 | +693 | 0.35 | 0.34 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 399,073 | 400,900 | +1,827 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 486,138 | 399,044 | -87,094 | 0.01 | 0.01 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 720,898 | 397,261 | -323,637 | 0.38 | 0.21 | -0.17 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 646,714 | 396,245 | -250,469 | 0.06 | 0.04 | -0.02 | sell |
| Polar Capital Holdings Plc | 344,228 | 368,107 | +23,879 | 0.27 | 0.26 | -0.01 | buy |
| GATEWAY INVESTMENT ADVISERS LLC | 365,000 | 365,000 | 0 | 0.59 | 0.67 | +0.07 | hold |
| Sofinnova Investments, Inc. | 156,801 | 346,075 | +189,274 | 1.18 | 2.84 | +1.66 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 354,909 | 344,612 | -10,297 | 0.04 | 0.03 | -0.00 | sell |
| Rock Springs Capital Management LP | 319,250 | 314,300 | -4,950 | 2.85 | 3.03 | +0.18 | sell |
| MARSHALL WACE, LLP | 389,881 | 312,565 | -77,316 | 0.07 | 0.05 | -0.01 | sell |
| National Pension Service | 280,442 | 311,881 | +31,439 | 0.04 | 0.04 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 310,330 | 303,182 | -7,148 | 0.05 | 0.05 | -0.00 | sell |
| Nearwater Capital Markets, Ltd | 500,000 | 300,000 | -200,000 | 1.49 | 1.16 | -0.33 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 276,105 | 299,925 | +23,820 | 0.01 | 0.01 | -0.00 | buy |
| Bridgewater Associates, LP | 0 | 295,579 | +295,579 | 0.00 | 0.22 | +0.22 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 276,284 | 293,546 | +17,262 | 0.06 | 0.07 | +0.00 | buy |
| ProShare Advisors LLC | 340,740 | 283,141 | -57,599 | 0.10 | 0.07 | -0.04 | sell |
| Allspring Global Investments Holdings, LLC | 220,084 | 282,734 | +62,650 | 0.06 | 0.08 | +0.01 | buy |
| Aberdeen Group plc | 253,112 | 277,016 | +23,904 | 0.07 | 0.07 | +0.00 | buy |
| BARCLAYS PLC | 444,706 | 275,731 | -168,975 | 0.03 | 0.02 | -0.01 | sell |
| RHUMBLINE ADVISERS | 268,326 | 272,615 | +4,289 | 0.04 | 0.04 | +0.00 | buy |
| Neuberger Berman Group LLC | 207,869 | 270,700 | +62,831 | 0.03 | 0.03 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 60,000 | 260,000 | +200,000 | 0.52 | 2.16 | +1.64 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 222,266 | 255,247 | +32,981 | 0.03 | 0.03 | +0.00 | buy |
| First Turn Management, LLC | 264,293 | 248,475 | -15,818 | 5.26 | 4.54 | -0.72 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 200,964 | 243,706 | +42,742 | 0.03 | 0.04 | +0.01 | buy |
| AXIOM INVESTORS LLC /DE | 255,849 | 239,447 | -16,402 | 0.39 | 0.44 | +0.04 | sell |
| TWO SIGMA INVESTMENTS, LP | 962,156 | 237,017 | -725,139 | 0.25 | 0.03 | -0.22 | sell |
| CITIGROUP INC | 237,914 | 233,304 | -4,610 | 0.03 | 0.02 | -0.00 | sell |
| Evergreen Quality Fund GP, Ltd. | 120,500 | 232,500 | +112,000 | 0.41 | 0.87 | +0.46 | buy |