| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 15,397,975 | 19,344,621 | +3,946,646 | 82.08 | 80.75 | -1.33 | buy |
| VANGUARD GROUP INC | 18,268,122 | 17,644,492 | -623,630 | 0.03 | 0.03 | +0.00 | sell |
| JPMORGAN CHASE & CO | 6,354,022 | 15,636,399 | +9,282,377 | 0.04 | 0.11 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,923,541 | 11,230,705 | -1,692,836 | 0.12 | 0.13 | +0.01 | sell |
| BlackRock, Inc. | 16,048,882 | 11,142,432 | -4,906,450 | 0.03 | 0.02 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 5,380,626 | 7,712,900 | +2,332,274 | 4.54 | 7.53 | +2.99 | buy |
| Capital International Investors | 7,198,485 | 7,478,859 | +280,374 | 0.11 | 0.13 | +0.02 | buy |
| FMR LLC | 3,394,384 | 5,093,261 | +1,698,877 | 0.02 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 5,747,293 | 4,277,888 | -1,469,405 | 0.02 | 0.02 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 734,880 | 3,422,619 | +2,687,739 | 0.07 | 0.34 | +0.28 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,288,735 | 3,340,707 | -948,028 | 0.03 | 0.02 | -0.00 | sell |
| Artisan Partners Limited Partnership | 3,217,268 | 3,314,341 | +97,073 | 0.40 | 0.50 | +0.10 | buy |
| RTW INVESTMENTS, LP | 3,014,558 | 3,084,558 | +70,000 | 3.52 | 4.42 | +0.90 | buy |
| AMERIPRISE FINANCIAL INC | 2,951,622 | 2,957,973 | +6,351 | 0.06 | 0.07 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,446,944 | 2,859,452 | -587,492 | 0.49 | 0.48 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 2,148,284 | 2,350,133 | +201,849 | 0.05 | 0.06 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 1,545,419 | 2,293,142 | +747,723 | 0.07 | 0.11 | +0.05 | buy |
| Duquesne Family Office LLC | 1,369,050 | 2,253,435 | +884,385 | 3.50 | 5.79 | +2.29 | buy |
| MILLENNIUM MANAGEMENT LLC | 679,191 | 2,121,717 | +1,442,526 | 0.05 | 0.19 | +0.14 | buy |
| Holocene Advisors, LP | 2,026,422 | 2,016,806 | -9,616 | 0.46 | 0.50 | +0.04 | sell |
| NORGES BANK | 1,742,843 | 1,934,899 | +192,056 | 0.02 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 1,791,324 | 1,896,333 | +105,009 | 0.03 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,402,621 | 1,810,895 | +408,274 | 0.02 | 0.03 | +0.01 | buy |
| Deep Track Capital, LP | 254,751 | 1,750,000 | +1,495,249 | 0.63 | 5.66 | +5.03 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 2,313,217 | 1,665,602 | -647,615 | 0.50 | 0.44 | -0.05 | sell |
| Integral Health Asset Management, LLC | 1,550,000 | 1,600,000 | +50,000 | 13.10 | 15.04 | +1.94 | buy |
| Pictet Asset Management Holding SA | 2,013,329 | 1,553,628 | -459,701 | 0.17 | 0.16 | -0.01 | sell |
| LORD, ABBETT & CO. LLC | 1,350,587 | 1,545,859 | +195,272 | 0.37 | 0.50 | +0.13 | buy |
| CITADEL ADVISORS LLC | 374,815 | 1,533,277 | +1,158,462 | 0.03 | 0.13 | +0.11 | buy |
| Orbis Allan Gray Ltd | 0 | 1,524,134 | +1,524,134 | 0.00 | 0.75 | +0.75 | buy |
| Clearbridge Investments, LLC | 1,828,728 | 1,424,562 | -404,166 | 0.12 | 0.12 | -0.01 | sell |
| JANE STREET GROUP, LLC | 124,587 | 1,352,922 | +1,228,335 | 0.02 | 0.22 | +0.20 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,755,373 | 1,348,027 | -407,346 | 0.08 | 0.07 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 2,423,513 | 1,343,212 | -1,080,301 | 0.07 | 0.04 | -0.02 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,406,609 | 1,339,288 | -67,321 | 0.52 | 0.57 | +0.04 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,602,655 | 1,299,568 | -303,087 | 0.02 | 0.02 | -0.00 | sell |
| GW&K Investment Management, LLC | 1,377,726 | 1,274,316 | -103,410 | 0.97 | 1.15 | +0.17 | sell |
| BANK OF AMERICA CORP /DE/ | 1,352,999 | 1,226,737 | -126,262 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 1,156,750 | 1,197,473 | +40,723 | 0.02 | 0.02 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,181,675 | 1,196,494 | +14,819 | 1.80 | 2.11 | +0.31 | buy |
| FIL Ltd | 2,390,201 | 1,165,464 | -1,224,737 | 0.17 | 0.10 | -0.07 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,222,627 | 1,159,699 | -62,928 | 0.02 | 0.02 | +0.00 | sell |
| MACQUARIE GROUP LTD | 2,362,105 | 1,128,898 | -1,233,207 | 0.22 | 0.14 | -0.08 | sell |
| MARSHALL WACE, LLP | 696,237 | 1,113,361 | +417,124 | 0.07 | 0.13 | +0.06 | buy |
| Qube Research & Technologies Ltd | 0 | 1,082,050 | +1,082,050 | 0.00 | 0.15 | +0.15 | buy |
| MORGAN STANLEY | 1,059,656 | 1,043,791 | -15,865 | 0.01 | 0.01 | +0.00 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 704,366 | 1,008,937 | +304,571 | 2.58 | 3.96 | +1.38 | buy |
| NORTHERN TRUST CORP | 1,683,838 | 969,800 | -714,038 | 0.02 | 0.01 | -0.01 | sell |
| Hood River Capital Management LLC | 1,558,286 | 899,603 | -658,683 | 2.03 | 1.26 | -0.76 | sell |
| TimesSquare Capital Management, LLC | 1,064,148 | 873,491 | -190,657 | 1.31 | 1.27 | -0.04 | sell |
| Palo Alto Investors LP | 987,153 | 865,113 | -122,040 | 14.34 | 18.52 | +4.18 | sell |
| MAVERICK CAPITAL LTD | 425,125 | 804,133 | +379,008 | 0.58 | 1.24 | +0.66 | buy |
| LOOMIS SAYLES & CO L P | 1,009,466 | 793,569 | -215,897 | 0.11 | 0.10 | -0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 408,937 | 784,551 | +375,614 | 0.01 | 0.03 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 461,663 | 754,160 | +292,497 | 0.03 | 0.06 | +0.03 | buy |
| Artia Global Partners LP | 318,239 | 752,712 | +434,473 | 7.12 | 19.48 | +12.36 | buy |
| Fiera Capital Corp | 579,237 | 748,037 | +168,800 | 0.16 | 0.26 | +0.10 | buy |
| HRT FINANCIAL LP | 0 | 729,597 | +729,597 | 0.00 | 0.32 | +0.32 | buy |
| NWI MANAGEMENT LP | 450,000 | 720,000 | +270,000 | 4.58 | 6.65 | +2.08 | buy |
| JENNISON ASSOCIATES LLC | 748,313 | 715,606 | -32,707 | 0.04 | 0.04 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 458,000 | 700,700 | +242,700 | 0.69 | 1.28 | +0.59 | buy |
| Polar Capital Holdings Plc | 728,755 | 697,960 | -30,795 | 0.34 | 0.37 | +0.03 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 539,484 | 695,961 | +156,477 | 0.01 | 0.01 | +0.00 | buy |
| Novo Holdings A/S | 724,666 | 680,000 | -44,666 | 4.21 | 4.83 | +0.63 | sell |
| PERCEPTIVE ADVISORS LLC | 509,300 | 650,252 | +140,952 | 1.38 | 2.46 | +1.08 | buy |
| Alyeska Investment Group, L.P. | 735,000 | 603,702 | -131,298 | 0.22 | 0.22 | -0.01 | sell |
| Nuveen, LLC | 1,158,094 | 588,987 | -569,107 | 0.03 | 0.02 | -0.01 | sell |
| BROWN ADVISORY INC | 672,450 | 579,846 | -92,604 | 0.07 | 0.08 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 589,399 | 564,389 | -25,010 | 0.09 | 0.10 | +0.01 | sell |
| Cormorant Asset Management, LP | 525,000 | 540,000 | +15,000 | 3.03 | 4.05 | +1.02 | buy |
| Rock Springs Capital Management LP | 515,900 | 525,000 | +9,100 | 2.25 | 3.29 | +1.04 | buy |
| Long Focus Capital Management, LLC | 630,800 | 520,200 | -110,600 | 3.27 | 3.38 | +0.11 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 0 | 500,000 | +500,000 | 0.00 | 0.24 | +0.24 | buy |
| Point72 Asset Management, L.P. | 0 | 490,667 | +490,667 | 0.00 | 0.12 | +0.12 | buy |
| Affinity Asset Advisors, LLC | 140,000 | 475,000 | +335,000 | 1.67 | 7.07 | +5.40 | buy |
| Castle Hook Partners LP | 0 | 452,656 | +452,656 | 0.00 | 0.67 | +0.67 | buy |
| Candriam S.C.A. | 455,408 | 438,688 | -16,720 | 0.22 | 0.25 | +0.04 | sell |
| SEI INVESTMENTS CO | 395,979 | 433,628 | +37,649 | 0.04 | 0.05 | +0.01 | buy |
| Eagle Health Investments LP | 443,300 | 428,600 | -14,700 | 8.78 | 10.65 | +1.86 | sell |
| ROYAL BANK OF CANADA | 245,262 | 427,801 | +182,539 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 355,722 | 427,753 | +72,031 | 0.04 | 0.06 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 372,000 | 411,744 | +39,744 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 585,428 | 407,679 | -177,749 | 0.05 | 0.04 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 502,232 | 395,194 | -107,038 | 0.04 | 0.03 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 406,903 | 376,508 | -30,395 | 0.07 | 0.07 | +0.00 | sell |
| First Turn Management, LLC | 401,629 | 372,672 | -28,957 | 6.18 | 7.00 | +0.82 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 325,307 | 365,827 | +40,520 | 0.01 | 0.01 | +0.00 | buy |
| Patient Square Capital LP | 330,250 | 358,800 | +28,550 | 10.42 | 13.02 | +2.59 | buy |
| Swiss National Bank | 329,300 | 347,400 | +18,100 | 0.02 | 0.02 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 339,825 | +339,825 | 0.00 | 0.54 | +0.54 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 12,084 | 330,800 | +318,716 | 0.00 | 0.12 | +0.12 | buy |
| Sofinnova Investments, Inc. | 304,254 | 313,923 | +9,669 | 1.75 | 2.15 | +0.40 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 2,677 | 313,053 | +310,376 | 0.00 | 0.12 | +0.12 | buy |
| Aberdeen Group plc | 336,357 | 309,749 | -26,608 | 0.05 | 0.05 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 308,687 | +308,687 | 0.00 | 0.04 | +0.04 | buy |
| Allspring Global Investments Holdings, LLC | 438,674 | 304,310 | -134,364 | 0.05 | 0.05 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 613,269 | 302,065 | -311,204 | 0.13 | 0.07 | -0.05 | sell |
| UBS Group AG | 477,636 | 293,454 | -184,182 | 0.01 | 0.01 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 283,102 | +283,102 | 0.00 | 0.31 | +0.31 | buy |
| C WorldWide Group Holding A/S | 321,110 | 271,110 | -50,000 | 0.30 | 0.37 | +0.07 | sell |