| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 367,000 | 1,284,000 | +917,000 | 1.08 | 5.71 | +4.63 | buy |
| RTW INVESTMENTS, LP | 1,000,000 | 1,865,108 | +865,108 | 0.40 | 0.99 | +0.59 | buy |
| LOOMIS SAYLES & CO L P | 1,613,596 | 2,383,039 | +769,443 | 0.05 | 0.10 | +0.05 | buy |
| FIL Ltd | 356,397 | 831,202 | +474,805 | 0.01 | 0.02 | +0.02 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,109,334 | 3,446,334 | +337,000 | 3.51 | 4.70 | +1.19 | buy |
| JANUS HENDERSON GROUP PLC | 2,195,188 | 1,914,802 | +280,386 | 0.03 | 0.03 | 0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,172,296 | 10,407,216 | +234,920 | 0.03 | 0.04 | +0.01 | buy |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 8,467,000 | 8,679,000 | +212,000 | 1.00 | 1.23 | +0.23 | buy |
| TD ASSET MANAGEMENT INC | 328,987 | 523,132 | +194,145 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 488,772 | 594,160 | +105,388 | 0.03 | 0.04 | 0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 112,292 | 59,292 | +53,000 | 0.09 | 0.04 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 485,459 | 446,104 | +39,355 | 0.05 | 0.06 | +0.01 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 109,182 | 148,419 | +39,237 | 0.32 | 0.61 | +0.29 | buy |
| Graham Capital Management, L.P. | 9,636 | 43,605 | +33,969 | 0.01 | 0.03 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,261,095 | 1,290,282 | +29,187 | 0.02 | 0.02 | 0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 8,304,314 | 8,324,884 | +20,570 | 0.12 | 0.15 | +0.03 | buy |
| OAK RIDGE INVESTMENTS LLC | 75,293 | 95,523 | +20,230 | 0.20 | 0.31 | +0.11 | buy |
| Lion Point Capital, LP | 50,335 | 70,335 | +20,000 | 0.79 | 1.63 | +0.84 | buy |
| AMERIPRISE FINANCIAL INC | 1,859,204 | 1,876,713 | +17,509 | 0.01 | 0.02 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 156,627 | 171,006 | +14,379 | 0.20 | 0.28 | +0.08 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 21,200 | 31,600 | +10,400 | 0.00 | 0.01 | +0.00 | buy |
| J. Goldman & Co LP | 18,080 | 26,661 | +8,581 | 0.02 | 0.03 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 9,694 | 16,283 | +6,589 | 0.02 | 0.04 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 144,464 | 150,387 | +5,923 | 1.03 | 1.41 | +0.39 | buy |
| ALPS ADVISORS INC | 100,285 | 106,160 | +5,875 | 0.02 | 0.02 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 284,621 | 289,736 | +5,115 | 0.02 | 0.02 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 111,436 | 113,796 | +2,360 | 0.21 | 0.26 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 1,788 | 3,698 | +1,910 | 0.01 | 0.03 | +0.02 | buy |
| Diversified Trust Co | 18,842 | 19,634 | +792 | 0.01 | 0.02 | +0.00 | buy |
| ProShare Advisors LLC | 25,973 | 26,525 | +552 | 0.00 | 0.00 | 0.00 | buy |
| GW&K Investment Management, LLC | 1,353,264 | 1,352,269 | -995 | 0.27 | 0.34 | +0.07 | sell |
| Legato Capital Management LLC | 51,569 | 50,258 | -1,311 | 0.15 | 0.18 | +0.04 | sell |
| VIRTUS ADVISERS, LLC | 17,814 | 15,777 | -2,037 | 0.22 | 0.24 | +0.02 | sell |
| First Light Asset Management, LLC | 645,686 | 643,588 | -2,098 | 1.07 | 1.54 | +0.48 | sell |
| MPM BioImpact LLC | 529,743 | 527,458 | -2,285 | 2.25 | 3.56 | +1.30 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 229,292 | 224,465 | -4,827 | 0.27 | 0.36 | +0.09 | sell |
| EFG Asset Management (North America) Corp. | 57,724 | 52,693 | -5,031 | 0.26 | 0.32 | +0.05 | sell |
| E Fund Management Co., Ltd. | 19,953 | 14,048 | -5,905 | 0.03 | 0.03 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 864,635 | 856,198 | -8,437 | 0.06 | 0.07 | +0.01 | sell |
| B. Metzler seel. Sohn & Co. AG | 30,590 | 16,621 | -13,969 | 0.01 | 0.01 | -0.00 | sell |
| Swedbank AB | 92,557 | 74,557 | -18,000 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 68,515 | 47,687 | -20,828 | 0.08 | 0.07 | -0.01 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 361,521 | 340,125 | -21,396 | 0.21 | 0.26 | +0.05 | sell |
| Atom Investors LP | 42,713 | 12,201 | -30,512 | 0.34 | 0.07 | -0.27 | sell |
| Sonora Investment Management Group, LLC | 575,000 | 540,000 | -35,000 | 0.04 | 0.05 | +0.01 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 4,285,919 | 4,241,935 | -43,984 | 0.29 | 0.36 | +0.07 | sell |
| Granahan Investment Management, LLC | 280,677 | 235,980 | -44,697 | 0.18 | 0.21 | +0.03 | sell |
| EMERALD ADVISERS, LLC | 989,026 | 937,516 | -51,510 | 0.91 | 1.15 | +0.23 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 835,296 | 744,733 | -90,563 | 0.96 | 1.13 | +0.18 | sell |
| Rafferty Asset Management, LLC | 371,126 | 273,524 | -97,602 | 0.04 | 0.04 | -0.00 | sell |
| Bellevue Group AG | 3,300,911 | 3,162,735 | -138,176 | 0.99 | 1.29 | +0.29 | sell |
| SECTORAL ASSET MANAGEMENT INC | 517,841 | 347,392 | -170,449 | 1.82 | 1.71 | -0.11 | sell |
| Holocene Advisors, LP | 2,082,878 | 1,808,488 | -274,390 | 0.19 | 0.20 | +0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 912,103 | 635,185 | -276,918 | 0.33 | 0.29 | -0.04 | sell |
| Ikarian Capital, LLC | 485,000 | 154,900 | -330,100 | 3.61 | 1.45 | -2.16 | sell |
| Candriam S.C.A. | 807,200 | 325,200 | -482,000 | 0.12 | 0.06 | -0.06 | sell |
| Deep Track Capital, LP | 6,500,000 | 6,000,000 | -500,000 | 6.41 | 5.87 | -0.53 | sell |
| SAMLYN CAPITAL, LLC | 1,977,290 | 1,381,057 | -596,233 | 0.72 | 0.62 | -0.11 | sell |
| Polar Capital Holdings Plc | 1,691,349 | 861,400 | -829,949 | 0.24 | 0.16 | -0.08 | sell |
| Hudson Bay Capital Management LP | 1,700,000 | 847,500 | -852,500 | 0.36 | 0.20 | -0.16 | sell |
| Monashee Investment Management LLC | 5,000,000 | 2,964,000 | -2,036,000 | 1.01 | 1.24 | +0.23 | sell |
| LORD, ABBETT & CO. LLC | 29,594,000 | 24,273,000 | -5,321,000 | 0.09 | 0.09 | +0.00 | sell |