| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital International Investors | 1,620,814 | 5,869,888 | +4,249,074 | 0.01 | 0.08 | +0.07 | buy |
| BAKER BROS. ADVISORS LP | 343,000 | 3,576,038 | +3,233,038 | 0.12 | 3.06 | +2.95 | buy |
| RTW INVESTMENTS, LP | 1,865,108 | 3,640,108 | +1,775,000 | 0.75 | 3.78 | +3.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,769,366 | 12,163,368 | +1,394,002 | 0.04 | 0.10 | +0.06 | buy |
| JANUS HENDERSON GROUP PLC | 30,615,000 | 29,535,000 | +1,080,000 | 0.02 | 0.03 | 0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 250,000 | 1,325,000 | +1,075,000 | 0.01 | 0.16 | +0.15 | buy |
| FIL Ltd | 720,245 | 1,518,114 | +797,869 | 0.02 | 0.10 | +0.08 | buy |
| Clearbridge Investments, LLC | 930,409 | 1,644,948 | +714,539 | 0.02 | 0.09 | +0.07 | buy |
| JENNISON ASSOCIATES LLC | 118,512 | 744,280 | +625,768 | 0.00 | 0.03 | +0.03 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,023,000 | 2,521,800 | +498,800 | 2.04 | 6.21 | +4.17 | buy |
| Hood River Capital Management LLC | 962,501 | 1,315,392 | +352,891 | 0.58 | 1.83 | +1.24 | buy |
| TWO SIGMA INVESTMENTS, LP | 460,173 | 107,744 | +352,429 | 0.03 | 0.02 | 0.00 | sell |
| LORD, ABBETT & CO. LLC | 8,216,000 | 8,553,000 | +337,000 | 0.03 | 0.06 | +0.03 | buy |
| Long Focus Capital Management, LLC | 431,649 | 740,900 | +309,251 | 0.60 | 1.90 | +1.30 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 450,394 | 160,747 | +289,647 | 0.03 | 0.03 | 0.00 | sell |
| First Light Asset Management, LLC | 282,766 | 551,303 | +268,537 | 0.59 | 3.24 | +2.65 | buy |
| Integral Health Asset Management, LLC | 1,300,000 | 1,550,000 | +250,000 | 3.46 | 10.34 | +6.87 | buy |
| Alyeska Investment Group, L.P. | 200,000 | 428,804 | +228,804 | 0.03 | 0.16 | +0.13 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,439,280 | 1,657,760 | +218,480 | 0.02 | 0.07 | 0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 455,000 | 625,000 | +170,000 | 1.63 | 6.47 | +4.83 | buy |
| Candriam S.C.A. | 390,200 | 555,934 | +165,734 | 0.07 | 0.23 | +0.16 | buy |
| Granahan Investment Management, LLC | 133,755 | 259,275 | +125,520 | 0.13 | 0.69 | +0.57 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 166,409 | 270,960 | +104,551 | 0.21 | 0.42 | +0.21 | buy |
| Cormorant Asset Management, LP | 575,000 | 675,000 | +100,000 | 0.68 | 2.61 | +1.93 | buy |
| TD ASSET MANAGEMENT INC | 427,178 | 525,682 | +98,504 | 0.01 | 0.03 | +0.02 | buy |
| Cinctive Capital Management LP | 60,263 | 145,557 | +85,294 | 0.08 | 0.52 | +0.44 | buy |
| MPM BioImpact LLC | 530,794 | 615,391 | +84,597 | 2.32 | 6.41 | +4.09 | buy |
| Altium Capital Management LLC | 120,000 | 190,000 | +70,000 | 1.45 | 5.26 | +3.80 | buy |
| AXIOM INVESTORS LLC /DE | 64,051 | 125,598 | +61,547 | 0.02 | 0.07 | +0.06 | buy |
| AMERICAN CENTURY COMPANIES INC | 702,624 | 755,271 | +52,647 | 0.01 | 0.03 | +0.02 | buy |
| ALGERT GLOBAL LLC | 111,560 | 161,375 | +49,815 | 0.12 | 0.37 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 82,083 | 41,908 | +40,175 | 0.01 | 0.01 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 635,185 | 675,185 | +40,000 | 0.27 | 0.77 | +0.50 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 53,507 | 14,169 | +39,338 | 0.11 | 0.06 | 0.00 | sell |
| NATIXIS | 7,040 | 37,500 | +30,460 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 52,943 | 23,020 | +29,923 | 0.06 | 0.06 | 0.00 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 747,331 | 774,404 | +27,073 | 0.19 | 0.51 | +0.32 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 113,616 | 140,000 | +26,384 | 0.86 | 2.32 | +1.45 | buy |
| Calamos Advisors LLC | 10,737 | 25,229 | +14,492 | 0.00 | 0.01 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 61,718 | 72,100 | +10,382 | 1.09 | 4.07 | +2.98 | buy |
| EMERALD ADVISERS, LLC | 630,179 | 640,267 | +10,088 | 0.69 | 1.80 | +1.11 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 484,714 | 493,849 | +9,135 | 0.68 | 1.73 | +1.05 | buy |
| ProShare Advisors LLC | 35,241 | 30,140 | +5,101 | 0.00 | 0.01 | 0.00 | sell |
| AlphaQuest LLC | 5,434 | 1,228 | +4,206 | 0.03 | 0.01 | 0.00 | sell |
| Polar Capital Holdings Plc | 251,700 | 255,000 | +3,300 | 0.04 | 0.10 | +0.06 | buy |
| Quarry LP | 4,900 | 2,400 | +2,500 | 0.06 | 0.07 | 0.00 | sell |
| Ameritas Investment Partners, Inc. | 13,786 | 15,218 | +1,432 | 0.01 | 0.04 | +0.02 | buy |
| Beacon Financial Advisory LLC | 13,220 | 13,825 | +605 | 0.17 | 0.35 | +0.17 | buy |
| Cutter Capital Management, LP | 227,337 | 227,637 | +300 | 2.38 | 4.65 | +2.27 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 9,859 | 10,097 | +238 | 0.01 | 0.01 | +0.01 | buy |
| BELLEVUE ASSET MANAGEMENT, LLC | 81 | 57 | -24 | 0.00 | 0.00 | +0.00 | sell |
| Washington Trust Advisors, Inc. | 211 | 149 | -62 | 0.00 | 0.00 | +0.00 | sell |
| Park Place Capital Corp | 115 | 23 | -92 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 1,206 | 1,004 | -202 | 0.03 | 0.10 | +0.07 | sell |
| Dana Investment Advisors, Inc. | 23,690 | 22,976 | -714 | 0.02 | 0.05 | +0.03 | sell |
| Stonegate Investment Group, LLC | 13,000 | 12,000 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| Fox Hill Wealth Management | 136,000 | 134,000 | -2,000 | 0.10 | 0.17 | +0.08 | sell |
| Ikarian Capital, LLC | 51,335 | 47,835 | -3,500 | 0.38 | 1.00 | +0.62 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 17,304 | 12,700 | -4,604 | 0.03 | 0.07 | +0.04 | sell |
| Legato Capital Management LLC | 50,258 | 45,067 | -5,191 | 0.16 | 0.41 | +0.24 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 108,629 | 103,184 | -5,445 | 0.58 | 1.29 | +0.71 | sell |
| Compound Planning, Inc. | 29,264 | 22,934 | -6,330 | 0.07 | 0.11 | +0.04 | sell |
| SECTORAL ASSET MANAGEMENT INC | 16,421 | 9,821 | -6,600 | 0.18 | 0.27 | +0.09 | sell |
| VIRTUS ADVISERS, LLC | 13,193 | 5,344 | -7,849 | 0.19 | 0.18 | -0.01 | sell |
| E Fund Management Co., Ltd. | 15,577 | 6,815 | -8,762 | 0.03 | 0.03 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 28,569 | 18,942 | -9,627 | 0.10 | 0.18 | +0.08 | sell |
| Susquehanna Portfolio Strategies, LLC | 21,419 | 11,319 | -10,100 | 0.01 | 0.03 | +0.02 | sell |
| Parkman Healthcare Partners LLC | 93,032 | 80,271 | -12,761 | 0.31 | 0.73 | +0.42 | sell |
| Belvedere Trading LLC | 17,568 | 4,624 | -12,944 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 71,700 | 56,800 | -14,900 | 1.67 | 3.39 | +1.72 | sell |
| WINTON GROUP Ltd | 29,794 | 12,884 | -16,910 | 0.06 | 0.06 | +0.00 | sell |
| EFG Asset Management (North America) Corp. | 72,538 | 53,898 | -18,640 | 0.34 | 0.63 | +0.29 | sell |
| Aberdeen Group plc | 133,499 | 111,612 | -21,887 | 0.01 | 0.01 | +0.01 | sell |
| OAK RIDGE INVESTMENTS LLC | 84,181 | 60,851 | -23,330 | 0.23 | 0.39 | +0.16 | sell |
| Hennion & Walsh Asset Management, Inc. | 146,912 | 114,651 | -32,261 | 0.21 | 0.39 | +0.18 | sell |
| Polar Asset Management Partners Inc. | 65,800 | 18,100 | -47,700 | 0.03 | 0.03 | -0.01 | sell |
| Artia Global Partners LP | 118,236 | 53,436 | -64,800 | 0.79 | 0.92 | +0.13 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 179,332 | 96,824 | -82,508 | 0.28 | 0.39 | +0.11 | sell |
| Knights of Columbus Asset Advisors LLC | 117,174 | 33,626 | -83,548 | 0.23 | 0.15 | -0.08 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 290,174 | 179,932 | -110,242 | 0.23 | 0.35 | +0.13 | sell |
| Ally Bridge Group (NY) LLC | 250,000 | 129,000 | -121,000 | 3.77 | 5.15 | +1.38 | sell |
| Soleus Capital Management, L.P. | 250,000 | 102,472 | -147,528 | 0.60 | 0.61 | +0.01 | sell |
| Hudson Bay Capital Management LP | 626,810 | 467,500 | -159,310 | 0.09 | 0.15 | +0.05 | sell |
| STEMPOINT CAPITAL LP | 272,448 | 86,980 | -185,468 | 1.97 | 1.71 | -0.26 | sell |
| AMERIPRISE FINANCIAL INC | 2,735,338 | 2,530,994 | -204,344 | 0.02 | 0.05 | +0.03 | sell |
| Rafferty Asset Management, LLC | 329,635 | 112,214 | -217,421 | 0.03 | 0.03 | -0.01 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 320,001 | 93,524 | -226,477 | 0.02 | 0.01 | -0.01 | sell |
| SAMLYN CAPITAL, LLC | 587,634 | 359,254 | -228,380 | 0.27 | 0.40 | +0.13 | sell |
| LOOMIS SAYLES & CO L P | 1,491,794 | 1,226,726 | -265,068 | 0.06 | 0.11 | +0.06 | sell |
| BNP Paribas Asset Management Holding S.A. | 972,313 | 654,348 | -317,965 | 0.07 | 0.11 | +0.04 | sell |
| Octagon Capital Advisors LP | 1,140,000 | 650,216 | -489,784 | 3.76 | 7.19 | +3.43 | sell |
| GW&K Investment Management, LLC | 1,269,898 | 761,732 | -508,166 | 0.30 | 0.47 | +0.16 | sell |
| GREAT POINT PARTNERS LLC | 775,585 | 250,000 | -525,585 | 3.28 | 3.21 | -0.07 | sell |
| Novo Holdings A/S | 1,339,304 | 800,000 | -539,304 | 2.51 | 2.89 | +0.38 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 4,214,719 | 3,469,728 | -744,991 | 0.30 | 0.61 | +0.31 | sell |
| T. Rowe Price Investment Management, Inc. | 3,451,580 | 2,435,962 | -1,015,618 | 0.06 | 0.10 | +0.05 | sell |
| Bellevue Group AG | 2,141,843 | 1,021,700 | -1,120,143 | 0.89 | 1.11 | +0.23 | sell |
| Palo Alto Investors LP | 4,423,369 | 2,138,963 | -2,284,406 | 13.53 | 16.61 | +3.07 | sell |
| Deep Track Capital, LP | 4,783,679 | 2,000,000 | -2,783,679 | 3.73 | 4.00 | +0.27 | sell |