| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital International Investors | 1,620,814 | 5,869,888 | +4,249,074 | 0.01 | 0.08 | +0.07 | buy |
| Darwin Global Management, Ltd. | 0 | 3,541,095 | +3,541,095 | 0.00 | 27.58 | +27.58 | buy |
| BAKER BROS. ADVISORS LP | 343,000 | 3,576,038 | +3,233,038 | 0.12 | 3.06 | +2.95 | buy |
| JPMORGAN CHASE & CO | 289,531 | 2,926,185 | +2,636,654 | 0.00 | 0.02 | +0.02 | buy |
| Artisan Partners Limited Partnership | 0 | 2,489,431 | +2,489,431 | 0.00 | 0.25 | +0.25 | buy |
| RTW INVESTMENTS, LP | 1,865,108 | 3,640,108 | +1,775,000 | 0.75 | 3.78 | +3.03 | buy |
| VANGUARD GROUP INC | 14,509,235 | 16,013,010 | +1,503,775 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,769,366 | 12,163,368 | +1,394,002 | 0.04 | 0.10 | +0.06 | buy |
| Eversept Partners, LP | 0 | 1,155,588 | +1,155,588 | 0.00 | 5.93 | +5.93 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 250,000 | 1,325,000 | +1,075,000 | 0.01 | 0.16 | +0.15 | buy |
| VIKING GLOBAL INVESTORS LP | 0 | 1,035,970 | +1,035,970 | 0.00 | 0.27 | +0.27 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 938,434 | +938,434 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 276,618 | 1,198,510 | +921,892 | 0.01 | 0.07 | +0.06 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 55,726 | 922,002 | +866,276 | 0.01 | 0.23 | +0.22 | buy |
| Point72 Asset Management, L.P. | 0 | 858,300 | +858,300 | 0.00 | 0.19 | +0.19 | buy |
| Rock Springs Capital Management LP | 0 | 808,356 | +808,356 | 0.00 | 1.63 | +1.63 | buy |
| FIL Ltd | 720,245 | 1,518,114 | +797,869 | 0.02 | 0.10 | +0.08 | buy |
| Clearbridge Investments, LLC | 930,409 | 1,644,948 | +714,539 | 0.02 | 0.09 | +0.07 | buy |
| JENNISON ASSOCIATES LLC | 118,512 | 744,280 | +625,768 | 0.00 | 0.03 | +0.03 | buy |
| Fiera Capital Corp | 0 | 605,527 | +605,527 | 0.00 | 0.13 | +0.13 | buy |
| Invesco Ltd. | 167,563 | 756,241 | +588,678 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 0 | 582,577 | +582,577 | 0.00 | 0.13 | +0.13 | buy |
| JANE STREET GROUP, LLC | 270,973 | 840,000 | +569,027 | 0.01 | 0.06 | +0.05 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 568,000 | +568,000 | 0.00 | 0.22 | +0.22 | buy |
| Eagle Health Investments LP | 0 | 513,700 | +513,700 | 0.00 | 6.15 | +6.15 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,023,000 | 2,521,800 | +498,800 | 2.32 | 6.90 | +4.58 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 498,572 | +498,572 | 0.00 | 0.16 | +0.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,163,751 | 3,640,720 | +476,969 | 0.01 | 0.02 | +0.01 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 470,700 | +470,700 | 0.00 | 0.71 | +0.71 | buy |
| GOLDMAN SACHS GROUP INC | 753,610 | 1,189,901 | +436,291 | 0.00 | 0.02 | +0.01 | buy |
| Avidity Partners Management LP | 0 | 430,000 | +430,000 | 0.00 | 1.22 | +1.22 | buy |
| Iron Triangle Partners LP | 0 | 413,196 | +413,196 | 0.00 | 2.90 | +2.90 | buy |
| Hood River Capital Management LLC | 962,501 | 1,315,392 | +352,891 | 0.58 | 1.83 | +1.24 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,146,479 | 2,492,275 | +345,796 | 0.02 | 0.06 | +0.04 | buy |
| LORD, ABBETT & CO. LLC | 8,216,000 | 8,553,000 | +337,000 | 0.03 | 0.06 | +0.03 | buy |
| Allspring Global Investments Holdings, LLC | 4,301 | 328,073 | +323,772 | 0.00 | 0.04 | +0.04 | buy |
| First Turn Management, LLC | 0 | 323,360 | +323,360 | 0.00 | 3.52 | +3.52 | buy |
| Tri Locum Partners LP | 0 | 316,501 | +316,501 | 0.00 | 5.36 | +5.36 | buy |
| Long Focus Capital Management, LLC | 431,649 | 740,900 | +309,251 | 1.35 | 5.13 | +3.78 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 472,006 | 743,725 | +271,719 | 0.01 | 0.05 | +0.04 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 271,535 | +271,535 | 0.00 | 0.84 | +0.84 | buy |
| First Light Asset Management, LLC | 282,766 | 551,303 | +268,537 | 0.59 | 3.24 | +2.65 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 55,209 | 322,299 | +267,090 | 0.00 | 0.03 | +0.03 | buy |
| Integral Health Asset Management, LLC | 1,300,000 | 1,550,000 | +250,000 | 3.46 | 10.34 | +6.87 | buy |
| PFM Health Sciences, LP | 0 | 241,315 | +241,315 | 0.00 | 0.88 | +0.88 | buy |
| Alyeska Investment Group, L.P. | 200,000 | 428,804 | +228,804 | 0.03 | 0.17 | +0.13 | buy |
| Sofinnova Investments, Inc. | 0 | 227,747 | +227,747 | 0.00 | 0.96 | +0.96 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,439,280 | 1,657,760 | +218,480 | 0.02 | 0.07 | +0.04 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 200,000 | +200,000 | 0.00 | 0.18 | +0.18 | buy |
| SEI INVESTMENTS CO | 81,073 | 277,712 | +196,639 | 0.00 | 0.03 | +0.02 | buy |
| Parallax Volatility Advisers, L.P. | 32 | 183,005 | +182,973 | 0.00 | 0.31 | +0.31 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 180,000 | +180,000 | 0.00 | 0.29 | +0.29 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,126,767 | 1,306,596 | +179,829 | 0.01 | 0.02 | +0.01 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 455,000 | 625,000 | +170,000 | 1.63 | 6.47 | +4.83 | buy |
| NORGES BANK | 1,588,541 | 1,757,425 | +168,884 | 0.01 | 0.02 | +0.01 | buy |
| Candriam S.C.A. | 390,200 | 555,934 | +165,734 | 0.07 | 0.23 | +0.16 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 40,100 | 196,917 | +156,817 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 155,155 | +155,155 | 0.00 | 0.10 | +0.10 | buy |
| ROYAL BANK OF CANADA | 37,448 | 189,076 | +151,628 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 146,676 | +146,676 | 0.00 | 0.17 | +0.17 | buy |
| WELLS FARGO & COMPANY/MN | 71,453 | 209,130 | +137,677 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 19,042 | 147,140 | +128,098 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 133,755 | 259,275 | +125,520 | 0.13 | 0.69 | +0.57 | buy |
| Affinity Asset Advisors, LLC | 0 | 125,000 | +125,000 | 0.00 | 1.32 | +1.32 | buy |
| BANK OF AMERICA CORP /DE/ | 996,128 | 1,119,208 | +123,080 | 0.00 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 56,250 | 175,464 | +119,214 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 174,022 | 288,551 | +114,529 | 0.01 | 0.03 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 107,781 | +107,781 | 0.00 | 1.17 | +1.17 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 166,409 | 270,960 | +104,551 | 0.21 | 0.42 | +0.21 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 104,041 | +104,041 | 0.00 | 0.07 | +0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.68 | +0.68 | buy |
| Cormorant Asset Management, LP | 575,000 | 675,000 | +100,000 | 0.69 | 2.63 | +1.94 | buy |
| Rhenman & Partners Asset Management AB | 0 | 99,513 | +99,513 | 0.00 | 0.64 | +0.64 | buy |
| TD ASSET MANAGEMENT INC | 427,178 | 525,682 | +98,504 | 0.01 | 0.03 | +0.02 | buy |
| ROYCE & ASSOCIATES LP | 0 | 95,027 | +95,027 | 0.00 | 0.06 | +0.06 | buy |
| Jump Financial, LLC | 0 | 94,960 | +94,960 | 0.00 | 0.13 | +0.13 | buy |
| Global IMC LLC | 0 | 94,392 | +94,392 | 0.00 | 1.42 | +1.42 | buy |
| Cinctive Capital Management LP | 60,263 | 145,557 | +85,294 | 0.08 | 0.52 | +0.44 | buy |
| MPM BioImpact LLC | 530,794 | 615,391 | +84,597 | 2.32 | 6.41 | +4.09 | buy |
| Nicholas Investment Partners, LP | 0 | 74,871 | +74,871 | 0.00 | 0.52 | +0.52 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 73,792 | +73,792 | 0.00 | 0.21 | +0.21 | buy |
| Altium Capital Management LLC | 120,000 | 190,000 | +70,000 | 1.45 | 5.26 | +3.80 | buy |
| FORA Capital, LLC | 0 | 69,487 | +69,487 | 0.00 | 0.57 | +0.57 | buy |
| AXIOM INVESTORS LLC /DE | 64,051 | 125,598 | +61,547 | 0.02 | 0.07 | +0.06 | buy |
| Hillsdale Investment Management Inc. | 0 | 56,600 | +56,600 | 0.00 | 0.30 | +0.30 | buy |
| NORTHERN TRUST CORP | 1,336,797 | 1,392,107 | +55,310 | 0.01 | 0.02 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 702,624 | 755,271 | +52,647 | 0.01 | 0.03 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 50,547 | +50,547 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 232,681 | 283,011 | +50,330 | 0.01 | 0.02 | +0.01 | buy |
| ALGERT GLOBAL LLC | 111,560 | 161,375 | +49,815 | 0.12 | 0.36 | +0.24 | buy |
| PRUDENTIAL FINANCIAL INC | 10,437 | 56,094 | +45,657 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 42,605 | +42,605 | 0.00 | 0.03 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 0 | 42,217 | +42,217 | 0.00 | 0.57 | +0.57 | buy |
| Man Group plc | 0 | 40,433 | +40,433 | 0.00 | 0.01 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 635,185 | 675,185 | +40,000 | 0.27 | 0.77 | +0.50 | buy |
| Atika Capital Management LLC | 0 | 36,000 | +36,000 | 0.00 | 0.28 | +0.28 | buy |
| Lighthouse Investment Partners, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.13 | +0.13 | buy |
| Russell Investments Group, Ltd. | 22,101 | 55,164 | +33,063 | 0.00 | 0.01 | +0.01 | buy |
| Pathstone Holdings, LLC | 0 | 32,474 | +32,474 | 0.00 | 0.01 | +0.01 | buy |
| NOMURA HOLDINGS INC | 0 | 31,536 | +31,536 | 0.00 | 0.01 | +0.01 | buy |