| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,160,167 | 16,143,583 | +2,983,416 | 0.11 | 0.07 | -0.04 | buy |
| BlackRock, Inc. | 16,678,146 | 15,807,984 | -870,162 | 0.05 | 0.03 | -0.02 | sell |
| JPMORGAN CHASE & CO | 24,150,499 | 10,428,170 | -13,722,329 | 0.25 | 0.06 | -0.19 | sell |
| BAKER BROS. ADVISORS LP | 7,421,111 | 8,796,111 | +1,375,000 | 6.97 | 4.70 | -2.27 | buy |
| Capital International Investors | 5,595,194 | 8,238,124 | +2,642,930 | 0.21 | 0.18 | -0.03 | buy |
| Darwin Global Management, Ltd. | 16,805,184 | 6,431,163 | -10,374,021 | 68.33 | 17.91 | -50.42 | sell |
| AMERIPRISE FINANCIAL INC | 3,057,718 | 6,179,571 | +3,121,853 | 0.12 | 0.13 | +0.02 | buy |
| Orbis Allan Gray Ltd | 1,872,824 | 6,076,487 | +4,203,663 | 1.29 | 2.23 | +0.93 | buy |
| STATE STREET CORP | 5,551,699 | 6,052,174 | +500,475 | 0.03 | 0.02 | -0.01 | buy |
| D. E. Shaw & Co., Inc. | 5,625,825 | 5,877,959 | +252,134 | 0.72 | 0.39 | -0.34 | buy |
| Artisan Partners Limited Partnership | 6,527,301 | 5,441,718 | -1,085,583 | 1.74 | 0.95 | -0.79 | sell |
| RTW INVESTMENTS, LP | 4,842,880 | 4,842,880 | 0 | 7.88 | 4.41 | -3.47 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 4,450,389 | 4,220,155 | -230,234 | 0.05 | 0.02 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,092,807 | 3,405,290 | +312,483 | 0.06 | 0.04 | -0.02 | buy |
| NORGES BANK | 0 | 3,377,641 | +3,377,641 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 1,737,481 | 2,584,446 | +846,965 | 0.05 | 0.04 | -0.01 | buy |
| CITADEL ADVISORS LLC | 2,182,571 | 2,556,973 | +374,402 | 0.25 | 0.16 | -0.10 | buy |
| FRANKLIN RESOURCES INC | 2,617,251 | 2,273,222 | -344,029 | 0.10 | 0.05 | -0.05 | sell |
| MAVERICK CAPITAL LTD | 0 | 2,150,762 | +2,150,762 | 0.00 | 2.07 | +2.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,157,786 | 2,048,005 | +890,219 | 0.14 | 0.15 | +0.01 | buy |
| Qube Research & Technologies Ltd | 148,515 | 1,682,334 | +1,533,819 | 0.03 | 0.20 | +0.16 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,468,459 | 1,629,561 | +161,102 | 1.01 | 0.57 | -0.44 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,622,675 | +1,622,675 | 0.00 | 0.11 | +0.11 | buy |
| Integral Health Asset Management, LLC | 1,500,000 | 1,600,000 | +100,000 | 12.98 | 7.00 | -5.98 | buy |
| Duquesne Family Office LLC | 1,154,090 | 1,424,690 | +270,600 | 6.43 | 3.49 | -2.94 | buy |
| GOLDMAN SACHS GROUP INC | 942,646 | 1,409,885 | +467,239 | 0.02 | 0.02 | -0.00 | buy |
| Bellevue Group AG | 10,034 | 1,393,418 | +1,383,384 | 0.04 | 3.13 | +3.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,215,025 | 1,335,071 | +120,046 | 0.04 | 0.03 | -0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 221,707 | 1,326,430 | +1,104,723 | 0.07 | 0.26 | +0.19 | buy |
| Paradigm Biocapital Advisors LP | 1,254,488 | 1,325,977 | +71,489 | 4.19 | 2.65 | -1.54 | buy |
| NORTHERN TRUST CORP | 1,294,000 | 1,315,325 | +21,325 | 0.03 | 0.02 | -0.01 | buy |
| Bank of New York Mellon Corp | 1,262,749 | 1,312,756 | +50,007 | 0.04 | 0.02 | -0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 237,017 | 1,242,222 | +1,005,205 | 0.03 | 0.10 | +0.07 | buy |
| MORGAN STANLEY | 1,331,542 | 1,233,498 | -98,044 | 0.01 | 0.01 | -0.01 | sell |
| Pictet Asset Management Holding SA | 1,102,248 | 1,220,353 | +118,105 | 0.19 | 0.12 | -0.06 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,213,963 | +1,213,963 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,069,390 | 1,213,963 | +144,573 | 0.03 | 0.02 | -0.01 | buy |
| Hood River Capital Management LLC | 688,554 | 1,056,871 | +368,317 | 1.13 | 0.82 | -0.31 | buy |
| BANK OF AMERICA CORP /DE/ | 1,502,281 | 1,023,114 | -479,167 | 0.02 | 0.01 | -0.01 | sell |
| SEI INVESTMENTS CO | 1,395,794 | 1,015,870 | -379,924 | 0.21 | 0.10 | -0.11 | sell |
| NWI MANAGEMENT LP | 1,014,000 | 1,014,000 | 0 | 10.14 | 6.91 | -3.23 | hold |
| Castle Hook Partners LP | 1,269,754 | 993,310 | -276,444 | 4.20 | 1.13 | -3.06 | sell |
| JENNISON ASSOCIATES LLC | 604,694 | 905,094 | +300,400 | 0.07 | 0.06 | -0.01 | buy |
| Polar Capital Holdings Plc | 368,107 | 890,872 | +522,765 | 0.26 | 0.27 | +0.01 | buy |
| FIL Ltd | 828,947 | 856,214 | +27,267 | 0.11 | 0.07 | -0.04 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 916,464 | 856,126 | -60,338 | 0.08 | 0.04 | -0.04 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 900,000 | 850,000 | -50,000 | 0.23 | 0.13 | -0.10 | sell |
| Fiera Capital Corp | 1,021,970 | 843,042 | -178,928 | 0.57 | 0.33 | -0.25 | sell |
| Legal & General Group Plc | 787,079 | 826,431 | +39,352 | 0.03 | 0.02 | -0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 469,561 | 795,242 | +325,681 | 0.79 | 0.79 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 925,799 | 759,735 | -166,064 | 0.08 | 0.04 | -0.04 | sell |
| SAMLYN CAPITAL, LLC | 417,205 | 732,568 | +315,363 | 1.17 | 1.29 | +0.12 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 173,630 | 729,354 | +555,724 | 0.04 | 0.07 | +0.03 | buy |
| TimesSquare Capital Management, LLC | 584,798 | 728,096 | +143,298 | 1.62 | 1.14 | -0.48 | buy |
| Clearbridge Investments, LLC | 643,435 | 715,922 | +72,487 | 0.09 | 0.06 | -0.03 | buy |
| Ensign Peak Advisors, Inc | 499,756 | 702,951 | +203,195 | 0.15 | 0.12 | -0.03 | buy |
| DEUTSCHE BANK AG\ | 562,474 | 690,590 | +128,116 | 0.03 | 0.02 | -0.01 | buy |
| HRT FINANCIAL LP | 0 | 689,981 | +689,981 | 0.00 | 0.13 | +0.13 | buy |
| RAYMOND JAMES FINANCIAL INC | 775,148 | 660,601 | -114,547 | 0.04 | 0.02 | -0.02 | sell |
| Affinity Asset Advisors, LLC | 480,000 | 650,000 | +170,000 | 4.60 | 3.39 | -1.21 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 902,666 | 629,831 | -272,835 | 0.49 | 0.20 | -0.29 | sell |
| GW&K Investment Management, LLC | 623,048 | 629,760 | +6,712 | 0.90 | 0.52 | -0.37 | buy |
| Squarepoint Ops LLC | 39,316 | 616,464 | +577,148 | 0.01 | 0.13 | +0.11 | buy |
| AQR CAPITAL MANAGEMENT LLC | 675,485 | 612,832 | -62,653 | 0.05 | 0.02 | -0.03 | sell |
| Railway Pension Investments Ltd | 0 | 604,700 | +604,700 | 0.00 | 0.81 | +0.81 | buy |
| Swiss National Bank | 625,912 | 593,512 | -32,400 | 0.06 | 0.03 | -0.03 | sell |
| Nuveen, LLC | 534,750 | 591,844 | +57,094 | 0.02 | 0.02 | -0.01 | buy |
| Artia Global Partners LP | 628,712 | 589,052 | -39,660 | 23.18 | 11.94 | -11.24 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 546,310 | 583,665 | +37,355 | 1.48 | 0.83 | -0.65 | buy |
| Aberdeen Group plc | 277,016 | 577,437 | +300,421 | 0.07 | 0.09 | +0.01 | buy |
| Candriam S.C.A. | 401,735 | 555,131 | +153,396 | 0.34 | 0.27 | -0.08 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 399,044 | 543,893 | +144,849 | 0.01 | 0.01 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 536,997 | +536,997 | 0.00 | 0.09 | +0.09 | buy |
| Long Focus Capital Management, LLC | 145,000 | 528,000 | +383,000 | 1.04 | 2.30 | +1.26 | buy |
| MARSHALL WACE, LLP | 312,565 | 501,930 | +189,365 | 0.05 | 0.05 | -0.01 | buy |
| Amundi | 804,977 | 487,525 | -317,452 | 0.04 | 0.01 | -0.02 | sell |
| BNP Paribas Asset Management Holding S.A. | 467,753 | 475,307 | +7,554 | 0.09 | 0.05 | -0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 688,734 | 462,796 | -225,938 | 0.04 | 0.03 | -0.01 | sell |
| Bridgewater Associates, LP | 295,579 | 455,392 | +159,813 | 0.22 | 0.20 | -0.02 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 501,282 | 437,713 | -63,569 | 0.05 | 0.03 | -0.03 | sell |
| ROYAL BANK OF CANADA | 523,101 | 416,487 | -106,614 | 0.02 | 0.01 | -0.01 | sell |
| Palo Alto Investors LP | 415,269 | 413,980 | -1,289 | 10.39 | 6.10 | -4.29 | sell |
| DIMENSIONAL FUND ADVISORS LP | 400,900 | 408,388 | +7,488 | 0.01 | 0.01 | -0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 604,600 | 400,765 | -203,835 | 0.07 | 0.02 | -0.04 | sell |
| Eagle Health Investments LP | 224,271 | 384,130 | +159,859 | 7.70 | 6.79 | -0.91 | buy |
| Neuberger Berman Group LLC | 270,700 | 378,816 | +108,116 | 0.03 | 0.03 | -0.01 | buy |
| Prosight Management, LP | 0 | 375,609 | +375,609 | 0.00 | 6.90 | +6.90 | buy |
| Invesco Ltd. | 4,523,921 | 368,261 | -4,155,660 | 0.09 | 0.00 | -0.09 | sell |
| GATEWAY INVESTMENT ADVISERS LLC | 365,000 | 365,000 | 0 | 0.67 | 0.38 | -0.28 | hold |
| Rock Springs Capital Management LP | 314,300 | 362,150 | +47,850 | 3.03 | 1.88 | -1.14 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 299,925 | 336,997 | +37,072 | 0.01 | 0.01 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 396,245 | 306,651 | -89,594 | 0.04 | 0.02 | -0.02 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 303,182 | 304,798 | +1,616 | 0.05 | 0.03 | -0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 293,546 | 304,236 | +10,690 | 0.07 | 0.04 | -0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 119,958 | 298,372 | +178,414 | 0.02 | 0.02 | +0.01 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 255,247 | 289,594 | +34,347 | 0.03 | 0.02 | -0.01 | buy |
| HSBC HOLDINGS PLC | 116,456 | 279,961 | +163,505 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 272,615 | 272,715 | +100 | 0.04 | 0.02 | -0.02 | buy |
| First Turn Management, LLC | 248,475 | 263,851 | +15,376 | 4.54 | 3.01 | -1.53 | buy |
| C WorldWide Group Holding A/S | 161,110 | 261,110 | +100,000 | 0.57 | 0.67 | +0.11 | buy |