| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Orbis Allan Gray Ltd | 1,872,824 | 6,076,487 | +4,203,663 | 1.29 | 2.23 | +0.93 | buy |
| NORGES BANK | 0 | 3,377,641 | +3,377,641 | 0.00 | 0.04 | +0.04 | buy |
| AMERIPRISE FINANCIAL INC | 3,057,718 | 6,179,571 | +3,121,853 | 0.12 | 0.13 | +0.02 | buy |
| FMR LLC | 13,160,167 | 16,143,583 | +2,983,416 | 0.11 | 0.07 | -0.04 | buy |
| Capital International Investors | 5,595,194 | 8,238,124 | +2,642,930 | 0.21 | 0.18 | -0.03 | buy |
| MAVERICK CAPITAL LTD | 0 | 2,150,762 | +2,150,762 | 0.00 | 2.07 | +2.07 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,622,675 | +1,622,675 | 0.00 | 0.11 | +0.11 | buy |
| Qube Research & Technologies Ltd | 148,515 | 1,682,334 | +1,533,819 | 0.03 | 0.20 | +0.16 | buy |
| Bellevue Group AG | 10,034 | 1,393,418 | +1,383,384 | 0.04 | 3.13 | +3.09 | buy |
| BAKER BROS. ADVISORS LP | 7,421,111 | 8,796,111 | +1,375,000 | 6.97 | 4.70 | -2.27 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,213,963 | +1,213,963 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 221,707 | 1,326,430 | +1,104,723 | 0.07 | 0.26 | +0.19 | buy |
| TWO SIGMA INVESTMENTS, LP | 237,017 | 1,242,222 | +1,005,205 | 0.03 | 0.10 | +0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,157,786 | 2,048,005 | +890,219 | 0.14 | 0.15 | +0.01 | buy |
| UBS Group AG | 1,737,481 | 2,584,446 | +846,965 | 0.05 | 0.04 | -0.01 | buy |
| HRT FINANCIAL LP | 0 | 689,981 | +689,981 | 0.00 | 0.13 | +0.13 | buy |
| Railway Pension Investments Ltd | 0 | 604,700 | +604,700 | 0.00 | 0.81 | +0.81 | buy |
| Squarepoint Ops LLC | 39,316 | 616,464 | +577,148 | 0.01 | 0.13 | +0.11 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 173,630 | 729,354 | +555,724 | 0.04 | 0.07 | +0.03 | buy |
| Point72 Asset Management, L.P. | 0 | 536,997 | +536,997 | 0.00 | 0.09 | +0.09 | buy |
| Polar Capital Holdings Plc | 368,107 | 890,872 | +522,765 | 0.26 | 0.27 | +0.01 | buy |
| STATE STREET CORP | 5,551,699 | 6,052,174 | +500,475 | 0.03 | 0.02 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 942,646 | 1,409,885 | +467,239 | 0.02 | 0.02 | -0.00 | buy |
| Long Focus Capital Management, LLC | 145,000 | 528,000 | +383,000 | 1.04 | 2.30 | +1.26 | buy |
| Prosight Management, LP | 0 | 375,609 | +375,609 | 0.00 | 6.90 | +6.90 | buy |
| CITADEL ADVISORS LLC | 2,182,571 | 2,556,973 | +374,402 | 0.25 | 0.16 | -0.10 | buy |
| Hood River Capital Management LLC | 688,554 | 1,056,871 | +368,317 | 1.13 | 0.82 | -0.31 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 469,561 | 795,242 | +325,681 | 0.79 | 0.79 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 417,205 | 732,568 | +315,363 | 1.17 | 1.29 | +0.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,092,807 | 3,405,290 | +312,483 | 0.06 | 0.04 | -0.02 | buy |
| Aberdeen Group plc | 277,016 | 577,437 | +300,421 | 0.07 | 0.09 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 604,694 | 905,094 | +300,400 | 0.07 | 0.06 | -0.01 | buy |
| Duquesne Family Office LLC | 1,154,090 | 1,424,690 | +270,600 | 6.43 | 3.49 | -2.94 | buy |
| D. E. Shaw & Co., Inc. | 5,625,825 | 5,877,959 | +252,134 | 0.72 | 0.39 | -0.34 | buy |
| Vestal Point Capital, LP | 0 | 250,000 | +250,000 | 0.00 | 0.62 | +0.62 | buy |
| Caption Management, LLC | 0 | 236,000 | +236,000 | 0.00 | 0.89 | +0.89 | buy |
| Ensign Peak Advisors, Inc | 499,756 | 702,951 | +203,195 | 0.15 | 0.12 | -0.03 | buy |
| Longaeva Partners L.P. | 0 | 201,226 | +201,226 | 0.00 | 0.62 | +0.62 | buy |
| USS Investment Management Ltd | 0 | 196,253 | +196,253 | 0.00 | 0.08 | +0.08 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 195,391 | +195,391 | 0.00 | 0.09 | +0.09 | buy |
| ADAR1 Capital Management, LLC | 35,392 | 228,520 | +193,128 | 0.35 | 1.15 | +0.80 | buy |
| Holocene Advisors, LP | 0 | 192,879 | +192,879 | 0.00 | 0.05 | +0.05 | buy |
| MARSHALL WACE, LLP | 312,565 | 501,930 | +189,365 | 0.05 | 0.05 | -0.01 | buy |
| JANE STREET GROUP, LLC | 11,401 | 193,528 | +182,127 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 119,958 | 298,372 | +178,414 | 0.02 | 0.02 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 480,000 | 650,000 | +170,000 | 4.60 | 3.39 | -1.21 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 46,230 | 212,676 | +166,446 | 0.02 | 0.04 | +0.03 | buy |
| HSBC HOLDINGS PLC | 116,456 | 279,961 | +163,505 | 0.01 | 0.01 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,468,459 | 1,629,561 | +161,102 | 1.01 | 0.57 | -0.44 | buy |
| DnB Asset Management AS | 53,170 | 213,259 | +160,089 | 0.03 | 0.06 | +0.03 | buy |
| Eagle Health Investments LP | 224,271 | 384,130 | +159,859 | 7.70 | 6.79 | -0.91 | buy |
| Bridgewater Associates, LP | 295,579 | 455,392 | +159,813 | 0.22 | 0.20 | -0.02 | buy |
| Trexquant Investment LP | 0 | 156,553 | +156,553 | 0.00 | 0.10 | +0.10 | buy |
| Assenagon Asset Management S.A. | 63,259 | 218,270 | +155,011 | 0.02 | 0.03 | +0.01 | buy |
| Candriam S.C.A. | 401,735 | 555,131 | +153,396 | 0.34 | 0.27 | -0.08 | buy |
| Eversept Partners, LP | 0 | 149,209 | +149,209 | 0.00 | 0.87 | +0.87 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 148,976 | +148,976 | 0.00 | 0.11 | +0.11 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 399,044 | 543,893 | +144,849 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,069,390 | 1,213,963 | +144,573 | 0.03 | 0.02 | -0.01 | buy |
| TimesSquare Capital Management, LLC | 584,798 | 728,096 | +143,298 | 1.62 | 1.14 | -0.48 | buy |
| Alyeska Investment Group, L.P. | 48,122 | 190,264 | +142,142 | 0.02 | 0.05 | +0.03 | buy |
| MARSICO CAPITAL MANAGEMENT LLC | 0 | 129,531 | +129,531 | 0.00 | 0.36 | +0.36 | buy |
| DEUTSCHE BANK AG\ | 562,474 | 690,590 | +128,116 | 0.03 | 0.02 | -0.01 | buy |
| Handelsbanken Fonder AB | 67,481 | 189,581 | +122,100 | 0.04 | 0.06 | +0.02 | buy |
| Novo Holdings A/S | 0 | 120,723 | +120,723 | 0.00 | 0.75 | +0.75 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,215,025 | 1,335,071 | +120,046 | 0.04 | 0.03 | -0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 118,800 | +118,800 | 0.00 | 1.81 | +1.81 | buy |
| Pictet Asset Management Holding SA | 1,102,248 | 1,220,353 | +118,105 | 0.19 | 0.12 | -0.06 | buy |
| Jain Global LLC | 0 | 111,204 | +111,204 | 0.00 | 0.14 | +0.14 | buy |
| Hudson Bay Capital Management LP | 0 | 109,352 | +109,352 | 0.00 | 0.05 | +0.05 | buy |
| Neuberger Berman Group LLC | 270,700 | 378,816 | +108,116 | 0.03 | 0.03 | -0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 101,908 | +101,908 | 0.00 | 0.22 | +0.22 | buy |
| C WorldWide Group Holding A/S | 161,110 | 261,110 | +100,000 | 0.57 | 0.67 | +0.11 | buy |
| Integral Health Asset Management, LLC | 1,500,000 | 1,600,000 | +100,000 | 12.98 | 7.00 | -5.98 | buy |
| Kynam Capital Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.59 | +0.59 | buy |
| Cinctive Capital Management LP | 73,063 | 161,996 | +88,933 | 0.79 | 0.69 | -0.10 | buy |
| Soleus Capital Management, L.P. | 10,250 | 90,250 | +80,000 | 0.07 | 0.33 | +0.26 | buy |
| TD ASSET MANAGEMENT INC | 163,424 | 240,182 | +76,758 | 0.02 | 0.02 | +0.00 | buy |
| Jump Financial, LLC | 0 | 73,500 | +73,500 | 0.00 | 0.07 | +0.07 | buy |
| Clearbridge Investments, LLC | 643,435 | 715,922 | +72,487 | 0.09 | 0.06 | -0.03 | buy |
| IMC-Chicago, LLC | 4,472 | 76,126 | +71,654 | 0.01 | 0.07 | +0.06 | buy |
| Paradigm Biocapital Advisors LP | 1,254,488 | 1,325,977 | +71,489 | 4.19 | 2.65 | -1.54 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 0 | 69,199 | +69,199 | 0.00 | 0.03 | +0.03 | buy |
| CenterBook Partners LP | 35,232 | 103,151 | +67,919 | 0.31 | 0.54 | +0.23 | buy |
| EULAV Asset Management | 92,000 | 150,000 | +58,000 | 0.48 | 0.51 | +0.03 | buy |
| Nuveen, LLC | 534,750 | 591,844 | +57,094 | 0.02 | 0.02 | -0.01 | buy |
| XTX Topco Ltd | 4,662 | 59,663 | +55,001 | 0.01 | 0.08 | +0.07 | buy |
| Illinois Municipal Retirement Fund | 0 | 52,668 | +52,668 | 0.00 | 0.06 | +0.06 | buy |
| Redmile Group, LLC | 0 | 51,234 | +51,234 | 0.00 | 0.37 | +0.37 | buy |
| Bank of New York Mellon Corp | 1,262,749 | 1,312,756 | +50,007 | 0.04 | 0.02 | -0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 39,900 | 89,500 | +49,600 | 0.00 | 0.01 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 48,355 | +48,355 | 0.00 | 0.04 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 56,056 | 104,378 | +48,322 | 0.07 | 0.06 | -0.02 | buy |
| Rock Springs Capital Management LP | 314,300 | 362,150 | +47,850 | 3.03 | 1.88 | -1.14 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 47,266 | +47,266 | 0.00 | 0.09 | +0.09 | buy |
| OFI INVEST ASSET MANAGEMENT | 0 | 47,000 | +47,000 | 0.00 | 0.04 | +0.04 | buy |
| Swedbank AB | 82,865 | 129,518 | +46,653 | 0.01 | 0.01 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 44,473 | +44,473 | 0.00 | 0.01 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 43,856 | +43,856 | 0.00 | 0.25 | +0.25 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 936 | 43,092 | +42,156 | 0.00 | 0.02 | +0.02 | buy |