| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 16,013,010 | 17,143,177 | +1,130,167 | 0.02 | 0.02 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,163,368 | 12,580,981 | +417,613 | 0.10 | 0.11 | +0.01 | buy |
| Darwin Global Management, Ltd. | 3,541,095 | 10,497,277 | +6,956,182 | 27.58 | 62.31 | +34.73 | buy |
| JANUS HENDERSON GROUP PLC | 29,535,000 | 8,573,000 | -20,962,000 | 0.03 | 0.01 | -0.02 | sell |
| FMR LLC | 7,305,130 | 7,191,518 | -113,612 | 0.03 | 0.03 | +0.00 | sell |
| Capital International Investors | 5,869,888 | 6,523,791 | +653,903 | 0.08 | 0.09 | +0.01 | buy |
| STATE STREET CORP | 4,662,439 | 6,178,230 | +1,515,791 | 0.01 | 0.02 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 3,576,038 | 4,415,918 | +839,880 | 3.06 | 3.34 | +0.28 | buy |
| LORD, ABBETT & CO. LLC | 8,553,000 | 4,244,000 | -4,309,000 | 0.06 | 0.03 | -0.03 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,640,720 | 3,813,384 | +172,664 | 0.02 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 2,926,185 | 3,306,346 | +380,161 | 0.02 | 0.02 | +0.00 | buy |
| RTW INVESTMENTS, LP | 3,640,108 | 3,272,008 | -368,100 | 3.78 | 3.46 | -0.32 | sell |
| Artisan Partners Limited Partnership | 2,489,431 | 2,884,097 | +394,666 | 0.25 | 0.32 | +0.06 | buy |
| FRANKLIN RESOURCES INC | 2,718,290 | 2,721,389 | +3,099 | 0.06 | 0.06 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,530,994 | 2,580,419 | +49,425 | 0.05 | 0.05 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,492,275 | 2,450,093 | -42,182 | 0.06 | 0.06 | +0.00 | sell |
| FIL Ltd | 1,518,114 | 2,439,748 | +921,634 | 0.10 | 0.16 | +0.06 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 3,469,728 | 2,420,908 | -1,048,820 | 0.61 | 0.44 | -0.17 | sell |
| MACQUARIE GROUP LTD | 2,746,628 | 2,285,921 | -460,707 | 0.21 | 0.18 | -0.03 | sell |
| T. Rowe Price Investment Management, Inc. | 2,435,962 | 2,277,143 | -158,819 | 0.10 | 0.10 | -0.00 | sell |
| Palo Alto Investors LP | 2,138,963 | 1,940,993 | -197,970 | 16.61 | 18.40 | +1.80 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 1,657,760 | 1,871,890 | +214,130 | 0.07 | 0.07 | +0.01 | buy |
| Pictet Asset Management Holding SA | 1,491,135 | 1,863,341 | +372,206 | 0.11 | 0.15 | +0.04 | buy |
| Clearbridge Investments, LLC | 1,644,948 | 1,808,767 | +163,819 | 0.09 | 0.10 | +0.01 | buy |
| NORGES BANK | 1,757,425 | 1,656,767 | -100,658 | 0.02 | 0.02 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,521,800 | 1,635,709 | -886,091 | 6.90 | 4.29 | -2.61 | sell |
| Vestal Point Capital, LP | 750,000 | 1,600,000 | +850,000 | 3.75 | 9.22 | +5.47 | buy |
| JANUS HENDERSON GROUP PLC | 2,091,778 | 1,488,904 | -602,874 | 0.08 | 0.06 | -0.02 | sell |
| Hood River Capital Management LLC | 1,315,392 | 1,472,555 | +157,163 | 1.83 | 1.74 | -0.09 | buy |
| LORD, ABBETT & CO. LLC | 582,577 | 1,470,961 | +888,384 | 0.13 | 0.34 | +0.21 | buy |
| Bank of New York Mellon Corp | 1,807,370 | 1,470,217 | -337,153 | 0.02 | 0.02 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,392,107 | 1,459,964 | +67,857 | 0.02 | 0.02 | +0.00 | buy |
| Integral Health Asset Management, LLC | 1,550,000 | 1,450,000 | -100,000 | 10.34 | 12.46 | +2.13 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,306,596 | 1,444,266 | +137,670 | 0.02 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,189,901 | 1,393,049 | +203,148 | 0.02 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 822,804 | 1,320,991 | +498,187 | 0.00 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,250,000 | 1,250,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| LOOMIS SAYLES & CO L P | 1,226,726 | 1,210,187 | -16,539 | 0.11 | 0.12 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,119,208 | 1,153,898 | +34,690 | 0.01 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 761,732 | 1,153,515 | +391,783 | 0.47 | 0.72 | +0.25 | buy |
| Eversept Partners, LP | 1,155,588 | 1,089,404 | -66,184 | 5.93 | 6.10 | +0.18 | sell |
| Invesco Ltd. | 756,241 | 1,062,395 | +306,154 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,325,000 | 1,032,562 | -292,438 | 0.16 | 0.13 | -0.03 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 938,434 | 962,459 | +24,025 | 0.01 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 675,185 | 906,395 | +231,210 | 0.77 | 1.14 | +0.37 | buy |
| Assenagon Asset Management S.A. | 391,054 | 857,360 | +466,306 | 0.07 | 0.13 | +0.06 | buy |
| TWO SIGMA INVESTMENTS, LP | 107,744 | 801,139 | +693,395 | 0.02 | 0.13 | +0.12 | buy |
| MARSHALL WACE, LLP | 1,249,351 | 771,211 | -478,140 | 0.12 | 0.07 | -0.05 | sell |
| JENNISON ASSOCIATES LLC | 744,280 | 769,253 | +24,973 | 0.03 | 0.03 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 428,804 | 747,402 | +318,598 | 0.17 | 0.28 | +0.11 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 743,725 | 745,794 | +2,069 | 0.05 | 0.06 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 922,002 | 738,951 | -183,051 | 0.23 | 0.20 | -0.03 | sell |
| Novo Holdings A/S | 800,000 | 724,666 | -75,334 | 2.89 | 2.63 | -0.26 | sell |
| AMERICAN CENTURY COMPANIES INC | 755,271 | 723,683 | -31,588 | 0.03 | 0.03 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 640,267 | 689,807 | +49,540 | 1.80 | 1.95 | +0.15 | buy |
| First Light Asset Management, LLC | 551,303 | 688,910 | +137,607 | 3.24 | 4.18 | +0.95 | buy |
| Rock Springs Capital Management LP | 808,356 | 683,344 | -125,012 | 1.63 | 1.62 | -0.01 | sell |
| Polar Capital Holdings Plc | 255,000 | 680,000 | +425,000 | 0.10 | 0.24 | +0.14 | buy |
| JANE STREET GROUP, LLC | 840,000 | 659,675 | -180,325 | 0.06 | 0.08 | +0.02 | sell |
| Long Focus Capital Management, LLC | 740,900 | 628,900 | -112,000 | 5.13 | 4.06 | -1.07 | sell |
| Man Group plc | 40,433 | 615,946 | +575,513 | 0.01 | 0.13 | +0.12 | buy |
| MPM BioImpact LLC | 615,391 | 615,391 | 0 | 6.41 | 6.74 | +0.33 | hold |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 774,404 | 594,106 | -180,298 | 0.51 | 0.41 | -0.11 | sell |
| Fiera Capital Corp | 605,527 | 592,415 | -13,112 | 0.13 | 0.13 | +0.00 | sell |
| Avidity Partners Management LP | 430,000 | 592,000 | +162,000 | 1.22 | 2.20 | +0.98 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 271,535 | 578,356 | +306,821 | 0.84 | 1.90 | +1.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,198,510 | 564,856 | -633,654 | 0.07 | 0.04 | -0.03 | sell |
| Bellevue Group AG | 1,021,700 | 525,434 | -496,266 | 1.11 | 0.62 | -0.49 | sell |
| Eagle Health Investments LP | 513,700 | 513,700 | 0 | 6.15 | 7.23 | +1.08 | hold |
| TD ASSET MANAGEMENT INC | 525,682 | 513,082 | -12,600 | 0.03 | 0.03 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 654,348 | 509,439 | -144,909 | 0.11 | 0.09 | -0.02 | sell |
| Cormorant Asset Management, LP | 675,000 | 500,000 | -175,000 | 2.63 | 1.94 | -0.69 | sell |
| Qube Research & Technologies Ltd | 0 | 489,307 | +489,307 | 0.00 | 0.07 | +0.07 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 493,849 | 487,664 | -6,185 | 1.73 | 1.85 | +0.12 | sell |
| Squarepoint Ops LLC | 50,547 | 485,618 | +435,071 | 0.01 | 0.12 | +0.10 | buy |
| Ensign Peak Advisors, Inc | 359,029 | 484,121 | +125,092 | 0.04 | 0.06 | +0.02 | buy |
| TimesSquare Capital Management, LLC | 0 | 483,869 | +483,869 | 0.00 | 0.53 | +0.53 | buy |
| Sonora Investment Management Group, LLC | 540,000 | 480,000 | -60,000 | 0.05 | 0.08 | +0.04 | sell |
| SOROS FUND MANAGEMENT LLC | 470,700 | 478,601 | +7,901 | 0.71 | 0.70 | -0.01 | buy |
| Candriam S.C.A. | 555,934 | 476,494 | -79,440 | 0.23 | 0.20 | -0.03 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 147,140 | 455,959 | +308,819 | 0.01 | 0.03 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 498,572 | 452,316 | -46,256 | 0.16 | 0.16 | -0.00 | sell |
| Octagon Capital Advisors LP | 650,216 | 436,820 | -213,396 | 7.19 | 5.10 | -2.08 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 437,255 | 422,936 | -14,319 | 0.01 | 0.01 | -0.00 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 625,000 | 400,000 | -225,000 | 6.47 | 4.29 | -2.18 | sell |
| TWO SIGMA ADVISERS, LP | 295,400 | 392,700 | +97,300 | 0.04 | 0.07 | +0.02 | buy |
| Allspring Global Investments Holdings, LLC | 328,073 | 390,134 | +62,061 | 0.04 | 0.04 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 12,089 | 367,252 | +355,163 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 323,360 | 356,451 | +33,091 | 3.52 | 4.12 | +0.60 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 140,000 | 347,695 | +207,695 | 2.32 | 5.72 | +3.40 | buy |
| C WorldWide Group Holding A/S | 343,110 | 343,110 | 0 | 0.25 | 0.26 | +0.01 | hold |
| CITADEL ADVISORS LLC | 799,746 | 336,562 | -463,184 | 0.05 | 0.03 | -0.03 | sell |
| SEI INVESTMENTS CO | 277,712 | 333,597 | +55,885 | 0.03 | 0.03 | +0.01 | buy |
| BARCLAYS PLC | 108,595 | 332,063 | +223,468 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 61,608 | 316,876 | +255,268 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 858,300 | 315,151 | -543,149 | 0.19 | 0.08 | -0.11 | sell |
| UBS Group AG | 233,989 | 309,992 | +76,003 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 277,500 | 302,500 | +25,000 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 322,299 | 292,779 | -29,520 | 0.03 | 0.03 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 356,135 | 290,470 | -65,665 | 0.12 | 0.10 | -0.02 | sell |