| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 3,743,018 | 3,702,967 | -40,051 | 1.58 | 0.81 | -0.77 | sell |
| BlackRock, Inc. | 3,075,837 | 3,007,110 | -68,727 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,392,052 | 2,278,465 | -113,587 | 0.00 | 0.00 | -0.00 | sell |
| Artisan Partners Limited Partnership | 1,767,523 | 2,252,544 | +485,021 | 0.07 | 0.04 | -0.03 | buy |
| D. E. Shaw & Co., Inc. | 22,000 | 1,321,330 | +1,299,330 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 655,511 | 1,229,262 | +573,751 | 0.01 | 0.01 | -0.00 | buy |
| No Street GP LP | 600,000 | 1,200,000 | +600,000 | 1.19 | 1.17 | -0.02 | buy |
| BROWN CAPITAL MANAGEMENT LLC | 947,288 | 1,119,240 | +171,952 | 0.72 | 0.42 | -0.30 | buy |
| CITADEL ADVISORS LLC | 230,221 | 1,027,863 | +797,642 | 0.01 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 406,386 | 1,001,723 | +595,337 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 897,846 | 951,177 | +53,331 | 0.02 | 0.01 | -0.01 | buy |
| STATE STREET CORP | 898,669 | 916,215 | +17,546 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 392,332 | 888,950 | +496,618 | 0.20 | 0.21 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 863,260 | 862,669 | -591 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 727,952 | +727,952 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 631,238 | 633,874 | +2,636 | 1.89 | 0.95 | -0.94 | buy |
| ROYAL BANK OF CANADA | 476,992 | 529,226 | +52,234 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 215,075 | 481,064 | +265,989 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 392,231 | 468,945 | +76,714 | 0.01 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 407,035 | 466,923 | +59,888 | 0.02 | 0.01 | -0.01 | buy |
| WASATCH ADVISORS LP | 383,487 | 448,539 | +65,052 | 0.05 | 0.03 | -0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 118,890 | 440,456 | +321,566 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 451,600 | 426,400 | -25,200 | 0.02 | 0.01 | -0.01 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 525,882 | 401,635 | -124,247 | 0.05 | 0.02 | -0.03 | sell |
| Qube Research & Technologies Ltd | 323,023 | 386,210 | +63,187 | 0.01 | 0.01 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 391,663 | 385,972 | -5,691 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 157,055 | 374,663 | +217,608 | 0.01 | 0.01 | +0.00 | buy |
| Atika Capital Management LLC | 512,773 | 354,907 | -157,866 | 1.99 | 0.48 | -1.51 | sell |
| NORTHERN TRUST CORP | 438,425 | 341,749 | -96,676 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 451,602 | 312,220 | -139,382 | 0.03 | 0.01 | -0.02 | sell |
| Kent Lake PR LLC | 0 | 300,000 | +300,000 | 0.00 | 1.72 | +1.72 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 287,323 | 292,317 | +4,994 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 139,063 | 280,135 | +141,072 | 0.09 | 0.08 | -0.01 | buy |
| Schonfeld Strategic Advisors LLC | 164,969 | 265,006 | +100,037 | 0.03 | 0.03 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 261,311 | +261,311 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 81,425 | 259,775 | +178,350 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 144,405 | 259,378 | +114,973 | 0.04 | 0.04 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 310,411 | 252,247 | -58,164 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 85,138 | 249,336 | +164,198 | 0.03 | 0.04 | +0.01 | buy |
| Vitruvian Partners LLP | 230,743 | 230,743 | 0 | 5.56 | 1.83 | -3.73 | hold |
| Divisadero Street Capital Management, LP | 885,432 | 218,918 | -666,514 | 2.57 | 0.19 | -2.38 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 93,382 | 208,663 | +115,281 | 0.00 | 0.00 | -0.00 | buy |
| Grandeur Peak Global Advisors, LLC | 99,179 | 194,050 | +94,871 | 0.28 | 0.30 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 94,500 | 181,400 | +86,900 | 0.01 | 0.00 | -0.00 | buy |
| Circle Wealth Management, LLC | 165,719 | 165,719 | 0 | 0.10 | 0.05 | -0.05 | hold |
| Ensign Peak Advisors, Inc | 205,914 | 159,100 | -46,814 | 0.01 | 0.00 | -0.01 | sell |
| FMR LLC | 1,033,754 | 157,137 | -876,617 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 2,183,866 | 142,782 | -2,041,084 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 142,000 | +142,000 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 41,400 | 131,400 | +90,000 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 58,025 | 126,353 | +68,328 | 0.01 | 0.01 | +0.00 | buy |
| 4D Advisors, LLC | 65,000 | 125,000 | +60,000 | 1.28 | 0.87 | -0.40 | buy |
| WELLS FARGO & COMPANY/MN | 27,604 | 120,487 | +92,883 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 119,009 | +119,009 | 0.00 | 0.03 | +0.03 | buy |
| Nuveen, LLC | 220,175 | 111,923 | -108,252 | 0.00 | 0.00 | -0.00 | sell |
| Militia Capital Partners, LP | 30,000 | 110,900 | +80,900 | 0.38 | 0.68 | +0.30 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 110,051 | +110,051 | 0.00 | 0.03 | +0.03 | buy |
| GROUP ONE TRADING LLC | 0 | 108,509 | +108,509 | 0.00 | 0.05 | +0.05 | buy |
| Carnegie Lake Advisors LLC | 0 | 107,000 | +107,000 | 0.00 | 0.55 | +0.55 | buy |
| Bank of New York Mellon Corp | 103,659 | 106,563 | +2,904 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 88,889 | 103,419 | +14,530 | 0.04 | 0.02 | -0.02 | buy |
| TWINBEECH CAPITAL LP | 0 | 94,590 | +94,590 | 0.00 | 0.03 | +0.03 | buy |
| PDT Partners, LLC | 0 | 89,624 | +89,624 | 0.00 | 0.07 | +0.07 | buy |
| BRADLEY FOSTER & SARGENT INC/CT | 0 | 86,055 | +86,055 | 0.00 | 0.02 | +0.02 | buy |
| GILDER GAGNON HOWE & CO LLC | 176,751 | 84,047 | -92,704 | 0.06 | 0.01 | -0.05 | sell |
| FIRST CITIZENS BANK & TRUST CO | 76,816 | 76,816 | 0 | 0.05 | 0.02 | -0.03 | hold |
| Dynamic Technology Lab Private Ltd | 0 | 76,728 | +76,728 | 0.00 | 0.14 | +0.14 | buy |
| BARCLAYS PLC | 55,066 | 74,510 | +19,444 | 0.00 | 0.00 | -0.00 | buy |
| CAXTON ASSOCIATES LLP | 0 | 70,279 | +70,279 | 0.00 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 38,456 | 67,772 | +29,316 | 0.09 | 0.06 | -0.03 | buy |
| XTX Topco Ltd | 21,404 | 67,304 | +45,900 | 0.03 | 0.04 | +0.01 | buy |
| SG Americas Securities, LLC | 36,267 | 66,600 | +30,333 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 66,300 | 66,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 38,307 | 64,300 | +25,993 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 36,898 | 62,927 | +26,029 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 197,855 | 60,358 | -137,497 | 0.06 | 0.01 | -0.05 | sell |
| Nebula Research & Development LLC | 60,048 | 60,048 | 0 | 0.14 | 0.07 | -0.07 | hold |
| RHUMBLINE ADVISERS | 51,576 | 58,091 | +6,515 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 50,059 | 54,893 | +4,834 | 0.01 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 87,193 | 54,433 | -32,760 | 0.07 | 0.02 | -0.05 | sell |
| TUDOR INVESTMENT CORP ET AL | 87,304 | 51,262 | -36,042 | 0.02 | 0.01 | -0.01 | sell |
| One Capital Management, LLC | 0 | 46,749 | +46,749 | 0.00 | 0.02 | +0.02 | buy |
| Future Fund LLC | 0 | 46,749 | +46,749 | 0.00 | 0.27 | +0.27 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,641 | 46,151 | +1,510 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 42,453 | 44,574 | +2,121 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 31,934 | 43,998 | +12,064 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 333,617 | 40,901 | -292,716 | 0.11 | 0.01 | -0.10 | sell |
| ALLIANCEBERNSTEIN L.P. | 37,100 | 37,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Voleon Capital Management LP | 0 | 35,733 | +35,733 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 162,803 | 34,147 | -128,656 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 32,602 | 32,602 | 0 | 0.01 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,731 | 31,731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AXQ CAPITAL, LP | 0 | 31,125 | +31,125 | 0.00 | 0.13 | +0.13 | buy |
| IHT Wealth Management, LLC | 14,335 | 28,610 | +14,275 | 0.01 | 0.01 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 26,969 | 27,064 | +95 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 11,693 | 25,314 | +13,621 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,748 | 23,102 | +5,354 | 0.00 | 0.00 | -0.00 | buy |
| Tempus Wealth Planning, LLC | 10,788 | 22,565 | +11,777 | 0.08 | 0.07 | -0.01 | buy |
| PEAK6 LLC | 0 | 22,303 | +22,303 | 0.00 | 0.01 | +0.01 | buy |
| NOMURA HOLDINGS INC | 0 | 21,937 | +21,937 | 0.00 | 0.00 | +0.00 | buy |