| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 15,397,975 | 19,344,621 | +3,946,646 | 82.08 | 80.75 | -1.33 | buy |
| D. E. Shaw & Co., Inc. | 734,880 | 3,422,619 | +2,687,739 | 0.07 | 0.38 | 0.00 | buy |
| BAKER BROS. ADVISORS LP | 5,380,626 | 7,712,900 | +2,332,274 | 4.54 | 7.53 | +2.99 | buy |
| Deep Track Capital, LP | 254,751 | 1,750,000 | +1,495,249 | 0.63 | 5.66 | +5.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 679,191 | 2,121,717 | +1,442,526 | 0.06 | 0.25 | 0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,288,735 | 3,340,707 | +948,028 | 0.03 | 0.02 | 0.00 | sell |
| Duquesne Family Office LLC | 1,369,050 | 2,253,435 | +884,385 | 3.41 | 5.57 | +2.16 | buy |
| JANUS HENDERSON GROUP PLC | 1,545,419 | 2,293,142 | +747,723 | 0.07 | 0.11 | 0.00 | buy |
| VANGUARD GROUP INC | 18,268,122 | 17,644,492 | +623,630 | 0.03 | 0.03 | 0.00 | sell |
| Artia Global Partners LP | 318,239 | 752,712 | +434,473 | 7.12 | 19.48 | +12.36 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,755,373 | 1,348,027 | +407,346 | 0.08 | 0.07 | 0.00 | sell |
| MAVERICK CAPITAL LTD | 425,125 | 804,133 | +379,008 | 0.58 | 1.24 | +0.66 | buy |
| Affinity Asset Advisors, LLC | 140,000 | 475,000 | +335,000 | 1.67 | 7.07 | +5.40 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 12,084 | 330,800 | +318,716 | 0.00 | 0.12 | 0.00 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 704,366 | 1,008,937 | +304,571 | 1.38 | 2.57 | +1.19 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 461,663 | 754,160 | +292,497 | 0.03 | 0.06 | 0.00 | buy |
| Capital International Investors | 7,198,485 | 7,478,859 | +280,374 | 0.11 | 0.13 | +0.02 | buy |
| NWI MANAGEMENT LP | 450,000 | 720,000 | +270,000 | 4.51 | 3.76 | -0.75 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 458,000 | 700,700 | +242,700 | 0.69 | 1.28 | +0.59 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 409,114 | 182,773 | +226,341 | 0.03 | 0.01 | -0.02 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 15,143 | 226,142 | +210,999 | 0.01 | 0.08 | +0.08 | buy |
| LORD, ABBETT & CO. LLC | 1,350,587 | 1,545,859 | +195,272 | 0.37 | 0.50 | +0.13 | buy |
| Fiera Capital Corp | 579,237 | 748,037 | +168,800 | 0.16 | 0.26 | +0.10 | buy |
| PERCEPTIVE ADVISORS LLC | 509,300 | 650,252 | +140,952 | 1.37 | 2.43 | +1.05 | buy |
| Allspring Global Investments Holdings, LLC | 438,674 | 304,310 | +134,364 | 0.06 | 0.05 | 0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 200,000 | +100,000 | 0.42 | 1.02 | +0.60 | buy |
| Artisan Partners Limited Partnership | 3,217,268 | 3,314,341 | +97,073 | 0.40 | 0.49 | +0.09 | buy |
| RHUMBLINE ADVISERS | 303,557 | 208,345 | +95,212 | 0.02 | 0.02 | 0.00 | sell |
| Quadrature Capital Ltd | 7,486 | 96,703 | +89,217 | 0.01 | 0.17 | +0.15 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 1,458 | 85,102 | +83,644 | 0.00 | 0.08 | +0.08 | buy |
| Ikarian Capital, LLC | 84,800 | 163,751 | +78,951 | 2.11 | 5.45 | +3.35 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 355,722 | 427,753 | +72,031 | 0.04 | 0.06 | +0.02 | buy |
| RTW INVESTMENTS, LP | 3,014,558 | 3,084,558 | +70,000 | 3.52 | 4.42 | +0.90 | buy |
| Integral Health Asset Management, LLC | 1,550,000 | 1,600,000 | +50,000 | 13.10 | 15.04 | +1.94 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 127,495 | 87,615 | +39,880 | 0.01 | 0.01 | -0.00 | sell |
| ProShare Advisors LLC | 45,489 | 6,801 | +38,688 | 0.01 | 0.00 | 0.00 | sell |
| ALGERT GLOBAL LLC | 44,424 | 81,924 | +37,500 | 0.08 | 0.17 | 0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 49,784 | 85,604 | +35,820 | 0.07 | 0.09 | +0.02 | buy |
| Nebula Research & Development LLC | 3,379 | 36,661 | +33,282 | 0.02 | 0.31 | +0.29 | buy |
| LMR Partners LLP | 36,928 | 69,000 | +32,072 | 0.06 | 0.11 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 406,903 | 376,508 | +30,395 | 0.07 | 0.07 | 0.00 | sell |
| Patient Square Capital LP | 330,250 | 358,800 | +28,550 | 10.42 | 13.02 | +2.59 | buy |
| Legal & General Group Plc | 180,202 | 207,851 | +27,649 | 0.00 | 0.01 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 72,816 | 46,786 | +26,030 | 0.25 | 0.20 | 0.00 | sell |
| MYDA Advisors LLC | 8,000 | 32,000 | +24,000 | 0.11 | 0.56 | +0.46 | buy |
| Swiss National Bank | 329,300 | 347,400 | +18,100 | 0.02 | 0.02 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 157,698 | 173,529 | +15,831 | 0.02 | 0.02 | +0.00 | buy |
| Cormorant Asset Management, LP | 525,000 | 540,000 | +15,000 | 3.01 | 4.05 | +1.04 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,181,675 | 1,196,494 | +14,819 | 1.80 | 2.11 | +0.31 | buy |
| GROUPAMA ASSET MANAGMENT | 0 | 13,175 | +13,175 | 0.02 | 0.02 | +0.00 | buy |
| Neo Ivy Capital Management | 4,452 | 17,256 | +12,804 | 0.11 | 0.55 | +0.45 | buy |
| Sofinnova Investments, Inc. | 304,254 | 313,923 | +9,669 | 1.52 | 1.93 | +0.42 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 144,379 | 153,986 | +9,607 | 0.03 | 0.03 | +0.01 | buy |
| Cinctive Capital Management LP | 23,553 | 32,874 | +9,321 | 0.14 | 0.18 | +0.04 | buy |
| Rock Springs Capital Management LP | 515,900 | 525,000 | +9,100 | 2.25 | 3.29 | +1.04 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,574 | 51,467 | +7,893 | 0.01 | 0.01 | 0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,951,622 | 2,957,973 | +6,351 | 0.06 | 0.08 | +0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 35,446 | 41,391 | +5,945 | 0.03 | 0.03 | 0.00 | buy |
| ExodusPoint Capital Management, LP | 87,783 | 92,717 | +4,934 | 0.09 | 0.12 | 0.00 | buy |
| CANADA LIFE ASSURANCE Co | 42,458 | 46,250 | +3,792 | 0.01 | 0.01 | +0.00 | buy |
| Northwest & Ethical Investments L.P. | 1,500 | 4,900 | +3,400 | 0.00 | 0.01 | +0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 45,683 | 49,013 | +3,330 | 0.01 | 0.02 | +0.01 | buy |
| Orion Porfolio Solutions, LLC | 38,735 | 35,530 | +3,205 | 0.03 | 0.04 | 0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 16,065 | 18,165 | +2,100 | 0.01 | 0.01 | +0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 3,397 | 1,685 | +1,712 | 0.02 | 0.01 | 0.00 | sell |
| SHELL ASSET MANAGEMENT CO | 10,135 | 8,592 | +1,543 | 0.04 | 0.03 | 0.00 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 19,935 | 21,374 | +1,439 | 0.02 | 0.02 | 0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 8,280 | 9,459 | +1,179 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 17,928 | 19,081 | +1,153 | 0.06 | 0.08 | +0.02 | buy |
| FULTON BANK, N.A. | 4,476 | 5,416 | +940 | 0.01 | 0.02 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 25,427 | 26,301 | +874 | 0.16 | 0.14 | 0.00 | buy |
| Fourth Dimension Wealth, LLC | 1,622 | 2,332 | +710 | 0.06 | 0.10 | +0.04 | buy |
| Values First Advisors, Inc. | 5,237 | 5,711 | +474 | 0.23 | 0.31 | +0.08 | buy |
| Meeder Advisory Services, Inc. | 3,507 | 3,875 | +368 | 0.02 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 36,305 | 36,582 | +277 | 0.26 | 0.35 | +0.09 | buy |
| PRUDENTIAL FINANCIAL INC | 155,177 | 155,440 | +263 | 0.02 | 0.02 | 0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 4,731 | 4,975 | +244 | 0.01 | 0.01 | +0.00 | buy |
| HighPoint Advisor Group LLC | 3,264 | 3,457 | +193 | 0.01 | 0.02 | +0.00 | buy |
| Woodline Partners LP | 248,770 | 248,921 | +151 | 0.12 | 0.13 | +0.01 | buy |
| CI INVESTMENTS INC. | 2,836 | 2,723 | +113 | 0.00 | 0.00 | 0.00 | sell |
| PARK AVENUE SECURITIES LLC | 11,036 | 11,088 | +52 | 0.01 | 0.01 | +0.00 | buy |
| COMMERCE BANK | 6,851 | 6,876 | +25 | 0.00 | 0.00 | 0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 44 | 63 | +19 | 0.00 | 0.00 | +0.00 | buy |
| MONTAG A & ASSOCIATES INC | 517 | 518 | +1 | 0.00 | 0.39 | +0.39 | buy |
| Avior Wealth Management, LLC | 4,151 | 4,152 | +1 | 0.01 | 0.01 | +0.00 | buy |
| Principia Wealth Advisory, LLC | 4 | 3 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Hughes Financial Services, LLC | 20 | 7 | -13 | 0.00 | 0.00 | -0.00 | sell |
| Whalen Wealth Management Inc. | 2,845 | 2,832 | -13 | 0.14 | 0.18 | +0.03 | sell |
| BELLEVUE ASSET MANAGEMENT, LLC | 57 | 41 | -16 | 0.00 | 0.00 | -0.00 | sell |
| Washington Trust Advisors, Inc. | 149 | 108 | -41 | 0.00 | 0.00 | -0.00 | sell |
| WOLFF WIESE MAGANA LLC | 94 | 34 | -60 | 0.00 | 0.00 | -0.00 | sell |
| BINGHAM PRIVATE WEALTH, LLC | 3,270 | 3,198 | -72 | 0.26 | 0.31 | +0.05 | sell |
| REGIONS FINANCIAL CORP | 3,078 | 2,956 | -122 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 18,804 | 18,680 | -124 | 0.01 | 0.02 | +0.00 | sell |
| Beacon Financial Advisory LLC | 8,695 | 8,480 | -215 | 0.20 | 0.22 | +0.02 | sell |
| Forum Financial Management, LP | 3,067 | 2,756 | -311 | 0.00 | 0.00 | +0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 15,230 | 14,880 | -350 | 0.90 | 0.99 | +0.08 | sell |
| RWC Asset Management LLP | 3,420 | 3,052 | -368 | 0.01 | 0.02 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 4,986 | 4,587 | -399 | 0.10 | 0.16 | +0.05 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 66,800 | 66,345 | -455 | 1.06 | 1.21 | +0.15 | sell |