| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 3,541,095 | 10,497,277 | +6,956,182 | 27.58 | 62.31 | +34.73 | buy |
| STATE STREET CORP | 4,662,439 | 6,178,230 | +1,515,791 | 0.01 | 0.02 | +0.00 | buy |
| VANGUARD GROUP INC | 16,013,010 | 17,143,177 | +1,130,167 | 0.02 | 0.02 | +0.00 | buy |
| FIL Ltd | 1,518,114 | 2,439,748 | +921,634 | 0.10 | 0.16 | +0.06 | buy |
| LORD, ABBETT & CO. LLC | 582,577 | 1,470,961 | +888,384 | 0.13 | 0.34 | +0.21 | buy |
| Vestal Point Capital, LP | 750,000 | 1,600,000 | +850,000 | 3.75 | 9.22 | +5.47 | buy |
| BAKER BROS. ADVISORS LP | 3,576,038 | 4,415,918 | +839,880 | 3.06 | 3.34 | +0.28 | buy |
| TWO SIGMA INVESTMENTS, LP | 107,744 | 801,139 | +693,395 | 0.02 | 0.13 | +0.12 | buy |
| Capital International Investors | 5,869,888 | 6,523,791 | +653,903 | 0.08 | 0.09 | +0.01 | buy |
| Man Group plc | 40,433 | 615,946 | +575,513 | 0.01 | 0.13 | +0.12 | buy |
| MORGAN STANLEY | 822,804 | 1,320,991 | +498,187 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 489,307 | +489,307 | 0.00 | 0.07 | +0.07 | buy |
| TimesSquare Capital Management, LLC | 0 | 483,869 | +483,869 | 0.00 | 0.53 | +0.53 | buy |
| Assenagon Asset Management S.A. | 391,054 | 857,360 | +466,306 | 0.07 | 0.13 | +0.06 | buy |
| Squarepoint Ops LLC | 50,547 | 485,618 | +435,071 | 0.01 | 0.12 | +0.10 | buy |
| Polar Capital Holdings Plc | 255,000 | 680,000 | +425,000 | 0.10 | 0.24 | +0.14 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,163,368 | 12,580,981 | +417,613 | 0.10 | 0.11 | +0.01 | buy |
| Artisan Partners Limited Partnership | 2,489,431 | 2,884,097 | +394,666 | 0.25 | 0.32 | +0.06 | buy |
| GW&K Investment Management, LLC | 761,732 | 1,153,515 | +391,783 | 0.47 | 0.72 | +0.25 | buy |
| JPMORGAN CHASE & CO | 2,926,185 | 3,306,346 | +380,161 | 0.02 | 0.02 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,491,135 | 1,863,341 | +372,206 | 0.11 | 0.15 | +0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 12,089 | 367,252 | +355,163 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 428,804 | 747,402 | +318,598 | 0.17 | 0.28 | +0.11 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 147,140 | 455,959 | +308,819 | 0.01 | 0.03 | +0.02 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 271,535 | 578,356 | +306,821 | 0.84 | 1.90 | +1.06 | buy |
| Invesco Ltd. | 756,241 | 1,062,395 | +306,154 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 262,868 | +262,868 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 61,608 | 316,876 | +255,268 | 0.00 | 0.02 | +0.02 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 251,739 | +251,739 | 0.00 | 0.08 | +0.08 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 675,185 | 906,395 | +231,210 | 0.77 | 1.14 | +0.37 | buy |
| FIRST TRUST ADVISORS LP | 55,448 | 280,819 | +225,371 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 108,595 | 332,063 | +223,468 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,657,760 | 1,871,890 | +214,130 | 0.07 | 0.07 | +0.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 211,789 | +211,789 | 0.00 | 0.81 | +0.81 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 140,000 | 347,695 | +207,695 | 2.32 | 5.72 | +3.40 | buy |
| GOLDMAN SACHS GROUP INC | 1,189,901 | 1,393,049 | +203,148 | 0.02 | 0.02 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 191,229 | +191,229 | 0.00 | 0.21 | +0.21 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,640,720 | 3,813,384 | +172,664 | 0.02 | 0.02 | +0.00 | buy |
| Patient Square Capital LP | 0 | 171,704 | +171,704 | 0.00 | 4.65 | +4.65 | buy |
| GROUP ONE TRADING LLC | 0 | 170,710 | +170,710 | 0.00 | 0.49 | +0.49 | buy |
| Clearbridge Investments, LLC | 1,644,948 | 1,808,767 | +163,819 | 0.09 | 0.10 | +0.01 | buy |
| Avidity Partners Management LP | 430,000 | 592,000 | +162,000 | 1.22 | 2.20 | +0.98 | buy |
| Hood River Capital Management LLC | 1,315,392 | 1,472,555 | +157,163 | 1.83 | 1.74 | -0.09 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,306,596 | 1,444,266 | +137,670 | 0.02 | 0.02 | +0.00 | buy |
| First Light Asset Management, LLC | 551,303 | 688,910 | +137,607 | 3.24 | 4.18 | +0.95 | buy |
| VAN ECK ASSOCIATES CORP | 0 | 127,024 | +127,024 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 359,029 | 484,121 | +125,092 | 0.04 | 0.06 | +0.02 | buy |
| Rafferty Asset Management, LLC | 112,214 | 226,800 | +114,586 | 0.03 | 0.06 | +0.03 | buy |
| Trexquant Investment LP | 0 | 111,682 | +111,682 | 0.00 | 0.10 | +0.10 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,024 | 261,546 | +110,522 | 0.02 | 0.03 | +0.01 | buy |
| Ikarian Capital, LLC | 47,835 | 154,835 | +107,000 | 1.00 | 3.51 | +2.51 | buy |
| Caption Management, LLC | 0 | 98,800 | +98,800 | 0.00 | 0.77 | +0.77 | buy |
| NWI MANAGEMENT LP | 0 | 97,540 | +97,540 | 0.00 | 0.85 | +0.85 | buy |
| TWO SIGMA ADVISERS, LP | 295,400 | 392,700 | +97,300 | 0.04 | 0.07 | +0.02 | buy |
| HAP Trading, LLC | 0 | 83,481 | +83,481 | 0.00 | 3.09 | +3.09 | buy |
| CenterBook Partners LP | 0 | 81,336 | +81,336 | 0.00 | 0.36 | +0.36 | buy |
| Engineers Gate Manager LP | 0 | 80,790 | +80,790 | 0.00 | 0.12 | +0.12 | buy |
| PRUDENTIAL FINANCIAL INC | 56,094 | 134,590 | +78,496 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 233,989 | 309,992 | +76,003 | 0.00 | 0.01 | +0.00 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 0 | 75,869 | +75,869 | 0.00 | 0.07 | +0.07 | buy |
| NORTHERN TRUST CORP | 1,392,107 | 1,459,964 | +67,857 | 0.02 | 0.02 | +0.00 | buy |
| CITIGROUP INC | 54,939 | 121,266 | +66,327 | 0.00 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 175,464 | 241,131 | +65,667 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 195,062 | 258,877 | +63,815 | 0.01 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 104,041 | 167,430 | +63,389 | 0.07 | 0.10 | +0.04 | buy |
| Allspring Global Investments Holdings, LLC | 328,073 | 390,134 | +62,061 | 0.04 | 0.04 | +0.01 | buy |
| Woodline Partners LP | 155,155 | 216,379 | +61,224 | 0.10 | 0.13 | +0.03 | buy |
| Verition Fund Management LLC | 15,821 | 76,406 | +60,585 | 0.01 | 0.04 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 0 | 59,561 | +59,561 | 0.00 | 0.15 | +0.15 | buy |
| Sofinnova Investments, Inc. | 227,747 | 286,307 | +58,560 | 0.96 | 1.73 | +0.77 | buy |
| SEI INVESTMENTS CO | 277,712 | 333,597 | +55,885 | 0.03 | 0.03 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 93,524 | 148,330 | +54,806 | 0.01 | 0.02 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 640,267 | 689,807 | +49,540 | 1.80 | 1.95 | +0.15 | buy |
| AMERIPRISE FINANCIAL INC | 2,530,994 | 2,580,419 | +49,425 | 0.05 | 0.05 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 46,593 | +46,593 | 0.00 | 0.04 | +0.04 | buy |
| ExodusPoint Capital Management, LP | 42,605 | 85,183 | +42,578 | 0.03 | 0.06 | +0.03 | buy |
| Treasurer of the State of North Carolina | 0 | 42,500 | +42,500 | 0.00 | 0.01 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 11,359 | 52,861 | +41,502 | 0.01 | 0.06 | +0.04 | buy |
| BAMCO INC /NY/ | 0 | 40,500 | +40,500 | 0.00 | 0.01 | +0.01 | buy |
| Polar Asset Management Partners Inc. | 18,100 | 57,500 | +39,400 | 0.03 | 0.10 | +0.07 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 38,649 | +38,649 | 0.00 | 0.21 | +0.21 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 72,100 | 107,500 | +35,400 | 4.07 | 6.36 | +2.28 | buy |
| BANK OF AMERICA CORP /DE/ | 1,119,208 | 1,153,898 | +34,690 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 323,360 | 356,451 | +33,091 | 3.52 | 4.12 | +0.60 | buy |
| FEDERATED HERMES, INC. | 10,063 | 42,983 | +32,920 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 55,164 | 86,759 | +31,595 | 0.01 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 13,416 | 43,717 | +30,301 | 0.03 | 0.09 | +0.07 | buy |
| Rhenman & Partners Asset Management AB | 99,513 | 129,513 | +30,000 | 0.64 | 0.77 | +0.13 | buy |
| CASTLEARK MANAGEMENT LLC | 16,660 | 43,300 | +26,640 | 0.05 | 0.13 | +0.08 | buy |
| RHUMBLINE ADVISERS | 236,527 | 263,045 | +26,518 | 0.01 | 0.02 | +0.00 | buy |
| Nicholas Investment Partners, LP | 74,871 | 101,145 | +26,274 | 0.52 | 0.68 | +0.16 | buy |
| Atika Capital Management LLC | 36,000 | 62,000 | +26,000 | 0.28 | 0.48 | +0.20 | buy |
| Swiss National Bank | 277,500 | 302,500 | +25,000 | 0.01 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 744,280 | 769,253 | +24,973 | 0.03 | 0.03 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 938,434 | 962,459 | +24,025 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 23,020 | 46,186 | +23,166 | 0.06 | 0.13 | +0.07 | buy |
| Qsemble Capital Management, LP | 0 | 23,155 | +23,155 | 0.00 | 0.31 | +0.31 | buy |
| Aquatic Capital Management LLC | 0 | 23,000 | +23,000 | 0.00 | 0.04 | +0.04 | buy |
| TRUIST FINANCIAL CORP | 6,166 | 29,038 | +22,872 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 129,000 | 150,833 | +21,833 | 5.15 | 5.89 | +0.75 | buy |