| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 8,573,000 | 5,404,000 | +3,169,000 | 0.01 | 0.01 | 0.00 | sell |
| Darwin Global Management, Ltd. | 10,497,277 | 12,960,538 | +2,463,261 | 62.31 | 84.75 | +22.44 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 251,739 | 938,551 | +686,812 | 0.08 | 0.28 | +0.20 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,032,562 | 1,647,562 | +615,000 | 0.13 | 0.20 | +0.07 | buy |
| Capital International Investors | 6,523,791 | 7,116,997 | +593,206 | 0.09 | 0.09 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,415,918 | 5,006,863 | +590,945 | 3.34 | 3.69 | +0.35 | buy |
| Duquesne Family Office LLC | 20,000 | 593,470 | +573,470 | 0.05 | 1.10 | +1.05 | buy |
| Soleus Capital Management, L.P. | 30,272 | 320,272 | +290,000 | 0.18 | 1.67 | +1.49 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,813,384 | 4,087,143 | +273,759 | 0.02 | 0.02 | 0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,580,419 | 2,850,097 | +269,678 | 0.05 | 0.05 | +0.00 | buy |
| Artisan Partners Limited Partnership | 2,884,097 | 3,126,339 | +242,242 | 0.31 | 0.32 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 801,139 | 593,996 | +207,143 | 0.14 | 0.10 | 0.00 | sell |
| TimesSquare Capital Management, LLC | 483,869 | 684,384 | +200,515 | 0.53 | 100.00 | +99.47 | buy |
| FIL Ltd | 2,439,748 | 2,638,160 | +198,412 | 0.16 | 0.17 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 906,395 | 1,100,993 | +194,598 | 1.14 | 1.38 | +0.24 | buy |
| Alyeska Investment Group, L.P. | 747,402 | 935,779 | +188,377 | 0.28 | 0.24 | -0.04 | buy |
| NWI MANAGEMENT LP | 97,540 | 279,000 | +181,460 | 0.19 | 0.85 | +0.66 | buy |
| Aberdeen Group plc | 111,612 | 289,653 | +178,041 | 0.01 | 0.04 | +0.02 | buy |
| Cormorant Asset Management, LP | 500,000 | 650,000 | +150,000 | 1.94 | 2.46 | +0.53 | buy |
| BNP Paribas Asset Management Holding S.A. | 509,439 | 654,901 | +145,462 | 0.09 | 0.11 | +0.02 | buy |
| Patient Square Capital LP | 171,704 | 307,167 | +135,463 | 4.65 | 7.93 | +3.28 | buy |
| MILLENNIUM MANAGEMENT LLC | 564,856 | 699,006 | +134,150 | 0.04 | 0.05 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 140,422 | 268,063 | +127,641 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,580,981 | 12,704,410 | +123,429 | 0.11 | 0.10 | -0.00 | buy |
| Artia Global Partners LP | 52,939 | 167,939 | +115,000 | 1.09 | 4.68 | +3.58 | buy |
| Qube Research & Technologies Ltd | 489,307 | 389,033 | +100,274 | 0.07 | 0.05 | 0.00 | sell |
| Integral Health Asset Management, LLC | 1,450,000 | 1,550,000 | +100,000 | 12.46 | 9.46 | -3.00 | buy |
| J. Goldman & Co LP | 11,226 | 104,179 | +92,953 | 0.02 | 0.19 | +0.16 | buy |
| First Turn Management, LLC | 356,451 | 446,980 | +90,529 | 4.12 | 5.53 | +1.41 | buy |
| AMERICAN CENTURY COMPANIES INC | 723,683 | 812,780 | +89,097 | 0.03 | 0.03 | +0.00 | buy |
| Nicholas Investment Partners, LP | 101,145 | 182,743 | +81,598 | 0.68 | 1.11 | +0.43 | buy |
| Clearbridge Investments, LLC | 1,808,767 | 1,878,450 | +69,683 | 0.10 | 0.11 | +0.00 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 578,356 | 638,848 | +60,492 | 1.31 | 0.84 | -0.47 | buy |
| EFG Asset Management (North America) Corp. | 50,867 | 107,625 | +56,758 | 0.62 | 1.01 | +0.39 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,871,890 | 1,817,643 | +54,247 | 0.08 | 0.07 | 0.00 | sell |
| Hood River Capital Management LLC | 1,472,555 | 1,525,628 | +53,073 | 1.74 | 1.56 | -0.18 | buy |
| Polar Capital Holdings Plc | 680,000 | 730,000 | +50,000 | 0.24 | 0.28 | +0.05 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 455,959 | 410,577 | +45,382 | 0.03 | 0.03 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 17,682 | 59,600 | +41,918 | 0.06 | 0.18 | 0.00 | buy |
| Edgestream Partners, L.P. | 3,250 | 43,619 | +40,369 | 0.01 | 0.13 | +0.12 | buy |
| Allspring Global Investments Holdings, LLC | 390,134 | 423,094 | +32,960 | 0.04 | 0.05 | 0.00 | buy |
| RHUMBLINE ADVISERS | 263,045 | 288,337 | +25,292 | 0.02 | 0.02 | 0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 292,779 | 317,753 | +24,974 | 0.03 | 0.03 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 46,593 | 71,227 | +24,634 | 0.04 | 0.05 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 347,695 | 372,230 | +24,535 | 5.72 | 5.75 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 12,118 | 36,058 | +23,940 | 0.02 | 0.06 | +0.04 | buy |
| Long Focus Capital Management, LLC | 628,900 | 650,800 | +21,900 | 1.61 | 1.46 | -0.15 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 172,837 | 193,479 | +20,642 | 0.38 | 0.40 | +0.01 | buy |
| BAMCO INC /NY/ | 40,500 | 60,000 | +19,500 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 302,500 | 321,100 | +18,600 | 0.01 | 0.02 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 3,634 | 21,974 | +18,340 | 0.04 | 0.31 | +0.27 | buy |
| ProShare Advisors LLC | 39,850 | 56,991 | +17,141 | 0.01 | 0.01 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 513,082 | 526,890 | +13,808 | 0.03 | 0.03 | -0.00 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 2,420,908 | 2,433,443 | +12,535 | 0.44 | 0.41 | -0.03 | buy |
| PRUDENTIAL FINANCIAL INC | 134,590 | 146,722 | +12,132 | 0.01 | 0.01 | 0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 94,961 | 105,313 | +10,352 | 0.02 | 0.02 | -0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 43,300 | 52,780 | +9,480 | 0.13 | 0.13 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 38,866 | 48,337 | +9,471 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 46,186 | 37,085 | +9,101 | 0.13 | 0.09 | 0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 4,069 | 11,936 | +7,867 | 0.06 | 0.15 | +0.09 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 36,721 | 43,476 | +6,755 | 0.01 | 0.01 | 0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 146,742 | 153,343 | +6,601 | 0.01 | 0.01 | -0.00 | buy |
| ALGERT GLOBAL LLC | 81,501 | 75,754 | +5,747 | 0.16 | 0.12 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 33,052 | 37,934 | +4,882 | 0.27 | 0.25 | -0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 21,819 | 26,615 | +4,796 | 0.13 | 0.15 | 0.00 | buy |
| JENNISON ASSOCIATES LLC | 769,253 | 773,813 | +4,560 | 0.03 | 0.03 | -0.00 | buy |
| Catalyst Funds Management Pty Ltd | 7,000 | 11,250 | +4,250 | 0.11 | 0.19 | +0.08 | buy |
| HAP Trading, LLC | 83,481 | 87,533 | +4,052 | 0.70 | 0.52 | -0.17 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 167,430 | 171,289 | +3,859 | 0.10 | 0.10 | -0.01 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 45,543 | 48,897 | +3,354 | 0.11 | 0.07 | -0.04 | buy |
| GUGGENHEIM CAPITAL LLC | 37,305 | 34,342 | +2,963 | 0.02 | 0.02 | 0.00 | sell |
| Altium Capital Management LLC | 130,000 | 132,000 | +2,000 | 2.83 | 2.84 | +0.01 | buy |
| STRS OHIO | 23,000 | 24,900 | +1,900 | 0.01 | 0.01 | +0.00 | buy |
| Corebridge Financial, Inc. | 84,034 | 85,719 | +1,685 | 0.03 | 0.03 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 15,921 | 17,551 | +1,630 | 0.04 | 0.04 | +0.00 | buy |
| Compound Planning, Inc. | 23,248 | 24,774 | +1,526 | 0.11 | 0.09 | -0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 10,179 | 9,205 | +974 | 0.00 | 0.00 | 0.00 | sell |
| Legato Capital Management LLC | 36,079 | 36,871 | +792 | 0.33 | 0.33 | +0.01 | buy |
| Treasurer of the State of North Carolina | 42,500 | 41,770 | +730 | 0.01 | 0.01 | 0.00 | sell |
| CI INVESTMENTS INC. | 3,765 | 4,396 | +631 | 0.00 | 0.00 | 0.00 | buy |
| Quarry LP | 2,400 | 3,000 | +600 | 0.05 | 0.04 | 0.00 | buy |
| INTRUST BANK NA | 4,966 | 5,566 | +600 | 0.04 | 0.04 | +0.00 | buy |
| RWC Asset Management LLP | 3,084 | 3,485 | +401 | 0.01 | 0.01 | -0.00 | buy |
| Vise Technologies, Inc. | 5,298 | 5,634 | +336 | 0.05 | 0.03 | -0.02 | buy |
| Orion Porfolio Solutions, LLC | 28,087 | 27,762 | +325 | 0.02 | 0.02 | 0.00 | sell |
| Hillsdale Investment Management Inc. | 56,700 | 57,000 | +300 | 0.32 | 0.20 | -0.12 | buy |
| V-Square Quantitative Management LLC | 411 | 659 | +248 | 0.00 | 0.01 | +0.00 | buy |
| CIBC Asset Management Inc | 4,438 | 4,685 | +247 | 0.00 | 0.00 | 0.00 | buy |
| Parkman Healthcare Partners LLC | 35,433 | 35,668 | +235 | 0.33 | 0.33 | -0.00 | buy |
| Values First Advisors, Inc. | 4,978 | 5,199 | +221 | 0.20 | 0.20 | +0.00 | buy |
| Abel Hall, LLC | 3,182 | 3,333 | +151 | 0.15 | 0.15 | -0.01 | buy |
| COMMERCE BANK | 6,833 | 6,758 | +75 | 0.00 | 0.00 | 0.00 | sell |
| COLDSTREAM CAPITAL MANAGEMENT INC | 3,490 | 3,551 | +61 | 0.01 | 0.01 | -0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 14,449 | 14,482 | +33 | 0.01 | 0.01 | 0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 10,567 | 10,556 | +11 | 0.03 | 0.03 | 0.00 | sell |
| MEEDER ASSET MANAGEMENT INC | 55 | 62 | +7 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 6,123 | 6,120 | -3 | 0.87 | 0.96 | +0.09 | sell |
| MIRAE ASSET SECURITIES (USA) INC. | 13,942 | 13,936 | -6 | 0.06 | 0.04 | -0.01 | sell |
| Johnson Financial Group, Inc. | 95 | 75 | -20 | 0.00 | 0.00 | -0.00 | sell |
| PITCAIRN CO | 6,079 | 6,020 | -59 | 0.03 | 0.02 | -0.00 | sell |