| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 29,535,000 | 8,573,000 | +20,962,000 | 0.03 | 0.01 | 0.00 | sell |
| Darwin Global Management, Ltd. | 3,541,095 | 10,497,277 | +6,956,182 | 27.58 | 62.31 | +34.73 | buy |
| FIL Ltd | 1,518,114 | 2,439,748 | +921,634 | 0.10 | 0.16 | +0.06 | buy |
| LORD, ABBETT & CO. LLC | 582,577 | 1,470,961 | +888,384 | 0.13 | 0.34 | +0.21 | buy |
| Vestal Point Capital, LP | 750,000 | 1,600,000 | +850,000 | 3.75 | 9.22 | +5.47 | buy |
| BAKER BROS. ADVISORS LP | 3,576,038 | 4,415,918 | +839,880 | 3.06 | 3.34 | +0.28 | buy |
| TWO SIGMA INVESTMENTS, LP | 107,744 | 801,139 | +693,395 | 0.02 | 0.14 | 0.00 | buy |
| Capital International Investors | 5,869,888 | 6,523,791 | +653,903 | 0.08 | 0.09 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,198,510 | 564,856 | +633,654 | 0.08 | 0.04 | 0.00 | sell |
| Polar Capital Holdings Plc | 255,000 | 680,000 | +425,000 | 0.10 | 0.24 | +0.14 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,163,368 | 12,580,981 | +417,613 | 0.10 | 0.11 | +0.01 | buy |
| Artisan Partners Limited Partnership | 2,489,431 | 2,884,097 | +394,666 | 0.25 | 0.31 | +0.06 | buy |
| GW&K Investment Management, LLC | 761,732 | 1,153,515 | +391,783 | 0.47 | 0.72 | +0.25 | buy |
| Alyeska Investment Group, L.P. | 428,804 | 747,402 | +318,598 | 0.16 | 0.28 | +0.11 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 271,535 | 578,356 | +306,821 | 0.70 | 1.31 | +0.61 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 675,185 | 906,395 | +231,210 | 0.77 | 1.14 | +0.37 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,657,760 | 1,871,890 | +214,130 | 0.07 | 0.08 | 0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 140,000 | 347,695 | +207,695 | 2.32 | 5.72 | +3.40 | buy |
| JANE STREET GROUP, LLC | 840,000 | 659,675 | +180,325 | 0.08 | 0.11 | +0.03 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,640,720 | 3,813,384 | +172,664 | 0.02 | 0.02 | 0.00 | buy |
| Clearbridge Investments, LLC | 1,644,948 | 1,808,767 | +163,819 | 0.09 | 0.10 | +0.01 | buy |
| Avidity Partners Management LP | 430,000 | 592,000 | +162,000 | 1.22 | 2.20 | +0.98 | buy |
| Hood River Capital Management LLC | 1,315,392 | 1,472,555 | +157,163 | 1.83 | 1.74 | -0.09 | buy |
| First Light Asset Management, LLC | 551,303 | 688,910 | +137,607 | 3.24 | 4.18 | +0.95 | buy |
| Rafferty Asset Management, LLC | 112,214 | 226,800 | +114,586 | 0.03 | 0.06 | +0.03 | buy |
| Ikarian Capital, LLC | 47,835 | 154,835 | +107,000 | 1.00 | 3.51 | +2.51 | buy |
| ALGERT GLOBAL LLC | 161,375 | 81,501 | +79,874 | 0.37 | 0.16 | 0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 104,041 | 167,430 | +63,389 | 0.07 | 0.10 | +0.04 | buy |
| Allspring Global Investments Holdings, LLC | 328,073 | 390,134 | +62,061 | 0.04 | 0.04 | 0.00 | buy |
| Woodline Partners LP | 155,155 | 216,379 | +61,224 | 0.10 | 0.13 | +0.03 | buy |
| Sofinnova Investments, Inc. | 227,747 | 286,307 | +58,560 | 0.79 | 1.66 | +0.87 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 196,917 | 140,422 | +56,495 | 0.01 | 0.01 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 93,524 | 148,330 | +54,806 | 0.01 | 0.02 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 640,267 | 689,807 | +49,540 | 1.80 | 1.95 | +0.15 | buy |
| AMERIPRISE FINANCIAL INC | 2,530,994 | 2,580,419 | +49,425 | 0.05 | 0.05 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 42,605 | 85,183 | +42,578 | 0.03 | 0.07 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 11,359 | 52,861 | +41,502 | 0.01 | 0.06 | +0.04 | buy |
| Polar Asset Management Partners Inc. | 18,100 | 57,500 | +39,400 | 0.03 | 0.09 | +0.06 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 72,100 | 107,500 | +35,400 | 4.07 | 6.36 | +2.29 | buy |
| First Turn Management, LLC | 323,360 | 356,451 | +33,091 | 3.52 | 4.12 | +0.60 | buy |
| Rhenman & Partners Asset Management AB | 99,513 | 129,513 | +30,000 | 0.64 | 0.77 | +0.13 | buy |
| CASTLEARK MANAGEMENT LLC | 16,660 | 43,300 | +26,640 | 0.05 | 0.13 | +0.08 | buy |
| RHUMBLINE ADVISERS | 236,527 | 263,045 | +26,518 | 0.02 | 0.02 | 0.00 | buy |
| Nicholas Investment Partners, LP | 74,871 | 101,145 | +26,274 | 0.52 | 0.68 | +0.16 | buy |
| Atika Capital Management LLC | 36,000 | 62,000 | +26,000 | 0.24 | 0.46 | +0.23 | buy |
| Swiss National Bank | 277,500 | 302,500 | +25,000 | 0.01 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 744,280 | 769,253 | +24,973 | 0.03 | 0.03 | +0.00 | buy |
| PROFUND ADVISORS LLC | 23,020 | 46,186 | +23,166 | 0.06 | 0.13 | 0.00 | buy |
| Ally Bridge Group (NY) LLC | 129,000 | 150,833 | +21,833 | 5.15 | 5.89 | +0.75 | buy |
| Boussard & Gavaudan Investment Management LLP | 13,309 | 28,004 | +14,695 | 4.40 | 5.93 | +1.53 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 80,734 | 94,961 | +14,227 | 0.01 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 18,942 | 33,052 | +14,110 | 0.18 | 0.27 | +0.09 | buy |
| ProShare Advisors LLC | 30,140 | 39,850 | +9,710 | 0.01 | 0.01 | 0.00 | buy |
| Allianz Asset Management GmbH | 115,177 | 105,677 | +9,500 | 0.01 | 0.01 | -0.00 | sell |
| Orion Porfolio Solutions, LLC | 18,917 | 28,087 | +9,170 | 0.01 | 0.02 | 0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 138,734 | 146,742 | +8,008 | 0.01 | 0.01 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 470,700 | 478,601 | +7,901 | 0.57 | 0.50 | -0.06 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 30,981 | 38,866 | +7,885 | 0.01 | 0.01 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 6,698 | 14,449 | +7,751 | 0.01 | 0.01 | 0.00 | buy |
| E Fund Management Co., Ltd. | 6,815 | 14,551 | +7,736 | 0.03 | 0.05 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 14,169 | 21,819 | +7,650 | 0.06 | 0.13 | 0.00 | buy |
| Lighthouse Investment Partners, LLC | 35,000 | 42,000 | +7,000 | 0.09 | 0.12 | +0.02 | buy |
| EntryPoint Capital, LLC | 1,004 | 5,563 | +4,559 | 0.10 | 0.23 | +0.13 | buy |
| SHELL ASSET MANAGEMENT CO | 14,294 | 10,567 | +3,727 | 0.04 | 0.03 | 0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 17,892 | 21,084 | +3,192 | 64.12 | 11.10 | -53.03 | buy |
| Calamos Advisors LLC | 25,229 | 28,276 | +3,047 | 0.01 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 34,236 | 36,721 | +2,485 | 0.01 | 0.01 | 0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 10,097 | 12,118 | +2,021 | 0.01 | 0.02 | +0.01 | buy |
| HighMark Wealth Management LLC | 4,575 | 6,010 | +1,435 | 0.18 | 0.24 | +0.06 | buy |
| Bridgefront Capital, LLC | 4,800 | 6,028 | +1,228 | 0.13 | 0.17 | +0.04 | buy |
| GUGGENHEIM CAPITAL LLC | 36,500 | 37,305 | +805 | 0.02 | 0.02 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 15,218 | 15,921 | +703 | 0.04 | 0.04 | +0.00 | buy |
| STRS OHIO | 22,300 | 23,000 | +700 | 0.01 | 0.01 | +0.00 | buy |
| Corebridge Financial, Inc. | 83,567 | 84,034 | +467 | 0.03 | 0.03 | 0.00 | buy |
| Global IMC LLC | 94,392 | 94,842 | +450 | 1.42 | 1.40 | -0.02 | buy |
| Compound Planning, Inc. | 22,934 | 23,248 | +314 | 0.11 | 0.11 | -0.01 | buy |
| Informed Momentum Co LLC | 107,781 | 107,972 | +191 | 1.17 | 1.18 | +0.00 | buy |
| COMMERCE BANK | 6,670 | 6,833 | +163 | 0.00 | 0.00 | 0.00 | buy |
| CIBC Asset Management Inc | 4,289 | 4,438 | +149 | 0.00 | 0.00 | 0.00 | buy |
| INTRUST BANK NA | 4,828 | 4,966 | +138 | 0.03 | 0.04 | +0.00 | buy |
| Meeder Advisory Services, Inc. | 3,511 | 3,619 | +108 | 0.02 | 0.02 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 56,600 | 56,700 | +100 | 0.30 | 0.32 | +0.02 | buy |
| SAXON INTERESTS, INC. | 6,585 | 6,617 | +32 | 0.21 | 0.22 | +0.01 | buy |
| MEEDER ASSET MANAGEMENT INC | 47 | 55 | +8 | 0.00 | 0.00 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 8,775 | 8,781 | +6 | 0.00 | 0.00 | +0.00 | buy |
| VALLEY NATIONAL ADVISERS INC | 32 | 22 | -10 | 0.00 | 0.00 | -0.00 | sell |
| MONTAG A & ASSOCIATES INC | 631 | 500 | -131 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 9,821 | 9,681 | -140 | 0.27 | 0.42 | +0.15 | sell |
| Artia Global Partners LP | 53,436 | 52,939 | -497 | 0.92 | 1.09 | +0.17 | sell |
| Northwest & Ethical Investments L.P. | 1,600 | 1,050 | -550 | 0.00 | 0.00 | -0.00 | sell |
| Vise Technologies, Inc. | 6,506 | 5,298 | -1,208 | 0.08 | 0.05 | -0.03 | sell |
| PITCAIRN CO | 7,358 | 6,079 | -1,279 | 0.03 | 0.03 | -0.00 | sell |
| Dana Investment Advisors, Inc. | 22,976 | 21,596 | -1,380 | 0.05 | 0.05 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,700 | 11,049 | -1,651 | 0.07 | 0.06 | -0.01 | sell |
| Beacon Financial Advisory LLC | 13,825 | 11,675 | -2,150 | 0.35 | 0.29 | -0.06 | sell |
| OAK RIDGE INVESTMENTS LLC | 60,851 | 58,354 | -2,497 | 0.39 | 0.37 | -0.02 | sell |
| Semanteon Capital Management, LP | 16,156 | 13,455 | -2,701 | 0.77 | 0.67 | -0.10 | sell |
| EFG Asset Management (North America) Corp. | 53,898 | 50,867 | -3,031 | 0.63 | 0.62 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 96,824 | 93,492 | -3,332 | 0.39 | 0.37 | -0.02 | sell |
| Edgestream Partners, L.P. | 8,055 | 3,250 | -4,805 | 0.03 | 0.01 | -0.02 | sell |