| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 10,497,277 | 12,960,538 | +2,463,261 | 62.31 | 84.75 | +22.44 | buy |
| VANGUARD GROUP INC | 17,143,177 | 18,218,973 | +1,075,796 | 0.02 | 0.02 | -0.00 | buy |
| BlackRock, Inc. | 14,970,152 | 16,032,944 | +1,062,792 | 0.02 | 0.02 | -0.00 | buy |
| Holocene Advisors, LP | 0 | 687,712 | +687,712 | 0.00 | 0.15 | +0.15 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 251,739 | 938,551 | +686,812 | 0.08 | 0.28 | +0.20 | buy |
| BROWN ADVISORY INC | 0 | 662,997 | +662,997 | 0.00 | 0.06 | +0.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,032,562 | 1,647,562 | +615,000 | 0.13 | 0.20 | +0.07 | buy |
| Capital International Investors | 6,523,791 | 7,116,997 | +593,206 | 0.09 | 0.09 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,415,918 | 5,006,863 | +590,945 | 3.34 | 3.69 | +0.35 | buy |
| Duquesne Family Office LLC | 20,000 | 593,470 | +573,470 | 0.05 | 1.15 | +1.10 | buy |
| Logos Global Management LP | 0 | 450,000 | +450,000 | 0.00 | 3.64 | +3.64 | buy |
| D. E. Shaw & Co., Inc. | 66,735 | 508,787 | +442,052 | 0.01 | 0.04 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 1,393,049 | 1,720,049 | +327,000 | 0.02 | 0.02 | +0.00 | buy |
| MARSHALL WACE, LLP | 771,211 | 1,064,215 | +293,004 | 0.07 | 0.09 | +0.02 | buy |
| NORTHERN TRUST CORP | 1,459,964 | 1,750,642 | +290,678 | 0.02 | 0.02 | -0.00 | buy |
| Soleus Capital Management, L.P. | 30,272 | 320,272 | +290,000 | 0.18 | 1.67 | +1.49 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,813,384 | 4,087,143 | +273,759 | 0.02 | 0.02 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,580,419 | 2,850,097 | +269,678 | 0.05 | 0.05 | +0.00 | buy |
| Caption Management, LLC | 98,800 | 348,994 | +250,194 | 0.77 | 0.99 | +0.22 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 243,748 | +243,748 | 0.00 | 2.04 | +2.04 | buy |
| Artisan Partners Limited Partnership | 2,884,097 | 3,126,339 | +242,242 | 0.32 | 0.33 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 276,942 | 488,966 | +212,024 | 0.01 | 0.01 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 483,869 | 684,384 | +200,515 | 0.53 | 0.69 | +0.16 | buy |
| FIL Ltd | 2,439,748 | 2,638,160 | +198,412 | 0.16 | 0.17 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 906,395 | 1,100,993 | +194,598 | 1.14 | 1.38 | +0.24 | buy |
| FEDERATED HERMES, INC. | 42,983 | 235,836 | +192,853 | 0.01 | 0.04 | +0.03 | buy |
| Alyeska Investment Group, L.P. | 747,402 | 935,779 | +188,377 | 0.28 | 0.24 | -0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 261,546 | 444,435 | +182,889 | 0.03 | 0.05 | +0.01 | buy |
| NWI MANAGEMENT LP | 97,540 | 279,000 | +181,460 | 0.85 | 1.52 | +0.68 | buy |
| Aberdeen Group plc | 111,612 | 289,653 | +178,041 | 0.01 | 0.04 | +0.02 | buy |
| NORGES BANK | 1,656,767 | 1,833,810 | +177,043 | 0.02 | 0.02 | -0.00 | buy |
| Cormorant Asset Management, LP | 500,000 | 650,000 | +150,000 | 1.94 | 2.46 | +0.53 | buy |
| BNP Paribas Asset Management Holding S.A. | 509,439 | 654,901 | +145,462 | 0.09 | 0.11 | +0.02 | buy |
| Patient Square Capital LP | 171,704 | 307,167 | +135,463 | 4.65 | 7.93 | +3.28 | buy |
| MILLENNIUM MANAGEMENT LLC | 564,856 | 699,006 | +134,150 | 0.04 | 0.04 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 140,422 | 268,063 | +127,641 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 121,266 | 247,443 | +126,177 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,580,981 | 12,704,410 | +123,429 | 0.11 | 0.10 | -0.00 | buy |
| Senator Investment Group LP | 0 | 120,000 | +120,000 | 0.00 | 0.24 | +0.24 | buy |
| Artia Global Partners LP | 52,939 | 167,939 | +115,000 | 1.09 | 4.68 | +3.58 | buy |
| COMERICA BANK | 62,094 | 170,780 | +108,686 | 0.02 | 0.05 | +0.03 | buy |
| STEMPOINT CAPITAL LP | 0 | 106,610 | +106,610 | 0.00 | 1.85 | +1.85 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,444,266 | 1,546,607 | +102,341 | 0.02 | 0.02 | -0.00 | buy |
| Integral Health Asset Management, LLC | 1,450,000 | 1,550,000 | +100,000 | 12.46 | 9.46 | -3.00 | buy |
| Pictet Asset Management Holding SA | 1,863,341 | 1,959,718 | +96,377 | 0.15 | 0.15 | -0.00 | buy |
| UBS Group AG | 309,992 | 405,725 | +95,733 | 0.01 | 0.01 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 94,559 | +94,559 | 0.00 | 0.14 | +0.14 | buy |
| J. Goldman & Co LP | 11,226 | 104,179 | +92,953 | 0.04 | 0.25 | +0.22 | buy |
| First Turn Management, LLC | 356,451 | 446,980 | +90,529 | 4.12 | 5.53 | +1.41 | buy |
| AMERICAN CENTURY COMPANIES INC | 723,683 | 812,780 | +89,097 | 0.03 | 0.03 | +0.00 | buy |
| Nicholas Investment Partners, LP | 101,145 | 182,743 | +81,598 | 0.68 | 1.11 | +0.43 | buy |
| Clearbridge Investments, LLC | 1,808,767 | 1,878,450 | +69,683 | 0.10 | 0.11 | +0.00 | buy |
| Aquatic Capital Management LLC | 23,000 | 91,268 | +68,268 | 0.04 | 0.17 | +0.13 | buy |
| Twin Tree Management, LP | 0 | 65,147 | +65,147 | 0.00 | 0.11 | +0.11 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 422,936 | 486,847 | +63,911 | 0.01 | 0.01 | -0.00 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 578,356 | 638,848 | +60,492 | 1.90 | 1.48 | -0.43 | buy |
| EFG Asset Management (North America) Corp. | 50,867 | 107,625 | +56,758 | 0.62 | 1.01 | +0.39 | buy |
| Hood River Capital Management LLC | 1,472,555 | 1,525,628 | +53,073 | 1.74 | 1.56 | -0.18 | buy |
| Polar Capital Holdings Plc | 680,000 | 730,000 | +50,000 | 0.24 | 0.28 | +0.05 | buy |
| Russell Investments Group, Ltd. | 86,759 | 132,154 | +45,395 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 484,121 | 529,049 | +44,928 | 0.06 | 0.06 | +0.00 | buy |
| F/m Investments LLC | 0 | 42,793 | +42,793 | 0.00 | 0.11 | +0.11 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 17,682 | 59,600 | +41,918 | 0.06 | 0.18 | +0.12 | buy |
| Edgestream Partners, L.P. | 3,250 | 43,619 | +40,369 | 0.01 | 0.13 | +0.12 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 20,815 | 58,970 | +38,155 | 0.00 | 0.01 | +0.01 | buy |
| Neuberger Berman Group LLC | 111,838 | 149,241 | +37,403 | 0.01 | 0.01 | +0.00 | buy |
| NWAM LLC | 0 | 36,096 | +36,096 | 0.00 | 0.15 | +0.15 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 35,966 | +35,966 | 0.00 | 2.18 | +2.18 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 35,478 | +35,478 | 0.00 | 0.45 | +0.45 | buy |
| WELLS FARGO & COMPANY/MN | 127,495 | 160,709 | +33,214 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 390,134 | 423,094 | +32,960 | 0.04 | 0.05 | +0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 31,390 | +31,390 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 1,320,991 | 1,351,365 | +30,374 | 0.01 | 0.01 | -0.00 | buy |
| SEI INVESTMENTS CO | 333,597 | 362,616 | +29,019 | 0.03 | 0.03 | +0.00 | buy |
| MACQUARIE GROUP LTD | 2,285,921 | 2,313,159 | +27,238 | 0.18 | 0.19 | +0.01 | buy |
| Proficio Capital Partners LLC | 0 | 26,995 | +26,995 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 290,470 | 317,162 | +26,692 | 0.10 | 0.10 | -0.00 | buy |
| RHUMBLINE ADVISERS | 263,045 | 288,337 | +25,292 | 0.02 | 0.02 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 25,287 | +25,287 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 288,073 | 313,181 | +25,108 | 0.02 | 0.02 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 292,779 | 317,753 | +24,974 | 0.03 | 0.03 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 46,593 | 71,227 | +24,634 | 0.04 | 0.05 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 347,695 | 372,230 | +24,535 | 5.72 | 5.75 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 12,118 | 36,058 | +23,940 | 0.02 | 0.06 | +0.04 | buy |
| BARCLAYS PLC | 332,063 | 354,436 | +22,373 | 0.01 | 0.01 | +0.00 | buy |
| Baird Financial Group, Inc. | 0 | 22,289 | +22,289 | 0.00 | 0.00 | +0.00 | buy |
| Long Focus Capital Management, LLC | 628,900 | 650,800 | +21,900 | 4.06 | 3.44 | -0.62 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 172,837 | 193,479 | +20,642 | 0.38 | 0.40 | +0.01 | buy |
| Simplify Asset Management Inc. | 0 | 20,520 | +20,520 | 0.00 | 0.10 | +0.10 | buy |
| BAMCO INC /NY/ | 40,500 | 60,000 | +19,500 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 302,500 | 321,100 | +18,600 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 3,634 | 21,974 | +18,340 | 0.04 | 0.31 | +0.27 | buy |
| ProShare Advisors LLC | 39,850 | 56,991 | +17,141 | 0.01 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,293 | 18,487 | +16,194 | 0.00 | 0.03 | +0.02 | buy |
| CIBC WORLD MARKETS CORP | 0 | 16,135 | +16,135 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 241,131 | 256,358 | +15,227 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 161,768 | 176,014 | +14,246 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 513,082 | 526,890 | +13,808 | 0.03 | 0.03 | -0.00 | buy |
| MetLife Investment Management, LLC | 89,622 | 103,429 | +13,807 | 0.04 | 0.04 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 109,325 | 122,111 | +12,786 | 0.02 | 0.02 | +0.00 | buy |