| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 17,143,177 | 18,218,973 | +1,075,796 | 0.02 | 0.02 | -0.00 | buy |
| BlackRock, Inc. | 14,970,152 | 16,032,944 | +1,062,792 | 0.02 | 0.02 | -0.00 | buy |
| Darwin Global Management, Ltd. | 10,497,277 | 12,960,538 | +2,463,261 | 62.31 | 84.75 | +22.44 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,580,981 | 12,704,410 | +123,429 | 0.11 | 0.10 | -0.00 | buy |
| Capital International Investors | 6,523,791 | 7,116,997 | +593,206 | 0.09 | 0.09 | +0.00 | buy |
| STATE STREET CORP | 6,178,230 | 6,106,153 | -72,077 | 0.02 | 0.02 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 8,573,000 | 5,404,000 | -3,169,000 | 0.01 | 0.01 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 4,415,918 | 5,006,863 | +590,945 | 3.34 | 3.69 | +0.35 | buy |
| FMR LLC | 7,191,518 | 4,856,249 | -2,335,269 | 0.03 | 0.02 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,813,384 | 4,087,143 | +273,759 | 0.02 | 0.02 | -0.00 | buy |
| JPMORGAN CHASE & CO | 3,306,346 | 3,286,248 | -20,098 | 0.02 | 0.02 | -0.00 | sell |
| Artisan Partners Limited Partnership | 2,884,097 | 3,126,339 | +242,242 | 0.32 | 0.33 | +0.02 | buy |
| RTW INVESTMENTS, LP | 3,272,008 | 3,014,558 | -257,450 | 3.46 | 3.15 | -0.31 | sell |
| AMERIPRISE FINANCIAL INC | 2,580,419 | 2,850,097 | +269,678 | 0.05 | 0.05 | +0.00 | buy |
| FIL Ltd | 2,439,748 | 2,638,160 | +198,412 | 0.16 | 0.17 | +0.01 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 2,420,908 | 2,433,443 | +12,535 | 0.44 | 0.41 | -0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,450,093 | 2,363,561 | -86,532 | 0.06 | 0.06 | -0.00 | sell |
| MACQUARIE GROUP LTD | 2,285,921 | 2,313,159 | +27,238 | 0.18 | 0.19 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 2,721,389 | 2,160,103 | -561,286 | 0.06 | 0.04 | -0.02 | sell |
| T. Rowe Price Investment Management, Inc. | 2,277,143 | 1,982,707 | -294,436 | 0.10 | 0.08 | -0.02 | sell |
| Pictet Asset Management Holding SA | 1,863,341 | 1,959,718 | +96,377 | 0.15 | 0.15 | -0.00 | buy |
| Clearbridge Investments, LLC | 1,808,767 | 1,878,450 | +69,683 | 0.10 | 0.11 | +0.00 | buy |
| NORGES BANK | 1,656,767 | 1,833,810 | +177,043 | 0.02 | 0.02 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,871,890 | 1,817,643 | -54,247 | 0.07 | 0.07 | -0.01 | sell |
| NORTHERN TRUST CORP | 1,459,964 | 1,750,642 | +290,678 | 0.02 | 0.02 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,393,049 | 1,720,049 | +327,000 | 0.02 | 0.02 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,032,562 | 1,647,562 | +615,000 | 0.13 | 0.20 | +0.07 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,635,709 | 1,611,561 | -24,148 | 4.29 | 4.12 | -0.16 | sell |
| Palo Alto Investors LP | 1,940,993 | 1,603,465 | -337,528 | 18.40 | 17.15 | -1.25 | sell |
| Integral Health Asset Management, LLC | 1,450,000 | 1,550,000 | +100,000 | 12.46 | 9.46 | -3.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,444,266 | 1,546,607 | +102,341 | 0.02 | 0.02 | -0.00 | buy |
| Hood River Capital Management LLC | 1,472,555 | 1,525,628 | +53,073 | 1.74 | 1.56 | -0.18 | buy |
| LORD, ABBETT & CO. LLC | 1,470,961 | 1,457,210 | -13,751 | 0.34 | 0.32 | -0.02 | sell |
| JANUS HENDERSON GROUP PLC | 1,488,904 | 1,445,696 | -43,208 | 0.06 | 0.05 | -0.00 | sell |
| Bank of New York Mellon Corp | 1,470,217 | 1,438,466 | -31,751 | 0.02 | 0.02 | -0.00 | sell |
| MORGAN STANLEY | 1,320,991 | 1,351,365 | +30,374 | 0.01 | 0.01 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,250,000 | 1,250,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| LOOMIS SAYLES & CO L P | 1,210,187 | 1,174,791 | -35,396 | 0.12 | 0.10 | -0.01 | sell |
| GW&K Investment Management, LLC | 1,153,515 | 1,135,393 | -18,122 | 0.72 | 0.67 | -0.05 | sell |
| BANK OF AMERICA CORP /DE/ | 1,153,898 | 1,107,666 | -46,232 | 0.01 | 0.01 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 906,395 | 1,100,993 | +194,598 | 1.14 | 1.38 | +0.24 | buy |
| MARSHALL WACE, LLP | 771,211 | 1,064,215 | +293,004 | 0.07 | 0.09 | +0.02 | buy |
| Invesco Ltd. | 1,062,395 | 1,016,090 | -46,305 | 0.01 | 0.01 | -0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 251,739 | 938,551 | +686,812 | 0.08 | 0.28 | +0.20 | buy |
| Alyeska Investment Group, L.P. | 747,402 | 935,779 | +188,377 | 0.28 | 0.24 | -0.04 | buy |
| Vestal Point Capital, LP | 1,600,000 | 900,000 | -700,000 | 9.22 | 3.68 | -5.53 | sell |
| AMERICAN CENTURY COMPANIES INC | 723,683 | 812,780 | +89,097 | 0.03 | 0.03 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 769,253 | 773,813 | +4,560 | 0.03 | 0.03 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 962,459 | 752,226 | -210,233 | 0.01 | 0.01 | -0.00 | sell |
| Polar Capital Holdings Plc | 680,000 | 730,000 | +50,000 | 0.24 | 0.28 | +0.05 | buy |
| Novo Holdings A/S | 724,666 | 724,666 | 0 | 2.63 | 3.03 | +0.40 | hold |
| MILLENNIUM MANAGEMENT LLC | 564,856 | 699,006 | +134,150 | 0.04 | 0.04 | +0.01 | buy |
| Holocene Advisors, LP | 0 | 687,712 | +687,712 | 0.00 | 0.15 | +0.15 | buy |
| EMERALD ADVISERS, LLC | 689,807 | 684,636 | -5,171 | 1.95 | 1.83 | -0.12 | sell |
| TimesSquare Capital Management, LLC | 483,869 | 684,384 | +200,515 | 0.53 | 0.69 | +0.16 | buy |
| BROWN ADVISORY INC | 0 | 662,997 | +662,997 | 0.00 | 0.06 | +0.06 | buy |
| BNP Paribas Asset Management Holding S.A. | 509,439 | 654,901 | +145,462 | 0.09 | 0.11 | +0.02 | buy |
| Long Focus Capital Management, LLC | 628,900 | 650,800 | +21,900 | 4.06 | 3.44 | -0.62 | buy |
| Cormorant Asset Management, LP | 500,000 | 650,000 | +150,000 | 1.94 | 2.46 | +0.53 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 578,356 | 638,848 | +60,492 | 1.90 | 1.48 | -0.43 | buy |
| TWO SIGMA INVESTMENTS, LP | 801,139 | 593,996 | -207,143 | 0.13 | 0.09 | -0.04 | sell |
| Duquesne Family Office LLC | 20,000 | 593,470 | +573,470 | 0.05 | 1.15 | +1.10 | buy |
| Fiera Capital Corp | 592,415 | 581,854 | -10,561 | 0.13 | 0.13 | -0.00 | sell |
| Rock Springs Capital Management LP | 683,344 | 550,000 | -133,344 | 1.62 | 1.45 | -0.18 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 745,794 | 548,867 | -196,927 | 0.06 | 0.04 | -0.02 | sell |
| Ensign Peak Advisors, Inc | 484,121 | 529,049 | +44,928 | 0.06 | 0.06 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 513,082 | 526,890 | +13,808 | 0.03 | 0.03 | -0.00 | buy |
| Assenagon Asset Management S.A. | 857,360 | 525,193 | -332,167 | 0.13 | 0.07 | -0.06 | sell |
| Eagle Health Investments LP | 513,700 | 513,700 | 0 | 7.23 | 8.69 | +1.47 | hold |
| D. E. Shaw & Co., Inc. | 66,735 | 508,787 | +442,052 | 0.01 | 0.04 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 276,942 | 488,966 | +212,024 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 422,936 | 486,847 | +63,911 | 0.01 | 0.01 | -0.00 | buy |
| Sonora Investment Management Group, LLC | 480,000 | 475,000 | -5,000 | 0.08 | 0.08 | -0.00 | sell |
| First Light Asset Management, LLC | 688,910 | 470,192 | -218,718 | 4.18 | 3.11 | -1.08 | sell |
| SOROS FUND MANAGEMENT LLC | 478,601 | 455,089 | -23,512 | 0.70 | 0.55 | -0.15 | sell |
| Candriam S.C.A. | 476,494 | 453,520 | -22,974 | 0.20 | 0.18 | -0.02 | sell |
| Logos Global Management LP | 0 | 450,000 | +450,000 | 0.00 | 3.64 | +3.64 | buy |
| First Turn Management, LLC | 356,451 | 446,980 | +90,529 | 4.12 | 5.53 | +1.41 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 261,546 | 444,435 | +182,889 | 0.03 | 0.05 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 594,106 | 435,006 | -159,100 | 0.41 | 0.29 | -0.12 | sell |
| Allspring Global Investments Holdings, LLC | 390,134 | 423,094 | +32,960 | 0.04 | 0.05 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 455,959 | 410,577 | -45,382 | 0.03 | 0.03 | -0.00 | sell |
| UBS Group AG | 309,992 | 405,725 | +95,733 | 0.01 | 0.01 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 487,664 | 400,624 | -87,040 | 1.85 | 1.68 | -0.17 | sell |
| MPM BioImpact LLC | 615,391 | 389,611 | -225,780 | 6.74 | 3.82 | -2.92 | sell |
| Qube Research & Technologies Ltd | 489,307 | 389,033 | -100,274 | 0.07 | 0.04 | -0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 452,316 | 385,460 | -66,856 | 0.16 | 0.13 | -0.03 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 347,695 | 372,230 | +24,535 | 5.72 | 5.75 | +0.03 | buy |
| SEI INVESTMENTS CO | 333,597 | 362,616 | +29,019 | 0.03 | 0.03 | +0.00 | buy |
| BARCLAYS PLC | 332,063 | 354,436 | +22,373 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 367,252 | 350,939 | -16,313 | 0.01 | 0.01 | -0.00 | sell |
| Caption Management, LLC | 98,800 | 348,994 | +250,194 | 0.77 | 0.99 | +0.22 | buy |
| C WorldWide Group Holding A/S | 343,110 | 343,110 | 0 | 0.26 | 0.29 | +0.03 | hold |
| Octagon Capital Advisors LP | 436,820 | 332,000 | -104,820 | 5.10 | 3.90 | -1.21 | sell |
| TWO SIGMA ADVISERS, LP | 392,700 | 326,500 | -66,200 | 0.07 | 0.05 | -0.01 | sell |
| CITADEL ADVISORS LLC | 336,562 | 323,735 | -12,827 | 0.03 | 0.02 | -0.00 | sell |
| Swiss National Bank | 302,500 | 321,100 | +18,600 | 0.01 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 30,272 | 320,272 | +290,000 | 0.18 | 1.67 | +1.49 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 292,779 | 317,753 | +24,974 | 0.03 | 0.03 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 290,470 | 317,162 | +26,692 | 0.10 | 0.10 | -0.00 | buy |