| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NORGES BANK | 0 | 2,910,971 | +2,910,971 | 0.00 | 0.05 | +0.05 | buy |
| Invesco Ltd. | 2,003,871 | 4,791,481 | +2,787,610 | 0.05 | 0.10 | +0.06 | buy |
| BlackRock, Inc. | 12,364,904 | 15,065,052 | +2,700,148 | 0.03 | 0.04 | +0.01 | buy |
| RTW INVESTMENTS, LP | 3,084,558 | 4,842,879 | +1,758,321 | 5.47 | 8.44 | +2.97 | buy |
| STATE STREET CORP | 3,984,354 | 5,201,744 | +1,217,390 | 0.02 | 0.03 | +0.01 | buy |
| VANGUARD GROUP INC | 19,935,820 | 21,076,344 | +1,140,524 | 0.04 | 0.05 | +0.01 | buy |
| Orbis Allan Gray Ltd | 3,250,868 | 4,179,957 | +929,089 | 2.01 | 3.05 | +1.04 | buy |
| Jefferies Financial Group Inc. | 108,097 | 926,339 | +818,242 | 0.14 | 1.32 | +1.18 | buy |
| FMR LLC | 9,180,963 | 9,927,936 | +746,973 | 0.07 | 0.09 | +0.02 | buy |
| MORGAN STANLEY | 963,631 | 1,631,906 | +668,275 | 0.01 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 2,139,725 | 2,755,536 | +615,811 | 0.08 | 0.12 | +0.04 | buy |
| Amundi | 317,096 | 916,998 | +599,902 | 0.02 | 0.04 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,759,427 | 4,299,052 | +539,625 | 0.03 | 0.05 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 433,340 | 915,419 | +482,079 | 0.05 | 0.10 | +0.05 | buy |
| Darwin Global Management, Ltd. | 20,457,445 | 20,933,277 | +475,832 | 80.54 | 73.78 | -6.76 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 0 | 435,442 | +435,442 | 0.00 | 0.04 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 512,749 | 943,306 | +430,557 | 0.02 | 0.03 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 829,317 | 1,244,913 | +415,596 | 0.02 | 0.03 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 204,354 | 590,030 | +385,676 | 0.01 | 0.03 | +0.02 | buy |
| GATEWAY INVESTMENT ADVISERS LLC | 0 | 365,000 | +365,000 | 0.00 | 0.59 | +0.59 | buy |
| TWO SIGMA ADVISERS, LP | 51,300 | 395,000 | +343,700 | 0.01 | 0.13 | +0.12 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 37,481 | 380,561 | +343,080 | 0.01 | 0.12 | +0.11 | buy |
| ProShare Advisors LLC | 7,530 | 340,740 | +333,210 | 0.00 | 0.10 | +0.10 | buy |
| Legal & General Group Plc | 208,021 | 540,313 | +332,292 | 0.01 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 114,196 | 444,706 | +330,510 | 0.01 | 0.03 | +0.03 | buy |
| FEDERATED HERMES, INC. | 328,223 | 632,298 | +304,075 | 0.08 | 0.18 | +0.10 | buy |
| Nearwater Capital Markets, Ltd | 200,000 | 500,000 | +300,000 | 0.39 | 1.49 | +1.10 | buy |
| SEI INVESTMENTS CO | 593,885 | 890,170 | +296,285 | 0.09 | 0.15 | +0.06 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 354,907 | 646,714 | +291,807 | 0.03 | 0.06 | +0.03 | buy |
| Zurich Insurance Group Ltd/FI | 0 | 281,098 | +281,098 | 0.00 | 0.34 | +0.34 | buy |
| National Pension Service | 0 | 280,442 | +280,442 | 0.00 | 0.04 | +0.04 | buy |
| Bank of New York Mellon Corp | 1,138,901 | 1,390,042 | +251,141 | 0.03 | 0.04 | +0.01 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 321 | 222,266 | +221,945 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 1,646,239 | 1,867,635 | +221,396 | 0.05 | 0.06 | +0.02 | buy |
| Swiss National Bank | 371,300 | 579,112 | +207,812 | 0.03 | 0.06 | +0.03 | buy |
| Alberta Investment Management Corp | 0 | 206,532 | +206,532 | 0.00 | 0.22 | +0.22 | buy |
| TWO SIGMA INVESTMENTS, LP | 772,780 | 962,156 | +189,376 | 0.17 | 0.25 | +0.08 | buy |
| Fiera Capital Corp | 809,121 | 992,892 | +183,771 | 0.38 | 0.55 | +0.17 | buy |
| AQR CAPITAL MANAGEMENT LLC | 287,286 | 468,260 | +180,974 | 0.03 | 0.04 | +0.02 | buy |
| TREMBLANT CAPITAL GROUP | 0 | 175,650 | +175,650 | 0.00 | 0.78 | +0.78 | buy |
| NORTHERN TRUST CORP | 1,072,942 | 1,238,438 | +165,496 | 0.02 | 0.03 | +0.01 | buy |
| Castle Hook Partners LP | 1,091,405 | 1,253,568 | +162,163 | 2.38 | 3.14 | +0.76 | buy |
| CITIGROUP INC | 80,086 | 237,914 | +157,828 | 0.01 | 0.03 | +0.02 | buy |
| JPMORGAN CHASE & CO | 23,047,676 | 23,199,512 | +151,836 | 0.21 | 0.27 | +0.06 | buy |
| AXIOM INVESTORS LLC /DE | 107,733 | 255,849 | +148,116 | 0.11 | 0.39 | +0.28 | buy |
| Perpetual Ltd | 0 | 141,517 | +141,517 | 0.00 | 0.36 | +0.36 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 179,402 | 310,330 | +130,928 | 0.03 | 0.05 | +0.03 | buy |
| Caption Management, LLC | 81 | 130,000 | +129,919 | 0.00 | 1.00 | +1.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 198,702 | 328,328 | +129,626 | 0.07 | 0.07 | -0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,601,806 | 1,725,681 | +123,875 | 0.02 | 0.02 | +0.00 | buy |
| HSBC HOLDINGS PLC | 1,512 | 123,267 | +121,755 | 0.00 | 0.01 | +0.01 | buy |
| Evergreen Quality Fund GP, Ltd. | 0 | 120,500 | +120,500 | 0.00 | 0.41 | +0.41 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,975 | 120,381 | +116,406 | 0.00 | 0.03 | +0.03 | buy |
| AVIVA PLC | 0 | 109,401 | +109,401 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 76,679 | 185,090 | +108,411 | 0.01 | 0.02 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 54,200 | 161,824 | +107,624 | 0.02 | 0.06 | +0.04 | buy |
| NATIONAL BANK OF CANADA /FI/ | 2,481 | 108,706 | +106,225 | 0.00 | 0.02 | +0.02 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 0 | 83,032 | +83,032 | 0.00 | 0.03 | +0.03 | buy |
| Asset Management One Co., Ltd. | 0 | 80,887 | +80,887 | 0.00 | 0.04 | +0.04 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 3,363 | 83,544 | +80,181 | 0.00 | 0.04 | +0.04 | buy |
| ExodusPoint Capital Management, LP | 0 | 80,087 | +80,087 | 0.00 | 0.16 | +0.16 | buy |
| SAMLYN CAPITAL, LLC | 292,643 | 369,575 | +76,932 | 0.60 | 1.03 | +0.43 | buy |
| WELLS FARGO & COMPANY/MN | 513,849 | 586,651 | +72,802 | 0.02 | 0.02 | +0.00 | buy |
| Korea Investment CORP | 0 | 72,629 | +72,629 | 0.00 | 0.02 | +0.02 | buy |
| Mirae Asset Global Investments Co., Ltd. | 9,082 | 78,492 | +69,410 | 0.00 | 0.04 | +0.03 | buy |
| Squarepoint Ops LLC | 0 | 66,402 | +66,402 | 0.00 | 0.02 | +0.02 | buy |
| TimesSquare Capital Management, LLC | 425,085 | 490,506 | +65,421 | 0.88 | 1.29 | +0.41 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 65,313 | +65,313 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 588,122 | 650,404 | +62,282 | 0.02 | 0.03 | +0.01 | buy |
| Resona Asset Management Co.,Ltd. | 0 | 60,381 | +60,381 | 0.00 | 0.05 | +0.05 | buy |
| Alyeska Investment Group, L.P. | 0 | 60,000 | +60,000 | 0.00 | 0.03 | +0.03 | buy |
| Swedbank AB | 0 | 59,552 | +59,552 | 0.00 | 0.01 | +0.01 | buy |
| AGF MANAGEMENT LTD | 0 | 58,835 | +58,835 | 0.00 | 0.04 | +0.04 | buy |
| Neuberger Berman Group LLC | 150,106 | 207,869 | +57,763 | 0.02 | 0.03 | +0.01 | buy |
| NISSAY ASSET MANAGEMENT CORP /JAPAN | 0 | 57,665 | +57,665 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 212,903 | 268,326 | +55,423 | 0.02 | 0.04 | +0.01 | buy |
| Sofinnova Investments, Inc. | 104,339 | 156,801 | +52,462 | 0.92 | 1.18 | +0.25 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 975,279 | 1,027,355 | +52,076 | 0.02 | 0.03 | +0.01 | buy |
| FJARDE AP-FONDEN /FOURTH SWEDISH NATIONAL PENSION FUND | 0 | 50,500 | +50,500 | 0.00 | 0.07 | +0.07 | buy |
| Monashee Investment Management LLC | 0 | 50,000 | +50,000 | 0.00 | 4.90 | +4.90 | buy |
| SG Americas Securities, LLC | 17,406 | 66,762 | +49,356 | 0.01 | 0.02 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 54,529 | 103,308 | +48,779 | 0.01 | 0.03 | +0.02 | buy |
| Soleus Capital Management, L.P. | 2,550 | 48,500 | +45,950 | 0.02 | 0.36 | +0.34 | buy |
| Rafferty Asset Management, LLC | 55,159 | 100,812 | +45,653 | 0.03 | 0.06 | +0.03 | buy |
| GUGGENHEIM CAPITAL LLC | 36,860 | 82,291 | +45,431 | 0.04 | 0.11 | +0.07 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 135,020 | 180,295 | +45,275 | 0.03 | 0.06 | +0.02 | buy |
| FORSTA AP-FONDEN | 0 | 45,100 | +45,100 | 0.00 | 0.05 | +0.05 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 310,886 | 354,909 | +44,023 | 0.03 | 0.04 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 44,009 | +44,009 | 0.00 | 0.54 | +0.54 | buy |
| CIBC Asset Management Inc | 4,777 | 48,463 | +43,686 | 0.00 | 0.02 | +0.02 | buy |
| NEOS Investment Management LLC | 4,297 | 47,957 | +43,660 | 0.00 | 0.05 | +0.04 | buy |
| PARNASSUS INVESTMENTS, LLC | 8,727 | 51,643 | +42,916 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 12,468 | 54,783 | +42,315 | 0.02 | 0.11 | +0.09 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 54,784 | 96,353 | +41,569 | 0.03 | 0.07 | +0.04 | buy |
| IFM Investors Pty Ltd | 0 | 40,165 | +40,165 | 0.00 | 0.06 | +0.06 | buy |
| GF FUND MANAGEMENT CO. LTD. | 4,548 | 42,227 | +37,679 | 0.01 | 0.13 | +0.11 | buy |
| DnB Asset Management AS | 3,396 | 40,918 | +37,522 | 0.00 | 0.02 | +0.02 | buy |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 0 | 37,507 | +37,507 | 0.00 | 0.03 | +0.03 | buy |
| Andra AP-fonden | 0 | 36,300 | +36,300 | 0.00 | 0.08 | +0.08 | buy |
| Freestone Grove Partners LP | 0 | 36,200 | +36,200 | 0.00 | 0.05 | +0.05 | buy |