| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 6,354,022 | 15,636,399 | +9,282,377 | 0.04 | 0.11 | +0.07 | buy |
| Darwin Global Management, Ltd. | 15,397,975 | 19,344,621 | +3,946,646 | 82.08 | 80.75 | -1.33 | buy |
| D. E. Shaw & Co., Inc. | 734,880 | 3,422,619 | +2,687,739 | 0.07 | 0.34 | +0.28 | buy |
| BAKER BROS. ADVISORS LP | 5,380,626 | 7,712,900 | +2,332,274 | 4.54 | 7.53 | +2.99 | buy |
| FMR LLC | 3,394,384 | 5,093,261 | +1,698,877 | 0.02 | 0.03 | +0.01 | buy |
| Orbis Allan Gray Ltd | 0 | 1,524,134 | +1,524,134 | 0.00 | 0.75 | +0.75 | buy |
| Deep Track Capital, LP | 254,751 | 1,750,000 | +1,495,249 | 0.63 | 5.66 | +5.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 679,191 | 2,121,717 | +1,442,526 | 0.05 | 0.19 | +0.14 | buy |
| JANE STREET GROUP, LLC | 124,587 | 1,352,922 | +1,228,335 | 0.02 | 0.22 | +0.20 | buy |
| CITADEL ADVISORS LLC | 374,815 | 1,533,277 | +1,158,462 | 0.03 | 0.13 | +0.11 | buy |
| Qube Research & Technologies Ltd | 0 | 1,082,050 | +1,082,050 | 0.00 | 0.15 | +0.15 | buy |
| Duquesne Family Office LLC | 1,369,050 | 2,253,435 | +884,385 | 3.50 | 5.79 | +2.29 | buy |
| JANUS HENDERSON GROUP PLC | 1,545,419 | 2,293,142 | +747,723 | 0.07 | 0.11 | +0.05 | buy |
| HRT FINANCIAL LP | 0 | 729,597 | +729,597 | 0.00 | 0.32 | +0.32 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 0 | 500,000 | +500,000 | 0.00 | 0.24 | +0.24 | buy |
| Point72 Asset Management, L.P. | 0 | 490,667 | +490,667 | 0.00 | 0.12 | +0.12 | buy |
| Castle Hook Partners LP | 0 | 452,656 | +452,656 | 0.00 | 0.67 | +0.67 | buy |
| Artia Global Partners LP | 318,239 | 752,712 | +434,473 | 7.12 | 19.48 | +12.36 | buy |
| MARSHALL WACE, LLP | 696,237 | 1,113,361 | +417,124 | 0.07 | 0.13 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 1,402,621 | 1,810,895 | +408,274 | 0.02 | 0.03 | +0.01 | buy |
| MAVERICK CAPITAL LTD | 425,125 | 804,133 | +379,008 | 0.58 | 1.24 | +0.66 | buy |
| RAYMOND JAMES FINANCIAL INC | 408,937 | 784,551 | +375,614 | 0.01 | 0.03 | +0.02 | buy |
| Weiss Asset Management LP | 0 | 339,825 | +339,825 | 0.00 | 0.54 | +0.54 | buy |
| Affinity Asset Advisors, LLC | 140,000 | 475,000 | +335,000 | 1.67 | 7.07 | +5.40 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 12,084 | 330,800 | +318,716 | 0.00 | 0.12 | +0.12 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 2,677 | 313,053 | +310,376 | 0.00 | 0.12 | +0.12 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 308,687 | +308,687 | 0.00 | 0.04 | +0.04 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 704,366 | 1,008,937 | +304,571 | 2.58 | 3.96 | +1.38 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 461,663 | 754,160 | +292,497 | 0.03 | 0.06 | +0.03 | buy |
| Cubist Systematic Strategies, LLC | 0 | 283,102 | +283,102 | 0.00 | 0.31 | +0.31 | buy |
| Capital International Investors | 7,198,485 | 7,478,859 | +280,374 | 0.11 | 0.13 | +0.02 | buy |
| NWI MANAGEMENT LP | 450,000 | 720,000 | +270,000 | 4.58 | 6.65 | +2.08 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 250,100 | +250,100 | 0.00 | 0.05 | +0.05 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 458,000 | 700,700 | +242,700 | 0.69 | 1.28 | +0.59 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 224,302 | +224,302 | 0.00 | 0.55 | +0.55 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 15,143 | 226,142 | +210,999 | 0.01 | 0.08 | +0.08 | buy |
| Caption Management, LLC | 0 | 210,928 | +210,928 | 0.00 | 1.94 | +1.94 | buy |
| Squarepoint Ops LLC | 0 | 210,647 | +210,647 | 0.00 | 0.05 | +0.05 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 207,527 | +207,527 | 0.00 | 0.46 | +0.46 | buy |
| Brevan Howard Capital Management LP | 0 | 202,594 | +202,594 | 0.00 | 0.22 | +0.22 | buy |
| FRANKLIN RESOURCES INC | 2,148,284 | 2,350,133 | +201,849 | 0.05 | 0.06 | +0.02 | buy |
| LORD, ABBETT & CO. LLC | 1,350,587 | 1,545,859 | +195,272 | 0.37 | 0.50 | +0.13 | buy |
| NORGES BANK | 1,742,843 | 1,934,899 | +192,056 | 0.02 | 0.02 | +0.01 | buy |
| ROYAL BANK OF CANADA | 245,262 | 427,801 | +182,539 | 0.00 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 0 | 181,554 | +181,554 | 0.00 | 0.24 | +0.24 | buy |
| Fiera Capital Corp | 579,237 | 748,037 | +168,800 | 0.16 | 0.26 | +0.10 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 539,484 | 695,961 | +156,477 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 509,300 | 650,252 | +140,952 | 1.38 | 2.46 | +1.08 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 134,010 | +134,010 | 0.00 | 0.10 | +0.10 | buy |
| Jain Global LLC | 0 | 127,161 | +127,161 | 0.00 | 0.20 | +0.20 | buy |
| Aquatic Capital Management LLC | 73,614 | 199,934 | +126,320 | 0.14 | 0.41 | +0.26 | buy |
| Invesco Ltd. | 1,791,324 | 1,896,333 | +105,009 | 0.03 | 0.03 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 200,000 | +100,000 | 0.42 | 1.02 | +0.60 | buy |
| Artisan Partners Limited Partnership | 3,217,268 | 3,314,341 | +97,073 | 0.40 | 0.50 | +0.10 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 37,632 | 130,165 | +92,533 | 0.01 | 0.02 | +0.02 | buy |
| Polar Asset Management Partners Inc. | 0 | 92,300 | +92,300 | 0.00 | 0.23 | +0.23 | buy |
| Quadrature Capital Ltd | 7,486 | 96,703 | +89,217 | 0.01 | 0.17 | +0.15 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 87,600 | +87,600 | 0.00 | 0.01 | +0.01 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 1,458 | 85,102 | +83,644 | 0.00 | 0.08 | +0.08 | buy |
| Treasurer of the State of North Carolina | 0 | 83,390 | +83,390 | 0.00 | 0.03 | +0.03 | buy |
| Ikarian Capital, LLC | 84,800 | 163,751 | +78,951 | 2.11 | 5.45 | +3.35 | buy |
| Quantessence Capital LLC | 0 | 75,728 | +75,728 | 0.00 | 2.24 | +2.24 | buy |
| Trexquant Investment LP | 0 | 75,265 | +75,265 | 0.00 | 0.09 | +0.09 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 355,722 | 427,753 | +72,031 | 0.04 | 0.06 | +0.02 | buy |
| RTW INVESTMENTS, LP | 3,014,558 | 3,084,558 | +70,000 | 3.52 | 4.42 | +0.90 | buy |
| Iron Triangle Partners LP | 0 | 70,000 | +70,000 | 0.00 | 1.11 | +1.11 | buy |
| Point72 Hong Kong Ltd | 0 | 69,814 | +69,814 | 0.00 | 0.49 | +0.49 | buy |
| Schonfeld Strategic Advisors LLC | 16,221 | 83,439 | +67,218 | 0.01 | 0.06 | +0.05 | buy |
| Verition Fund Management LLC | 26,474 | 93,370 | +66,896 | 0.01 | 0.05 | +0.04 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 55,425 | +55,425 | 0.00 | 0.02 | +0.02 | buy |
| Virtu Financial LLC | 0 | 54,302 | +54,302 | 0.00 | 0.28 | +0.28 | buy |
| Walleye Capital LLC | 34,478 | 88,406 | +53,928 | 0.03 | 0.08 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 205,511 | 259,207 | +53,696 | 0.00 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 1,550,000 | 1,600,000 | +50,000 | 13.10 | 15.04 | +1.94 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 47,175 | +47,175 | 0.00 | 1.31 | +1.31 | buy |
| Hudson Bay Capital Management LP | 40,170 | 81,743 | +41,573 | 0.02 | 0.05 | +0.03 | buy |
| Bank of New York Mellon Corp | 1,156,750 | 1,197,473 | +40,723 | 0.02 | 0.02 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 325,307 | 365,827 | +40,520 | 0.01 | 0.01 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 40,000 | +40,000 | 0.00 | 2.12 | +2.12 | buy |
| DIMENSIONAL FUND ADVISORS LP | 372,000 | 411,744 | +39,744 | 0.01 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,415 | 45,235 | +37,820 | 0.02 | 0.12 | +0.11 | buy |
| SEI INVESTMENTS CO | 395,979 | 433,628 | +37,649 | 0.04 | 0.05 | +0.01 | buy |
| ALGERT GLOBAL LLC | 44,424 | 81,924 | +37,500 | 0.08 | 0.17 | +0.09 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 49,784 | 85,604 | +35,820 | 0.13 | 0.12 | -0.01 | buy |
| XTX Topco Ltd | 21,250 | 56,380 | +35,130 | 0.08 | 0.24 | +0.15 | buy |
| Assenagon Asset Management S.A. | 39,778 | 73,404 | +33,626 | 0.01 | 0.01 | +0.01 | buy |
| Nebula Research & Development LLC | 3,379 | 36,661 | +33,282 | 0.02 | 0.31 | +0.29 | buy |
| LMR Partners LLP | 36,928 | 69,000 | +32,072 | 0.06 | 0.11 | +0.05 | buy |
| Police & Firemen's Retirement System of New Jersey | 37,100 | 67,903 | +30,803 | 0.03 | 0.06 | +0.03 | buy |
| Patient Square Capital LP | 330,250 | 358,800 | +28,550 | 10.42 | 13.02 | +2.59 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 24,415 | 52,751 | +28,336 | 0.06 | 0.16 | +0.10 | buy |
| Legal & General Group Plc | 180,202 | 207,851 | +27,649 | 0.00 | 0.01 | +0.00 | buy |
| Scientech Research LLC | 0 | 27,642 | +27,642 | 0.00 | 0.68 | +0.68 | buy |
| CSS LLC/IL | 0 | 27,375 | +27,375 | 0.00 | 0.17 | +0.17 | buy |
| Resolute Capital Asset Partners LLC | 0 | 27,301 | +27,301 | 0.00 | 1.44 | +1.44 | buy |
| Baird Financial Group, Inc. | 0 | 25,721 | +25,721 | 0.00 | 0.00 | +0.00 | buy |
| MYDA Advisors LLC | 8,000 | 32,000 | +24,000 | 0.22 | 0.90 | +0.69 | buy |
| AXA S.A. | 203,857 | 226,603 | +22,746 | 0.05 | 0.07 | +0.01 | buy |
| WINTON GROUP Ltd | 0 | 22,268 | +22,268 | 0.00 | 0.11 | +0.11 | buy |
| Quantbot Technologies LP | 0 | 22,067 | +22,067 | 0.00 | 0.06 | +0.06 | buy |