| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 15,636,399 | 23,047,676 | +7,411,277 | 0.11 | 0.21 | +0.10 | buy |
| Darwin Global Management, Ltd. | 19,344,621 | 20,457,445 | +1,112,824 | 80.75 | 80.54 | -0.21 | buy |
| VANGUARD GROUP INC | 17,644,492 | 19,935,820 | +2,291,328 | 0.03 | 0.04 | +0.01 | buy |
| BlackRock, Inc. | 11,142,432 | 12,364,904 | +1,222,472 | 0.02 | 0.03 | +0.01 | buy |
| FMR LLC | 5,093,261 | 9,180,963 | +4,087,702 | 0.03 | 0.07 | +0.04 | buy |
| Capital International Investors | 7,478,859 | 7,553,853 | +74,994 | 0.13 | 0.18 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,230,705 | 6,931,466 | -4,299,239 | 0.13 | 0.11 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 7,712,900 | 6,703,484 | -1,009,416 | 7.53 | 6.98 | -0.55 | sell |
| D. E. Shaw & Co., Inc. | 3,422,619 | 5,657,464 | +2,234,845 | 0.34 | 0.66 | +0.31 | buy |
| Artisan Partners Limited Partnership | 3,314,341 | 4,937,683 | +1,623,342 | 0.50 | 1.02 | +0.53 | buy |
| STATE STREET CORP | 4,277,888 | 3,984,354 | -293,534 | 0.02 | 0.02 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,340,707 | 3,759,427 | +418,720 | 0.02 | 0.03 | +0.01 | buy |
| Orbis Allan Gray Ltd | 1,524,134 | 3,250,868 | +1,726,734 | 0.75 | 2.01 | +1.26 | buy |
| RTW INVESTMENTS, LP | 3,084,558 | 3,084,558 | 0 | 4.42 | 5.47 | +1.05 | hold |
| AMERIPRISE FINANCIAL INC | 2,957,973 | 2,721,879 | -236,094 | 0.07 | 0.09 | +0.02 | sell |
| Duquesne Family Office LLC | 2,253,435 | 2,423,435 | +170,000 | 5.79 | 8.88 | +3.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,121,717 | 2,336,112 | +214,395 | 0.19 | 0.26 | +0.07 | buy |
| FRANKLIN RESOURCES INC | 2,350,133 | 2,139,725 | -210,408 | 0.06 | 0.08 | +0.01 | sell |
| CITADEL ADVISORS LLC | 1,533,277 | 2,057,641 | +524,364 | 0.13 | 0.24 | +0.10 | buy |
| Invesco Ltd. | 1,896,333 | 2,003,871 | +107,538 | 0.03 | 0.05 | +0.01 | buy |
| UBS Group AG | 293,454 | 1,646,239 | +1,352,785 | 0.01 | 0.05 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 1,226,737 | 1,601,806 | +375,069 | 0.01 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 1,600,000 | 1,600,000 | 0 | 15.04 | 16.80 | +1.75 | hold |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,665,602 | 1,555,057 | -110,545 | 0.44 | 0.58 | +0.13 | sell |
| Qube Research & Technologies Ltd | 1,082,050 | 1,544,315 | +462,265 | 0.15 | 0.31 | +0.16 | buy |
| LORD, ABBETT & CO. LLC | 1,545,859 | 1,444,656 | -101,203 | 0.50 | 0.62 | +0.12 | sell |
| ROYAL BANK OF CANADA | 427,801 | 1,355,331 | +927,530 | 0.01 | 0.03 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,859,452 | 1,252,503 | -1,606,949 | 0.48 | 0.29 | -0.20 | sell |
| JANUS HENDERSON GROUP PLC | 2,293,142 | 1,202,783 | -1,090,359 | 0.11 | 0.08 | -0.03 | sell |
| Pictet Asset Management Holding SA | 1,553,628 | 1,140,827 | -412,801 | 0.16 | 0.16 | -0.00 | sell |
| Bank of New York Mellon Corp | 1,197,473 | 1,138,901 | -58,572 | 0.02 | 0.03 | +0.01 | sell |
| Castle Hook Partners LP | 452,656 | 1,091,405 | +638,749 | 0.67 | 2.38 | +1.71 | buy |
| Holocene Advisors, LP | 2,016,806 | 1,083,681 | -933,125 | 0.50 | 0.36 | -0.14 | sell |
| NORTHERN TRUST CORP | 969,800 | 1,072,942 | +103,142 | 0.01 | 0.02 | +0.01 | buy |
| Clearbridge Investments, LLC | 1,424,562 | 1,068,018 | -356,544 | 0.12 | 0.12 | -0.00 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 1,008,937 | 1,041,845 | +32,908 | 3.96 | 4.89 | +0.93 | buy |
| NWI MANAGEMENT LP | 720,000 | 1,021,000 | +301,000 | 6.65 | 14.52 | +7.87 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,196,494 | 1,005,107 | -191,387 | 2.11 | 2.38 | +0.27 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,299,568 | 975,279 | -324,289 | 0.02 | 0.02 | -0.00 | sell |
| MORGAN STANLEY | 1,043,791 | 963,631 | -80,160 | 0.01 | 0.01 | +0.00 | sell |
| Hood River Capital Management LLC | 899,603 | 881,403 | -18,200 | 1.26 | 1.50 | +0.23 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,343,212 | 868,772 | -474,440 | 0.04 | 0.04 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 1,348,027 | 864,294 | -483,733 | 0.07 | 0.06 | -0.01 | sell |
| FIL Ltd | 1,165,464 | 851,954 | -313,510 | 0.10 | 0.10 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,810,895 | 829,317 | -981,578 | 0.03 | 0.02 | -0.01 | sell |
| Fiera Capital Corp | 748,037 | 809,121 | +61,084 | 0.26 | 0.38 | +0.12 | buy |
| JANE STREET GROUP, LLC | 1,352,922 | 791,734 | -561,188 | 0.22 | 0.13 | -0.09 | sell |
| TWO SIGMA INVESTMENTS, LP | 376,508 | 772,780 | +396,272 | 0.07 | 0.17 | +0.10 | buy |
| RAYMOND JAMES FINANCIAL INC | 784,551 | 759,978 | -24,573 | 0.03 | 0.04 | +0.01 | sell |
| Artia Global Partners LP | 752,712 | 732,212 | -20,500 | 19.48 | 18.55 | -0.93 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,159,699 | 718,043 | -441,656 | 0.02 | 0.02 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 650,252 | 702,130 | +51,878 | 2.46 | 2.92 | +0.47 | buy |
| MARSHALL WACE, LLP | 1,113,361 | 658,647 | -454,714 | 0.13 | 0.10 | -0.03 | sell |
| MAVERICK CAPITAL LTD | 804,133 | 656,539 | -147,594 | 1.24 | 1.27 | +0.02 | sell |
| MACQUARIE GROUP LTD | 1,128,898 | 649,847 | -479,051 | 0.14 | 0.11 | -0.03 | sell |
| Ensign Peak Advisors, Inc | 564,389 | 642,034 | +77,645 | 0.10 | 0.15 | +0.05 | buy |
| JENNISON ASSOCIATES LLC | 715,606 | 602,775 | -112,831 | 0.04 | 0.05 | +0.01 | sell |
| GW&K Investment Management, LLC | 1,274,316 | 601,803 | -672,513 | 1.15 | 0.77 | -0.38 | sell |
| SEI INVESTMENTS CO | 433,628 | 593,885 | +160,257 | 0.05 | 0.09 | +0.04 | buy |
| Nuveen, LLC | 588,987 | 588,122 | -865 | 0.02 | 0.02 | +0.01 | sell |
| 1832 Asset Management L.P. | 0 | 584,800 | +584,800 | 0.00 | 0.14 | +0.14 | buy |
| WELLS FARGO & COMPANY/MN | 259,207 | 513,849 | +254,642 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 695,961 | 512,749 | -183,212 | 0.01 | 0.02 | +0.00 | sell |
| BANK OF NOVA SCOTIA | 0 | 506,245 | +506,245 | 0.00 | 0.13 | +0.13 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 500,000 | 500,000 | 0 | 0.24 | 0.33 | +0.08 | hold |
| LOOMIS SAYLES & CO L P | 793,569 | 492,296 | -301,273 | 0.10 | 0.08 | -0.02 | sell |
| Palo Alto Investors LP | 865,113 | 491,805 | -373,308 | 18.52 | 13.11 | -5.42 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,339,288 | 487,927 | -851,361 | 0.57 | 0.29 | -0.27 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 313,053 | 471,649 | +158,596 | 0.12 | 0.23 | +0.11 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 700,700 | 471,000 | -229,700 | 1.28 | 1.04 | -0.24 | sell |
| Point72 Asset Management, L.P. | 490,667 | 464,217 | -26,450 | 0.12 | 0.15 | +0.03 | sell |
| Affinity Asset Advisors, LLC | 475,000 | 450,000 | -25,000 | 7.07 | 6.03 | -1.04 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 427,753 | 445,876 | +18,123 | 0.06 | 0.08 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 754,160 | 433,340 | -320,820 | 0.06 | 0.05 | -0.01 | sell |
| Cormorant Asset Management, LP | 540,000 | 430,000 | -110,000 | 4.05 | 4.27 | +0.22 | sell |
| TimesSquare Capital Management, LLC | 873,491 | 425,085 | -448,406 | 1.27 | 0.88 | -0.39 | sell |
| TD ASSET MANAGEMENT INC | 395,194 | 398,256 | +3,062 | 0.03 | 0.05 | +0.01 | buy |
| Candriam S.C.A. | 438,688 | 397,588 | -41,100 | 0.25 | 0.30 | +0.05 | sell |
| DIMENSIONAL FUND ADVISORS LP | 411,744 | 386,671 | -25,073 | 0.01 | 0.01 | +0.00 | sell |
| Rock Springs Capital Management LP | 525,000 | 385,000 | -140,000 | 3.29 | 3.24 | -0.05 | sell |
| ING GROEP NV | 0 | 373,500 | +373,500 | 0.00 | 0.29 | +0.29 | buy |
| Polar Capital Holdings Plc | 697,960 | 371,887 | -326,073 | 0.37 | 0.26 | -0.11 | sell |
| Swiss National Bank | 347,400 | 371,300 | +23,900 | 0.02 | 0.03 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 182,773 | 354,907 | +172,134 | 0.01 | 0.03 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 308,687 | 352,887 | +44,200 | 0.04 | 0.07 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 365,827 | 342,785 | -23,042 | 0.01 | 0.01 | +0.00 | sell |
| Long Focus Capital Management, LLC | 520,200 | 338,000 | -182,200 | 3.38 | 2.78 | -0.60 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 147,801 | 328,884 | +181,083 | 0.14 | 0.42 | +0.29 | buy |
| FEDERATED HERMES, INC. | 108,385 | 328,223 | +219,838 | 0.02 | 0.08 | +0.06 | buy |
| Patient Square Capital LP | 358,800 | 326,400 | -32,400 | 13.02 | 12.57 | -0.44 | sell |
| First Turn Management, LLC | 372,672 | 319,773 | -52,899 | 7.00 | 6.91 | -0.08 | sell |
| Amundi | 11,499 | 317,096 | +305,597 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 222,236 | 310,886 | +88,650 | 0.01 | 0.03 | +0.01 | buy |
| Brevan Howard Capital Management LP | 202,594 | 294,047 | +91,453 | 0.22 | 0.61 | +0.38 | buy |
| SAMLYN CAPITAL, LLC | 0 | 292,643 | +292,643 | 0.00 | 0.60 | +0.60 | buy |
| AQR CAPITAL MANAGEMENT LLC | 49,715 | 287,286 | +237,571 | 0.00 | 0.03 | +0.02 | buy |
| Eagle Health Investments LP | 428,600 | 271,600 | -157,000 | 10.65 | 10.27 | -0.38 | sell |
| FIRST TRUST ADVISORS LP | 47,392 | 240,646 | +193,254 | 0.00 | 0.03 | +0.02 | buy |
| Aberdeen Group plc | 309,749 | 234,622 | -75,127 | 0.05 | 0.05 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 212,222 | 233,106 | +20,884 | 0.03 | 0.05 | +0.02 | buy |