| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 2,174,829 | 1,605,001 | +569,828 | 0.07 | 0.06 | 0.00 | sell |
| JANUS HENDERSON GROUP PLC | 1,914,802 | 1,403,091 | +511,711 | 0.03 | 0.03 | 0.00 | sell |
| AMERIPRISE FINANCIAL INC | 1,876,713 | 2,282,491 | +405,778 | 0.02 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,407,216 | 10,763,771 | +356,555 | 0.04 | 0.05 | +0.01 | buy |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 8,679,000 | 9,000,000 | +321,000 | 1.23 | 1.50 | +0.27 | buy |
| TWO SIGMA INVESTMENTS, LP | 594,160 | 352,612 | +241,548 | 0.04 | 0.03 | 0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,873,697 | 3,069,378 | +195,681 | 0.01 | 0.01 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 446,104 | 271,312 | +174,792 | 0.06 | 0.04 | -0.02 | sell |
| Knights of Columbus Asset Advisors LLC | 113,796 | 228,783 | +114,987 | 0.26 | 0.46 | +0.19 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,290,282 | 1,359,563 | +69,281 | 0.02 | 0.03 | 0.00 | buy |
| Informed Momentum Co LLC | 64,558 | 132,979 | +68,421 | 0.31 | 0.73 | +0.42 | buy |
| Rafferty Asset Management, LLC | 273,524 | 321,087 | +47,563 | 0.04 | 0.04 | +0.00 | buy |
| HighVista Strategies LLC | 80,000 | 126,780 | +46,780 | 0.93 | 1.43 | +0.49 | buy |
| BNP Paribas Asset Management Holding S.A. | 856,198 | 895,946 | +39,748 | 0.07 | 0.08 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 38,387 | 68,984 | +30,597 | 0.09 | 0.20 | 0.00 | buy |
| Parkman Healthcare Partners LLC | 125,000 | 150,816 | +25,816 | 0.58 | 0.66 | +0.08 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 4,241,935 | 4,256,687 | +14,752 | 0.36 | 0.38 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 3,698 | 16,551 | +12,853 | 0.03 | 0.10 | +0.07 | buy |
| Y-Intercept (Hong Kong) Ltd | 16,283 | 25,270 | +8,987 | 0.04 | 0.07 | 0.00 | buy |
| EFG Asset Management (North America) Corp. | 52,693 | 59,724 | +7,031 | 0.32 | 0.35 | +0.04 | buy |
| PROFUND ADVISORS LLC | 47,687 | 54,027 | +6,340 | 0.07 | 0.07 | 0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 289,736 | 295,328 | +5,592 | 0.02 | 0.03 | +0.00 | buy |
| ProShare Advisors LLC | 26,525 | 32,023 | +5,498 | 0.00 | 0.00 | 0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 150,387 | 155,504 | +5,117 | 1.41 | 1.49 | +0.07 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 744,733 | 748,344 | +3,611 | 1.13 | 1.23 | +0.09 | buy |
| E Fund Management Co., Ltd. | 14,048 | 17,178 | +3,130 | 0.03 | 0.03 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 59,292 | 56,727 | +2,565 | 0.04 | 0.13 | 0.00 | sell |
| First Light Asset Management, LLC | 643,588 | 646,057 | +2,469 | 1.54 | 1.61 | +0.07 | buy |
| B. Metzler seel. Sohn & Co. AG | 16,621 | 18,672 | +2,051 | 0.01 | 0.01 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 13,097 | 14,309 | +1,212 | 0.01 | 0.02 | +0.00 | buy |
| Diversified Trust Co | 19,634 | 20,606 | +972 | 0.02 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 527,458 | 528,150 | +692 | 3.56 | 3.83 | +0.27 | buy |
| Dana Investment Advisors, Inc. | 15,365 | 15,630 | +265 | 0.02 | 0.02 | +0.00 | buy |
| Atom Investors LP | 12,201 | 11,764 | -437 | 0.07 | 0.06 | -0.01 | sell |
| J. Goldman & Co LP | 26,661 | 26,014 | -647 | 0.02 | 0.03 | +0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 224,465 | 221,270 | -3,195 | 0.36 | 0.40 | +0.04 | sell |
| VIRTUS ADVISERS, LLC | 15,777 | 11,295 | -4,482 | 0.24 | 0.22 | -0.02 | sell |
| EMERALD ADVISERS, LLC | 937,516 | 930,849 | -6,667 | 1.15 | 1.23 | +0.09 | sell |
| OAK RIDGE INVESTMENTS LLC | 95,523 | 87,348 | -8,175 | 0.31 | 0.31 | +0.00 | sell |
| Candriam S.C.A. | 325,200 | 310,200 | -15,000 | 0.06 | 0.07 | +0.01 | sell |
| Graham Capital Management, L.P. | 43,605 | 11,308 | -32,297 | 0.03 | 0.01 | -0.02 | sell |
| Hennion & Walsh Asset Management, Inc. | 171,006 | 138,035 | -32,971 | 0.28 | 0.24 | -0.03 | sell |
| Granahan Investment Management, LLC | 235,980 | 202,193 | -33,787 | 0.21 | 0.21 | -0.01 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 148,419 | 108,007 | -40,412 | 0.61 | 0.66 | +0.05 | sell |
| Sonora Investment Management Group, LLC | 6,124,000 | 6,074,000 | -50,000 | 0.52 | 0.52 | +0.01 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 340,125 | 290,088 | -50,037 | 0.26 | 0.27 | +0.01 | sell |
| Soleus Capital Management, L.P. | 218,000 | 167,100 | -50,900 | 0.55 | 0.57 | +0.02 | sell |
| LOOMIS SAYLES & CO L P | 2,383,039 | 2,331,505 | -51,534 | 0.10 | 0.11 | +0.01 | sell |
| TD ASSET MANAGEMENT INC | 523,132 | 463,532 | -59,600 | 0.02 | 0.01 | -0.00 | sell |
| GW&K Investment Management, LLC | 1,352,269 | 1,291,772 | -60,497 | 0.34 | 0.37 | +0.03 | sell |
| SAMLYN CAPITAL, LLC | 1,381,057 | 1,286,868 | -94,189 | 0.57 | 0.79 | +0.22 | sell |
| FIL Ltd | 831,202 | 691,431 | -139,771 | 0.02 | 0.02 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 394,872 | 225,912 | -168,960 | 1.82 | 1.19 | -0.62 | sell |
| Holocene Advisors, LP | 1,808,488 | 1,614,862 | -193,626 | 0.20 | 0.20 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 347,392 | 13,811 | -333,581 | 1.71 | 0.18 | -1.52 | sell |
| Polar Capital Holdings Plc | 861,400 | 504,275 | -357,125 | 0.16 | 0.10 | -0.07 | sell |
| Palo Alto Investors LP | 5,889,491 | 5,511,721 | -377,770 | 14.07 | 15.39 | +1.32 | sell |
| Hudson Bay Capital Management LP | 847,500 | 467,500 | -380,000 | 0.17 | 0.09 | -0.08 | sell |
| Deep Track Capital, LP | 6,000,000 | 5,350,000 | -650,000 | 5.87 | 5.81 | -0.07 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,446,334 | 2,684,487 | -761,847 | 4.70 | 3.76 | -0.94 | sell |
| Bellevue Group AG | 3,162,735 | 2,290,958 | -871,777 | 1.29 | 1.09 | -0.20 | sell |
| T. Rowe Price Investment Management, Inc. | 8,324,884 | 5,850,606 | -2,474,278 | 0.15 | 0.12 | -0.03 | sell |
| LORD, ABBETT & CO. LLC | 24,273,000 | 18,718,000 | -5,555,000 | 0.09 | 0.08 | -0.01 | sell |